Catalytic inhibitors of topoisomerase II are DNA-damaging agents: Induction of chromosomal damage by merbarone and ICRF-187

Environmental and Molecular Mutagenesis

Volumn 39, Issue 4, 2002, Pages 348-356

  Wang, Ling ^a   Eastmond, David A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Etoposide; Genotoxicity; ICRF 187; Merbarone; Micronucleus assay; Topoisomerase II inhibitors

Indexed keywords

ACRIDINE ORANGE; CLASTOGEN; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; GYRASE INHIBITOR; MERBARONE; PROTEIN P53; RAZOXANE;

ANIMAL CELL; ANIMAL EXPERIMENT; CELL VIABILITY; CENTROMERE; CHROMOSOME DAMAGE; CONFERENCE PAPER; CONTROLLED STUDY; DNA CLEAVAGE; DNA DAMAGE; DNA PROTEIN COMPLEX; DRUG CYTOTOXICITY; ERYTHROCYTE; GENOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; LYMPHOBLASTOID CELL; MALE; MICRONUCLEUS; MOUSE; NONHUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; CELL SURVIVAL; DNA DAMAGE; DNA TOPOISOMERASES, TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; KINETOCHORES; MICE; MICRONUCLEUS TESTS; RAZOXANE; THIOBARBITURATES;

STAPHYLOCOCCUS PHAGE 187;

EID: 0036304758     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.10072     Document Type: Conference Paper

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