Germ cell mutagenicity of γ-ethyl-γ-phenyl-butyrolactone (EPBL) detected in the CF1 mouse-dominant lethal study

Toxicology Letters

Volumn 142, Issue 1-2, 2003, Pages 37-43

  Chamorro, Germán ^a   Vega, Fernando ^a   Madrigal, Eduardo ^a   Mercado, Efraín ^b   Salazar, María ^a  

^a INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^b UNIVERSIDAD AUTÓNOMA METROPOLITANA   (Mexico)

Author keywords

Dominant lethal; Germ cell mutagenicity; Ethyl phenyl butyrolactone

Indexed keywords

GAMMA BUTYROLACTONE DERIVATIVE; GAMMA ETHYL GAMMA PHENYLBUTYROLACTONE; MUTAGENIC AGENT; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GERM CELL; INCIDENCE; MALE; MATING; MEIOSIS; MOUSE; MUTAGENICITY; NONHUMAN; OVARY; PREGNANCY; PRIORITY JOURNAL; UTERUS;

EID: 0345268658     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(02)00482-4     Document Type: Article

References (19)

1. Adler I.D., Anderson D. Dominant lethal effects after inhalation exposure to 1,3-butadiene. Mutat. Res. 309:1994;295-297.
2. Albert M., Roussel C. Changes from puberty to adulthood in the concentration, motility and morphology of mouse epididymal spermatozoa. Int. J. Androl. 6:1983;446-460.
3. Bateman A.J. Testing chemicals for mutagenicity in a mammal. Nature. 210:1966;205-206.
4. Chamorro G., Salazar M., Salazar S., Ulloa V., Carvajal G., Martínez D. Evaluation of the toxic and teratogenic potential of the anticonvulsant drug 4-hydroxy, 4-ethyl, 4-phenylbutyramide in mice. Arch. Med. Res. 25:1994;441-446.
5. Chamorro G., Vega F., Madrigal E., Salazar M. Reproductive toxicity of a new anticonvulsant and hypnotic drug in mice: fertility and peri- and postnatal studies of γ-ethyl-γ-phenyl-butyrolactone. Arzneimittel-Forsch. 52:2002;524-528.
6. Epstein D.S., Arnold E., Bass J., Bishop Y. Detection of chemical mutagens by the dominant lethal assay in the mouse. Toxicol. Appl. Pharmacol. 23:1972;288-325.
7. Holmstrom L.M., Palmer A.K., Favor J. The rodent-dominant lethal assay. Kirkland D.J., Fox M. Supplementary Mutagenicity Tests. UKEMS Recommended Procedures. 1993;129-156 Cambridge University Press, Cambridge.
8. Katoh M.A., Caind K.T., Hughes L.A., Foxworth L.B., Bishop J.B., Generoso W.M. Female-specific dominant lethal effects in mice. Mutat. Res. 230:1990;205-217.
9. Kronevi T., Holmberg B., Arvidson S. Teratogenicity test of γ-butyrolactone in the Sprague-Dawley rat. Pharmacol. Toxicol. 62:1988;57-58.
10. Nagao T. Frequency of congenital defects and dominant lethals in the offspring of male mice treated with methylnitrosourea. Mutat. Res. 177:1987;171-178.
11. Odeigah P.G.C. Sperm head abnormalities and dominant lethal effects of formaldehyde in albino rats. Mutat. Res. 389:1997;141-148.
12. Rao U.N., Aravindakshan M., Chauhan P.S. Studies on the effect of ethanol on dominant lethal mutations in Swiss, C57Bl6 and CBA mice. Mutat. Res. 311:1994;69-76.
13. Rodríguez, M.A., 1994. Evaluación del efecto teratogénico de la 4-etil-4-fenil-butirolactona. Thesis. Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México D.F.
14. Salazar, M., Rojas, M., Chamorro, G., 1989. Estudio teratogénico de la 4-hidroxi, 4-etil, 4-fenilbutiramida en rata. VI Congreso Brasileiro de Toxicología. Sociedad Brasileira de Toxicología, Sao Paulo, Brasil, 21 al 26 de Octubre. Livro de Resumos. p. N. 2.5.
15. Shelby M.D., Gutiérrez-Espeleta G.A., Generoso W.M., McFee A.F. Mouse-dominant lethal and bone marrow micronucleus studies on methyl vinyl sulphone and divinyl sulphone. Mutat. Res. 250:1991;431-437.
16. Short R.D., Minor J.L., Winston J.M., Lee Ch. A dominant lethal study in male rats after repeated exposures to vinyl chloride or vinylidene chloride. J. Toxicol. Environ. Health. 3:1977;965-968.
17. Sudman P.D., Generoso W.M. Female-specific mutagenic response of mice to hycanthone. Mutat. Res. 246:1991;31-43.
18. Vega-Díaz F., Vega-Rasgado F. 4-Etil-4-fenil-butirolactona, nuevo anticonvulsionante. Ann. Esc. Nal. Cien. Biol. 34:1991;23-36.
19. Vega-Díaz F., García S., Vega-Rasgado F. Propiedades hipnóticas de la 4-etil-4-fenil-butirolactona. Ann. Esc. Nal. Cien. Biol. 37:1992;155-170.