-
1
-
-
2342488852
-
New insights into TGF-beta-Smad signalling
-
10.1016/j.tibs.2004.03.008, 15130563
-
ten Dijke P, Hill CS. New insights into TGF-beta-Smad signalling. Trends Biochem Sci 2004, 29:265-273. 10.1016/j.tibs.2004.03.008, 15130563.
-
(2004)
Trends Biochem Sci
, vol.29
, pp. 265-273
-
-
ten Dijke, P.1
Hill, C.S.2
-
2
-
-
23044466047
-
Specificity and versatility in tgf-beta signaling through Smads
-
10.1146/annurev.cellbio.21.022404.142018, 16212511
-
Feng XH, Derynck R. Specificity and versatility in tgf-beta signaling through Smads. Annu Rev Cell Dev Biol 2005, 21:659-693. 10.1146/annurev.cellbio.21.022404.142018, 16212511.
-
(2005)
Annu Rev Cell Dev Biol
, vol.21
, pp. 659-693
-
-
Feng, X.H.1
Derynck, R.2
-
3
-
-
21344455768
-
BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk
-
10.1016/j.cytogfr.2005.01.009, 15871923
-
Miyazono K, Maeda S, Imamura T. BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk. Cytokine Growth Factor Rev 2005, 16:251-263. 10.1016/j.cytogfr.2005.01.009, 15871923.
-
(2005)
Cytokine Growth Factor Rev
, vol.16
, pp. 251-263
-
-
Miyazono, K.1
Maeda, S.2
Imamura, T.3
-
4
-
-
0242499448
-
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
-
10.1038/nrc1208, 14557817
-
Siegel PM, Massague J. Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer 2003, 3:807-821. 10.1038/nrc1208, 14557817.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 807-821
-
-
Siegel, P.M.1
Massague, J.2
-
5
-
-
0038682002
-
Mechanisms of TGF-beta signaling from cell membrane to the nucleus
-
10.1016/S0092-8674(03)00432-X, 12809600
-
Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003, 113:685-700. 10.1016/S0092-8674(03)00432-X, 12809600.
-
(2003)
Cell
, vol.113
, pp. 685-700
-
-
Shi, Y.1
Massague, J.2
-
7
-
-
0030765945
-
Smad6 inhibits signalling by the TGF-beta superfamily
-
10.1038/39355, 9335505
-
Imamura T, Takase M, Nishihara A, Oeda E, Hanai J, Kawabata M, Miyazono K. Smad6 inhibits signalling by the TGF-beta superfamily. Nature 1997, 389:622-626. 10.1038/39355, 9335505.
-
(1997)
Nature
, vol.389
, pp. 622-626
-
-
Imamura, T.1
Takase, M.2
Nishihara, A.3
Oeda, E.4
Hanai, J.5
Kawabata, M.6
Miyazono, K.7
-
8
-
-
0031587828
-
The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling
-
10.1016/S0092-8674(00)80303-7, 9215638
-
Hayashi H, Abdollah S, Qiu Y, Cai J, Xu YY, Grinnell BW, Richardson MA, Topper JN, Gimbrone MA, Wrana JL, Falb D. The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell 1997, 89:1165-1173. 10.1016/S0092-8674(00)80303-7, 9215638.
-
(1997)
Cell
, vol.89
, pp. 1165-1173
-
-
Hayashi, H.1
Abdollah, S.2
Qiu, Y.3
Cai, J.4
Xu, Y.Y.5
Grinnell, B.W.6
Richardson, M.A.7
Topper, J.N.8
Gimbrone, M.A.9
Wrana, J.L.10
Falb, D.11
-
9
-
-
0035918274
-
Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation
-
10.1074/jbc.C100008200, 11278251
-
Ebisawa T, Fukuchi M, Murakami G, Chiba T, Tanaka K, Imamura T, Miyazono K. Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J Biol Chem 2001, 276:12477-12480. 10.1074/jbc.C100008200, 11278251.
-
(2001)
J Biol Chem
, vol.276
, pp. 12477-12480
-
-
Ebisawa, T.1
Fukuchi, M.2
Murakami, G.3
Chiba, T.4
Tanaka, K.5
Imamura, T.6
Miyazono, K.7
-
10
-
-
0034517389
-
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation
-
10.1016/S1097-2765(00)00134-9, 11163210
-
Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Mol Cell 2000, 6:1365-1375. 10.1016/S1097-2765(00)00134-9, 11163210.
-
(2000)
Mol Cell
, vol.6
, pp. 1365-1375
-
-
Kavsak, P.1
Rasmussen, R.K.2
Causing, C.G.3
Bonni, S.4
Zhu, H.5
Thomsen, G.H.6
Wrana, J.L.7
-
11
-
-
58149213801
-
Non-Smad pathways in TGF-beta signaling
-
10.1038/cr.2008.328, 2635127, 19114990
-
Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res 2009, 19:128-139. 10.1038/cr.2008.328, 2635127, 19114990.
-
(2009)
Cell Res
, vol.19
, pp. 128-139
-
-
Zhang, Y.E.1
-
12
-
-
44949231368
-
Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling
-
10.1371/journal.pone.0001487, 2198940, 18213395
-
Li W, Bengtson MH, Ulbrich A, Matsuda A, Reddy VA, Orth A, Chanda SK, Batalov S, Joazeiro CA. Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS One 2008, 3:e1487. 10.1371/journal.pone.0001487, 2198940, 18213395.
-
(2008)
PLoS One
, vol.3
-
-
Li, W.1
Bengtson, M.H.2
Ulbrich, A.3
Matsuda, A.4
Reddy, V.A.5
Orth, A.6
Chanda, S.K.7
Batalov, S.8
Joazeiro, C.A.9
-
13
-
-
68049084674
-
Breaking the chains: structure and function of the deubiquitinases
-
10.1038/nrm2731, 19626045
-
Komander D, Clague MJ, Urbe S. Breaking the chains: structure and function of the deubiquitinases. Nat Rev Mol Cell Biol 2009, 10:550-563. 10.1038/nrm2731, 19626045.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 550-563
-
-
Komander, D.1
Clague, M.J.2
Urbe, S.3
-
14
-
-
65249186662
-
Polyubiquitin binding and disassembly by deubiquitinating enzymes
-
10.1021/cr800470j, 2734106, 19243136
-
Reyes-Turcu FE, Wilkinson KD. Polyubiquitin binding and disassembly by deubiquitinating enzymes. Chem Rev 2009, 109:1495-1508. 10.1021/cr800470j, 2734106, 19243136.
-
(2009)
Chem Rev
, vol.109
, pp. 1495-1508
-
-
Reyes-Turcu, F.E.1
Wilkinson, K.D.2
-
15
-
-
0031657807
-
The ubiquitin system
-
10.1146/annurev.biochem.67.1.425, 9759494
-
Hershko A, Ciechanover A. The ubiquitin system. Annu Rev Biochem 1998, 67:425-479. 10.1146/annurev.biochem.67.1.425, 9759494.
-
(1998)
Annu Rev Biochem
, vol.67
, pp. 425-479
-
-
Hershko, A.1
Ciechanover, A.2
-
16
-
-
27144529182
-
Ubiquitylation and cell signaling
-
10.1038/sj.emboj.7600808, 1276169, 16148945
-
Haglund K, Dikic I. Ubiquitylation and cell signaling. EMBO J 2005, 24:3353-3359. 10.1038/sj.emboj.7600808, 1276169, 16148945.
-
(2005)
EMBO J
, vol.24
, pp. 3353-3359
-
-
Haglund, K.1
Dikic, I.2
-
17
-
-
55449107515
-
Regulation of TGF-beta family signaling by E3 ubiquitin ligases
-
10.1111/j.1349-7006.2008.00925.x, 18808420
-
Inoue Y, Imamura T. Regulation of TGF-beta family signaling by E3 ubiquitin ligases. Cancer Sci 2008, 99:2107-2112. 10.1111/j.1349-7006.2008.00925.x, 18808420.
-
(2008)
Cancer Sci
, vol.99
, pp. 2107-2112
-
-
Inoue, Y.1
Imamura, T.2
-
18
-
-
1942534004
-
Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation
-
10.1038/sj.onc.1207412, 15021894
-
Izzi L, Attisano L. Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation. Oncogene 2004, 23:2071-2078. 10.1038/sj.onc.1207412, 15021894.
-
(2004)
Oncogene
, vol.23
, pp. 2071-2078
-
-
Izzi, L.1
Attisano, L.2
-
19
-
-
4444223733
-
Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation
-
10.1016/j.molcel.2004.07.021, 15350225
-
Bai Y, Yang C, Hu K, Elly C, Liu YC. Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation. Mol Cell 2004, 15:825-831. 10.1016/j.molcel.2004.07.021, 15350225.
-
(2004)
Mol Cell
, vol.15
, pp. 825-831
-
-
Bai, Y.1
Yang, C.2
Hu, K.3
Elly, C.4
Liu, Y.C.5
-
20
-
-
0042858169
-
Differential ubiquitination defines the functional status of the tumor suppressor Smad4
-
10.1074/jbc.M300159200, 12794086
-
Moren A, Hellman U, Inada Y, Imamura T, Heldin CH, Moustakas A. Differential ubiquitination defines the functional status of the tumor suppressor Smad4. J Biol Chem 2003, 278:33571-33582. 10.1074/jbc.M300159200, 12794086.
-
(2003)
J Biol Chem
, vol.278
, pp. 33571-33582
-
-
Moren, A.1
Hellman, U.2
Inada, Y.3
Imamura, T.4
Heldin, C.H.5
Moustakas, A.6
-
21
-
-
80455143831
-
USP15 is a deubiquitylating enzyme for receptor-activated SMADs
-
10.1038/ncb2346, 21947082
-
Inui M, Manfrin A, Mamidi A, Martello G, Morsut L, Soligo S, Enzo E, Moro S, Polo S, Dupont S, Cordenonsi M, Piccolo S. USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Nat Cell Biol 2011, 13:1368-1375. 10.1038/ncb2346, 21947082.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 1368-1375
-
-
Inui, M.1
Manfrin, A.2
Mamidi, A.3
Martello, G.4
Morsut, L.5
Soligo, S.6
Enzo, E.7
Moro, S.8
Polo, S.9
Dupont, S.10
Cordenonsi, M.11
Piccolo, S.12
-
22
-
-
82455210962
-
Ablation of Smurf2 reveals an inhibition in TGF-beta signalling through multiple mono-ubiquitination of Smad3
-
10.1038/emboj.2011.393, 22045334
-
Tang LY, Yamashita M, Coussens NP, Tang Y, Wang X, Li C, Deng CX, Cheng SY, Zhang YE. Ablation of Smurf2 reveals an inhibition in TGF-beta signalling through multiple mono-ubiquitination of Smad3. EMBO J 2011, 30:4777-4789. 10.1038/emboj.2011.393, 22045334.
-
(2011)
EMBO J
, vol.30
, pp. 4777-4789
-
-
Tang, L.Y.1
Yamashita, M.2
Coussens, N.P.3
Tang, Y.4
Wang, X.5
Li, C.6
Deng, C.X.7
Cheng, S.Y.8
Zhang, Y.E.9
-
23
-
-
0344758986
-
Regulation of cell polarity and protrusion formation by targeting RhoA for degradation
-
10.1126/science.1090772, 14657501
-
Wang HR, Zhang Y, Ozdamar B, Ogunjimi AA, Alexandrova E, Thomsen GH, Wrana JL. Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. Science 2003, 302:1775-1779. 10.1126/science.1090772, 14657501.
-
(2003)
Science
, vol.302
, pp. 1775-1779
-
-
Wang, H.R.1
Zhang, Y.2
Ozdamar, B.3
Ogunjimi, A.A.4
Alexandrova, E.5
Thomsen, G.H.6
Wrana, J.L.7
-
24
-
-
17044414102
-
Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation
-
10.1016/j.cell.2005.01.035, 15820682
-
Yamashita M, Ying SX, Zhang GM, Li C, Cheng SY, Deng CX, Zhang YE. Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell 2005, 121:101-113. 10.1016/j.cell.2005.01.035, 15820682.
-
(2005)
Cell
, vol.121
, pp. 101-113
-
-
Yamashita, M.1
Ying, S.X.2
Zhang, G.M.3
Li, C.4
Cheng, S.Y.5
Deng, C.X.6
Zhang, Y.E.7
-
25
-
-
64249102010
-
Regulation of planar cell polarity by Smurf ubiquitin ligases
-
10.1016/j.cell.2009.02.025, 19379695
-
Narimatsu M, Bose R, Pye M, Zhang L, Miller B, Ching P, Sakuma R, Luga V, Roncari L, Attisano L, Wrana JL. Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell 2009, 137:295-307. 10.1016/j.cell.2009.02.025, 19379695.
-
(2009)
Cell
, vol.137
, pp. 295-307
-
-
Narimatsu, M.1
Bose, R.2
Pye, M.3
Zhang, L.4
Miller, B.5
Ching, P.6
Sakuma, R.7
Luga, V.8
Roncari, L.9
Attisano, L.10
Wrana, J.L.11
-
26
-
-
70350785179
-
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling
-
10.1016/j.molcel.2009.09.043, 2796330, 19917253
-
Gao S, Alarcon C, Sapkota G, Rahman S, Chen PY, Goerner N, Macias MJ, Erdjument-Bromage H, Tempst P, Massague J. Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol Cell 2009, 36:457-468. 10.1016/j.molcel.2009.09.043, 2796330, 19917253.
-
(2009)
Mol Cell
, vol.36
, pp. 457-468
-
-
Gao, S.1
Alarcon, C.2
Sapkota, G.3
Rahman, S.4
Chen, P.Y.5
Goerner, N.6
Macias, M.J.7
Erdjument-Bromage, H.8
Tempst, P.9
Massague, J.10
-
27
-
-
70350780570
-
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways
-
10.1016/j.cell.2009.09.035, 2818353, 19914168
-
Alarcon C, Zaromytidou AI, Xi Q, Gao S, Yu J, Fujisawa S, Barlas A, Miller AN, Manova-Todorova K, Macias MJ, Sapkota G, Pan D, Massague J. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell 2009, 139:757-769. 10.1016/j.cell.2009.09.035, 2818353, 19914168.
-
(2009)
Cell
, vol.139
, pp. 757-769
-
-
Alarcon, C.1
Zaromytidou, A.I.2
Xi, Q.3
Gao, S.4
Yu, J.5
Fujisawa, S.6
Barlas, A.7
Miller, A.N.8
Manova-Todorova, K.9
Macias, M.J.10
Sapkota, G.11
Pan, D.12
Massague, J.13
-
28
-
-
65649084845
-
Transforming growth factor-{beta}-inducible phosphorylation of Smad3
-
10.1074/jbc.M809281200, 2665087, 19218245
-
Wang G, Matsuura I, He D, Liu F. Transforming growth factor-{beta}-inducible phosphorylation of Smad3. J Biol Chem 2009, 284:9663-9673. 10.1074/jbc.M809281200, 2665087, 19218245.
-
(2009)
J Biol Chem
, vol.284
, pp. 9663-9673
-
-
Wang, G.1
Matsuura, I.2
He, D.3
Liu, F.4
-
29
-
-
4444250157
-
Structural basis of heteromeric smad protein assembly in TGF-beta signaling
-
10.1016/j.molcel.2004.07.016, 15350224
-
Chacko BM, Qin BY, Tiwari A, Shi G, Lam S, Hayward LJ, De Caestecker M, Lin K. Structural basis of heteromeric smad protein assembly in TGF-beta signaling. Mol Cell 2004, 15:813-823. 10.1016/j.molcel.2004.07.016, 15350224.
-
(2004)
Mol Cell
, vol.15
, pp. 813-823
-
-
Chacko, B.M.1
Qin, B.Y.2
Tiwari, A.3
Shi, G.4
Lam, S.5
Hayward, L.J.6
De Caestecker, M.7
Lin, K.8
-
30
-
-
0037757793
-
Role of Smad4 (DPC4) inactivation in human cancer
-
10.1016/S0006-291X(03)01066-0, 12821112
-
Miyaki M, Kuroki T. Role of Smad4 (DPC4) inactivation in human cancer. Biochem Biophys Res Commun 2003, 306:799-804. 10.1016/S0006-291X(03)01066-0, 12821112.
-
(2003)
Biochem Biophys Res Commun
, vol.306
, pp. 799-804
-
-
Miyaki, M.1
Kuroki, T.2
-
31
-
-
10744224096
-
Squamous cell carcinoma and mammary abscess formation through squamous metaplasia in Smad4/Dpc4 conditional knockout mice
-
10.1242/dev.00820, 14597578
-
Li W, Qiao W, Chen L, Xu X, Yang X, Li D, Li C, Brodie SG, Meguid MM, Hennighausen L, Deng CX. Squamous cell carcinoma and mammary abscess formation through squamous metaplasia in Smad4/Dpc4 conditional knockout mice. Development 2003, 130:6143-6153. 10.1242/dev.00820, 14597578.
-
(2003)
Development
, vol.130
, pp. 6143-6153
-
-
Li, W.1
Qiao, W.2
Chen, L.3
Xu, X.4
Yang, X.5
Li, D.6
Li, C.7
Brodie, S.G.8
Meguid, M.M.9
Hennighausen, L.10
Deng, C.X.11
-
32
-
-
30544444184
-
Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin
-
Qiao W, Li AG, Owens P, Xu X, Wang XJ, Deng CX. Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin. Oncogene 2006, 25:207-217.
-
(2006)
Oncogene
, vol.25
, pp. 207-217
-
-
Qiao, W.1
Li, A.G.2
Owens, P.3
Xu, X.4
Wang, X.J.5
Deng, C.X.6
-
33
-
-
0034106184
-
Gastro-intestinal tumorigenesis in Smad4 mutant mice
-
10.1016/S1359-6101(99)00038-6, 10708962
-
Taketo MM, Takaku K. Gastro-intestinal tumorigenesis in Smad4 mutant mice. Cytokine Growth Factor Rev 2000, 11:147-157. 10.1016/S1359-6101(99)00038-6, 10708962.
-
(2000)
Cytokine Growth Factor Rev
, vol.11
, pp. 147-157
-
-
Taketo, M.M.1
Takaku, K.2
-
34
-
-
58149093172
-
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination
-
10.1016/j.cell.2008.10.051, 19135894
-
Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, Martello G, Stinchfield MJ, Soligo S, Morsut L, Inui M, Moro S, Argenton F, Newfeld SJ, Piccolo S. FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Cell 2009, 136:123-135. 10.1016/j.cell.2008.10.051, 19135894.
-
(2009)
Cell
, vol.136
, pp. 123-135
-
-
Dupont, S.1
Mamidi, A.2
Cordenonsi, M.3
Montagner, M.4
Zacchigna, L.5
Adorno, M.6
Martello, G.7
Stinchfield, M.J.8
Soligo, S.9
Morsut, L.10
Inui, M.11
Moro, S.12
Argenton, F.13
Newfeld, S.J.14
Piccolo, S.15
|