메뉴 건너뛰기




Volumn 27, Issue 2, 2012, Pages 143-148

Steroid response in refractory asthmatics

Author keywords

Asthma; Drug resistance; Glucocorticoids

Indexed keywords

FLUTICASONE PROPIONATE; GLUCOCORTICOID;

EID: 84862836197     PISSN: 12263303     EISSN: 20056648     Source Type: Journal    
DOI: 10.3904/kjim.2012.27.2.143     Document Type: Review
Times cited : (16)

References (41)
  • 1
    • 84862880053 scopus 로고    scopus 로고
    • The Korean Academy of Asthma, Allergy and Clinical Immunology, Treatment, Korea adult asthma treatment guideline [Internet]. Seoul (KR): The Korean Academy of Asthma, Allergy and Clinical Immunology, c2005 [cited 2012 Mar 20]. Available from
    • The Korean Academy of Asthma, Allergy and Clinical Immunology. Treatment 2007 Korea adult asthma treatment guideline [Internet]. Seoul (KR): The Korean Academy of Asthma, Allergy and Clinical Immunology, c2005 [cited 2012 Mar 20]. Available from: http://www.allergy.or.kr.
    • (2007)
  • 2
    • 84862876432 scopus 로고    scopus 로고
    • The Korean Academy of Asthma, Allergy and Clinical Immunology. Treatment guideline of asthma in Korea [Internet]. Seoul (KR): The Korean Academy of Asthma, Allergy and Clinical Immunology, c2005 [cited 2012 Mar 20]. Available from
    • The Korean Academy of Asthma, Allergy and Clinical Immunology. Treatment guideline of asthma in Korea [Internet]. Seoul (KR): The Korean Academy of Asthma, Allergy and Clinical Immunology, c2005 [cited 2012 Mar 20]. Available from: http://www.allergy.or.kr.
  • 3
    • 84862894132 scopus 로고    scopus 로고
    • National Heart, Lung, and Blood Institute, Guidelines for the diagnosis and management of asthma (EPR-3) [Internet]. Bethesda (MD): National Heart, Lung, and Blood Institute, 2007 [cited 2012 Mar 20]. Available from
    • National Heart, Lung, and Blood Institute. Guidelines for the diagnosis and management of asthma (EPR-3) [Internet]. Bethesda (MD): National Heart, Lung, and Blood Institute, 2007 [cited 2012 Mar 20]. Available from: http://www.nhlbi.nih.gov/guidelines/asthma.
  • 4
    • 0037115314 scopus 로고    scopus 로고
    • The relationship of reticular basement membrane thickness to airway wall remodeling in asthma
    • James AL, Maxwell PS, Pearce-Pinto G, Elliot JG, Carroll NG. The relationship of reticular basement membrane thickness to airway wall remodeling in asthma. Am J Respir Crit Care Med 2002;166(12 Pt 1):1590-1595.
    • (2002) Am J Respir Crit Care Med , vol.166 , Issue.12 Pt 1 , pp. 1590-1595
    • James, A.L.1    Maxwell, P.S.2    Pearce-Pinto, G.3    Elliot, J.G.4    Carroll, N.G.5
  • 5
    • 0030933944 scopus 로고    scopus 로고
    • Airways remodeling is a distinctive feature of asthma and is related to severity of disease
    • Chetta A, Foresi A, Del Donno M, Bertorelli G, Pesci A, Olivieri D. Airways remodeling is a distinctive feature of asthma and is related to severity of disease. Chest 1997;111:852-857.
    • (1997) Chest , vol.111 , pp. 852-857
    • Chetta, A.1    Foresi, A.2    Del, D.M.3    Bertorelli, G.4    Pesci, A.5    Olivieri, D.6
  • 6
    • 0033022464 scopus 로고    scopus 로고
    • The natural history of asthma in adults: The problem of irreversibility
    • Reed CE. The natural history of asthma in adults: the problem of irreversibility. J Allergy Clin Immunol 1999;103:539-547.
    • (1999) J Allergy Clin Immunol , vol.103 , pp. 539-547
    • Reed, C.E.1
  • 7
    • 0037212774 scopus 로고    scopus 로고
    • Airway remodeling and long-term decline in lung function in asthma
    • Ten Hacken NH, Postma DS, Timens W. Airway remodeling and long-term decline in lung function in asthma. Curr Opin Pulm Med 2003;9:9-14.
    • (2003) Curr Opin Pulm Med , vol.9 , pp. 9-14
    • Ten, H.N.H.1    Postma, D.S.2    Timens, W.3
  • 8
    • 0346216130 scopus 로고    scopus 로고
    • Mechanisms of severe asthma
    • Wenzel S. Mechanisms of severe asthma. Clin Exp Allergy 2003;33:1622-1628.
    • (2003) Clin Exp Allergy , vol.33 , pp. 1622-1628
    • Wenzel, S.1
  • 9
    • 0037338025 scopus 로고    scopus 로고
    • Severe/fatal asthma
    • Wenzel S. Severe/fatal asthma. Chest 2003;123(3 Suppl):405S- 410S.
    • (2003) Chest , vol.123 , Issue.3 SUPPL
    • Wenzel, S.1
  • 10
    • 0038325627 scopus 로고    scopus 로고
    • Severe asthma: Epidemiology, pathophysiology and treatment
    • Wenzel S. Severe asthma: epidemiology, pathophysiology and treatment. Mt Sinai J Med 2003;70:185-190.
    • (2003) Mt Sinai J Med , vol.70 , pp. 185-190
    • Wenzel, S.1
  • 11
    • 15844363866 scopus 로고    scopus 로고
    • Severe asthma treatment: Need for characterizing patients
    • Heaney LG, Robinson DS. Severe asthma treatment: need for characterizing patients. Lancet 2005;365:974-976.
    • (2005) Lancet , vol.365 , pp. 974-976
    • Heaney, L.G.1    Robinson, D.S.2
  • 12
    • 0038015441 scopus 로고    scopus 로고
    • Predictors of therapy resistant asthma: Outcome of a systematic evaluation protocol
    • Heaney LG, Conway E, Kelly C, et al. Predictors of therapy resistant asthma: outcome of a systematic evaluation protocol. Thorax 2003;58:561-566.
    • (2003) Thorax , vol.58 , pp. 561-566
    • Heaney, L.G.1    Conway, E.2    Kelly, C.3
  • 13
    • 0034861628 scopus 로고    scopus 로고
    • Severe asthma: Definition and mechanisms
    • Stirling RG, Chung KF. Severe asthma: definition and mechanisms. Allergy 2001;56:825-840.
    • (2001) Allergy , vol.56 , pp. 825-840
    • Stirling, R.G.1    Chung, K.F.2
  • 15
    • 10744224453 scopus 로고    scopus 로고
    • Systematic assessment of difficult-to-treat asthma
    • Robinson DS, Campbell DA, Durham SR, et al. Systematic assessment of difficult-to-treat asthma. Eur Respir J 2003;22:478-483.
    • (2003) Eur Respir J , vol.22 , pp. 478-483
    • Robinson, D.S.1    Campbell, D.A.2    Durham, S.R.3
  • 16
    • 0034526865 scopus 로고    scopus 로고
    • Proceedings of the ATS workshop on refractory asthma: Current understanding, recommendations, and unanswered questions: American Thoracic Society
    • Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions: American Thoracic Society. Am J Respir Crit Care Med 2000;162:2341-2351.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 2341-2351
  • 18
    • 0033025989 scopus 로고    scopus 로고
    • Difficult/therapy-resistant asthma: The need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies
    • ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society
    • Chung KF, Godard P, Adelroth E, et al. Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society. Eur Respir J 1999;13:1198-1208.
    • (1999) Eur Respir J , vol.13 , pp. 1198-1208
    • Chung, K.F.1    Godard, P.2    Adelroth, E.3
  • 19
    • 0034541314 scopus 로고    scopus 로고
    • Peripheral blood and airway tissue expression of transforming growth factor beta by neutrophils in asthmatic subjects and normal control subjects
    • Chu HW, Trudeau JB, Balzar S, Wenzel SE. Peripheral blood and airway tissue expression of transforming growth factor beta by neutrophils in asthmatic subjects and normal control subjects. J Allergy Clin Immunol 2000;106:1115-1123.
    • (2000) J Allergy Clin Immunol , vol.106 , pp. 1115-1123
    • Chu, H.W.1    Trudeau, J.B.2    Balzar, S.3    Wenzel, S.E.4
  • 20
    • 10744231300 scopus 로고    scopus 로고
    • The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma
    • European Network for Understanding Mechanisms of Severe Asthma
    • The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. European Network for Understanding Mechanisms of Severe Asthma. Eur Respir J 2003;22:470-477.
    • (2003) Eur Respir J , vol.22 , pp. 470-477
  • 21
    • 12444297936 scopus 로고    scopus 로고
    • Inflammatory events in severe acute asthma
    • Tillie-Leblond I, Gosset P, Tonnel AB. Inflammatory events in severe acute asthma. Allergy 2005;60:23-29.
    • (2005) Allergy , vol.60 , pp. 23-29
    • Tillie-Leblond, I.1    Gosset, P.2    Tonnel, A.B.3
  • 22
    • 0036855114 scopus 로고    scopus 로고
    • National asthma education and prevention program. expert panel report: Guidelines for the diagnosis and management of asthma update on selected topics-2002
    • National Asthma Education and Prevention Program
    • National Asthma Education and Prevention Program. National Asthma Education and Prevention Program. Expert Panel Report: Guidelines for the Diagnosis and Management of Asthma Update on Selected Topics-2002. J Allergy Clin Immunol 2002;110(5 Suppl):S141-S219.
    • (2002) J Allergy Clin Immunol , vol.110 , Issue.5 SUPPL
  • 23
    • 18744429855 scopus 로고    scopus 로고
    • Polymorphisms in the IL4, IL4RA, and FCERIB genes and asthma severity
    • Sandford AJ, Chagani T, Zhu S, et al. Polymorphisms in the IL4, IL4RA, and FCERIB genes and asthma severity. J Allergy Clin Immunol 2000;106(1 Pt 1):135-140.
    • (2000) J Allergy Clin Immunol , vol.106 , Issue.1 Pt 1 , pp. 135-140
    • Sandford, A.J.1    Chagani, T.2    Zhu, S.3
  • 24
    • 0033946186 scopus 로고    scopus 로고
    • Polymorphisms at the glutathione Stransferase, GSTP1 locus: A novel mechanism for susceptibility and development of atopic airway inflammation
    • Spiteri MA, Bianco A, Strange RC, Fryer AA. Polymorphisms at the glutathione Stransferase, GSTP1 locus: a novel mechanism for susceptibility and development of atopic airway inflammation. Allergy 2000;55 Suppl 61:15-20.
    • (2000) Allergy , vol.55 , Issue.SUPPL. 61 , pp. 15-20
    • Spiteri, M.A.1    Bianco, A.2    Strange, R.C.3    Fryer, A.A.4
  • 25
    • 0036434681 scopus 로고    scopus 로고
    • Expression and activation of 15-lipoxygenase pathway in severe asthma: Relation- ship to eosinophilic phenotype and collagen deposition
    • Chu HW, Balzar S, Westcott JY, et al. Expression and activation of 15-lipoxygenase pathway in severe asthma: relation- ship to eosinophilic phenotype and collagen deposition. Clin Exp Allergy 2002;32:1558-1565.
    • (2002) Clin Exp Allergy , vol.32 , pp. 1558-1565
    • Chu, H.W.1    Balzar, S.2    Westcott, J.Y.3
  • 26
    • 0034820353 scopus 로고    scopus 로고
    • Polymorphism in the gene regulatory region of MCP-1 is associated with asthma susceptibility and severity
    • Szalai C, Kozma GT, Nagy A, et al. Polymorphism in the gene regulatory region of MCP-1 is associated with asthma susceptibility and severity. J Allergy Clin Immunol 2001;108:375-381.
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 375-381
    • Szalai, C.1    Kozma, G.T.2    Nagy, A.3
  • 27
    • 0032875377 scopus 로고    scopus 로고
    • Evidence that severe asthma can be divided pathologically into two inflam- matory subtypes with distinct physiologic and clinical characteristics
    • Wenzel SE, Schwartz LB, Langmack EL, et al. Evidence that severe asthma can be divided pathologically into two inflam- matory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 1999;160:1001-1008.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 1001-1008
    • Wenzel, S.E.1    Schwartz, L.B.2    Langmack, E.L.3
  • 28
    • 24944446693 scopus 로고    scopus 로고
    • Factors influencing the responsiveness to inhaled glucocorticoids of patients with moderate-to-severe asthma
    • Jang AS, Lee JH, Park SW, et al. Factors influencing the responsiveness to inhaled glucocorticoids of patients with moderate-to-severe asthma. Chest 2005;128:1140-1145.
    • (2005) Chest , vol.128 , pp. 1140-1145
    • Jang, A.S.1    Lee, J.H.2    Park, S.W.3
  • 29
    • 0037335980 scopus 로고    scopus 로고
    • Airway remodeling in asthma
    • Vignola AM, Mirabella F, Costanzo G, et al. Airway remodeling in asthma. Chest 2003;123(3 Suppl):417S-422S.
    • (2003) Chest , vol.123 , Issue.3 SUPPL
    • Vignola, A.M.1    Mirabella, F.2    Costanzo, G.3
  • 30
    • 0024828192 scopus 로고
    • Bronchial biopsies in asthma: An ultrastructural, quantitative study and correlation with hyperreactivity
    • Jeffery PK, Wardlaw AJ, Nelson FC, Collins JV, Kay AB. Bronchial biopsies in asthma: an ultrastructural, quantitative study and correlation with hyperreactivity. Am Rev Respir Dis 1989;140:1745-1753.
    • (1989) Am Rev Respir Dis , vol.140 , pp. 1745-1753
    • Jeffery, P.K.1    Wardlaw, A.J.2    Nelson, F.C.3    Collins, J.V.4    Kay, A.B.5
  • 31
    • 0035131224 scopus 로고    scopus 로고
    • Relationship of epidermal growth factor receptors to goblet cell production in human bronchi
    • Takeyama K, Fahy JV, Nadel JA. Relationship of epidermal growth factor receptors to goblet cell production in human bronchi. Am J Respir Crit Care Med 2001;163:511-516.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 511-516
    • Takeyama, K.1    Fahy, J.V.2    Nadel, J.A.3
  • 32
    • 0036014530 scopus 로고    scopus 로고
    • Distribution and degranulation of airway mast cells in normal and asthmatic subjects
    • Carroll NG, Mutavdzic S, James AL. Distribution and degranulation of airway mast cells in normal and asthmatic subjects. Eur Respir J 2002;19:879-885.
    • (2002) Eur Respir J , vol.19 , pp. 879-885
    • Carroll, N.G.1    Mutavdzic, S.2    James, A.L.3
  • 33
    • 33644784718 scopus 로고    scopus 로고
    • Corticosteroids: The drugs to beat
    • Barnes PJ. Corticosteroids: the drugs to beat. Eur J Pharmacol 2006;533:2-14.
    • (2006) Eur J Pharmacol , vol.533 , pp. 2-14
    • Barnes, P.J.1
  • 34
    • 0030702823 scopus 로고    scopus 로고
    • Association of gluco-corticoid insensitivity with increased expression of glucocorticoid receptor beta
    • Leung DY, Hamid Q, Vottero A, et al. Association of gluco-corticoid insensitivity with increased expression of glucocorticoid receptor beta. J Exp Med 1997;186:1567-1574.
    • (1997) J Exp Med , vol.186 , pp. 1567-1574
    • Leung, D.Y.1    Hamid, Q.2    Vottero, A.3
  • 35
    • 22144452574 scopus 로고    scopus 로고
    • Severe asthma in adults
    • Wenzel S. Severe asthma in adults. Am J Respir Crit Care Med 2005;172:149-160.
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 149-160
    • Wenzel, S.1
  • 36
    • 23044502066 scopus 로고    scopus 로고
    • Corticosteroid resistance in airway disease
    • Barnes PJ. Corticosteroid resistance in airway disease. Proc Am Thorac Soc 2004;1:264-268.
    • (2004) Proc Am Thorac Soc , vol.1 , pp. 264-268
    • Barnes, P.J.1
  • 37
    • 0345832388 scopus 로고    scopus 로고
    • Individual cytokines contributing to asthma pathophysiology: Valid targets for asthma therapy
    • Chung KF. Individual cytokines contributing to asthma pathophysiology: valid targets for asthma therapy? Curr Opin Investig Drugs 2003;4:1320-1326.
    • (2003) Curr Opin Investig Drugs , vol.4 , pp. 1320-1326
    • Chung, K.F.1
  • 38
    • 6444222929 scopus 로고    scopus 로고
    • New drugs for asthma
    • Barnes PJ. New drugs for asthma. Nat Rev Drug Discov 2004;3:831-844.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 831-844
    • Barnes, P.J.1
  • 39
    • 0034670150 scopus 로고    scopus 로고
    • Gene therapy of chronic inflammatory disease
    • Hedley ML. Gene therapy of chronic inflammatory disease. Adv Drug Deliv Rev 2000;44:195-207.
    • (2000) Adv Drug Deliv Rev , vol.44 , pp. 195-207
    • Hedley, M.L.1
  • 41
    • 52049113214 scopus 로고    scopus 로고
    • New targets for drug development in asthma
    • Adcock IM, Caramori G, Chung KF. New targets for drug development in asthma. Lancet 2008;372:1073-1087.
    • (2008) Lancet , vol.372 , pp. 1073-1087
    • Adcock, I.M.1    Caramori, G.2    Chung, K.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.