5-aza-2′-deoxycytidine increases the sensitivity of human bone marrow mesenchymal stem cells to chemotherapeutic agents by demethylation of p73

Journal of Pediatric Hematology/Oncology

Volumn 34, Issue 2, 2012, Pages 108-115

  Liang, Wei ^a   Xia, Hailong ^a   Li, Jing ^b   Chunhua Zhao, Robert ^b  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

apoptosis; bone marrow mesenchymal stem cells; chemosensitivity; DNA damage; methylation; p73

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CASPASE 3; CISPLATIN; MESSENGER RNA; PROTEIN P73;

APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL STRUCTURE; CHEMOSENSITIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DNA DAMAGE; DNA FRAGMENTATION; DNA METHYLATION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENTIATION; DRUG SENSITIVITY; EPIGENETICS; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INACTIVATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; MESENCHYMAL STEM CELL; P73 GENE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; UPREGULATION;

ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; AZACITIDINE; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; DNA METHYLATION; DNA-BINDING PROTEINS; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOPHENOTYPING; MESENCHYMAL STROMAL CELLS; NUCLEAR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEINS;

EID: 84862831368     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/MPH.0b013e31823e0a87     Document Type: Article

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