P73α regulates the sensitivity of bone marrow mesenchymal stem cells to DNA damage agents

Toxicology

Volumn 270, Issue 1, 2010, Pages 49-56

  Liang, Wei ^a   Lu, Chunhua ^a   Li, Jing ^a   Yin, James Q ^b   Zhao, Robert Chunhua ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b INSTITUTE OF BIOPHYSICS   (China)

Author keywords

Bax; Chemosensitivity; MSC; P21; P53; P73

Indexed keywords

CISPLATIN; PROTEIN BAX; PROTEIN P21; PROTEIN P73; PROTEIN P73 ALPHA; RETROVIRUS VECTOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DNA BINDING PROTEIN; NUCLEAR PROTEIN; TUMOR SUPPRESSOR PROTEIN; TUMOR SUPPRESSOR PROTEIN P73;

APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL STRAIN K 562; CELL STRUCTURE; CHEMOSENSITIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; MESENCHYMAL STEM CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; BIOSYNTHESIS; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SEPARATION; CELL SURVIVAL; DRUG EFFECT; GENETICS; PHYSIOLOGY; PLASMID; POLYACRYLAMIDE GEL ELECTROPHORESIS; RETROVIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SEPARATION; CELL SURVIVAL; CELLS, CULTURED; CISPLATIN; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; K562 CELLS; MESENCHYMAL STEM CELLS; NUCLEAR PROTEINS; PLASMIDS; RETROVIRIDAE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEINS;

EID: 77950022028     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2010.01.011     Document Type: Article

References (44)

1. Aggarwal S., Pittenger M.F. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005, 105:1815-1822.
2. Aust L., Devlin B., Foster S.J., Halvorsen Y.D., Hicok K., du Laney T., Sen A., Willingmyre G.D., Gimble J.M. Yield of human adipose-derived adult stem cells from liposuction aspirates. Cytotherapy 2004, 6:7-14.
3. Barbieri C.E., Pietenpol J.A. p53 family members: similar biochemistry, different biology. Cancer Biol. Ther. 2005, 4:419-420.
4. Boland G.M., Perkins G., Hall D.J., Tuan R.S. Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. J. Cell. Biochem. 2004, 93:1210-1230.
5. Devine S.M., Hoffman R. Role of mesenchymal stem cells in hematopoietic stem cell transplantation. Curr. Opin. Hematol. 2000, 7:358-363.
6. Ferrari G., Cusella-De Angelis G., Coletta M., Paolucci E., Stornaiuolo A., Cossu G., Mavilio F. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 1998, 279:1528-1530.
7. Flores E.R., Tsai K.Y., Crowley D., Sengupta S., Yang A., McKeon F., Jacks T. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature 2002, 416:560-564.
8. Gong J.G., Costanzo A., Yang H.Q., Melino G., Kaelin W.G., Levrero M., Wang J.Y. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 1999, 399:806-809.
9. Grob T.J., Novak U., Maisse C., Barcaroli D., Luthi A.U., Pirnia F., Hugli B., Graber H.U., De Laurenzi V., Fey M.F., Melino G., Tobler A. Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53. Cell Death Differ. 2001, 8:1213-1223.
10. Harvey R.L., Chopp M. The therapeutic effects of cellular therapy for functional recovery after brain injury. Phys. Med. Rehabil. Clin. N. Am. 2003, 14:S143-S151.
11. Haupt S., Berger M., Goldberg Z., Haupt Y. Apoptosis-the p53 network. J. Cell Sci. 2003, 116:4077-4085.
12. Horwitz E.M., Gordon P.L., Koo W.K., Marx J.C., Neel M.D., McNall R.Y., Muul L., Hofmann T. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:8932-8937.
13. Hu Y., Liao L., Wang Q., Ma L., Ma G., Jiang X., Zhao R.C. Isolation and identification of mesenchymal stem cells from human fetal pancreas. J. Lab. Clin. Med. 2003, 141:342-349.
14. Irwin M.S., Kondo K., Marin M.C., Cheng L.S., Hahn W.C., Kaelin W.G. Chemosensitivity linked to p73 function. Cancer Cell 2003, 3:403-410.
15. Jiang Y., Jahagirdar B.N., Reinhardt R.L., Schwartz R.E., Keene C.D., Ortiz-Gonzalez X.R., Reyes M., Lenvik T., Lund T., Blackstad M., Du J., Aldrich S., Lisberg A., Low W.C., Largaespada D.A., Verfaillie C.M. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002, 418:41-49.
16. Jiang Y., Vaessen B., Lenvik T., Blackstad M., Reyes M., Verfaillie C.M. Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. Exp. Hematol. 2002, 30:896-904.
17. Jiang Y., Lo W., Akhmametyeva E.M., Chang L.S. Over-expression of p73beta results in apoptotic death of post-mitotic hNT neurons. J. Neurol. Sci. 2006, 240:1-6.
18. Johnstone B., Hering T.M., Caplan A.I., Goldberg V.M., Yoo J.U. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp. Cell Res. 1998, 238:265-272.
19. Jorgensen C., Djouad F., Apparailly F., Noel D. Engineering mesenchymal stem cells for immunotherapy. Gene Ther. 2003, 10:928-931.
20. Jost C.A., Marin M.C., Kaelin W.G. p73 is a simian [correction of human] p53-related protein that can induce apoptosis. Nature 1997, 389:191-194.
21. Kaghad M., Bonnet H., Yang A., Creancier L., Biscan J.C., Valent A., Minty A., Chalon P., Lelias J.M., Dumont X., Ferrara P., McKeon F., Caput D. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 1997, 90:809-819.
22. Kawada H., Fujita J., Kinjo K., Matsuzaki Y., Tsuma M., Miyatake H., Muguruma Y., Tsuboi K., Itabashi Y., Ikeda Y., Ogawa S., Okano H., Hotta T., Ando K., Fukuda K. Nonhematopoietic mesenchymal stem cells can be mobilized and differentiate into cardiomyocytes after myocardial infarction. Blood 2004, 104:3581-3587.
23. Kim K.C., Jung C.S., Choi K.H. Overexpression of p73 enhances cisplatin-induced apoptosis in HeLa cells. Arch. Pharmacol. Res. 2006, 29:152-158.
24. Koc O.N., Gerson S.L., Cooper B.W., Dyhouse S.M., Haynesworth S.E., Caplan A.I., Lazarus H.M. Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J. Clin. Oncol. 2000, 18:307-316.
25. Koivusalo R., Krausz E., Ruotsalainen P., Helenius H., Hietanen S. Chemoradiation of cervical cancer cells: targeting human papillomavirus E6 and p53 leads to either augmented or attenuated apoptosis depending on the platinum carrier ligand. Cancer Res. 2002, 62:7364-7371.
26. Le Blanc K., Rasmusson I., Sundberg B., Gotherstrom C., Hassan M., Uzunel M., Ringden O. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 2004, 363:1439-1441.
27. Li J., Law H.K., Lau Y.L., Chan G.C. Differential damage and recovery of human mesenchymal stem cells after exposure to chemotherapeutic agents. Br. J. Haematol. 2004, 127:326-334.
28. Lissy N.A., Davis P.K., Irwin M., Kaelin W.G., Dowdy S.F. A common E2F-1 and p73 pathway mediates cell death induced by TCR activation. Nature 2000, 407:642-645.
29. Liu S.S., Leung R.C., Chan K.Y., Chiu P.M., Cheung A.N., Tam K.F., Ng T.Y., Wong L.C., Ngan H.Y. p73 expression is associated with the cellular radiosensitivity in cervical cancer after radiotherapy. Clin. Cancer Res. 2004, 10:3309-3316.
30. Liu L., Sun Z., Chen B., Han Q., Liao L., Jia M., Cao Y., Ma J., Sun Q., Guo M., Liu Z., Ai H., Zhao R.C. Ex vivo expansion and in vivo infusion of bone marrow-derived Flk-1+CD31-CD34-mesenchymal stem cells: feasibility and safety from monkey to human. Stem Cells Dev. 2006, 15:349-357.
31. Melino G., De Laurenzi V., Vousden K.H. p73: friend or foe in tumorigenesis. Nat. Rev. Cancer 2002, 2:605-615.
32. Moll U.M., Slade N. p63 and p73: roles in development and tumor formation. Mol. Cancer Res. 2004, 2:371-386.
33. Mueller L.P., Luetzkendorf J., Mueller T., Reichelt K., Simon H., Schmoll H.J. Presence of mesenchymal stem cells in human bone marrow after exposure to chemotherapy: evidence of resistance to apoptosis induction. Stem Cells 2006, 24:2753-2765.
34. Muller M., Schleithoff E.S., Stremmel W., Melino G., Krammer P.H., Schilling T. One, two, three-p53, p63, p73 and chemosensitivity. Drug Resist. Updat. 2006, 9:288-306.
35. Sato Y., Araki H., Kato J., Nakamura K., Kawano Y., Kobune M., Sato T., Miyanishi K., Takayama T., Takahashi M., Takimoto R., Iyama S., Matsunaga T., Ohtani S., Matsuura A., Hamada H., Niitsu Y. Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion. Blood 2005, 106:756-763.
36. Shi M., Li J., Liao L., Chen B., Li B., Chen L., Jia H., Zhao R.C. Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in NOD/SCID mice. Haematologica 2007, 92:897-904.
37. Stamm C., Kleine H.D., Westphal B., Petzsch M., Kittner C., Nienaber C.A., Freund M., Steinhoff G. CABG and bone marrow stem cell transplantation after myocardial infarction. Thorac. Cardiovasc. Surg. 2004, 52:152-158.
38. Tao H., Ma D.D. Evidence for transdifferentiation of human bone marrow-derived stem cells: recent progress and controversies. Pathology 2003, 35:6-13.
39. Tao H., Rao R., Ma D.D. Cytokine-induced stable neuronal differentiation of human bone marrow mesenchymal stem cells in a serum/feeder cell-free condition. Dev. Growth Differ. 2005, 47:423-433.
40. Wolter K.G., Hsu Y.T., Smith C.L., Nechushtan A., Xi X.G., Youle R.J. Movement of Bax from the cytosol to mitochondria during apoptosis. J. Cell. Biol. 1997, 139:1281-1292.
41. Xu D., Wilson T.J., Chan D., De Luca E., Zhou J., Hertzog P.J., Kola I. Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells. EMBO J. 2002, 21:4081-4093.
42. Yang A., McKeon F. P63 and P73: P53 mimics, menaces and more. Nat. Rev. Mol. Cell. Biol. 2000, 1:199-207.
43. Zhao Z., Liao L., Cao Y., Jiang X., Zhao R.C. Establishment and properties of fetal dermis-derived mesenchymal stem cell lines: plasticity in vitro and hematopoietic protection in vivo. Bone Marrow Transplant. 2005, 36:355-365.
44. Zhu J., Nozell S., Wang J., Jiang J., Zhou W., Chen X. p73 cooperates with DNA damage agents to induce apoptosis in MCF7 cells in a p53-dependent manner. Oncogene 2001, 20:4050-4057.