Inhibition of p38 MAPK activity promotes ex vivo expansion of human cord blood hematopoietic stem cells

Annals of Hematology

Volumn 91, Issue 6, 2012, Pages 813-823

  Zou, Jing ^a   Zou, Ping ^a   Wang, Jie ^a   Li, Lei ^a   Wang, Yong ^b   Zhou, Daohong ^c   Liu, Lingbo ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Ex vivo expansion; Hematopoietic stem cells; Human umbilical cord blood; p38; Senescence

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CD133 ANTIGEN; CD38 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; MITOGEN ACTIVATED PROTEIN KINASE P38;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL AGING; CELL DIFFERENTIATION; CELL FUNCTION; CELL HOMING; CELL PROLIFERATION; CLONOGENESIS; CONTROLLED STUDY; CORD BLOOD STEM CELL TRANSPLANTATION; DRUG EFFECT; DRUG MECHANISM; ENGRAFTMENT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; EX VIVO STUDY; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SCID MOUSE; SENESCENCE; STEM CELL EXPANSION; UMBILICAL CORD BLOOD;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; CORD BLOOD STEM CELL TRANSPLANTATION; FEMALE; FETAL BLOOD; HEMATOPOIETIC STEM CELLS; HUMANS; IMIDAZOLES; MICE; MICE, INBRED NOD; MICE, SCID; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; PYRIDINES; TRANSPLANTATION, HETEROLOGOUS; UP-REGULATION;

EID: 84862829412     PISSN: 09395555     EISSN: 14320584     Source Type: Journal    
DOI: 10.1007/s00277-011-1397-7     Document Type: Article

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