The use of psychostimulants in cancer patients

Current Opinion in Supportive and Palliative Care

Volumn 5, Issue 2, 2011, Pages 164-168

  Portela, María A ^a   Rubiales, Álvaro S ^b   Centenoa, Carlos ^a  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

^b HOSPITAL UNIVERSITARIO RÍO HORTEGA   (Spain)

Author keywords

Cancer; Depression; Fatigue; Methylphenidate; Modafinil; Palliative care; Psychostimulants

Indexed keywords

ANTINEOPLASTIC AGENT; BENZHYDRYL DERIVATIVE; CENTRAL STIMULANT AGENT; METHYLPHENIDATE; MODAFINIL;

ADULT; ASTHENIA; CHILD; DEPRESSION; FATIGUE; FEMALE; HUMAN; MALE; METHODOLOGY; NEOPLASM; PALLIATIVE THERAPY; PSYCHOLOGICAL ASPECT; REVIEW; SURVIVOR;

ADULT; ANTINEOPLASTIC AGENTS; ASTHENIA; BENZHYDRYL COMPOUNDS; CENTRAL NERVOUS SYSTEM STIMULANTS; CHILD; DEPRESSION; FATIGUE; FEMALE; HUMANS; MALE; METHYLPHENIDATE; NEOPLASMS; PALLIATIVE CARE; SURVIVORS;

EID: 80052334938     PISSN: 17514258     EISSN: 17514266     Source Type: Journal    
DOI: 10.1097/SPC.0b013e3283462ff3     Document Type: Review

References (27)

1. Harris J, Cahtterjee A. Is it acceptable for people to take methylphenidate to enhance performance? BMJ 2009; 338:1532-1533.
2. Candy B, Jones L, Williams R, et al. Psychostimulants for depression. Cochrane Database Syst Rev 2008; CD006722. doi: 10.1002/14651858.CD006722. pub2.
3. Rabkin JG, McElhiney MC, Rabkin R, McGrath P. Modafinil treatment for fatigue in patients with HIV/AIDS: a placebo controlled trial. J Clin Psychiatry 2010; 71:707-715.
4. Lasheen W, Walsh D, Mahmoud F, et al. Methylphenidate side effects in advanced cancer: a retrospective analysis. Am J Hosp Palliat Care 2010; 27:16-23.
5. Mulhern RK, Khan RB, Kaplan S, et al. Short-term efficacy of methylphenidate: a randomized, double-blind, placebo-controlled trial among survivors of childhood cancer. J Clin Oncol 2004; 22:4743-4751. (Pubitemid 41185091)
6. Conklin HM, Helton S, Ashford J, et al. Predicting methylphenidate response in long-term survivors of childhood cancer: a randomized, double- blind, placebo-controlled, crossover trial. J Pediatr Psychol 2010; 35:144-155.
7. Conklin HM, Reddick WE, Ashford J, et al. Long-term efficacy of methylphenidate in enhancing attention regulation, social skills, and academic abilities of childhood cancer survivors. J Clin Oncol 2010; 28:4465-4472.
8. Conklin HM, Lawford J, Jasper BW, et al. Side effects of methylphenidate in survivors of childhood cancer: a randomized, double-blind, placebocontrolled trial. Pediatrics 2009; 124:226-233.
9. Jasper BW, Conklin HM, Lawford J, et al. Growth effects of methylphenidate among childhood cancer survivors: a 12-month case-matched open-label study. Pediatr Blood Cancer 2009; 52:39-43.
10. Cueva JF, Calvo M, Anido U, et al. Methylphenidate in the management of asthenia in breast cancer patients treated with docetaxel: results of a pilot study. Invest New Drugs 2010 [Epub ahead of print].
11. Mar Fan HG, Clemons M, Xu W, et al. A randomised, placebo-controlled, double-blind trial of the effects of d-methylphenidate on fatigue and cognitive dysfunction in women undergoing adjuvant chemotherapy for breast cancer. Support Care Cancer 2008; 16:577-583.
12. Lower EE, Fleishman S, Cooper A, et al. Efficacy of dexmethylphenidate for the treatment of fatigue after cancer chemotherapy: a randomized clinical trial. J Pain Symptom Manage 2009; 38:650-662.
13. Jean-Pierre P, Morrow GR, Roscoe JA, et al. A phase 3 randomized, placebocontrolled, double-blind, clinical trial of the effect of modafinil on cancerrelated fatigue among 631 patients receiving chemotherapy. Cancer 2010; 116:3513-3520.
14. Minton O, Richardson A, Sharpe M, et al. Drug therapy for the management of cancer-related fatigue. Cochrane Database Syst Rev 2010; CD006704.
15. Peuckmann V, Elsner F, Krumm N, et al. Pharmacological treatments for fatigue associated with palliative care. Cochrane Database Syst Rev 2010; CD006788. doi: 10.1002/14651858.CD006788.pub2.
16. Hardy SE. Methylphenidate for treatment of depressive symptoms, apathy, and fatigue in medically ill older adults and terminally ill adults. Am J Geriatr Pharmacother 2009; 7:34-59.
17. Hardy JR, Carmont SA, O'Shea A, et al. Pilot study to determine the optimal dose of methylphenidate for an n-of-1 trial for fatigue in patients with cancer. J Palliat Med 2010; 13:1193-1197.
18. Johnson RL, Block I, Gold MA, et al. Effect of methylphenidate on fatigue in women with recurrent gynecologic cancer. Psychooncology 2010; 19:955-958.
19. Blackhall L, Petroni G, Shu J, et al. A pilot study evaluating the safety and efficacy of modafinil for cancer-related fatigue. J Palliat Med 2009; 12:433-439.
20. Spathis A, Dhillan R, Booden D, et al. Modafinil for the treatment of fatigue in lung cancer: a pilot study. Palliat Med 2009; 23:325-331.
21. Laval G, Paris A. Methylphenidate in palliative care in cancer patients: a double-blind randomised trial versus placebo. Bull Cancer 2008; 95:241-246. (Pubitemid 351341294)
22. Moraska AR, Sood A, Dakhil SR, et al. Phase III, randomized, double-blind, placebo-controlled study of long-acting methylphenidate for cancer-related fatigue: North Central Cancer Treatment Group NCCTG-N05C7. Trial J Clin Oncol 2010; 28:3673-3679.
23. Roth AJ, Nelson C, Rosenfeld, et al. Methylphenidate for fatigue in ambulatory men with prostate cancer. Cancer 2010; 116:5102-5110.
24. Howard P, Shuster J, Twycross R, et al. Psychostimulants. J Pain Symptom Manage 2010; 40:789-795.
25. Centeno C, Sanz-Rubiales A, Cuervo MA, et al., Metioron Study Group. Multicenter randomized double-blinded placebo-controlled trial of methylphenidate for depressive symptoms in advanced cancer patients. Palliat Med 2010; 24:S134.
26. Elie D, Gagnon P, Gagnon B, Giguère A. Using psychostimulants in end-oflife patients with hypoactive delirium and cognitive disorders: a literature review. Can J Psychiatry 2010; 55:386-393.
27. Lundorff LE, Jonsson BE, Sjogren P. Modafinil for attentional and psychomotor dysfunction in advanced cancer: a double-blind, randomised, crossover trial. Palliat Med 2009; 23:731-738.