메뉴 건너뛰기




Volumn 120, Issue 7, 2012, Pages 572-581

Pentoxifylline inhibits hepatic stellate cells proliferation via the Raf/ERK pathway

Author keywords

Hepatic fibrosis; Hepatic stellate cells; Pentoxifylline; Proliferation; Raf 1

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; MITOGEN ACTIVATED PROTEIN KINASE; PENTOXIFYLLINE; RAF PROTEIN;

EID: 84862819944     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2011.02868.x     Document Type: Article
Times cited : (8)

References (41)
  • 2
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of hepatic fibrogenesis
    • Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008;134:1655-69.
    • (2008) Gastroenterology , vol.134 , pp. 1655-1669
    • Friedman, S.L.1
  • 4
    • 0035209823 scopus 로고    scopus 로고
    • Hepatic stellate cell proliferation is an early platelet-derived growth factor-mediated cellular event in rat cholestatic liver injury
    • Kinnman N, Goria O, Wendum D, Gendron MC, Rey C, Poupon R, et al. Hepatic stellate cell proliferation is an early platelet-derived growth factor-mediated cellular event in rat cholestatic liver injury. Lab Invest 2001;81:1709-16.
    • (2001) Lab Invest , vol.81 , pp. 1709-1716
    • Kinnman, N.1    Goria, O.2    Wendum, D.3    Gendron, M.C.4    Rey, C.5    Poupon, R.6
  • 5
    • 33847776557 scopus 로고    scopus 로고
    • Sequential assessment of the intrahepatic expression of epidermal growth factor and transforming growth factor-beta1 in hepatofibrogenesis of a rat cirrhosis model
    • Kuriyama S, Yokoyama F, Inoue H, Takano J, Ogawa M, Kita Y, et al. Sequential assessment of the intrahepatic expression of epidermal growth factor and transforming growth factor-beta1 in hepatofibrogenesis of a rat cirrhosis model. Int J Mol Med 2007;19:317-24.
    • (2007) Int J Mol Med , vol.19 , pp. 317-324
    • Kuriyama, S.1    Yokoyama, F.2    Inoue, H.3    Takano, J.4    Ogawa, M.5    Kita, Y.6
  • 7
    • 27344452928 scopus 로고    scopus 로고
    • As2O3-induced c-Src/EGFR/ERK signaling is via Sp1 binding sites to stimulate p21WAF1/CIP1 expression in human epidermoid carcinoma A431 cells
    • Liu ZM, Huang HS. As2O3-induced c-Src/EGFR/ERK signaling is via Sp1 binding sites to stimulate p21WAF1/CIP1 expression in human epidermoid carcinoma A431 cells. Cell Signal 2006;18:244-55.
    • (2006) Cell Signal , vol.18 , pp. 244-255
    • Liu, Z.M.1    Huang, H.S.2
  • 8
    • 1542346788 scopus 로고    scopus 로고
    • Effects of phosphodiesterase inhibition on the inflammatory response after shock: role of pentoxifylline
    • Coimbra R, Melbostad H, Hoyt DB. Effects of phosphodiesterase inhibition on the inflammatory response after shock: role of pentoxifylline. J Trauma 2004;56:442-9.
    • (2004) J Trauma , vol.56 , pp. 442-449
    • Coimbra, R.1    Melbostad, H.2    Hoyt, D.B.3
  • 10
    • 64849083690 scopus 로고    scopus 로고
    • Burn-induced gut barrier injury is attenuated by phosphodiesterase inhibition: effects on tight junction structural proteins
    • Costantini TW, Loomis WH, Putnam JG, Drusinsky D, Deree J, Choi S, et al. Burn-induced gut barrier injury is attenuated by phosphodiesterase inhibition: effects on tight junction structural proteins. Shock 2009;31:416-22.
    • (2009) Shock , vol.31 , pp. 416-422
    • Costantini, T.W.1    Loomis, W.H.2    Putnam, J.G.3    Drusinsky, D.4    Deree, J.5    Choi, S.6
  • 11
    • 34247237289 scopus 로고    scopus 로고
    • Hypertonic saline and pentoxifylline attenuates gut injury after hemorrhagic shock: the kinder, gentler resuscitation
    • Deree J, de Campos T, Shenvi E, Loomis WH, Hoyt DB, Coimbra R. Hypertonic saline and pentoxifylline attenuates gut injury after hemorrhagic shock: the kinder, gentler resuscitation. J Trauma 2007;62:818-27.
    • (2007) J Trauma , vol.62 , pp. 818-827
    • Deree, J.1    de Campos, T.2    Shenvi, E.3    Loomis, W.H.4    Hoyt, D.B.5    Coimbra, R.6
  • 12
    • 34247641700 scopus 로고    scopus 로고
    • The effects of pentoxifylline on liver regeneration after portal vein ligation in rats
    • Kucuktulu U, Alhan E, Tekelioglu Y, Ozekin A. The effects of pentoxifylline on liver regeneration after portal vein ligation in rats. Liver Int 2007;27:274-9.
    • (2007) Liver Int , vol.27 , pp. 274-279
    • Kucuktulu, U.1    Alhan, E.2    Tekelioglu, Y.3    Ozekin, A.4
  • 13
    • 0030734831 scopus 로고    scopus 로고
    • Effect of pentoxifylline on the degradation of procollagen type I produced by human hepatic stellate cells in response to transforming growth factor-beta 1
    • Romanelli RG, Caligiuri A, Carloni V, DeFranco R, Montalto P, Ceni E, et al. Effect of pentoxifylline on the degradation of procollagen type I produced by human hepatic stellate cells in response to transforming growth factor-beta 1. Br J Pharmacol 1997;122:1047-54.
    • (1997) Br J Pharmacol , vol.122 , pp. 1047-1054
    • Romanelli, R.G.1    Caligiuri, A.2    Carloni, V.3    DeFranco, R.4    Montalto, P.5    Ceni, E.6
  • 14
    • 62749124854 scopus 로고    scopus 로고
    • Raf kinase inhibitor protein inhibits cell proliferation but promotes cell migration in rat hepatic stellate cells
    • Ma J, Li F, Liu L, Cui D, Wu X, Jiang X, et al. Raf kinase inhibitor protein inhibits cell proliferation but promotes cell migration in rat hepatic stellate cells. Liver Int 2009;29:567-74.
    • (2009) Liver Int , vol.29 , pp. 567-574
    • Ma, J.1    Li, F.2    Liu, L.3    Cui, D.4    Wu, X.5    Jiang, X.6
  • 16
    • 0033921113 scopus 로고    scopus 로고
    • An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro
    • Vogel S, Piantedosi R, Frank J, Lalazar A, Rockey DC, Friedman SL, et al. An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro. J Lipid Res 2000;41:882-93.
    • (2000) J Lipid Res , vol.41 , pp. 882-893
    • Vogel, S.1    Piantedosi, R.2    Frank, J.3    Lalazar, A.4    Rockey, D.C.5    Friedman, S.L.6
  • 17
    • 77953552969 scopus 로고    scopus 로고
    • New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis
    • Wang Y, Gao J, Zhang D, Zhang J, Ma J, Jiang H. New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis. J Hepatol 2010;53:132-44.
    • (2010) J Hepatol , vol.53 , pp. 132-144
    • Wang, Y.1    Gao, J.2    Zhang, D.3    Zhang, J.4    Ma, J.5    Jiang, H.6
  • 18
    • 9444223845 scopus 로고    scopus 로고
    • Leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation
    • Saxena NK, Titus MA, Ding X, Floyd J, Srinivasan S, Sitaraman SV, et al. Leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation. FASEB J 2004;18:1612-4.
    • (2004) FASEB J , vol.18 , pp. 1612-1614
    • Saxena, N.K.1    Titus, M.A.2    Ding, X.3    Floyd, J.4    Srinivasan, S.5    Sitaraman, S.V.6
  • 19
    • 58149237916 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt pathway regulates hepatic stellate cell apoptosis
    • Wang Y, Jiang XY, Liu L, Jiang HQ. Phosphatidylinositol 3-kinase/Akt pathway regulates hepatic stellate cell apoptosis. World J Gastroenterol 2008;14:5186-91.
    • (2008) World J Gastroenterol , vol.14 , pp. 5186-5191
    • Wang, Y.1    Jiang, X.Y.2    Liu, L.3    Jiang, H.Q.4
  • 20
    • 24944454305 scopus 로고    scopus 로고
    • Vasodilator agents inhibit opossum kidney proximal tubular cell growth
    • Chu TS, Wu MS, Hsieh BS. Vasodilator agents inhibit opossum kidney proximal tubular cell growth. J Formos Med Assoc 2005;104:374-7.
    • (2005) J Formos Med Assoc , vol.104 , pp. 374-377
    • Chu, T.S.1    Wu, M.S.2    Hsieh, B.S.3
  • 21
    • 0036260996 scopus 로고    scopus 로고
    • Immunomodulatory effect of pentoxifylline in suppressing experimental autoimmune myocarditis
    • Takehana H, Inomata T, Niwano H, Nishii M, Matsuda C, Kohno K, et al. Immunomodulatory effect of pentoxifylline in suppressing experimental autoimmune myocarditis. Circ J 2002;66:499-504.
    • (2002) Circ J , vol.66 , pp. 499-504
    • Takehana, H.1    Inomata, T.2    Niwano, H.3    Nishii, M.4    Matsuda, C.5    Kohno, K.6
  • 22
    • 0033119248 scopus 로고    scopus 로고
    • Pentoxifylline inhibits PDGF-induced proliferation of and TGF-beta-stimulated collagen synthesis by vascular smooth muscle cells
    • Chen YM, Wu KD, Tsai TJ, Hsieh BS. Pentoxifylline inhibits PDGF-induced proliferation of and TGF-beta-stimulated collagen synthesis by vascular smooth muscle cells. J Mol Cell Cardiol 1999;31:773-83.
    • (1999) J Mol Cell Cardiol , vol.31 , pp. 773-783
    • Chen, Y.M.1    Wu, K.D.2    Tsai, T.J.3    Hsieh, B.S.4
  • 23
    • 0030004239 scopus 로고    scopus 로고
    • Pentoxifylline and pentifylline inhibit proliferation of human Tenon's capsule fibroblasts and production of type-I collagen and laminin in vitro
    • Saika S, Yamanaka O, Okada Y, Tanaka S, Ohnishi Y, Ooshima A. Pentoxifylline and pentifylline inhibit proliferation of human Tenon's capsule fibroblasts and production of type-I collagen and laminin in vitro. Ophthalmic Res 1996;28:165-70.
    • (1996) Ophthalmic Res , vol.28 , pp. 165-170
    • Saika, S.1    Yamanaka, O.2    Okada, Y.3    Tanaka, S.4    Ohnishi, Y.5    Ooshima, A.6
  • 24
    • 84988267441 scopus 로고    scopus 로고
    • Inhibition of endothelial cell proliferation and tumor-induced angiogenesis by pentoxifylline
    • Gude RP, Binda MM, Boquete AL, Bonfil RD. Inhibition of endothelial cell proliferation and tumor-induced angiogenesis by pentoxifylline. J Cancer Res Clin Oncol 2001;127:625-30.
    • (2001) J Cancer Res Clin Oncol , vol.127 , pp. 625-630
    • Gude, R.P.1    Binda, M.M.2    Boquete, A.L.3    Bonfil, R.D.4
  • 25
    • 66049117801 scopus 로고    scopus 로고
    • Pentoxifylline prevents pig serum-induced rat liver fibrosis by inhibiting interleukin-6 production
    • Toda K, Kumagai N, Kaneko F, Tsunematsu S, Tsuchimoto K, Saito H, et al. Pentoxifylline prevents pig serum-induced rat liver fibrosis by inhibiting interleukin-6 production. J Gastroenterol Hepatol 2009;24:860-5.
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 860-865
    • Toda, K.1    Kumagai, N.2    Kaneko, F.3    Tsunematsu, S.4    Tsuchimoto, K.5    Saito, H.6
  • 26
    • 33744912534 scopus 로고    scopus 로고
    • The phyto-chemical (-)-epigallocatechin gallate suppresses gene expression of epidermal growth factor receptor in rat hepatic stellate cells in vitro by reducing the activity of Egr-1
    • Fu Y, Chen A. The phyto-chemical (-)-epigallocatechin gallate suppresses gene expression of epidermal growth factor receptor in rat hepatic stellate cells in vitro by reducing the activity of Egr-1. Biochem Pharmacol 2006;72:227-38.
    • (2006) Biochem Pharmacol , vol.72 , pp. 227-238
    • Fu, Y.1    Chen, A.2
  • 27
    • 33745763267 scopus 로고    scopus 로고
    • Akt binds to and phosphorylates phospholipase C-gamma1 in response to epidermal growth factor
    • Wang Y, Wu J, Wang Z. Akt binds to and phosphorylates phospholipase C-gamma1 in response to epidermal growth factor. Mol Biol Cell 2006;17:2267-77.
    • (2006) Mol Biol Cell , vol.17 , pp. 2267-2277
    • Wang, Y.1    Wu, J.2    Wang, Z.3
  • 28
    • 70350475035 scopus 로고    scopus 로고
    • Activation of cytosolic phospholipase A2alpha by epidermal growth factor (EGF) and phorbol ester in HeLa cells: different effects of inhibitors for EGF receptor, protein kinase C, Src and C-Raf
    • Matsuzawa Y, Kiuchi Y, Toyomura K, Matsumoto I, Nakamura H, Fujino H, et al. Activation of cytosolic phospholipase A2alpha by epidermal growth factor (EGF) and phorbol ester in HeLa cells: different effects of inhibitors for EGF receptor, protein kinase C, Src and C-Raf. J Pharmacol Sci 2009;111:182-92.
    • (2009) J Pharmacol Sci , vol.111 , pp. 182-192
    • Matsuzawa, Y.1    Kiuchi, Y.2    Toyomura, K.3    Matsumoto, I.4    Nakamura, H.5    Fujino, H.6
  • 29
    • 17844362213 scopus 로고    scopus 로고
    • Peroxynitrite activates ERK via Raf-1 and MEK, independently from EGF receptor and p21Ras in H9C2 cardiomyocytes
    • Pesse B, Levrand S, Feihl F, Waeber B, Gavillet B, Pacher P, et al. Peroxynitrite activates ERK via Raf-1 and MEK, independently from EGF receptor and p21Ras in H9C2 cardiomyocytes. J Mol Cell Cardiol 2005;38:765-75.
    • (2005) J Mol Cell Cardiol , vol.38 , pp. 765-775
    • Pesse, B.1    Levrand, S.2    Feihl, F.3    Waeber, B.4    Gavillet, B.5    Pacher, P.6
  • 30
    • 33845455068 scopus 로고    scopus 로고
    • EGF induces cell motility and multi-drug resistance gene expression in breast cancer cells
    • Garcia R, Franklin RA, McCubrey JA. EGF induces cell motility and multi-drug resistance gene expression in breast cancer cells. Cell Cycle 2006;5:2820-6.
    • (2006) Cell Cycle , vol.5 , pp. 2820-2826
    • Garcia, R.1    Franklin, R.A.2    McCubrey, J.A.3
  • 31
    • 78651080669 scopus 로고    scopus 로고
    • Predictive and prognostic biomarkers for targeted therapy in metastatic colorectal cancer
    • Asghar U, Hawkes E, Cunningham D. Predictive and prognostic biomarkers for targeted therapy in metastatic colorectal cancer. Clin Colorectal Cancer 2010;9:274-81.
    • (2010) Clin Colorectal Cancer , vol.9 , pp. 274-281
    • Asghar, U.1    Hawkes, E.2    Cunningham, D.3
  • 32
    • 0033919424 scopus 로고    scopus 로고
    • Impaired nuclear accumulation and shortened phosphorylation of ERK after growth factor stimulation in cultured hepatocytes from rats exposed to 2-acetylaminofluorene
    • Skarpen E, Lindeman B, Thoresen GH, Guren TK, Oksvold MP, Christoffersen T, et al. Impaired nuclear accumulation and shortened phosphorylation of ERK after growth factor stimulation in cultured hepatocytes from rats exposed to 2-acetylaminofluorene. Mol Carcinog 2000;28:84-96.
    • (2000) Mol Carcinog , vol.28 , pp. 84-96
    • Skarpen, E.1    Lindeman, B.2    Thoresen, G.H.3    Guren, T.K.4    Oksvold, M.P.5    Christoffersen, T.6
  • 33
    • 0027501802 scopus 로고
    • cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor
    • Burgering BM, Pronk GJ, van Weeren PC, Chardin P, Bos JL. cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor. EMBO J 1993;12:4211-20.
    • (1993) EMBO J , vol.12 , pp. 4211-4220
    • Burgering, B.M.1    Pronk, G.J.2    van Weeren, P.C.3    Chardin, P.4    Bos, J.L.5
  • 34
    • 77249123939 scopus 로고    scopus 로고
    • Pentoxifylline modulates p47phox activation and downregulates neutrophil oxidative burst through PKA-dependent and -independent mechanisms
    • Costantini TW, Deree J, Peterson CY, Putnam JG, Woon T, Loomis WH, et al. Pentoxifylline modulates p47phox activation and downregulates neutrophil oxidative burst through PKA-dependent and -independent mechanisms. Immunopharmacol Immunotoxicol 2010;32:82-91.
    • (2010) Immunopharmacol Immunotoxicol , vol.32 , pp. 82-91
    • Costantini, T.W.1    Deree, J.2    Peterson, C.Y.3    Putnam, J.G.4    Woon, T.5    Loomis, W.H.6
  • 35
    • 20444477097 scopus 로고    scopus 로고
    • Cell signaling through the protein kinases cAMP-dependent protein kinase, protein kinase Cepsilon, and RAF-1 regulates amphotropic murine leukemia virus envelope protein-induced syncytium formation
    • Wang W, Jobbagy Z, Bird TH, Eiden MV, Anderson WB. Cell signaling through the protein kinases cAMP-dependent protein kinase, protein kinase Cepsilon, and RAF-1 regulates amphotropic murine leukemia virus envelope protein-induced syncytium formation. J Biol Chem 2005;280:16772-83.
    • (2005) J Biol Chem , vol.280 , pp. 16772-16783
    • Wang, W.1    Jobbagy, Z.2    Bird, T.H.3    Eiden, M.V.4    Anderson, W.B.5
  • 36
    • 0029958518 scopus 로고    scopus 로고
    • Inhibition by pentoxifylline of extracellular signal-regulated kinase activation by platelet-derived growth factor in hepatic stellate cells
    • Pinzani M, Marra F, Caligiuri A, Defranco R, Gentilini A, Failli P, et al. Inhibition by pentoxifylline of extracellular signal-regulated kinase activation by platelet-derived growth factor in hepatic stellate cells. Br J Pharmacol 1996;119:1117-24.
    • (1996) Br J Pharmacol , vol.119 , pp. 1117-1124
    • Pinzani, M.1    Marra, F.2    Caligiuri, A.3    Defranco, R.4    Gentilini, A.5    Failli, P.6
  • 37
    • 33751233529 scopus 로고    scopus 로고
    • Blocking of Akt/NF-kappaB signaling by pentoxifylline inhibits platelet-derived growth factor-stimulated proliferation in Brown Norway rat airway smooth muscle cells
    • Chiou YL, Shieh JJ, Lin CY. Blocking of Akt/NF-kappaB signaling by pentoxifylline inhibits platelet-derived growth factor-stimulated proliferation in Brown Norway rat airway smooth muscle cells. Pediatr Res 2006;60:657-62.
    • (2006) Pediatr Res , vol.60 , pp. 657-662
    • Chiou, Y.L.1    Shieh, J.J.2    Lin, C.Y.3
  • 38
    • 21244496787 scopus 로고    scopus 로고
    • Modulation of DNA damage by pentoxifylline and α-tocopherol in skin fibroblasts exposed to Gamma rays
    • Laurent C, Pouget JP, Voisin P. Modulation of DNA damage by pentoxifylline and α-tocopherol in skin fibroblasts exposed to Gamma rays. Radiat Res 2005;164:63-72.
    • (2005) Radiat Res , vol.164 , pp. 63-72
    • Laurent, C.1    Pouget, J.P.2    Voisin, P.3
  • 39
    • 66449114614 scopus 로고    scopus 로고
    • Aldosterone-induced mesangual cell proliferation is mediated by EGF receptor transactivation
    • Huang S, Zhang A, Ding G, Chen R. Aldosterone-induced mesangual cell proliferation is mediated by EGF receptor transactivation. Am J Physiol Renal Physiol 2009;296:F1323-33.
    • (2009) Am J Physiol Renal Physiol , vol.296
    • Huang, S.1    Zhang, A.2    Ding, G.3    Chen, R.4
  • 40
    • 78649476090 scopus 로고    scopus 로고
    • Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1, a FGF2 downstream gene
    • Pellicano F, Thomson RE, Inman GJ, Iwata T. Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1, a FGF2 downstream gene. BMC Cancer 2010;10:657.
    • (2010) BMC Cancer , vol.10 , pp. 657
    • Pellicano, F.1    Thomson, R.E.2    Inman, G.J.3    Iwata, T.4
  • 41
    • 70350664219 scopus 로고    scopus 로고
    • Antiapoptotic and proliferative effects of low concentrations of 7beta-hydroxycholesterol in human endothelial cells via ERK activation
    • Trevisi L, Bertoldo A, Agnoletto L, Poggiani C, Cusinato F, Luciani S. Antiapoptotic and proliferative effects of low concentrations of 7beta-hydroxycholesterol in human endothelial cells via ERK activation. J Vasc Res 2010;47:241-51.
    • (2010) J Vasc Res , vol.47 , pp. 241-251
    • Trevisi, L.1    Bertoldo, A.2    Agnoletto, L.3    Poggiani, C.4    Cusinato, F.5    Luciani, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.