메뉴 건너뛰기




Volumn 32, Issue 1, 2010, Pages 82-91

Pentoxifylline modulates p47phox activation and downregulates neutrophil oxidative burst through PKA-dependent and -independent mechanisms

Author keywords

Akt; Inflammation; MAPK; NADPH; PMN; Sepsis

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOCHROME C; FORMYLMETHIONYLLEUCYLPHENYLALANINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PENTOXIFYLLINE; PROTEIN KINASE B; PROTEIN P47; RAF PROTEIN; RAS PROTEIN;

EID: 77249123939     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923970903183557     Document Type: Article
Times cited : (23)

References (39)
  • 2
    • 1342270880 scopus 로고    scopus 로고
    • Pathogenesis of multiple organ dysfunction syndrome-- endotoxin, inflammatory cells, and their mediators: Cytokines and reactive oxygen species
    • discussion 204-1195
    • Maier, R.V. Pathogenesis of multiple organ dysfunction syndrome-- endotoxin, inflammatory cells, and their mediators: cytokines and reactive oxygen species. Surg Infect (Larchmt). 2000, 1, (3), 197-204; discussion 204-1195
    • (2000) Surg Infect (Larchmt) , vol.1 , Issue.3 , pp. 197-204
    • Maier, R.V.1
  • 3
    • 55549117812 scopus 로고    scopus 로고
    • Regulation of superoxide production in neutrophils: Role of calcium influx
    • Brechard, S., Tschirhart, E.J. Regulation of superoxide production in neutrophils: role of calcium influx. J Leukoc Biol. 2008, 84, (5), 1223-1237.
    • (2008) J Leukoc Biol , vol.84 , Issue.5 , pp. 1223-1237
    • Brechard, S.1    Tschirhart, E.J.2
  • 4
    • 0033593090 scopus 로고    scopus 로고
    • Tangled webs: Evidence of cross-talk between c-Raf-1 and Akt
    • Jun, T., Gjoerup, O., Roberts, T.M. Tangled webs: evidence of cross-talk between c-Raf-1 and Akt. Sci STKE. 1999, 1999, (13), PE1.
    • (1999) Sci STKE , vol.1999 , Issue.13
    • Jun, T.1    Gjoerup, O.2    Roberts, T.M.3
  • 5
    • 0030937347 scopus 로고    scopus 로고
    • Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP
    • Nick, J.A., Avdi, N.J., Young, S.K., Knall, C., Gerwins, P., Johnson, G.L., Worthen, G.S. Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. J Clin Invest. 1997, 99, (5), 975-986.
    • (1997) J Clin Invest , vol.99 , Issue.5 , pp. 975-986
    • Nick, J.A.1    Avdi, N.J.2    Young, S.K.3    Knall, C.4    Gerwins, P.5    Johnson, G.L.6    Worthen, G.S.7
  • 6
    • 0030588188 scopus 로고    scopus 로고
    • Activation of p38 in stimulated human neutrophils: Phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK
    • El Benna, J., Han, J., Park, J.W., Schmid, E., Ulevitch, R.J., Babior, B.M. Activation of p38 in stimulated human neutrophils: phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK. Arch Biochem Biophys. 1996, 334, (2), 395-400.
    • (1996) Arch Biochem Biophys , vol.334 , Issue.2 , pp. 395-400
    • El Benna, J.1    Han, J.2    Park, J.W.3    Schmid, E.4    Ulevitch, R.J.5    Babior, B.M.6
  • 7
    • 0034604569 scopus 로고    scopus 로고
    • Stimulation of human neutrophils by chemotactic factors is associated with the activation of phosphatidylinositol 3-kinase gamma
    • Naccache, P.H., Levasseur, S., Lachance, G., Chakravarti, S., Bourgoin, S.G., McColl, S.R. Stimulation of human neutrophils by chemotactic factors is associated with the activation of phosphatidylinositol 3-kinase gamma. J Biol Chem. 2000, 275, (31), 23636-23641.
    • (2000) J Biol Chem , vol.275 , Issue.31 , pp. 23636-23641
    • Naccache, P.H.1    Levasseur, S.2    Lachance, G.3    Chakravarti, S.4    Bourgoin, S.G.5    McColl, S.R.6
  • 8
    • 0037883614 scopus 로고    scopus 로고
    • Akt phosphorylates p47phox and mediates respiratory burst activity in human neutrophils
    • Chen, Q., Powell, D.W., Rane, M.J., Singh, S., Butt, W., Klein, J.B., McLeish, K.R. Akt phosphorylates p47phox and mediates respiratory burst activity in human neutrophils. J Immunol. 2003, 170, (10), 5302-5308.
    • (2003) J Immunol , vol.170 , Issue.10 , pp. 5302-5308
    • Chen, Q.1    Powell, D.W.2    Rane, M.J.3    Singh, S.4    Butt, W.5    Klein, J.B.6    McLeish, K.R.7
  • 9
    • 0033105874 scopus 로고    scopus 로고
    • NADPH oxidase: An update
    • Babior, B.M. NADPH oxidase: an update. Blood. 1999, 93, (5), 1464-1476.
    • (1999) Blood , vol.93 , Issue.5 , pp. 1464-1476
    • Babior, B.M.1
  • 10
    • 1542346788 scopus 로고    scopus 로고
    • Effects of phosphodiesterase inhibition on the inflammatory response after shock: Role of pentoxifylline
    • Coimbra, R., Melbostad, H., Hoyt, D.B. Effects of phosphodiesterase inhibition on the inflammatory response after shock: role of pentoxifylline. J Trauma. 2004, 56, (2), 442-449.
    • (2004) J Trauma , vol.56 , Issue.2 , pp. 442-449
    • Coimbra, R.1    Melbostad, H.2    Hoyt, D.B.3
  • 13
    • 67649195008 scopus 로고    scopus 로고
    • Pentoxifylline modulates intestinal tight junction signaling after burn injury: Effects on myosin light chain kinase
    • discussion 24-115
    • Costantini, T.W., Loomis, W.H., Putnam, J.G., Kroll, L., Eliceiri, B.P., Baird, A., Bansal, V., Coimbra, R. Pentoxifylline modulates intestinal tight junction signaling after burn injury: effects on myosin light chain kinase. J Trauma. 2009, 66, (1), 17-24; discussion 24-115
    • (2009) J Trauma , vol.66 , Issue.1 , pp. 17-24
    • Costantini, T.W.1    Loomis, W.H.2    Putnam, J.G.3    Kroll, L.4    Eliceiri, B.P.5    Baird, A.6    Bansal, V.7    Coimbra, R.8
  • 14
    • 34247237289 scopus 로고    scopus 로고
    • Hypertonic saline and pentoxifylline attenuates gut injury after hemorrhagic shock: The kinder, gentler resuscitation
    • discussion, 827-1818
    • Deree, J., de Campos, T., Shenvi, E., Loomis, W.H., Hoyt, D.B., Coimbra, R. Hypertonic saline and pentoxifylline attenuates gut injury after hemorrhagic shock: the kinder, gentler resuscitation. J Trauma. 2007, 62, (4), 818-827; discussion 827-1818
    • (2007) J Trauma , vol.62 , Issue.4 , pp. 818-827
    • Deree, J.1    De Campos, T.2    Shenvi, E.3    Loomis, W.H.4    Hoyt, D.B.5    Coimbra, R.6
  • 15
    • 27844463498 scopus 로고    scopus 로고
    • Role of hypertonic saline and pentoxifylline on neutrophil activation and tumor necrosis factor-alpha synthesis: A novel resuscitation strategy
    • discussion 264-1255
    • Coimbra, R., Loomis, W., Melbostad, H., Tobar, M., Porcides, R.D., Lall, R., Holbrook, T., Hoyt, D.B. Role of hypertonic saline and pentoxifylline on neutrophil activation and tumor necrosis factor-alpha synthesis: a novel resuscitation strategy. J Trauma. 2005, 59, (2), 257-264; discussion 264-1255
    • (2005) J Trauma , vol.59 , Issue.2 , pp. 257-264
    • Coimbra, R.1    Loomis, W.2    Melbostad, H.3    Tobar, M.4    Porcides, R.D.5    Lall, R.6    Holbrook, T.7    Hoyt, D.B.8
  • 16
    • 49649083093 scopus 로고    scopus 로고
    • Pentoxifylline attenuates pulmonary inflammation and neutrophil activation in experimental acute pancreatitis
    • de Campos, T., Deree, J., Martins, J.O., Loomis, W.H., Shenvi, E., Putnam, J.G., Coimbra, R. Pentoxifylline attenuates pulmonary inflammation and neutrophil activation in experimental acute pancreatitis. Pancreas. 2008, 37, (1), 42-49.
    • (2008) Pancreas , vol.37 , Issue.1 , pp. 42-49
    • De Campos, T.1    Deree, J.2    Martins, J.O.3    Loomis, W.H.4    Shenvi, E.5    Putnam, J.G.6    Coimbra, R.7
  • 17
    • 33646240128 scopus 로고    scopus 로고
    • Neutrophil degranulation and the effects of phosphodiesterase inhibition
    • Deree, J., Lall, R., Melbostad, H., Grant, M., Hoyt, D.B., Coimbra, R. Neutrophil degranulation and the effects of phosphodiesterase inhibition. J Surg Res. 2006, 133, (1), 22-28.
    • (2006) J Surg Res , vol.133 , Issue.1 , pp. 22-28
    • Deree, J.1    Lall, R.2    Melbostad, H.3    Grant, M.4    Hoyt, D.B.5    Coimbra, R.6
  • 18
    • 33746795015 scopus 로고    scopus 로고
    • Pentoxifylline attenuates stored blood-induced inflammation: A new perspective on an old problem
    • Deree, J., Lall, R., Melbostad, H., Loomis, W., Hoyt, D.B., Coimbra, R. Pentoxifylline attenuates stored blood-induced inflammation: A new perspective on an old problem. Surgery. 2006, 140, (2), 186-191.
    • (2006) Surgery , vol.140 , Issue.2 , pp. 186-191
    • Deree, J.1    Lall, R.2    Melbostad, H.3    Loomis, W.4    Hoyt, D.B.5    Coimbra, R.6
  • 19
    • 29244445118 scopus 로고    scopus 로고
    • Phosphodiesterase inhibition attenuates stored blood-induced neutrophil activation: A novel adjunct to blood transfusion
    • Lall, R.N., Loomis, W., Melbostad, H., Hoyt, D.B., Lane, T., Coimbra, R. Phosphodiesterase inhibition attenuates stored blood-induced neutrophil activation: a novel adjunct to blood transfusion. J Am Coll Surg. 2006, 202, (1), 10-17.
    • (2006) J Am Coll Surg , vol.202 , Issue.1 , pp. 10-17
    • Lall, R.N.1    Loomis, W.2    Melbostad, H.3    Hoyt, D.B.4    Lane, T.5    Coimbra, R.6
  • 20
    • 0026026007 scopus 로고
    • Cyclic nucleotides differentially regulate the synthesis of tumour necrosis factor-alpha and interleukin-1 beta by human mononuclear cells
    • Endres, S., Fulle, H.J., Sinha, B., Stoll, D., Dinarello, C.A., Gerzer, R., Weber, P.C. Cyclic nucleotides differentially regulate the synthesis of tumour necrosis factor-alpha and interleukin-1 beta by human mononuclear cells. Immunology. 1991, 72, (1), 56-60.
    • (1991) Immunology , vol.72 , Issue.1 , pp. 56-60
    • Endres, S.1    Fulle, H.J.2    Sinha, B.3    Stoll, D.4    Dinarello, C.A.5    Gerzer, R.6    Weber, P.C.7
  • 21
    • 11144234815 scopus 로고    scopus 로고
    • LPS-stimulated PMN activation and proinflammatory mediator synthesis is downregulated by phosphodiesterase inhibition: Role of pentoxifylline
    • Coimbra, R., Loomis, W., Melbostad, H., Tobar, M., Porcides, R.D., Hoyt, D.B. LPS-stimulated PMN activation and proinflammatory mediator synthesis is downregulated by phosphodiesterase inhibition: role of pentoxifylline. J Trauma. 2004, 57, (6), 1157-1163.
    • (2004) J Trauma , vol.57 , Issue.6 , pp. 1157-1163
    • Coimbra, R.1    Loomis, W.2    Melbostad, H.3    Tobar, M.4    Porcides, R.D.5    Hoyt, D.B.6
  • 22
    • 34547579265 scopus 로고    scopus 로고
    • The effects of a novel resuscitation strategy combining pentoxifylline and hypertonic saline on neutrophil MAPK signaling
    • Deree, J., Melbostad, H., Loomis, W.H., Putnam, J.G., Coimbra, R. The effects of a novel resuscitation strategy combining pentoxifylline and hypertonic saline on neutrophil MAPK signaling. Surgery. 2007, 142, (2), 276-283.
    • (2007) Surgery , vol.142 , Issue.2 , pp. 276-283
    • Deree, J.1    Melbostad, H.2    Loomis, W.H.3    Putnam, J.G.4    Coimbra, R.5
  • 23
    • 34249719445 scopus 로고    scopus 로고
    • Dissociation between the translocation and the activation of Akt in fMLPstimulated human neutrophils-effect of prostaglandin E2
    • Burelout, C., Naccache, P.H., Bourgoin, S.G. Dissociation between the translocation and the activation of Akt in fMLPstimulated human neutrophils-effect of prostaglandin E2. J Leukoc Biol. 2007, 81, (6), 1523-1534.
    • (2007) J Leukoc Biol , vol.81 , Issue.6 , pp. 1523-1534
    • Burelout, C.1    Naccache, P.H.2    Bourgoin, S.G.3
  • 25
    • 0027416454 scopus 로고
    • GTP-binding proteins in polymorphonuclear granulocytes of severely burned patients
    • Brom, J., Koller, M., Muller-Lange, P., Steinau, H.U., Konig, W. GTP-binding proteins in polymorphonuclear granulocytes of severely burned patients. J Leukoc Biol. 1993, 53, (3), 268-272.
    • (1993) J Leukoc Biol , vol.53 , Issue.3 , pp. 268-272
    • Brom, J.1    Koller, M.2    Muller-Lange, P.3    Steinau, H.U.4    Konig, W.5
  • 26
  • 27
    • 0027220460 scopus 로고
    • Receptormediated activation of multiple serine/threonine kinases in human leukocytes
    • Grinstein, S., Furuya, W., Butler, J.R., Tseng, J. Receptormediated activation of multiple serine/threonine kinases in human leukocytes. J Biol Chem. 1993, 268, (27), 20223-20231.
    • (1993) J Biol Chem , vol.268 , Issue.27 , pp. 20223-20231
    • Grinstein, S.1    Furuya, W.2    Butler, J.R.3    Tseng, J.4
  • 28
    • 0030460016 scopus 로고    scopus 로고
    • Activation of MEKK by formyl-methionyl-leucylphenylalanine in human neutrophils. Mapping pathways for mitogen-activated protein kinase activation
    • Avdi, N.J., Winston, B.W., Russel, M., Young, S.K., Johnson, G.L., Worthen, G.S. Activation of MEKK by formyl-methionyl-leucylphenylalanine in human neutrophils. Mapping pathways for mitogen-activated protein kinase activation. J Biol Chem. 1996, 271, (52), 33598-33606.
    • (1996) J Biol Chem , vol.271 , Issue.52 , pp. 33598-33606
    • Avdi, N.J.1    Winston, B.W.2    Russel, M.3    Young, S.K.4    Johnson, G.L.5    Worthen, G.S.6
  • 29
    • 0344921405 scopus 로고    scopus 로고
    • Phosphorylation of the NADPH oxidase component p67(PHOX) by ERK2 and P38MAPK: Selectivity of phosphorylated sites and existence of an intramolecular regulatory domain in the tetratricopeptide-rich region
    • Dang, P.M., Morel, F., Gougerot-Pocidalo, M.A., El Benna, J. Phosphorylation of the NADPH oxidase component p67(PHOX) by ERK2 and P38MAPK: selectivity of phosphorylated sites and existence of an intramolecular regulatory domain in the tetratricopeptide-rich region. Biochemistry. 2003, 42, (15), 4520-4526.
    • (2003) Biochemistry , vol.42 , Issue.15 , pp. 4520-4526
    • Dang, P.M.1    Morel, F.2    Gougerot-Pocidalo, M.A.3    El Benna, J.4
  • 31
    • 0141457722 scopus 로고    scopus 로고
    • Pentoxifylline inhibits platelet-derived growth factorstimulated cyclin D1 expression in mesangial cells by blocking Akt membrane translocation
    • Lin, S.L., Chen, R.H., Chen, Y.M., Chiang, W.C., Tsai, T.J., Hsieh, B.S. Pentoxifylline inhibits platelet-derived growth factorstimulated cyclin D1 expression in mesangial cells by blocking Akt membrane translocation. Mol Pharmacol. 2003, 64, (4), 811-822.
    • (2003) Mol Pharmacol , vol.64 , Issue.4 , pp. 811-822
    • Lin, S.L.1    Chen, R.H.2    Chen, Y.M.3    Chiang, W.C.4    Tsai, T.J.5    Hsieh, B.S.6
  • 32
    • 33751233529 scopus 로고    scopus 로고
    • Blocking of Akt/NF-kappaB signaling by pentoxifylline inhibits platelet-derived growth factorstimulated proliferation in Brown Norway rat airway smooth muscle cells
    • Chiou, Y.L., Shieh, J.J., Lin, C.Y. Blocking of Akt/NF-kappaB signaling by pentoxifylline inhibits platelet-derived growth factorstimulated proliferation in Brown Norway rat airway smooth muscle cells. Pediatr Res. 2006, 60, (6), 657-662.
    • (2006) Pediatr Res , vol.60 , Issue.6 , pp. 657-662
    • Chiou, Y.L.1    Shieh, J.J.2    Lin, C.Y.3
  • 33
    • 0032567417 scopus 로고    scopus 로고
    • Activation of p47(PHOX), a cytosolic subunit of the leukocyte NADPH oxidase. Phosphorylation of ser-359 or ser- 370 precedes phosphorylation at other sites and is required for activity
    • Johnson, J.L., Park, J.W., Benna, J.E., Faust, L.P., Inanami, O., Babior, B.M. Activation of p47(PHOX), a cytosolic subunit of the leukocyte NADPH oxidase. Phosphorylation of ser-359 or ser- 370 precedes phosphorylation at other sites and is required for activity. J Biol Chem. 1998, 273, (52), 35147-35152.
    • (1998) J Biol Chem , vol.273 , Issue.52 , pp. 35147-35152
    • Johnson, J.L.1    Park, J.W.2    Benna, J.E.3    Faust, L.P.4    Inanami, O.5    Babior, B.M.6
  • 34
    • 33646086502 scopus 로고    scopus 로고
    • LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: Effects on proinflammatory mediators, metalloproteinases, NF-kappaB, and ICAM-1 expression
    • Coimbra, R., Melbostad, H., Loomis, W., Porcides, R.D., Wolf, P., Tobar, M., Hoyt, D.B. LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: effects on proinflammatory mediators, metalloproteinases, NF-kappaB, and ICAM-1 expression. J Trauma. 2006, 60, (1), 115-125.
    • (2006) J Trauma , vol.60 , Issue.1 , pp. 115-125
    • Coimbra, R.1    Melbostad, H.2    Loomis, W.3    Porcides, R.D.4    Wolf, P.5    Tobar, M.6    Hoyt, D.B.7
  • 35
    • 0036083693 scopus 로고    scopus 로고
    • Hypertonicity increases cAMP in PMN and blocks oxidative burst by PKA-dependent and -independent mechanisms
    • Orlic, T., Loomis, W.H., Shreve, A., Namiki, S., Junger, W.G. Hypertonicity increases cAMP in PMN and blocks oxidative burst by PKA-dependent and -independent mechanisms. Am J Physiol Cell Physiol. 2002, 282, (6), C1261-1269.
    • (2002) Am J Physiol Cell Physiol , vol.282 , Issue.6
    • Orlic, T.1    Loomis, W.H.2    Shreve, A.3    Namiki, S.4    Junger, W.G.5
  • 36
    • 5444248710 scopus 로고    scopus 로고
    • Osmotic regulation of cell function and possible clinical applications
    • Shukla, A., Hashiguchi, N., Chen, Y., Coimbra, R., Hoyt, D.B., Junger, W.G. Osmotic regulation of cell function and possible clinical applications. Shock. 2004, 21, (5), 391-400.
    • (2004) Shock , vol.21 , Issue.5 , pp. 391-400
    • Shukla, A.1    Hashiguchi, N.2    Chen, Y.3    Coimbra, R.4    Hoyt, D.B.5    Junger, W.G.6
  • 37
    • 0027930914 scopus 로고
    • FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase
    • Worthen, G.S., Avdi, N., Buhl, A.M., Suzuki, N., Johnson, G.L. FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase. J Clin Invest. 1994, 94, (2), 815-823.
    • (1994) J Clin Invest , vol.94 , Issue.2 , pp. 815-823
    • Worthen, G.S.1    Avdi, N.2    Buhl, A.M.3    Suzuki, N.4    Johnson, G.L.5
  • 38
    • 33749077086 scopus 로고    scopus 로고
    • A RSK(y) relationship with promiscuous PKA
    • Houslay, M.D. A RSK(y) relationship with promiscuous PKA. Sci STKE. 2006, 2006, (349), pe32.
    • (2006) Sci STKE , vol.2006 , Issue.349
    • Houslay, M.D.1
  • 39
    • 0027971374 scopus 로고
    • Regulation of mitogen-activated protein kinase activation by protein kinases A and C in a cell-free system
    • VanRenterghem, B., Browning, M.D., Maller, J.L. Regulation of mitogen-activated protein kinase activation by protein kinases A and C in a cell-free system. J Biol Chem. 1994, 269, (40), 24666-24672.
    • (1994) J Biol Chem , vol.269 , Issue.40 , pp. 24666-24672
    • Van Renterghem, B.1    Browning, M.D.2    Maller, J.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.