The Prediction of Skin Permeability by Using Physicochemical Data

Alternatives to Laboratory Animals

Volumn 25, Issue 3, 1997, Pages 359-370

  Kirchner, Lisa A ^a   Moody, Richard P ^a   Doyle, Edward ^a   Bose, Ranjan ^a   Jeffery, Jamie ^a   Chu, Ih ^a  

^a HEALTH CANADA   (Canada)

Author keywords

Molar volume; Partition coefficient; Permeability; QSAR; Skin

Indexed keywords

EID: 2542594118     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Stringer, D.A , ed. (1993) ECETOC Monograph No, 20: Percutaneous Absorption, pp. 12-22. Brussels: ECETOC
2. Flynn, G L (1990) Physicochemical determinants of skin absorption In Principles of Route-to-route Extrapolation for Risk Assessment (ed TR Gerrity & C J Henry), pp 93-127. New York: Elsevier.
3. Potts, R O. & Guy, R H (1992). Predicting skin permeability Pharmaceutical Research 9, 663-669
4. Barratt, M.D (1995) Quantitative structure-activity relationships for skin permeability. Toxicology in Vitro 9, 27-37
5. Wittiker, C., Walker, J D , Gay, D A. & Neal, M.W (1993). OSHA chemical referred to the ISCA Interagency Testing Committee for percutaneous absorption testing and prioritization and analysis of OSHA skin notation criteria Toxicoiogist 13, 101
6. Reed, R.C., Prausnitz, J M & Sherwood, T.K. (1977) The Properties of Gases and Liquids, 3rd edn, pp 16-21. New York. McGraw Hill.
7. Meissner, H.P (1949). Critical constants from parachor and molar refractions Chemical Engineering Progress 45, 149-153.
8. Kasting, G B., Smith, R.L. & Cooper, E R (1987) Effect of lipid solubility and molecular size on percutaneous absorption. In Pharmacology and the Skin (ed. B. Shroot & H Schaefer), pp 138-153 Basel S Karger.
9. Roberts, M S , Anderson, R.A. & Swarbrick, J (1977) Permeability of human epidermis to phenolic compounds Journal of Pharmacy and Pharmacology 29, 677-683.
10. Scheuplein, R.J (1965). Mechanism of percutaneous absorption. I. Routes of penetration and influence of solubility. Journal of Investigative Dermatology 45, 334-346.
11. Scheuplein, R J , Blank, I.H., Brauner, G.J & MacFarlane, D J (1969) Percutaneous absorption of steroids Journal of Investigative Dermatology 52, 63-70
12. Bronaugh, R L & Congdon, E R, (1984). Percutaneous absorption of hair dyes: correlation with partition coefficients. Journal of Investigative Dermatology 83, 124-127
13. Bronaugh, R.L &. Barton, C.N (1993) Prediction of human percutaneous absorption with physicochemical data. In Health Risk Assessment: Dermal and Inhalation Exposure and Absorption of Toxicants (ed. R.G M Wang, J B Knaak & H I Maibach), pp. 117-126. Boca Raton, FL, USA. CRC Press.
14. Johnson, M E., Blankstein, D. & Langer, R (1995) Permeation of steroids through skin Journal of Pharmaceutical Science 84, 1144-1146
15. Pugh, W J., Roberts, M S & Hadgraft, J. (1996). Epidermal permeability-penetrant structure relationship III The effect of hydrogen bonding interactions and molecular size on diffusion across the stratum corneum International Journal of Pharmaceutics 138, 3-19.
16. Sanz, F , Giraldo, J & Manaut, F (1994). QSAR and molecular modelling: concepts, computational tools and biological applications In Proceedings of the 10th European Symposium on Structure-activity Relationships: QSAR and Molecular Modelling, 688pp. Barcelona. Prous.
17. Van de Waterbeemd, H (1996). Structure-property Correlations in Drug Research, 210 pp. Austin, TX, USA: R.G. Landes Company and Academic.
18. Moody, R.P & Chu, I. (1995). Dermal exposure to environmental contaminants in the Great Lakes. Environmental Health Perspectives 103, 103-114.
19. Chu, I. (1995) Alternative methods to animal testing. a Canadian Health Protection Branch perspective. ATLA 23, 257-261
20. Howes, D., Guy, R , Hadgraft, J., Heylings, J , Hoeck, U , Kemper, K , Maibach, H., Marty, J-P., Merk, H , Parra, J., Rekkas, D., Rondelli, I., Schaefer, H , Tauber, U & Verbiese, N. (1996). Methods for assessing percutaneous absorption The report and recommendations of ECVAM workshop 13. ATLA 24, 81-106