Biotransformation of geniposide by human intestinal microflora on cytotoxicity against HepG2 cells

Toxicology Letters

Volumn 209, Issue 3, 2012, Pages 246-254

  Khanal, Tilak ^a   Kim, Hyung Gyun ^a   Choi, Jae Ho ^a   Do, Minh Truong ^a   Kong, Min Jeong ^b   Kang, Mi Jeong ^b   Noh, Kyeumhan ^b   Yeo, Hee Kyung ^c   Ahn, Young Tae ^d   Kang, Wonku ^b   Kim, Dong Hyun ^c   Jeong, Tae Cheon ^b   Jeong, Hye Gwang ^a  

^a Chungnam National University   (South Korea)

^b Yeungnam University   (South Korea)

^c Kyung Hee University   (South Korea)

^d Korea Yakult Co   (South Korea)

Author keywords

Cytotoxicity; Genipin; Geniposide; Intestinal microflora; Metabolism

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; GENIPIN; GENIPOSIDE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG TRANSFORMATION; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; INTESTINE FLORA; MALE; METABOLIC ACTIVATION; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BIOTRANSFORMATION; BLOTTING, WESTERN; CASPASE 3; CELL SURVIVAL; FECES; FEMALE; HEP G2 CELLS; HUMANS; IN SITU NICK-END LABELING; INTESTINES; IRIDOIDS; MALE; MAP KINASE SIGNALING SYSTEM; MOLECULAR STRUCTURE; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84862812302     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.12.017     Document Type: Article

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