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Volumn 46, Issue 8, 2008, Pages 2764-2769

Metabolism and pharmacokinetics of genipin and geniposide in rats

Author keywords

Gardenia jasminoides; Genipin; Geniposide; Pharmacokinetics; Toxicity

Indexed keywords

BETA GLUCURONIDASE; DRUG METABOLITE; GENIPIN; GENIPIN GLUCURONIDE; GENIPIN SULFATE; GENIPOSIDE; SULFATASE;

EID: 47149111967     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2008.04.033     Document Type: Article
Times cited : (115)

References (25)
  • 1
    • 0028559399 scopus 로고
    • Enzymic studies on the animal and intestinal bacterial metabolism of geniposide
    • Akao T., Kobashi K., and Aburasa M. Enzymic studies on the animal and intestinal bacterial metabolism of geniposide. Biol. Pharm. Bull. 17 (1994) 1573-1576
    • (1994) Biol. Pharm. Bull. , vol.17 , pp. 1573-1576
    • Akao, T.1    Kobashi, K.2    Aburasa, M.3
  • 2
    • 0033671475 scopus 로고    scopus 로고
    • Absorption of chlorogenic acid and caffeic acid in rats after oral administration
    • Azuma K., Ippoushi K., Nakayama M., Ito H., Higashio H., and Terao J. Absorption of chlorogenic acid and caffeic acid in rats after oral administration. J. Agric. Food Chem. 48 (2000) 5496-5500
    • (2000) J. Agric. Food Chem. , vol.48 , pp. 5496-5500
    • Azuma, K.1    Ippoushi, K.2    Nakayama, M.3    Ito, H.4    Higashio, H.5    Terao, J.6
  • 4
    • 29044436458 scopus 로고    scopus 로고
    • Immunosuppressive iridoids from the fruits of Gardenia jasminoides
    • Chang W.L., Wang H.Y., Shi L.S., Lai J.H., and Lin H.C. Immunosuppressive iridoids from the fruits of Gardenia jasminoides. J. Nat. Prod. 68 (2005) 1683-1685
    • (2005) J. Nat. Prod. , vol.68 , pp. 1683-1685
    • Chang, W.L.1    Wang, H.Y.2    Shi, L.S.3    Lai, J.H.4    Lin, H.C.5
  • 5
    • 0036988408 scopus 로고    scopus 로고
    • Flavonoids in herbs: biological fates and potential interactions with xenobiotics
    • Chao P.D.L., Hsiu S.L., and Hou Y.C. Flavonoids in herbs: biological fates and potential interactions with xenobiotics. J. Food Drug Anal. 10 (2002) 219-228
    • (2002) J. Food Drug Anal. , vol.10 , pp. 219-228
    • Chao, P.D.L.1    Hsiu, S.L.2    Hou, Y.C.3
  • 6
  • 7
    • 47149091691 scopus 로고    scopus 로고
    • Hou, Y.C., Chao, P.D.L., Hsiu, S.L., Tsai, S.Y., 2008. Metabolism and pharmacokinetics of glycosides in Chinese herbs. In: Tsai, F.J., Lin, H.J. (Eds.), A Phoenix Arising from Fire: New Applications of Old Traditional Herbs. Research Signpost, Trivandrum, India, pp. 39-50.
    • Hou, Y.C., Chao, P.D.L., Hsiu, S.L., Tsai, S.Y., 2008. Metabolism and pharmacokinetics of glycosides in Chinese herbs. In: Tsai, F.J., Lin, H.J. (Eds.), A Phoenix Arising from Fire: New Applications of Old Traditional Herbs. Research Signpost, Trivandrum, India, pp. 39-50.
  • 8
    • 0031586739 scopus 로고    scopus 로고
    • Comparisons of geniposidic acid and geniposide on antitumor and radioprotection after sublethal irradiation
    • Hsu H.Y., Yang J.J., Lin S.Y., and Lin C.C. Comparisons of geniposidic acid and geniposide on antitumor and radioprotection after sublethal irradiation. Cancer Lett. 113 (1997) 31-37
    • (1997) Cancer Lett. , vol.113 , pp. 31-37
    • Hsu, H.Y.1    Yang, J.J.2    Lin, S.Y.3    Lin, C.C.4
  • 9
    • 0031439453 scopus 로고    scopus 로고
    • Modulation of cytochrome P-450-dependent monooxygenases, glutathione and glutathione S-transferase in rat liver by geniposide from Gardenia jasminoides
    • Kang J.J., Wang H.W., Liu T.Y., Chen Y.C., and Ueng T.H. Modulation of cytochrome P-450-dependent monooxygenases, glutathione and glutathione S-transferase in rat liver by geniposide from Gardenia jasminoides. Food Chem. Toxicol. 35 (1997) 957-965
    • (1997) Food Chem. Toxicol. , vol.35 , pp. 957-965
    • Kang, J.J.1    Wang, H.W.2    Liu, T.Y.3    Chen, Y.C.4    Ueng, T.H.5
  • 11
    • 2642544054 scopus 로고    scopus 로고
    • Geniposide, an anti-angiogenic compound from the fruits of Gardenia jasminoides
    • Koo H.J., Lee S., Shim K.H., Kim B.C., Lim C.J., and Park E.H. Geniposide, an anti-angiogenic compound from the fruits of Gardenia jasminoides. Planta Med. 70 (2004) 467-469
    • (2004) Planta Med. , vol.70 , pp. 467-469
    • Koo, H.J.1    Lee, S.2    Shim, K.H.3    Kim, B.C.4    Lim, C.J.5    Park, E.H.6
  • 12
    • 31344449552 scopus 로고    scopus 로고
    • Anti-inflammatory evaluation of gardenia extract, geniposide and genipin
    • Koo H.J., Lim K.H., Jung H.J., and Park E.H. Anti-inflammatory evaluation of gardenia extract, geniposide and genipin. J. Ethnopharmacol. 103 (2006) 496-500
    • (2006) J. Ethnopharmacol. , vol.103 , pp. 496-500
    • Koo, H.J.1    Lim, K.H.2    Jung, H.J.3    Park, E.H.4
  • 14
    • 25444440828 scopus 로고    scopus 로고
    • Geniposide activates GSH S-transferase by the induction of GST M1 and GST M2 subunits involving the transcription and phosphorylation of MEK-1 signaling in rat hepatocytes
    • Kuo W.H., Chou F.P., Young S.C., Chang Y.C., and Wang C.J. Geniposide activates GSH S-transferase by the induction of GST M1 and GST M2 subunits involving the transcription and phosphorylation of MEK-1 signaling in rat hepatocytes. Toxicol. Appl. Pharmacol. 208 (2005) 155-162
    • (2005) Toxicol. Appl. Pharmacol. , vol.208 , pp. 155-162
    • Kuo, W.H.1    Chou, F.P.2    Young, S.C.3    Chang, Y.C.4    Wang, C.J.5
  • 15
    • 0344197641 scopus 로고    scopus 로고
    • Differential induction of the expression of GST subunits by geniposide in rat hepatocytes
    • Kuo W.H., Wang C.J., Young S.C., Sun Y.C., Chen Y.J., and Chou F.P. Differential induction of the expression of GST subunits by geniposide in rat hepatocytes. Pharmacology 70 (2004) 15-22
    • (2004) Pharmacology , vol.70 , pp. 15-22
    • Kuo, W.H.1    Wang, C.J.2    Young, S.C.3    Sun, Y.C.4    Chen, Y.J.5    Chou, F.P.6
  • 16
    • 0037464373 scopus 로고    scopus 로고
    • Colorimetric determination of amino acids using genipin from Gardenia jasminoides
    • Lee S.W., Lim J.M., Bhoo S.H., Paik Y.S., and Hahn T.R. Colorimetric determination of amino acids using genipin from Gardenia jasminoides. Anal. Chim. Acta 480 (2003) 267-274
    • (2003) Anal. Chim. Acta , vol.480 , pp. 267-274
    • Lee, S.W.1    Lim, J.M.2    Bhoo, S.H.3    Paik, Y.S.4    Hahn, T.R.5
  • 17
    • 29844439092 scopus 로고    scopus 로고
    • Geniposide from Gardenia jasminoides attenuates neuronal cell death in oxygen and glucose deprivation-exposed rat hippocampal slice culture
    • Lee P., Lee J., Choi S.Y., Lee S.E., and Son D. Geniposide from Gardenia jasminoides attenuates neuronal cell death in oxygen and glucose deprivation-exposed rat hippocampal slice culture. Biol. Pharm. Bull. 29 (2006) 174-176
    • (2006) Biol. Pharm. Bull. , vol.29 , pp. 174-176
    • Lee, P.1    Lee, J.2    Choi, S.Y.3    Lee, S.E.4    Son, D.5
  • 18
    • 0037164092 scopus 로고    scopus 로고
    • Isolation and characterization of water-soluble intermediates of blue pigments transformed from geniposide of Gardenia jasminoides
    • Park J.E., Lee J.Y., Kim H.G., Hahn T.R., and Paik Y.S. Isolation and characterization of water-soluble intermediates of blue pigments transformed from geniposide of Gardenia jasminoides. J. Agric. Food Chem. 50 (2002) 6511-6514
    • (2002) J. Agric. Food Chem. , vol.50 , pp. 6511-6514
    • Park, J.E.1    Lee, J.Y.2    Kim, H.G.3    Hahn, T.R.4    Paik, Y.S.5
  • 19
    • 34447099632 scopus 로고    scopus 로고
    • A 13-week oral dose subchronic toxicity study of gardenia yellow containing geniposide in rats
    • Sato S., Kitamura H., Chino M., Takei Y., Hiruma M., and Nomura M. A 13-week oral dose subchronic toxicity study of gardenia yellow containing geniposide in rats. Food Chem. Toxicol. 45 (2007) 1537-1544
    • (2007) Food Chem. Toxicol. , vol.45 , pp. 1537-1544
    • Sato, S.1    Kitamura, H.2    Chino, M.3    Takei, Y.4    Hiruma, M.5    Nomura, M.6
  • 20
    • 0032534707 scopus 로고    scopus 로고
    • Feasibility study of a natural crosslinking reagent for biological tissue fixation
    • Sung H.W., Huang R.N., Huang L.L.H., Tsai C.C., and Chiu C.T. Feasibility study of a natural crosslinking reagent for biological tissue fixation. J. Biomed. Mater. Res. 42 (1998) 560-567
    • (1998) J. Biomed. Mater. Res. , vol.42 , pp. 560-567
    • Sung, H.W.1    Huang, R.N.2    Huang, L.L.H.3    Tsai, C.C.4    Chiu, C.T.5
  • 21
    • 0035676786 scopus 로고    scopus 로고
    • Antithrombotic effect of geniposide and genipin in the mouse thrombosis model
    • Suzuki Y., Kondo K., Ikeda Y., and Umemura K. Antithrombotic effect of geniposide and genipin in the mouse thrombosis model. Planta Med. 67 (2001) 807-810
    • (2001) Planta Med. , vol.67 , pp. 807-810
    • Suzuki, Y.1    Kondo, K.2    Ikeda, Y.3    Umemura, K.4
  • 22
    • 2942750059 scopus 로고    scopus 로고
    • Measurement of unbound geniposide in blood, liver, brain and bile of anesthetized rats: an application of pharmacokinetic study and its influence on acupuncture
    • Tseng T.Y., and Tsai T.H. Measurement of unbound geniposide in blood, liver, brain and bile of anesthetized rats: an application of pharmacokinetic study and its influence on acupuncture. Anal. Chim. Acta 517 (2004) 47-52
    • (2004) Anal. Chim. Acta , vol.517 , pp. 47-52
    • Tseng, T.Y.1    Tsai, T.H.2
  • 23
    • 0034755677 scopus 로고    scopus 로고
    • Simultaneous estimation of geniposide and genipin in mouse plasma using high-performance liquid chromatography
    • Ueno K., Takeda Y., Iwasaki Y., and Yoshizaki F. Simultaneous estimation of geniposide and genipin in mouse plasma using high-performance liquid chromatography. Anal. Sci. 17 (2001) 1237-1239
    • (2001) Anal. Sci. , vol.17 , pp. 1237-1239
    • Ueno, K.1    Takeda, Y.2    Iwasaki, Y.3    Yoshizaki, F.4
  • 24
    • 0035210937 scopus 로고    scopus 로고
    • Prevention of the neurotoxicity of the amyloid β protein by genipin
    • Yamazaki M., Sakura N., Chiba K., and Mohri T. Prevention of the neurotoxicity of the amyloid β protein by genipin. Biol. Pharm. Bull. 24 (2001) 1454-1455
    • (2001) Biol. Pharm. Bull. , vol.24 , pp. 1454-1455
    • Yamazaki, M.1    Sakura, N.2    Chiba, K.3    Mohri, T.4
  • 25
    • 33746998922 scopus 로고    scopus 로고
    • HPLC method for the determination and pharmacokinetic studies on geniposide in rat serum after oral administration of traditional Chinese medicinal preparation Yin-Zhi-Ku decoction
    • Ye G., Zhu H.Y., Zhao H.L., Xu B., and Huang C.G. HPLC method for the determination and pharmacokinetic studies on geniposide in rat serum after oral administration of traditional Chinese medicinal preparation Yin-Zhi-Ku decoction. Biomed. Chromatogr. 20 (2006) 743-747
    • (2006) Biomed. Chromatogr. , vol.20 , pp. 743-747
    • Ye, G.1    Zhu, H.Y.2    Zhao, H.L.3    Xu, B.4    Huang, C.G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.