Design, synthesis, computational and biological evaluation of some new hydrazino derivatives of DHA and pyranopyrazoles

European Journal of Medicinal Chemistry

Volumn 50, Issue , 2012, Pages 81-89

  Kumar, Ajay ^a   Lohan, Poonam ^a   Aneja, Deepak K ^a   Gupta, Girish Kumar ^b   Kaushik, Dhirender ^a   Prakash, Om ^a  

^a KURUKSHETRA UNIVERSITY   (India)

^b MAHARISHI MARKANDESHWAR DEEMED TO BE UNIVERSITY   (India)

Author keywords

Analgesic activity; Anti inflammatory activity; Dehydroacetic acid; Docking study; Hydrazine; Pyranopyrazole

Indexed keywords

3,6 DIMETHYL 2 (4 BROMOPHENYL)PYRANO[4,3 C]PYRAZOL 4(2H) ONE; 3,6 DIMETHYL 2 (4 CHLOROPHENYL)PYRANO[4,3 C]PYRAZOL 4(2H) ONE; 3,6 DIMETHYL 2 (4 METHOXYPHENYL)PYRANO[4,3 C]PYRAZOL 4(2H) ONE; 3,6 DIMETHYL 2 (4 METHYLPHENYL)PYRANO[4,3 C]PYRAZOL 4(2H) ONE; 3,6 DIMETHYL 2 (4 PHENYLTHIAZOL 2 YL)PYRANO[4,3 C]PYRAZOL 4(2H) ONE; 3,6 DIMETHYL 2 PHENYLPYRANO[4,3 C]PYRAZOL 4(2H) ONE; 4 (2 BENZOTHIAZOLYLHYDRAZINYL) 3 ACETYL 6 METHYL 2H PYRAN 2 ONE; 4 (2 PHENYLHYDRAZINYL) 3 ACETYL 6 METHYL 2H PYRAN 2 ONE; 4 (3,5 DIMETHYLPYRIMIDINYLLHYDRAZINYL) 3 ACETYL 6 METHYL 2H PYRAN 2 ONE; 4 (4 METHYLQUINOLINYLLHYDRAZINYL) 3 ACETYL 6 METHYL 2H PYRAN 2 ONE; 4 [2 (4 BROMOPHENYLHYDRAZINYL)] 3 ACETYL 6 METHYL 2H PYRAN 2 ONE; 4 [2 (4 CHLOROPHENYLHYDRAZINYL)] 3 ACETYL 6 METHYL 2H PYRAN 2 ONE; 4 [2 (4 METHOXYPHENYLHYDRAZINYL)] 3 ACETYL 6 METHYL 2H PYRAN 2 ONE; 4 [2 (4 METHYLPHENYLHYDRAZINYL)] 3 ACETYL 6 METHYL 2H PYRAN 2 ONE; 4 [2 (4 NITROPHENYLHYDRAZINYL)] 3 ACETYL 6 METHYL 2H PYRAN 2 ONE; 4 [2 (4 PHENYLTHIAZOL 2 YLHYDRAZINYL)] 3 ACETYL 6 METHYL 2H PYRAN 2 ONE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; DEHYDROACETIC ACID; DICLOFENAC; HYDRAZINE DERIVATIVE; PROSTAGLANDIN SYNTHASE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG METABOLISM; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; MOLECULAR DOCKING; MOUSE; NONHUMAN; PAIN; PAW EDEMA; WRITHING TEST;

ACETIC ACID; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; COMPUTATIONAL BIOLOGY; CYCLOOXYGENASE INHIBITORS; DICLOFENAC; DRUG DESIGN; EDEMA; INDICATORS AND REAGENTS; MICE; PAIN; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84862811610     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.01.042     Document Type: Article

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