Design, synthesis, computational and biological evaluation of new anxiolytics

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 24, 2004, Pages 6559-6568

  Geronikaki, Athina ^a   Babaev, Eugeni ^b   Dearden, John ^c   Dehaen, Wim ^d   Filimonov, Dmitrii ^e   Galaeva, Irina ^f   Krajneva, Valentina ^f   Lagunin, Alexey ^e   MacAev, Fliur ^g   Molodavkin, Guenadiy ^f   Poroikov, Vladimir ^e   Pogrebnoi, Serghei ^g   Saloutin, Victor ^h   Stepanchikova, Alla ^e   Stingaci, Eugenia ^g   Tkach, Natalia ^b   Vlad, Liudmila ^g   Voronina, Tatiana ^f  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

^c LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

^f INSTITUTE OF PHARMACOLOGY   (Russian Federation)

^g Moldova   (Moldova)

^h INSTITUTE OF ORGANIC SYNTHESIS   (Russian Federation)

Author keywords

2 Indolinones; Anxiolytics; Fused imidazoles; pass; Pyrazoles; Synthesis; Thiazoles

Indexed keywords

1 (4 METHYL 2 PHENYL 1,3 THIAZOL 5 YL) 3 MORPHOLIN 4 YLPROPAN 1 ONE; 1 [(4 BROMOPHENYL) 2 OXOETHYL] 3 (1,3 DIOXOLANO) 2 INDOLINONE; 1 [(4 FLUOROPHENYL) 2 OXOETHYL] 3 (1,3 DIOXOLANO) 2 INDOLINONE; 1 [2 (4 BROMOPHENYL) 2 OXOETHYL] 3 (1,3 DIOXOLANO) 2 INDOLINONE; 2 (4 FLUOROPHENYL) 3 (4 METHYLPIPERAZINOMETHYL)IMIDAZO[1,2 A]PYRIDINE; 2 (4 NITROPHENYL) 3 (4 PHENYLPIPERAZINOMETHYL)IMIDAZO[1,2 A]PYRIDINE; 3 (1,3 DIOXOLANO) 2 INDOLINONE; 3 (MORPHOLINOMETHYL) 2 (4 FLUOROPHENYL)IMIDAZO[2,1 B][1,3]THIAZOLE; 5 HYDROXY 3 (1,1,2,2 TETRAFLUOROETHYL) 1 PHENYLPYRAZOLE; 5 HYDROXY 3 METHOXYCARBONYL 1 PHENYLPYRAZOLE; ANXIOLYTIC AGENT; MEDAZEPAM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; PREDICTION; TRANQUILIZING ACTIVITY;

EID: 20844439370     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.09.016     Document Type: Article

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