Synthesis and structure-activity relationship of a new series of potent AT1 selective angiotensin II receptor antagonists: 5-(biphenyl-4- ylmethyl)pyrazoles

Journal of Medicinal Chemistry

Volumn 40, Issue 4, 1997, Pages 547-558

  Almansa, Carmen ^a   Gómez, Luis A ^a   Cavalcanti, Fernando L ^a   De Arriba, Alberto F ^a   García Rafanell, Julián ^a   Forn, Javier ^a  

^a Grupo Uriach   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

3 TERT BUTYL 1 PROPYL 5 [[2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL] 1H PYRAZOLE 4 CARBOXYLIC ACID; 5 (BIPHENYL 4 YLMETHYL)PYRAZOLE DERIVATIVE; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; FUROSEMIDE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BLOOD PRESSURE REGULATION; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HYPERTENSION; MALE; RAT; RECEPTOR AFFINITY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; STRUCTURE ACTIVITY RELATION;

ANGIOTENSIN I; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; PYRAZOLES; RATS; RECEPTORS, ANGIOTENSIN; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES;

EID: 0031055174     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9604383     Document Type: Article

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