Molecular properties prediction, synthesis and antimicrobial activity of some newer oxadiazole derivatives

European Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2010, Pages 5862-5869

  Bakht, Mohammed Afroz ^a   Yar, M Shahar ^b   Abdel Hamid, Sami Gaber ^a   Al Qasoumi, Saleh I ^a   Samad, Abdul ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b HAMDARD UNIVERSITY   (India)

Author keywords

1,3,4 Oxadiazole; Antimicrobial screening; Drug likeness; Lipinski Rule of 5; Molecular properties prediction

Indexed keywords

3 [4 [(5 PHENYL 1,3,4 OXADIAZOL 2 YL)METHOXY]3 METHOXYPHENYL] 1 PHENYLPROP 2 EN 1 ONE; 3 [4 [[5 (2 HYDROXYPHENYL) 1,3,4 OXADIAZOL 2 YL]METHOXY] 3 METHOXYPHENYL] 1 (4 HYDROXYPHENYLL)PROP 2 EN 1 ONE; 3 [4 [[5 (2 HYDROXYPHENYL) 1,3,4 OXADIAZOL 2 YL]METHOXY] 3 METHOXYPHENYL] 1 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 [4 [[5 (2 HYDROXYPHENYL) 1,3,4 OXADIAZOL 2 YL]METHOXY] 3 METHOXYPHENYL] 1 PHENYLPROP 2 EN 1 ONE; 3 [4 [[5 (4 CHLOROPHENYL) 1,3,4 OXADIAZOL 2 YL]METHOXY] 3 METHOXYPHENYL] 1 (4 HYDROXYPHENYLL)PROP 2 EN 1 ONE; 3 [4 [[5 (4 CHLOROPHENYL) 1,3,4 OXADIAZOL 2 YL]METHOXY] 3 METHOXYPHENYL] 1 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 [4 [[5 (4 CHLOROPHENYL) 1,3,4 OXADIAZOL 2 YL]METHOXY] 3 METHOXYPHENYL] 1 PHENYLPROP 2 EN 1 ONE; 3 [4 [[5 (4 NITROPHENYL) 1,3,4 OXADIAZOL 2 YL]METHOXY] 3 METHOXYPHENYL] 1 (4 HYDROXYPHENYLL)PROP 2 EN 1 ONE; 3 [4 [[5 (PHENOXYMETHYL) 1,3,4 OXADIAZOL 2 YL]METHOXY] 3 METHOXYPHENYL] 1 (4 HYDROXYPHENYLL)PROP 2 EN 1 ONE; 3 [4 [[5 (PHENOXYMETHYL) 1,3,4 OXADIAZOL 2 YL]METHOXY] 3 METHOXYPHENYL] 1 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 [4 [[5 (PHENOXYMETHYL) 1,3,4 OXADIAZOL 2 YL]METHOXY] 3 METHOXYPHENYL] 1 PHENYLPROP 2 EN 1 ONE; 3 [4 [[5 4 TOLYL 1,3,4 OXADIAZOL 2 YL]METHOXY] 3 METHOXYPHENYL] 1 (4 HYDROXYPHENYLL)PROP 2 EN 1 ONE; 3 [4 [[5 4 TOLYL 1,3,4 OXADIAZOL 2 YL]METHOXY] 3 METHOXYPHENYL] 1 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 [4 [[5 4 TOLYL 1,3,4 OXADIAZOL 2 YL]METHOXY] 3 METHOXYPHENYL] 1 PHENYLPROP 2 EN 1 ONE; 3 [4 [[5 PHENYL 1,3,4 OXADIAZOL 2 YL]METHOXY] 3 METHOXYPHENYL] 1 (4 HYDROXYPHENYLL)PROP 2 EN 1 ONE; 3 [4 [[5 PHENYL 1,3,4 OXADIAZOL 2 YL]METHOXY] 3 METHOXYPHENYL] 1 PHENYLPROP 2 EN 1 ONE; OXADIAZOLE DERIVATIVE; PHENYL GROUP; UNCLASSIFIED DRUG;

ABSORPTION; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; FUNGAL STRAIN; IRRADIATION; LIPOPHILICITY; MINIMUM INHIBITORY CONCENTRATION; NUCLEAR MAGNETIC RESONANCE; SCORING SYSTEM; SPECTROSCOPY;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; BACTERIA; FUNGI; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; OXADIAZOLES; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78649316934     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.07.069     Document Type: Article

References (36)

1. S.J. Dolman, F. Gosselin, P.D. O'Shea, and I.W. Davies J. Org. Chem. 71 2006 9548 9551
2. M.D. Mullican, M.W. Wilson, D.T. Connor, C.R. Kostlan, D.J. Schrier, and R.D. Dyer J. Med. Chem. 361 1993 1090 1099
3. D.H. Boschelli, D.T. Connor, D.A. Bornemeier, R.D. Dyer, J.A. Kennedy, P.J. Kuipers, G.C. Okonkwo, D.J. Schrier, and C.D. Wright J. Med. Chem. 36 1993 1802 1810
4. K. Raman, K.H. Singh, S.K. Salzman, and S.S. Parmar J. Pharm. Sci. 821 1993 167 169
5. G. Sahin, E. Palaska, P. Kelicen, R. Demirdamar, G. Altinok, and F. Arzneim Drug Res. 51 2001 478 484
6. S.L. Gaonkar, K.M.L. Rai, and B. Prabhuswamy Eur. J. Med. Chem. 41 2006 841 846
7. A.A. El-Emam, O.A. Al-Deeb, M. Al-Omar, and J. Lehmann Bioorg. Med. Chem. 12 2004 5107 5113
8. M.A. Bakht, M. Islam, and A.A. Siddiqui Ind. J. Het. Chem. 15 2006 297 298
9. W.e.i. Shi, X.u.h.o.n.g. Qian, R.o.n.g. Zhang, and G.o.n.g.h.u.a. Song J. Agric. Food Chem. 49 2001 124 130
10. X.u.h.o.n.g. Qian, and R.o.n.g. Zhang J. Chem. Technol. Biotechnol. 67 1996 124 130
11. T.J. Hou, and X.J. Xu Curr. Pharm. Des. 10 2004 1011 1033
12. H.V. de Waterbeemd, and E. Gifford Nat. Rev. Drug Discov. 2 2003 192 204
13. T. Hou, J. Wang, W. Zhang, and X. Xu J. Chem. Inf. Model. 47 2007 460 463
14. C.A. Lipinski, F. Lombardo, B.W. Dominy, and P.J. Feeney Adv. Drug Deliv. Rev. 23 1997 3 25
15. A. Avdeef Curr. Top. Med. Chem. 1 2001 277 351
16. T.T. Oprea J. Comput. Aided Mol. Des. 16 2002 325 334
17. U. Norinder, and A.S. Bergstr Chem. Med. Chem. 1 2006 920 934
18. I.V. Tetko, and V.Y. Tanchuk J. Chem. Inf. Comput. Sci. 42 2002 1136 1145
19. I.V. Tetko, V.Y. Tanchuk, and A.E.P. Villa J. Chem. Inf. Comput. Sci. 41 2001 1407 1421
20. I.V. Tetko, V.Y. Tanchuk, T.N. Kasheva, and A.E.P. Villa J. Chem. Inf. Comput. Sci. 41 2001 1488 1493
21. K.V. Balakin, N.P. Savchuk, and I.V. Tetko Curr. Med. Chem. 13 2006 223 241
22. W.M. Meylan, and P.H. Howard J. Pharm. Sci. 84 1995 83 92
23. M. Remko J. Mol. Struc: Theochem 897 2009 73 82
24. http://www.srcinc.com/what-we-do/databaseforms.aspx?id=385/10/06/2008.
25. R.X. Wang, Y. Fu, and L.H. Lai J. Chem. Inf. Comput. Sci. 37 1997 615 621
26. R.X. Wang, Y. Gao, and L.H. Lai Drug Discov. Des. 19 2000 47 66
27. Y.H. Zhao, M.H. Abraham, J. Lee, A. Hersey, C.h.N. Luscombe, G. Beck, B. Sherborne, and I. Cooper Pharm. Res. 19 2002 1446 1457
28. D.F. Veber, S.R. Johnson, H.Y. Cheng, B.R. Smith, K.W. Ward, and K.D. Kapple J. Med. Chem. 45 2002 2615 2623
29. H.H.F. Refsgaard, B.F. Jensen, P.B. Brockhoff, S.B. Padkjaer, M. Guldbrandt, and M.S. Christensen J. Med. Chem. 48 2005 805 811
30. I. Muegge Med. Res. Rev. 23 2003 302 321
31. P. Ertl, B. Rohde, and P. Selzer J. Med. Chem. 43 2000 3714 3717
32. . 10/06/2008.
33. R. Cruickshank, J.P. Duguid, B.P. Marmion, and R.H.A. Swain twelfth ed. Medicinal Microbiology vol. II 1975 Churchill Livingstone London 196-202
34. A.H. Collins Microbiological Methods second ed. 1976 Butterworth London
35. Z.K. Khan, In-vitro and in-vivo screening techniques for bioactivity screening and evaluation, In: Proc. Int. Workshop UNIDO-CDRI, 1997. pp. 210-211.
36. R.S. Varma, Antifungal Agents: Past, Present and Future Prospects 1998 National Academy of Chemistry & Biology Lucknow, India