TCP-FA4: A derivative of tranylcypromine showing improved blood-brain permeability

Biochemical Pharmacology

Volumn 78, Issue 11, 2009, Pages 1412-1417

  Desino, Kelly E ^a   Pignatello, Rosario ^b   Guccione, Salvatore ^b   Basile, Livia ^b   Ansar, Sabah ^a   Michaelis, Mary Lou ^a   Ramsay, Rona R ^c   Audus, Kenneth L ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b UNIVERSITY OF CATANIA   (Italy)

^c UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

Amyloid; Blood brain barrier (BBB); Fatty acid chains; Lipoamino acids; Monoamine oxidase inhibition; Neuroprotection

Indexed keywords

AMYLOID BETA PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; TRANYLCYPROMINE DERIVATIVE; TRANYLCYPROMINE FA4; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN NERVE CELL; BRAIN TISSUE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG PENETRATION; DRUG STRUCTURE; EMBRYO; ENDOTHELIUM CELL; FETUS; HUMAN; HUMAN CELL; LIPID BILAYER; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; UMBILICAL VEIN;

AMYLOID BETA-PROTEIN; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CATTLE; CELL SURVIVAL; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; MICROVESSELS; MONOAMINE OXIDASE INHIBITORS; NEURONS; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; TRANYLCYPROMINE; UMBILICAL VEINS; UP-REGULATION;

EID: 70349771755     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.07.027     Document Type: Article

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