Effect of influenza A virus non-structural protein 1(NS1) on a mouse model of diabetes mellitus induced by Streptozotocin

Biochemical and Biophysical Research Communications

Volumn 419, Issue 1, 2012, Pages 120-125

  Pei, Decui ^a   Dai, Jun ^a,b   Kuang, Yu ^a   Wang, Huan ^a   Ren, Laifeng ^a   Shao, Jingjing ^a   Zuo, Bin ^a   Li, Sha ^a   Jiang, Zhonghua ^a   Li, Mingyuan ^a,c  

^a SICHUAN UNIVERSITY   (China)

^b HEBEI MEDICAL UNIVERSITY   (China)

^c SICHUAN UNIVERSITY   (China)

Author keywords

Diabetes mellitus; Influenza A virus; Non structural protein; NS1

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; GAMMA INTERFERON; GLUCOSE; GLYCOGEN; INSULIN; INTERLEUKIN 10; NONSTRUCTURAL PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; STREPTOZOCIN; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; IMMUNOREACTIVITY; INNATE IMMUNITY; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULITIS; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SPLEEN LYMPHOCYTE; STREPTOZOCIN DIABETES; UPREGULATION;

ANIMALS; CELL LINE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; INJECTIONS, INTRAMUSCULAR; MALE; MICE; MICE, INBRED BALB C; PLASMIDS; RECOMBINANT PROTEINS; VIRAL NONSTRUCTURAL PROTEINS;

INFLUENZA A VIRUS; MUS;

EID: 84862804444     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.01.146     Document Type: Article

References (32)

1. Hamden K., Jaouadi B., Salami T., et al. Modulatory effect of fenugreek saponins on the activities of intestinal and hepatic disaccharidase and glycogen and liver function of diabetic rats. Biotechnol. Bioproc. E. 2010, 15:745-753.
2. Diabetes facts-fact sheet N°312, 2011 [http://www.who.int/mediacentre/ factsheets/fs312/en/]index.html. World Health Organization, Geneva, Switzerland Accessed September 15, 2011.
3. Thrower S.L., Bingley P.J. What is type 1 diabetes?. Medicine 2010, 38:592-596.
4. Heydari I., Radi V., Razmjou S., et al. Chronic complications of diabetes mellitus in newly diagnosed patients. Int. J. Diabet Mellit. 2010, 2:61-63.
5. Lehuen A., Diana J., Zaccone P., et al. Immune cell crosstalk in type 1 diabetes. Nat. Rev. Immunol. 2010, 10:501-513.
6. Sena C.M., Bento C.F., Pereira P., et al. Diabetes mellitus: new challenges and innovative therapies. EPMA. J. 2010, 1:138-163.
7. Peyrot M., Rubin R.R., Lauritzen T., et al. Resistance to insulin therapy among patients and providers: results of the cross-national diabetes attitudes, wishes, and needs (DAWN) study. Diabet. Care 2005, 28:2673-2679.
8. Ahmed U.S., Junaidi B., Ali A.W., et al. Barriers in initiating insulin therapy in a South Asian Muslim community. Diabetes Med. 2010, 27:169-174.
9. Baruah M.P. Insulin pens: the modern delivery devices. J. Assoc. Physicians India 2011, 59:38-40.
10. Pareek H., Sharma S., Khajja B.S. Evaluation of hypoglycemic and anti-hyperglycemic potential of Tridax procumbens (Linn.). BMC. Complement. Altern. Med. 2009, 9:48.
11. Bresson D., von Herrath M. Immunotherapy for the prevention and treatment of type 1 diabetes: optimizing the path from bench to bedside. Diabetes Care 2009, 32:1753-1768.
12. Hale B.G., Randall R.E., Ortín J., et al. The multifunctional NS1 protein of influenza A viruses. J. Gen. Virol. 2008, 89:2359-2376.
13. Zhirnov O.P., Konakova T.E., Wolff T., et al. NS1 protein of influenza A virus down-regulates apoptosis. J. Virol. 2002, 76:1617-1625.
14. Ehrhardt C., Wolff T., Pleschka S., et al. Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses. J. Virol. 2007, 81:3058-3067.
15. Matsuda M., Suizu F., Hirata N., et al. Characterization of the interaction of influenza virus NS1 with Akt. Biochem. Biophys. Res. Commun. 2010, 395:312-317.
16. Wang X.D., Shen Y., Qiu Y.F., et al. The non-structural (NS1) protein of influenza A virus associates with p53 and inhibits p53-mediated transcriptional activity and apoptosis. Biochem. Biophys. Res. Commun. 2010, 395:141-145.
17. Liu H.B., Golebiewski L., Dow E.C., et al. The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting scribble. J. Virol. 2010, 84:11164-11174.
18. Hale B.G., Batty I.H., Downes C.P., et al. Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation. J. Biol. Chem. 2008, 283:1372-1380.
19. Hale B.G., Kerry P.S., Jackson D., et al. Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein. PNAS 2010, 107:1954-1959.
20. Manning B.D., Cantley L.C. AKT/PKB signaling: navigating downstream. Cell 2007, 129:1261-1274.
21. Weiss L., Zeira M., Reich S., et al. Cannabidiol arrests onset of autoimmune diabetes in NOD mice. Neuropharmacology 2008, 54:244-249.
22. Zhang Z.L., Shen S.X., Lin B., et al. Intramuscular injection of interleukin-10 plasmid DNA prevented autoimmune diabetes in mice. Acta. Pharmacol. Sin. 2003, 24:751-756.
23. Shin Y.K., Liu Q., Tikoo S.K., et al. Influenza A virus NS1 protein activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway by direct interaction with the p85 subunit of PI3K. J. Gen. Virol. 2007, 88:13-18.
24. Hale B.G., Jackson D., Chen Y.H., et al. Influenza A virus NS1 protein binds p85β and activates phosphatidylinositol-3-kinase signaling. Proc. Natl. Acad. Sci. USA 2006, 103:14194-14199.
25. A PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia. Cell Metab. 2006, 3:355-366.
26. Taniguchi C.M., Kondo T., Sajan M., et al. Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKCλ/ζ. Cell Metab. 2006, 3:343-353.
27. Cnop M., Welsh N., Jonas J.C., et al. Mechanisms of pancreatic β-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 2005, 54:S97-S107.
28. Falzacappa C.V., Petrucci E., Patriarca V., et al. Thyroid hormone receptor TRβ1 mediates Akt activation by T3 in pancreatic β cells. J. Mol. Endocrinol. 2007, 38:221-233.
29. Cai Y., Wang Q.D., Ling Z.D., et al. Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR. Biochem. Pharmacol. 2008, 75:1981-1993.
30. Jia D., Rahbar R., Chan R.W., et al. Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling. PLoS ONE 2010, 5:e13927.
31. Stasakova J., Ferko B., Kittel C., et al. Influenza A mutant viruses with altered NS1 protein function provoke caspase-1 activation in primary human macrophages, resulting in fast apoptosis and release of high levels of interleukins 1β and 18. J. Gen. Virol. 2005, 86:185-195.
32. Fernandez-Sesma A., Marukian S., Ebersole B.J., et al. Influenza virus evades innate and adaptive immunity via the NS1 protein. J. Virol. 2006, 80:6295-6304.