NKG2D signaling on CD8 + T cells represses T-bet and rescues CD4-unhelped CD8 + T cell memory recall but not effector responses

Nature Medicine

Volumn 18, Issue 3, 2012, Pages 422-428

  Zloza, Andrew ^a,b   Kohlhapp, Frederick J ^a   Lyons, Gretchen E ^a   Schenkel, Jason M ^c   Moore, Tamson V ^a,b   Lacek, Andrew T ^a   O'Sullivan, Jeremy A ^a,b   Varanasi, Vineeth ^a   Williams, Jesse W ^a   Jagoda, Michael C ^a   Bellavance, Emily C ^a   Marzo, Amanda L ^d   Thomas, Paul G ^e   Zafirova, Biljana ^f   Polić, Bojan ^f   Al Harthi, Lena ^d   Sperling, Anne I ^a   Guevara Patiño, José A ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^d RUSH UNIVERSITY MEDICAL CENTER   (United States)

^e ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^f UNIVERSITY OF RIJEKA   (Croatia)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; NATURAL KILLER CELL RECEPTOR NKG2D; TRANSCRIPTION FACTOR T BET;

ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOLYSIS; EFFECTOR CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; IMMUNE RESPONSE; INFLUENZA; INTERFERON PRODUCTION; MEMORY CELL; MOUSE; NATURAL KILLER CELL; NATURAL KILLER T CELL; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY, IMMUNOLOGIC; DISEASE MODELS, ANIMAL; GENE EXPRESSION; HIV INFECTIONS; HIV-1; HUMANS; IMMUNITY, CELLULAR; INFLUENZA, HUMAN; INTERFERON-GAMMA; INTERLEUKIN-2; MICE; MICE, INBRED C57BL; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTES, HELPER-INDUCER; VACCINES, DNA;

MUS;

EID: 84862801958     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2683     Document Type: Article

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