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Volumn 114, Issue 18, 2009, Pages 3841-3853

Potent HIV-specific responses are enriched in a unique subset of CD8 + T cells that coexpresses CD4 on its surface

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TETRAMER; HLA ANTIGEN CLASS 2; HUMAN IMMUNODEFICIENCY VIRUS VACCINE;

EID: 70449704423     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-02-202481     Document Type: Article
Times cited : (36)

References (34)
  • 1
    • 7144227284 scopus 로고    scopus 로고
    • Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
    • Ogg GS, Jin X, Bonhoeffer S, et al. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science. 1998; 279(5359):2103-2106.
    • (1998) Science , vol.279 , Issue.5359 , pp. 2103-2106
    • Ogg, G.S.1    Jin, X.2    Bonhoeffer, S.3
  • 2
    • 0025891987 scopus 로고
    • CD8+ cell anti-HIV activity correlates with the clinical state of the infected individual
    • Mackewicz CE, Ortega HW, Levy JA. CD8+ cell anti-HIV activity correlates with the clinical state of the infected individual. J Clin Invest. 1991; 87(4):1462-1466.
    • (1991) J Clin Invest , vol.87 , Issue.4 , pp. 1462-1466
    • Mackewicz, C.E.1    Ortega, H.W.2    Levy, J.A.3
  • 3
    • 33646686040 scopus 로고    scopus 로고
    • HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
    • Betts MR, Nason MC, West SM, et al. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood. 2006; 107(12):4781-4789.
    • (2006) Blood , vol.107 , Issue.12 , pp. 4781-4789
    • Betts, M.R.1    Nason, M.C.2    West, S.M.3
  • 4
    • 0034931584 scopus 로고    scopus 로고
    • Upregulation of CD4 on CD8+ T cells: CD4dimCD8bright T cells constitute an activated phenotype of CD8+ T cells
    • Sullivan YB, Landay AL, Zack JA, Kitchen SG, Al-Harthi L. Upregulation of CD4 on CD8+ T cells: CD4dimCD8bright T cells constitute an activated phenotype of CD8+ T cells. Immunology. 2001;103(3):270-280.
    • (2001) Immunology , vol.103 , Issue.3 , pp. 270-280
    • Sullivan, Y.B.1    Landay, A.L.2    Zack, J.A.3    Kitchen, S.G.4    Al-Harthi, L.5
  • 5
    • 0141567584 scopus 로고    scopus 로고
    • CD8+ T cells that express CD4 on their surface (CD4dimCD8bright T cells) recognize an antigen-specific target, are detected in vivo, and can be productively infected by T-tropic HIV
    • Zloza A, Sullivan YB, Connick E, Landay AL, Al-Harthi L. CD8+ T cells that express CD4 on their surface (CD4dimCD8bright T cells) recognize an antigen-specific target, are detected in vivo, and can be productively infected by T-tropic HIV. Blood. 2003;102(6):2156-2164.
    • (2003) Blood , vol.102 , Issue.6 , pp. 2156-2164
    • Zloza, A.1    Sullivan, Y.B.2    Connick, E.3    Landay, A.L.4    Al-Harthi, L.5
  • 6
    • 30144437151 scopus 로고    scopus 로고
    • Multiple populations of T lymphocytes are distinguished by the level of CD4 and CD8 coexpression and require individual consideration
    • Zloza A, Al-Harthi L. Multiple populations of T lymphocytes are distinguished by the level of CD4 and CD8 coexpression and require individual consideration. J Leukoc Biol. 2006;79(1):4-6.
    • (2006) J Leukoc Biol , vol.79 , Issue.1 , pp. 4-6
    • Zloza, A.1    Al-Harthi, L.2
  • 7
    • 0032539865 scopus 로고    scopus 로고
    • Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: Implications for HIV pathogenesis
    • Flamand L, Crowley RW, Lusso P, Colombini-Hatch S, Margolis DM, Gallo RC. Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: implications for HIV pathogenesis. Proc Natl Acad Sci U S A. 1998;95(6):3111-3116.
    • (1998) Proc Natl Acad Sci U S a , vol.95 , Issue.6 , pp. 3111-3116
    • Flamand, L.1    Crowley, R.W.2    Lusso, P.3    Colombini-Hatch, S.4    Margolis, D.M.5    Gallo, R.C.6
  • 8
    • 0031660975 scopus 로고    scopus 로고
    • Costimulation of naive CD8(+) lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection
    • Kitchen SG, Korin YD, Roth MD, Landay A, Zack JA. Costimulation of naive CD8(+) lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection. J Virol. 1998;72(11):9054-9060.
    • (1998) J Virol , vol.72 , Issue.11 , pp. 9054-9060
    • Kitchen, S.G.1    Korin, Y.D.2    Roth, M.D.3    Landay, A.4    Zack, J.A.5
  • 9
    • 0036093062 scopus 로고    scopus 로고
    • Activation of CD8 T cells induces expression of CD4, which functions as a chemotactic receptor
    • Kitchen SG, LaForge S, Patel VP, Kitchen CM, Miceli MC, Zack JA. Activation of CD8 T cells induces expression of CD4, which functions as a chemotactic receptor. Blood. 2002;99(1):207-212.
    • (2002) Blood , vol.99 , Issue.1 , pp. 207-212
    • Kitchen, S.G.1    Laforge, S.2    Patel, V.P.3    Kitchen, C.M.4    Miceli, M.C.5    Zack, J.A.6
  • 10
    • 2942526960 scopus 로고    scopus 로고
    • CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infection
    • Kitchen SG, Jones NR, LaForge S, et al. CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infection. Proc Natl Acad Sci U S A. 2004;101(23):8727-8732.
    • (2004) Proc Natl Acad Sci U S a , vol.101 , Issue.23 , pp. 8727-8732
    • Kitchen, S.G.1    Jones, N.R.2    Laforge, S.3
  • 11
    • 14844340786 scopus 로고    scopus 로고
    • The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigens
    • Kitchen SG, Whitmire JK, Jones NR, et al. The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigens. Proc Natl Acad Sci U S A. 2005; 102(10):3794-3799.
    • (2005) Proc Natl Acad Sci U S a , vol.102 , Issue.10 , pp. 3794-3799
    • Kitchen, S.G.1    Whitmire, J.K.2    Jones, N.R.3
  • 12
    • 0004167774 scopus 로고    scopus 로고
    • Productive infection of neonatal CD8+ T lymphocytes by HIV-1
    • Yang LP, Riley JL, Carroll RG, et al. Productive infection of neonatal CD8+ T lymphocytes by HIV-1. J Exp Med. 1998;187(7):1139-1144.
    • (1998) J Exp Med , vol.187 , Issue.7 , pp. 1139-1144
    • Yang, L.P.1    Riley, J.L.2    Carroll, R.G.3
  • 13
    • 0021955612 scopus 로고
    • Coexpression of T4 and T8 on peripheral blood T cells demonstrated by two-color fluorescence flow cytometry
    • Blue ML, Daley JF, Levine H, Schlossman SF. Coexpression of T4 and T8 on peripheral blood T cells demonstrated by two-color fluorescence flow cytometry. J Immunol. 1985;134(4):2281-2286.
    • (1985) J Immunol , vol.134 , Issue.4 , pp. 2281-2286
    • Blue, M.L.1    Daley, J.F.2    Levine, H.3    Schlossman, S.F.4
  • 14
    • 0027250939 scopus 로고
    • Cytofluorimetric identification of two populations of double positive (CD4+,CD8+) T lymphocytes in human peripheral blood
    • Ortolani C, Forti E, Radin E, Cibin R, Cossarizza A. Cytofluorimetric identification of two populations of double positive (CD4+,CD8+) T lymphocytes in human peripheral blood. Biochem Biophys Res Commun. 1993;191(2):601-609.
    • (1993) Biochem Biophys Res Commun , vol.191 , Issue.2 , pp. 601-609
    • Ortolani, C.1    Forti, E.2    Radin, E.3    Cibin, R.4    Cossarizza, A.5
  • 15
    • 0032738062 scopus 로고    scopus 로고
    • Extrathymic CD4/CD8 double positive T cells
    • Zuckermann FA. Extrathymic CD4/CD8 double positive T cells. Vet Immunol Immunopathol. 1999;72(1-2):55-66.
    • (1999) Vet Immunol Immunopathol , vol.72 , Issue.1-2 , pp. 55-66
    • Zuckermann, F.A.1
  • 16
    • 0027321768 scopus 로고
    • Emergence of double-positive CD4/CD8 cells from adult peripheral blood mononuclear cells infected with human T cell leukemia virus type I (HTLV-I)
    • Macchi B, Graziani G, Zhang J, Mastino A. Emergence of double-positive CD4/CD8 cells from adult peripheral blood mononuclear cells infected with human T cell leukemia virus type I (HTLV-I). Cell Immunol. 1993;149(2):376-389.
    • (1993) Cell Immunol , vol.149 , Issue.2 , pp. 376-389
    • Macchi, B.1    Graziani, G.2    Zhang, J.3    Mastino, A.4
  • 17
    • 17344367915 scopus 로고    scopus 로고
    • Phenotypical heterogeneity of CD4+CD8+ double-positive chronic T lymphoid leukemia
    • Mizuki M, Tagawa S, Machii T, et al. Phenotypical heterogeneity of CD4+CD8+ double-positive chronic T lymphoid leukemia. Leukemia. 1998; 12(4):499-504.
    • (1998) Leukemia , vol.12 , Issue.4 , pp. 499-504
    • Mizuki, M.1    Tagawa, S.2    Machii, T.3
  • 18
    • 0028131523 scopus 로고
    • Phenotypic and functional abnormalities in the peripheral blood T-cells of patients with primary Sjogren's syndrome
    • Aziz KE, McCluskey PJ, Wakefield D. Phenotypic and functional abnormalities in the peripheral blood T-cells of patients with primary Sjogren's syndrome. Cytometry. 1994;18(1):35-41.
    • (1994) Cytometry , vol.18 , Issue.1 , pp. 35-41
    • Aziz, K.E.1    McCluskey, P.J.2    Wakefield, D.3
  • 19
    • 0024315973 scopus 로고
    • Circulating CD4+CD8+ cells in myasthenia gravis: Supplementary immunological parameter for long-term prognosis
    • Matsui M, Fukuyama H, Akiguchi I, Kameyama M. Circulating CD4+CD8+ cells in myasthenia gravis: supplementary immunological parameter for long-term prognosis. J Neurol. 1989;236(6): 329-335.
    • (1989) J Neurol , vol.236 , Issue.6 , pp. 329-335
    • Matsui, M.1    Fukuyama, H.2    Akiguchi, I.3    Kameyama, M.4
  • 20
    • 0027457181 scopus 로고
    • Circulating CD3+ CD4+ CD8+ T lymphocytes in multiple sclerosis
    • Munschauer FE, Stewart C, Jacobs L, et al. Circulating CD3+ CD4+ CD8+ T lymphocytes in multiple sclerosis. J Clin Immunol. 1993;13(2): 113-118.
    • (1993) J Clin Immunol , vol.13 , Issue.2 , pp. 113-118
    • Munschauer, F.E.1    Stewart, C.2    Jacobs, L.3
  • 21
    • 0021932154 scopus 로고
    • T-cell abnormalities in patients with idiopathic thrombocytopenic purpura: The presence of OKT4+8+ cells
    • Mizutani H, Katagiri S, Uejima K, et al. T-cell abnormalities in patients with idiopathic thrombocytopenic purpura: the presence of OKT4+8+ cells. Scand J Haematol. 1985;35(2):233-239.
    • (1985) Scand J Haematol , vol.35 , Issue.2 , pp. 233-239
    • Mizutani, H.1    Katagiri, S.2    Uejima, K.3
  • 23
    • 2442500442 scopus 로고    scopus 로고
    • The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentration
    • Betts MR, Price DA, Brenchley JM, et al. The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentration. J Immunol. 2004; 172(10):6407-6417.
    • (2004) J Immunol , vol.172 , Issue.10 , pp. 6407-6417
    • Betts, M.R.1    Price, D.A.2    Brenchley, J.M.3
  • 24
    • 0142185336 scopus 로고    scopus 로고
    • Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation
    • Betts MR, Brenchley JM, Price DA, et al. Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J Immunol Methods. 2003;281(1-2): 65-78.
    • (2003) J Immunol Methods , vol.281 , Issue.1-2 , pp. 65-78
    • Betts, M.R.1    Brenchley, J.M.2    Price, D.A.3
  • 25
    • 0021952907 scopus 로고
    • Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids
    • Salter RD, Howell DN, Cresswell P. Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids. Immunogenetics. 1985;21(3): 235-246.
    • (1985) Immunogenetics , vol.21 , Issue.3 , pp. 235-246
    • Salter, R.D.1    Howell, D.N.2    Cresswell, P.3
  • 26
    • 34948906159 scopus 로고    scopus 로고
    • Superior control of HIV-1 replication by CD8+T cells is reflected by their avidity, polyfunctionality, and clonal turnover
    • Almeida JR, Price DA, Papagno L, et al. Superior control of HIV-1 replication by CD8+T cells is reflected by their avidity, polyfunctionality, and clonal turnover. J Exp Med. 2007;204(10):2473-2485.
    • (2007) J Exp Med , vol.204 , Issue.10 , pp. 2473-2485
    • Almeida, J.R.1    Price, D.A.2    Papagno, L.3
  • 27
    • 33751071052 scopus 로고    scopus 로고
    • Polyfunctional analysis of human t cell responses: Importance in vaccine immunogenicity and natural infection
    • Makedonas G, Betts MR. Polyfunctional analysis of human t cell responses: importance in vaccine immunogenicity and natural infection. Springer Semin Immunopathol. 2006;28(3): 209-219.
    • (2006) Springer Semin Immunopathol , vol.28 , Issue.3 , pp. 209-219
    • Makedonas, G.1    Betts, M.R.2
  • 28
    • 18844454267 scopus 로고    scopus 로고
    • HIV-1-specific IFN-gamma/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells
    • Zimmerli SC, Harari A, Cellerai C, Vallelian F, Bart PA, Pantaleo G. HIV-1-specific IFN-gamma/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells. Proc Natl Acad Sci U S A. 2005;102(20):7239-7244.
    • (2005) Proc Natl Acad Sci U S a , vol.102 , Issue.20 , pp. 7239-7244
    • Zimmerli, S.C.1    Harari, A.2    Cellerai, C.3    Vallelian, F.4    Bart, P.A.5    Pantaleo, G.6
  • 29
    • 2142730100 scopus 로고    scopus 로고
    • Central memory and effector memory T cell subsets: Function, generation, and maintenance
    • Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol. 2004;22:745-763.
    • (2004) Annu Rev Immunol , vol.22 , pp. 745-763
    • Sallusto, F.1    Geginat, J.2    Lanzavecchia, A.3
  • 30
    • 3142590367 scopus 로고    scopus 로고
    • Peripheral CD4(+)CD8(+) T cells are differentiated effector memory cells with antiviral functions
    • Nascimbeni M, Shin EC, Chiriboga L, Kleiner DE, Rehermann B. Peripheral CD4(+)CD8(+) T cells are differentiated effector memory cells with antiviral functions. Blood. 2004;104(2):478-486.
    • (2004) Blood , vol.104 , Issue.2 , pp. 478-486
    • Nascimbeni, M.1    Shin, E.C.2    Chiriboga, L.3    Kleiner, D.E.4    Rehermann, B.5
  • 31
    • 9144261631 scopus 로고    scopus 로고
    • T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: Implications for HIV pathogenesis
    • Brenchley JM, Hill BJ, Ambrozak DR, et al. T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis. J Virol. 2004;78(3):1160-1168.
    • (2004) J Virol , vol.78 , Issue.3 , pp. 1160-1168
    • Brenchley, J.M.1    Hill, B.J.2    Ambrozak, D.R.3
  • 32
    • 33644947565 scopus 로고    scopus 로고
    • Intestinal double-positive CD4+CD8+ T cells are highly activated memory cells with an increased capacity to produce cytokines
    • Pahar B, Lackner AA, Veazey RS. Intestinal double-positive CD4+CD8+ T cells are highly activated memory cells with an increased capacity to produce cytokines. Eur J Immunol. 2006;36(3):583-592.
    • (2006) Eur J Immunol , vol.36 , Issue.3 , pp. 583-592
    • Pahar, B.1    Lackner, A.A.2    Veazey, R.S.3
  • 33
    • 14044269485 scopus 로고    scopus 로고
    • Natural killer dendritic cells have both antigen presenting and lytic function and in response to CpG produce IFN-gamma via autocrine IL-12
    • Pillarisetty VG, Katz SC, Bleier JI, Shah AB, Dematteo RP. Natural killer dendritic cells have both antigen presenting and lytic function and in response to CpG produce IFN-gamma via autocrine IL-12. J Immunol. 2005;174(5):2612-2618.
    • (2005) J Immunol , vol.174 , Issue.5 , pp. 2612-2618
    • Pillarisetty, V.G.1    Katz, S.C.2    Bleier, J.I.3    Shah, A.B.4    Dematteo, R.P.5
  • 34
    • 33845669440 scopus 로고    scopus 로고
    • In vivo overexpression of Flt3 ligand expands and activates murine spleen natural killer dendritic cells
    • Chaudhry UI, Katz SC, Kingham TP, et al. In vivo overexpression of Flt3 ligand expands and activates murine spleen natural killer dendritic cells. FASEB J. 2006;20(7):982-984.
    • (2006) FASEB J , vol.20 , Issue.7 , pp. 982-984
    • Chaudhry, U.I.1    Katz, S.C.2    Kingham, T.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.