CD8 co-receptor promotes susceptibility of CD8+ T cells to transforming growth factor-β (TGF-β)-mediated suppression

Cancer Immunology, Immunotherapy

Volumn 60, Issue 2, 2011, Pages 291-297

  Zloza, Andrew ^a   Jagoda, Michael C ^a   Lyons, Gretchen E ^a   Graves, Michael C ^b   Kohlhapp, Frederick J ^a   O'Sullivan, Jeremy A ^a   Lacek, Andrew T ^a   Nishimura, Michael I ^b   Guevara Patiño, José A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

CD8 co receptor; CD8 T cells; Lck; SMADs; TGF ; Tumor induced suppression

Indexed keywords

CD8 ANTIGEN; CD8 CO RECEPTOR; CD8ALPHA ANTIGEN; CD8BETA ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN KINASE LCK; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER INHIBITION; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; TUMOR IMMUNITY;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD8; CD8-POSITIVE T-LYMPHOCYTES; HUMANS; IMMUNE TOLERANCE; JURKAT CELLS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MICE; MICE, INBRED C57BL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 79151472759     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-010-0962-6     Document Type: Article

References (30)

1. GF Gao J Tormo UC Gerth JR Wyer AJ McMichael DI Stuart JI Bell EY Jones BK Jakobsen 1997 Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2 Nature 387 6633 630 634 10.1038/42523 1:CAS:528:DyaK2sXktFCitbo%3D 10.1038/42523 9177355
2. AM Norment RD Salter P Parham VH Engelhard DR Littman 1988 Cell-cell adhesion mediated by CD8 and MHC class I molecules Nature 336 6194 79 81 10.1038/336079a0 1:CAS:528:DyaL1MXlvVKi 10.1038/336079a0 3263576
3. MA Purbhoo JM Boulter DA Price AL Vuidepot CS Hourigan PR Dunbar K Olson SJ Dawson RE Phillips BK Jakobsen JI Bell AK Sewell 2001 The human CD8 co-receptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain J Biol Chem 276 35 32786 32792 10.1074/jbc.M102498200 1:CAS:528: DC%2BD3MXmvFCmtrY%3D 10.1074/jbc.M102498200 11438524
4. A Veillette MA Bookman EM Horak JB Bolen 1988 The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck Cell 55 2 301 308 0092-8674(88)90053-0 1:CAS:528: DyaL1cXmt1yisLg%3D 10.1016/0092-8674(88)90053-0 3262426
5. RJ Salmond A Filby I Qureshi S Caserta R Zamoyska 2009 T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance Immunol Rev 228 1 9 22 10.1111/j.1600-065X.2008.00745.x 1:CAS:528:DC%2BD1MXhsFGls73F 10.1111/j.1600-065X.2008.00745.x 19290918
6. GC Blobe WP Schiemann HF Lodish 2000 Role of transforming growth factor beta in human disease N Engl J Med 342 18 1350 1358 10.1056/NEJM200005043421807 1:CAS:528:DC%2BD3cXjtlyksrY%3D 10.1056/NEJM200005043421807 10793168
7. MO Li YY Wan S Sanjabi AK Robertson RA Flavell 2006 Transforming growth factor-beta regulation of immune responses Annu Rev Immunol 24 99 146 10.1146/annurev.immunol.24.021605.090737 1:CAS:528:DC%2BD28XkvFSqt7w%3D 10.1146/annurev.immunol.24.021605.090737 16551245
8. AB Kulkarni CG Huh D Becker A Geiser M Lyght KC Flanders AB Roberts MB Sporn JM Ward S Karlsson 1993 Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death Proc Natl Acad Sci USA 90 2 770 774 1:CAS:528:DyaK3sXhtVShtrY%3D 10.1073/pnas.90.2.770 8421714
9. W Chen W Jin N Hardegen KJ Lei L Li N Marinos G McGrady SM Wahl 2003 Conversion of peripheral CD4 + CD25- naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3 J Exp Med 198 12 1875 1886 10.1084/jem.20030152 1:CAS:528:DC%2BD3sXpvFaktLg%3D 10.1084/jem.20030152 14676299
10. PR Mangan LE Harrington DB O'Quinn WS Helms DC Bullard CO Elson RD Hatton SM Wahl TR Schoeb CT Weaver 2006 Transforming growth factor-beta induces development of the T(H)17 lineage Nature 441 7090 231 234 10.1038/nature04754 1:CAS:528:DC%2BD28XksVGns7k%3D 10.1038/nature04754 16648837
11. J Massague 1998 TGF-beta signal transduction Annu Rev Biochem 67 753 791 10.1146/annurev.biochem.67.1.753 1:CAS:528:DyaK1cXlsFOmsbY%3D 10.1146/annurev.biochem.67.1.753 9759503
12. L Zawel JL Dai P Buckhaults S Zhou KW Kinzler B Vogelstein SE Kern 1998 Human Smad3 and Smad4 are sequence-specific transcription activators Mol Cell 1 4 611 617 S1097-2765(00)80061-1 1:CAS:528:DyaK1cXit1Gisbg%3D 10.1016/S1097-2765(00)80061-1 9660945
13. A Nakao T Imamura S Souchelnytskyi M Kawabata A Ishisaki E Oeda K Tamaki J Hanai CH Heldin K Miyazono P ten Dijke 1997 TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4 EMBO J 16 17 5353 5362 10.1093/emboj/16.17.5353 1:CAS:528:DyaK2sXmsVGlsL8%3D 10.1093/emboj/16.17.5353 9311995
14. P Kavsak RK Rasmussen CG Causing S Bonni H Zhu GH Thomsen JL Wrana 2000 Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation Mol Cell 6 6 1365 1375 S1097-2765(00)00134-9 1:CAS:528:DC%2BD3MXlvFahug%3D%3D 10.1016/S1097-2765(00)00134-9 11163210
15. U Schneider HU Schwenk G Bornkamm 1977 Characterization of EBV-genome negative "null" and "T" cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non-Hodgkin lymphoma Int J Cancer 19 5 621 626 1:STN:280:DyaE2s7oslSmsA%3D%3D 10.1002/ijc.2910190505 68013
16. GE Lyons T Moore N Brasic M Li JJ Roszkowski MI Nishimura 2006 Influence of human CD8 on antigen recognition by T-cell receptor-transduced cells Cancer Res 66 23 11455 11461 10.1158/0008-5472.CAN-06-2379 1:CAS:528:DC%2BD28Xht1KnsLrM 10.1158/0008-5472.CAN-06-2379 17145893
17. L Wooldridge SL Hutchinson EM Choi A Lissina E Jones F Mirza PR Dunbar DA Price V Cerundolo AK Sewell 2003 Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface J Immunol 171 12 6650 6660 1:CAS:528:DC%2BD3sXpsV2rt7s%3D 14662868
18. DJ Cole DP Weil J Shilyansky M Custer Y Kawakami SA Rosenberg MI Nishimura 1995 Characterization of the functional specificity of a cloned T-cell receptor heterodimer recognizing the MART-1 melanoma antigen Cancer Res 55 4 748 752 1:CAS:528:DyaK2MXjslelsbY%3D 7531614
19. JJ Roszkowski GE Lyons WM Kast C Yee K Van Besien MI Nishimura 2005 Simultaneous generation of CD8+ and CD4+ melanoma-reactive T cells by retroviral-mediated transfer of a single T-cell receptor Cancer Res 65 4 1570 1576 10.1158/0008-5472.CAN-04-2076 1:CAS:528:DC%2BD2MXhsFKqtbs%3D 10.1158/0008-5472.CAN-04-2076 15735047
20. GG Callender HR Rosen JJ Roszkowski GE Lyons M Li T Moore N Brasic MD McKee MI Nishimura 2006 Identification of a hepatitis C virus-reactive T cell receptor that does not require CD8 for target cell recognition Hepatology 43 5 973 981 10.1002/hep.21157 1:CAS:528:DC%2BD28XkvFGmt7g%3D 10.1002/hep.21157 16628627
21. RT Abraham A Weiss 2004 Jurkat T cells and development of the T-cell receptor signalling paradigm Nat Rev Immunol 4 4 301 308 10.1038/nri1330 1:CAS:528:DC%2BD2cXis1GksLY%3D 10.1038/nri1330 15057788
22. A Weiss RL Wiskocil JD Stobo 1984 The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level J Immunol 133 1 123 128 1:CAS:528:DyaL2cXksFeju74%3D 6327821
23. DA Thomas J Massague 2005 TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance Cancer Cell 8 5 369 380 10.1016/j.ccr.2005.10.012 1:CAS:528:DC%2BD2MXht12gsbvK 10.1016/j.ccr.2005.10.012 16286245
24. MM Gorska SJ Stafford O Cen S Sur R Alam 2004 Unc119, a novel activator of Lck/Fyn, is essential for T cell activation J Exp Med 199 3 369 379 10.1084/jem.20030589 1:CAS:528:DC%2BD2cXhtVCitLk%3D 10.1084/jem. 20030589 14757743
25. AD Holdorf KH Lee WR Burack PM Allen AS Shaw 2002 Regulation of Lck activity by CD4 and CD28 in the immunological synapse Nat Immunol 3 3 259 264 10.1038/ni761 1:CAS:528:DC%2BD38XitVWltL8%3D 10.1038/ni761 11828322
26. Huppa JB, Axmann M, Mortelmaier MA, Lillemeier BF, Newell EW, Brameshuber M, Klein LO, Schutz GJ, Davis MM (2010) TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity. Nature 463 (7283):963-967. doi: 10.1038/nature08746
27. N Glaichenhaus N Shastri DR Littman JM Turner 1991 Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells Cell 64 3 511 520 0092-8674(91)90235-Q 1:CAS:528:DyaK3MXhtF2rtbg%3D 10.1016/0092-8674(91)90235-Q 1671341
28. R Campanelli B Palermo S Garbelli S Mantovani P Lucchi A Necker E Lantelme C Giachino 2002 Human CD8 co-receptor is strictly involved in MHC-peptide tetramer-TCR binding and T cell activation Int Immunol 14 1 39 44 1:CAS:528:DC%2BD38XnvVWgtw%3D%3D 10.1093/intimm/14.1.39 11751750
29. MA Daniels SC Jameson 2000 Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibility complex multimers J Exp Med 191 2 335 346 1:CAS:528:DC%2BD3cXntFemsQ%3D%3D 10.1084/jem.191.2.335 10637277
30. Giroux M, Delisle JS, O'Brien A, Hebert MJ, Perreault C (2010) T cell activation leads to protein kinase Ctheta-dependent inhibition of TGF-beta signaling. J Immunol 185 (3):1568-1576. doi: 10.4049/jimmunol.1000137