Methanol extract of Antrodia cinnamomea mycelia induces phenotypic and functional differentiation of HL60 into monocyte-like cells via an ERK/CEBP-β signaling pathway

Phytomedicine

Volumn 19, Issue 5, 2012, Pages 424-435

  Wen, Chi Luan ^a,b   Teng, Chieh Lin ^c,d,e   Chiang, Chih Hung ^c   Chang, Chia Chuan ^f   Hwang, Wen Lee ^c   Kuo, Chao Lin ^b   Hsu, Shih Lan ^b,c,e  

^a FISHERIES RESEARCH INSTITUTE   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^d TUNGHAI UNIVERSITY   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^f NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

Author keywords

Antrodia cinnamomea; CCAAT enhancer binding protein ; CD14; Differentiation; Extracellular signal regulated kinase; Leukemia

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANTRODIA CINNAMOMEA METHANOLIC EXTRACT; CCAAT ENHANCER BINDING PROTEIN BETA; CD11 ANTIGEN; CD14 ANTIGEN; FUNGAL EXTRACT; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ANTRODIA CINNAMOMEA; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRAIN HL 60; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; FUNGUS CULTURE; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; MONOCYTE; MUSHROOM; MYCELIUM; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION; UPREGULATION;

ANTIGENS, CD14; ANTRODIA; CARBOXYLESTERASE; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL DIFFERENTIATION; CELL SURVIVAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, FUNGAL; HL-60 CELLS; HUMANS; MALEIC ANHYDRIDES; MALEIMIDES; METHANOL; MONOCYTES; MYCELIUM; PHENOTYPE; PRIMARY CELL CULTURE; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

ANTRODIA CINNAMOMEA; BASIDIOMYCOTA;

EID: 84862796410     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2011.11.003     Document Type: Article

References (66)

1. H.G. Anwarul, N.G. Muhammad, J.H. Peter, J. Qaiser, F.K. Syed, J. Maliha, and A.S. Sheikh Studies on the hypotensive, cardio-suppressant, vasodilator and antiplatelet activities of betel nut crude extract and its constituents Int. J. Pharmacol. 2 2006 33 41
2. Z.H. Ao, Z.H. Xu, Z.M. Lu, H.Y. Xu, X.M. Zhang, and W.F. Dou Niuchangchih (Antrodia camphorata) and its potential in treating liver diseases J. Ethnopharmacol. 121 2009 194 212
3. A. Borchers, C. Keen, and M. Gershwin Mushrooms, tumors, and immunity: an update Exp. Biol. Med. (Maywood, NJ) 229 2004 393 406 (Pubitemid 38542348)
4. P. Chambon The retinoid signaling pathway: molecular and genetic analyses Semin. Cell Biol. 5 1994 115 125 (Pubitemid 124003277)
5. C.Y. Chang, Z.N. Huang, H.H. Yu, L.H. Chang, S.L. Li, Y.P. Chen, K.Y. Lee, and J.J. Chuu The adjuvant effects of Antrodia camphorata extracts combined with anti-tumor agents on multidrug resistant human hepatoma cells J. Ethnopharmacol. 118 2008 387 395
6. E. Duprez, K. Wagner, H. Koch, and D.G. Tenen C/EBPbeta: a major PML-RARA-responsive gene in retinoic acid-induced differentiation of APL cells EMBO J. 22 2003 5806 5816 (Pubitemid 37408819)
7. R. Gallagher, S. Collins, J. Trujillo, K. McCredie, M. Ahearn, S. Tsai, R. Metzgar, G. Aulakh, R. Ting, F. Ruscetti, and R. Gallo Characterization of the continuous, differentiating myeloid cell line (HL-60) from a patient with acute promyelocytic leukemia Blood 54 1979 713 733 (Pubitemid 10227870)
8. M. Geethangili, and Y. Tzeng Review of pharmacological effects of Antrodia camphorata and its bioactive compounds Evid.-Based Complement. Alternat. Med. 2009
9. S. Gery, A.F. Gombart, W.S. Yi, C. Koeffler, W.K. Hofmann, and H.P. Koeffler Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia Blood 106 2005 2827 2836 (Pubitemid 41510760)
10. A. Glasow, N. Prodromou, K. Xu, M. von Lindern, and A. Zelent Retinoids and myelomonocytic growth factors cooperatively activate RARA and induce human myeloid leukemia cell differentiation via MAP kinase pathways Blood 105 2005 341 349 (Pubitemid 40053102)
11. R. Herrera, S. Hubbell, S. Decker, and L. Petruzzelli A role for the MEK/MAPK pathway in PMA-induced cell cycle arrest: modulation of megakaryocytic differentiation of K562 cells Exp. Cell Res. 238 1998 407 414 (Pubitemid 28372828)
12. Z. Hmama, D. Nandan, L. Sly, K.L. Knutson, P. Herrera-Velit, and N.E. Reiner 1alpha, 25-dihydroxyvitamin D(3)-induced myeloid cell differentiation is regulated by a vitamin D receptor-phosphatidylinositol 3-kinase signaling complex J. Exp. Med. 190 1999 1583 1594 (Pubitemid 30002340)
13. Y.C. Hseu, W.C. Chang, Y.T. Hseu, C.Y. Lee, Y.J. Yech, P.C. Chen, J.Y. Chen, and H.L. Yang Protection of oxidative damage by aqueous extract from Antrodia camphorata mycelia in normal human erythrocytes Life Sci. 71 2002 469 482
14. Y.C. Hseu, F.Y. Wu, J.J. Wu, J.Y. Chen, W.H. Chang, F.J. Lu, Y.C. Lai, and H.L. Yang Anti-inflammatory potential of Antrodia camphorata through inhibition of iNOS, COX-2 and cytokines via the NF-kappaB pathway Int. Immunopharmacol. 5 2005 1914 1925
15. Y.C. Hseu, H.L. Yang, Y.C. Lai, J.G. Lin, G.W. Chen, and Y.H. Chang Induction of apoptosis by Antrodia camphorata in human premyelocytic leukemia HL-60 cells Nutr. Cancer 48 2004 189 197
16. Y.L. Hsu, Y.C. Kuo, P.L. Kuo, L.T. Ng, Y.H. Kuo, and C.C. Lin Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines Cancer Lett. 221 2005 77 89
17. P.J. Hughes, E. Marcinkowska, E. Gocek, G.P. Studzinski, and G. Brown Vitamin D3-driven signals for myeloid cell differentiation - implications for differentiation therapy Leuk. Res. 34 2010 553 565
18. Y. Ji, and G.P. Studzinski Retinoblastoma protein and CCAAT/enhancer-binding protein beta are required for 1,25-dihydroxyvitamin D3-induced monocytic differentiation of HL60 cells Cancer Res. 64 2004 370 377 (Pubitemid 38114120)
19. Y. Jing, S. Nakajo, L. Xia, K. Nakaya, Q. Fang, S. Waxman, and R. Han Boswellic acid acetate induces differentiation and apoptosis in leukemia cell lines Leuk. Res. 23 1999 43 50 (Pubitemid 28484867)
20. S. Kawaii, Y. Tomono, E. Katase, K. Ogawa, M. Yano, Y. Takemura, M. Ju-ichi, C. Ito, and H. Furukawa Acridones as inducers of HL-60 cell differentiation Leuk. Res. 23 1999 263 269 (Pubitemid 29083383)
21. S.H. Kim, J.C. Yoo, and T.S. Kim Nargenicin enhances 1,25- dihydroxyvitamin D(3)- and all-trans retinoic acid-induced leukemia cell differentiation via PKCbetaI/MAPK pathways Biochem. Pharmacol. 77 2009 1694 1701
22. S. Koschmieder, B. Halmos, E. Levantini, and D.G. Tenen Dysregulation of the C/EBPalpha differentiation pathway in human cancer J. Clin. Oncol. 27 2009 619 628
23. P.L. Kuo, Y.L. Hsu, C.Y. Cho, L.T. Ng, Y.H. Kuo, and C.C. Lin Apoptotic effects of Antrodia cinnamomea fruiting bodies extract are mediated through calcium and calpain-dependent pathways in Hep 3B cells Food Chem. Toxicol. 44 2006 1316 1326
24. M.N. Laszczyk Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy Planta Med. 75 2009 1549 1560
25. J. Lekstrom-Himes, and K.G. Xanthopoulos Biological role of the CCAAT/enhancer-binding protein family of transcription factors J. Biol. Chem. 273 1998 28545 28548 (Pubitemid 28507532)
26. E. Lengfelder, S. Saussele, A. Weisser, T. Buchner, and R. Hehlmann Treatment concepts of acute promyelocytic leukemia Crit. Rev. Oncol. Hematol. 56 2005 261 274 (Pubitemid 41565553)
27. B. Lowenberg, J.R. Downing, and A. Burnett Acute myeloid leukemia N. Engl. J. Med. 341 1999 1051 1062 (Pubitemid 29451802)
28. Z.M. Lu, W.Y. Tao, X.L. Zou, H.Z. Fu, and Z.H. Ao Protective effects of mycelia of Antrodia camphorata and Armillariella tabescens in submerged culture against ethanol-induced hepatic toxicity in rats J. Ethnopharmacol. 110 2007 160 164
29. D.M. Lucas, P.C. Still, L.B. Pérez, M.R. Grever, and A.D. Kinghorn Potential of plant-derived natural products in the treatment of leukemia and lymphoma Curr. Drug Targets 11 2010 812 822
30. E. Marcinkowska, E. Garay, E. Gocek, A. Chrobak, X. Wang, and G.P. Studzinski Regulation of C/EBPbeta isoforms by MAPK pathways in HL60 cells induced to differentiate by 1,25-dihydroxyvitamin D3 Exp. Cell Res. 312 2006 2054 2065 (Pubitemid 43850930)
31. E. Marcinkowska, and A. Kutner Side-chain modified vitamin D analogs require activation of both PI 3-K and erk1,2 signal transduction pathways to induce differentiation of human promyelocytic leukemia cells Acta Biochim. Pol. 49 2002 393 406 (Pubitemid 135686786)
32. A. Meshkini, and R. Yazdanparast Involvement of ERK/MAPK pathway in megakaryocytic differentiation of K562 cells induced by 3-hydrogenkwadaphnin Toxicol. In Vitro 22 2008 1503 1510
33. M. Miranda, T. McGuire, and D. Johnson Importance of MEK-1/-2 Signaling in Monocytic and Granulocytic Differentiation of Myeloid Cell Lines. Leukemia vol. 16 2002 Official Journal of the Leukemia Society of America, Leukemia Research Fund, UK p. 683
34. M.F. Moradali, H. Mostafavi, S. Ghods, and G.A. Hedjaroude Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi) Int. Immunopharmacol. 7 2007 701 724 (Pubitemid 46635272)
35. R. Morosetti, D.J. Park, A.M. Chumakov, I. Grillier, M. Shiohara, A.F. Gombart, T. Nakamaki, K. Weinberg, and H.P. Koeffler A novel, myeloid transcription factor, C/EBP epsilon, is upregulated during granulocytic, but not monocytic, differentiation Blood 90 1997 2591 2600 (Pubitemid 27413468)
36. N. Nakamura, A. Hirakawa, J.J. Gao, H. Kakuda, M. Shiro, Y. Komatsu, C.C. Sheu, and M. Hattori Five new maleic and succinic acid derivatives from the mycelium of Antrodia camphorata and their cytotoxic effects on LLC tumor cell line J. Natl. Prod. 67 2004 46 48 (Pubitemid 38141309)
37. S. Natsuka, S. Akira, Y. Nishio, S. Hashimoto, T. Sugita, H. Isshiki, and T. Kishimoto Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6 Blood 79 1992 460 466
38. P.E. Newburger, C. Speier, N. Borregaard, C.E. Walsh, J.C. Whitin, and E.R. Simons Development of the superoxide-generating system during differentiation of the HL-60 human promyelocytic leukemia cell line J. Biol. Chem. 259 1984 3771 3776 (Pubitemid 14173417)
39. T. Pabst, B.U. Mueller, P. Zhang, H.S. Radomska, S. Narravula, S. Schnittger, G. Behre, W. Hiddemann, and D.G. Tenen Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia Nat. Genet. 27 2001 263 270 (Pubitemid 32201846)
40. Z. Pan, C.J. Hetherington, and D.E. Zhang CCAAT/enhancer-binding protein activates the CD14 promoter and mediates transforming growth factor beta signaling in monocyte development J. Biol. Chem. 274 1999 23242 23248
41. M.H. Park, S.Y. Park, and Y. Kim Induction of proline-rich tyrosine kinase2 (Pyk2) through C/EBPbeta is involved in PMA-induced monocyte differentiation FEBS Lett. 582 2008 415 422
42. V. Poli The role of C/EBP isoforms in the control of inflammatory and native immunity functions J. Biol. Chem. 273 1998 29279 29282 (Pubitemid 28509923)
43. B.T. Porse, D. Bryder, K. Theilgaard-Monch, M.S. Hasemann, K. Anderson, I. Damgaard, S.E. Jacobsen, and C. Nerlov Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage J. Exp. Med. 202 2005 85 96 (Pubitemid 41002912)
44. D.P. Ramji, and P. Foka CCAAT/enhancer-binding proteins: structure, function and regulation Biochem. J. 365 2002 561 575 (Pubitemid 34864439)
45. Y.K. Rao, S.H. Fang, and Y.M. Tzeng Evaluation of the anti-inflammatory and anti-proliferation tumoral cells activities of Antrodia camphorata, Cordyceps sinensis, and Cinnamomum osmophloeum bark extracts J. Ethnopharmacol. 114 2007 78 85 (Pubitemid 47444512)
46. L.H. Reddy, and P. Couvreur Squalene: a natural triterpene for use in disease management and therapy Adv. Drug Deliv. Rev. 61 2009 1412 1426
47. P.H. Reitsma, P.G. Rothberg, S.M. Astrin, J. Trial, Z. Bar-Shavit, A. Hall, S.L. Teitelbaum, and A.J. Kahn Regulation of myc gene expression in HL-60 leukaemia cells by a vitamin D metabolite Nature 306 1983 492 494 (Pubitemid 14235574)
48. D. Renzi, M. Valtolina, and R. Foster The evaluation of a multi-endpoint cytotoxicity assay system ATLA 21 1993 89 96
49. L.M. Scott, C.I. Civin, P. Rorth, and A.D. Friedman A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells Blood 80 1992 1725 1735
50. T. Shimizu, N. Taira, M. Senou, and K. Takeda Involvement of diverse protein kinase C isoforms in the differentiation of ML-1 human myeloblastic leukemia cells induced by the vitamin D3 analogue KH1060 and the phorbol ester TPA Cancer Lett. 186 2002 67 74 (Pubitemid 35245328)
51. J. Singh, K. Murata, Y. Itahana, and P.Y. Desprez Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex Oncogene 21 2002 1812 1822 (Pubitemid 34259183)
52. T.Y. Song, S.L. Hsu, and G.C. Yen Induction of apoptosis in human hepatoma cells by mycelia of Antrodia camphorata in submerged culture J. Ethnopharmacol. 100 2005 158 167
53. R.M. Stone Novel therapeutic agents in acute myeloid leukemia Exp. Hematol. 35 2007 163 166 (Pubitemid 46427994)
54. G.P. Studzinski, E. Garay, R. Patel, J. Zhang, and X. Wang Vitamin D receptor signaling of monocytic differentiation in human leukemia cells: role of MAPK pathways in transcription factor activation Curr. Top. Med. Chem. 6 2006 1267 1271 (Pubitemid 44110915)
55. G.P. Studzinski, X. Wang, Y. Ji, Q. Wang, Y. Zhang, A. Kutner, and J.S. Harrison The rationale for deltanoids in therapy for myeloid leukemia: role of KSR-MAPK-C/EBP pathway J. Steroid Biochem. Mol. Biol. 97 2005 47 55 (Pubitemid 41546213)
56. D.G. Tenen, R. Hromas, J.D. Licht, and D.E. Zhang Transcription factors, normal myeloid development, and leukemia Blood 90 1997 489 519 (Pubitemid 27299089)
57. K. Traore, M. Trush, and M. George Signal transduction of phorbol 12-myristate 13-acetate (PMA)-induced growth inhibition of human monocytic leukemia THP-1 cells is reactive oxygen dependent Leuk. Res. 29 2005 863 879 (Pubitemid 40840714)
58. Q. Wang, X. Wang, and G.P. Studzinski N-terminal kinase pathway enhances signaling of monocytic differentiation of human leukemia cells induced by 1,25-dihydroxyvitamin D3 J. Cell Biochem. 89 June 2003 1087 1101 (Pubitemid 36959378)
59. X. Wang, J. Rao, and G.P. Studzinski Inhibition of p38 MAP kinase activity up-regulates multiple MAP kinase pathways and potentiates 1,25-dihydroxyvitamin D(3)-induced differentiation of human leukemia HL60 cells Exp. Cell Res. 258 2000 425 437 (Pubitemid 30483521)
60. X. Wang, and G.P. Studzinski Activation of extracellular signal-regulated kinases (ERKs) defines the first phase of 1,25-dihydroxyvitamin D3-induced differentiation of HL60 cells J. Cell Biochem. 80 2001 471 482 (Pubitemid 32127462)
61. Z.Y. Wang, and Z. Chen Acute promyelocytic leukemia: from highly fatal to highly curable Blood 111 2008 2505 2515
62. L.T. Yam, C.Y. Li, and W.H. Crosby Cytochemical identification of monocytes and granulocytes Am. J. Clin. Pathol. 55 1971 283 290
63. R. Yamanaka, J. Lekstrom-Himes, C. Barlow, A. Wynshaw-Boris, and K.G. Xanthopoulos CCAAT/enhancer binding proteins are critical components of the transcriptional regulation of hematopoiesis (Review) Int. J. Mol. Med. 1 1998 213 221
64. A. Yen, M.S. Roberson, S. Varvayanis, and A.T. Lee Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest Cancer Res. 58 1998 3163 3172 (Pubitemid 28335101)
65. Y. Zhang, J. Zhang, and G.P. Studzinski AKT pathway is activated by 1,25-dihydroxyvitamin D3 and participates in its anti-apoptotic effect and cell cycle control in differentiating HL60 cells Cell Cycle 5 2006 447 451
66. J.K. Zjawiony Biologically active compounds from Aphyllophorales (polypore) fungi J. Nat. Prod. 67 2004 300 310 (Pubitemid 38282922)