Valosin containing protein (VCP) interacts with macrolide antibiotics without mediating their anti-inflammatory activities

European Journal of Pharmacology

Volumn 677, Issue 1-3, 2012, Pages 163-172

  Nujić, Krunoslav ^a   Smith, Marjorie ^a,b   Lee, Michael ^a   Belamarić, Daniela ^a,c   Tomašković, Linda ^a,c   Alihodžić, Sulejman ^a,c   Malnar, Ivica ^a,c   Polančec, Denis ^a,c   Schneider, Klaus ^a,d   Haber, Vesna Eraković ^a,c  

^a GLAXOSMITHKLINE   (United Kingdom)

^b An Cala   (United Kingdom)

^c Galapagos Research Center Zagreb   (Croatia)

^d MERCK KGAA   (Germany)

Author keywords

Chemical proteomics; Inflammation; Macrolide; Target identification; Valosin containing protein

Indexed keywords

ACTIN; ADENOSINE TRIPHOSPHATE; ALBUMIN; AZITHROMYCIN; AZITHROMYCIN DERIVATIVE; CLARITHROMYCIN; CLARITHROMYCIN DERIVATIVE; DYNEIN ADENOSINE TRIPHOSPHATASE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HELICASE; HELICASE A; HEMOGLOBIN; I KAPPA B ALPHA; INITIATION FACTOR 2ALPHA; INTERLEUKIN 6; KARYOPHERIN; MACROLIDE; MYOSIN; TRANSCRIPTION FACTOR RELA; TRANSMEMBRANE CONDUCTANCE REGULATOR; TUBULIN; UNCLASSIFIED DRUG; VALOSIN CONTAINING PROTEIN; VOLTAGE DEPENDENT ANION CHANNEL;

AFFINITY CHROMATOGRAPHY; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CELL ASSAY; CELL LINE; CHEMICAL PROCEDURES; CHEMICAL PROTEOMICS; CONTROLLED STUDY; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR GENE; CYTOKINE PRODUCTION; DISSOCIATION CONSTANT; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TARGETING; GENE; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION;

ADENOSINE TRIPHOSPHATASES; ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; AZITHROMYCIN; CELL CYCLE PROTEINS; CELL LINE; CLARITHROMYCIN; DRUG DESIGN; GENE SILENCING; HUMANS; MICE; PROTEIN BINDING; PROTEOMICS; REPRODUCIBILITY OF RESULTS;

EID: 84862783596     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.12.022     Document Type: Article

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