Anti-inflammatory activity of macrolide antibiotics

Journal of Pharmacology and Experimental Therapeutics

Volumn 292, Issue 1, 2000, Pages 156-163

  Ianaro, Angela ^a   Ialenti, Armando ^a   Maffia, Pasquale ^a   Sautebin, Lidia ^a   Rombolà, Laura ^a   Carnuccio, Rosa ^a   Iuvone, Teresa ^a   D'Acquisto, Fulvio ^a   Di Rosa, Massimo ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; AZITHROMYCIN; CLARITHROMYCIN; CYCLOOXYGENASE 2; ERYTHROMYCIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROLIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN E2; ROXITHROMYCIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

6-KETOPROSTAGLANDIN F1 ALPHA; ADRENALECTOMY; ANESTHESIA; ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; AZITHROMYCIN; CARRAGEENAN; CELL LINE; CLARITHROMYCIN; CYCLOOXYGENASE 2; CYTOKINES; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROMYCIN; INFLAMMATION MEDIATORS; ISOENZYMES; LEUKOTRIENE B4; MACROPHAGES; MICE; NITRATES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; PLEURISY; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; ROXITHROMYCIN; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033971290     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Agen C, Danesi R, Blandizzi C, Costa M, Stacchini B, Favini P and Del Tacca M (1993) Macrolide antibiotics as antiinflammatory agents: Roxithiomycin in an unexpected role. Agents Actions 38:85-90.
2. Ajuebor MN, Virag L, Flower RJ, Perretti M and Szabo C (1998) Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan-induced inflammation. Immunology 95:625-630.
3. Barry AL, Thornsberry C and Jones RN (1987) In vitro activity of a new macrolide, A-56268, compared with that of roxithromycin, erythromycin and clindamycin. Antimicrob Agents Chemother 31:343-345.
4. Bryskier A, Agouridas C and Chantot JF (1994) New medical targets for macrolides. Exp Opin Invest Drugs 3:405-410.
5. D'Acquisto F, Ianaro A, Ialenti A, luvone T, Colantuoni V and Carnuccio R (1999) Activation of nuclear transcription factor κB in rat carrageenin-induced pleurisy. Eur J Pharmacol 369:233-236.
6. D'Acquisto F, Iuvone T, Rombolà L, Sautebin L, Di Rosa M and Carnuccio R (1997) Involvement of NF-κB in the regulation of cyclooxygenase-2 protein expression in LPS-stimulated J774 macrophages. FEBS Lett 418:175-178.
7. D'Acquisto F, Sautebin L, luvone T, Di Rosa M and Carnuccio R (1998) Prostaglandins prevent inducible nitric oxide synthase protein expression by inhibiting nuclear factor-κB activation in J774 macrophages. FEBS Lett 440:76-80.
8. Dalziel K, Dykes PJ and Marks R (1987) The effect of tetracycline and erythromycin in a model of acne-type inflammation. Br J Exp Pathol 68:67-70.
9. Denizot F and Lang R (1986) Rapid colorimetric assay for cell growth and survival: Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 89:271-277.
10. Di Rosa M, Radomski R, Carnuccio R and Moncada S (1990) Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages. Biochem Biophys Res Commun 172:1246-1252.
11. Granström E and Kindhal H (1978) Radioimmunoassay of prostaglandins and thromboxanes. Adv Prostagland Thromb Res 5:119-210.
12. Gurfinkel E, Bozovich G, Daroca A, Beck E and Mautner B (1997) Randomised trial of roxithromycin in non-Q-wave coronary syndromes: ROXIS pilot study. Lancet 350:404-407.
13. Hand WL, Hand DL and King-Thompson NL (1990) Antibiotic inhibition of the respiratory burst response in human polymorphonuclear leukocytes. Antimicrob Agents Chem 34:863-870.
14. Hand WL, King-Thompson N and Holman JW (1987) Entry of roxithromycin (RU 965) imipenem, cefotaxime, trimethoprim and metronidazole into human polymorphonuclear leukocytes. Antimicrob Agents Chemother 31:1535-1537.
15. Ialenti A, Ianaro A, Moncada S and Di Rosa M (1992) Modulation of acute inflammation by endogenous nitric oxide. Eur J Pharmacol 211:177-182.
16. Ialenti A, Moncada S and Di Rosa M (1993) Modulation of adjuvant arthritis by endogenous nitric oxide. Br J Pharmacol 110:701-706.
17. lino Y, Toriyama I, Kudo K, Natori Y and Yuo A (1992) Erythromycin inhibition of lipopolysaceharide-stimulated tumor necrosis factor alpha production by human monocytes in vitro. Ann Otol Rhinol Laryngeal Suppl 157:16-20.
18. Kadota J, Matsubara Y, Ishimatsu Y, Ashida M, Abe K, Shirai R, Iida K, Kawakami K, Taniguchi H, Fujii T, Kaseda M, Kawamoto S and Kohno S (1996) Significance of IL-1β and IL-1 receptor antagonist (IL-1Ra) in bronchoalveolar lavage fluid (BALF! in patients with diffuse parabronchiolitis (DPB). Clin Exp Immunol 103: 461-466.
19. Katori M, Harada Y, Hatanaka K, Majima M, Kawamura T, Onho A, Aizawa H and Yamamoto S (1995) Induction of prostaglandin H synthase-2 in rat carrageenin-induced pleurisy and effect of selective COX-2 inhibitors. Adv Prostagland Thromb Leukotr Res 23:345-347.
20. Konno S, Asano K, Kurokawa M, Ikeda K, Okamoto K and Adachi M (1994) Antiasthmatic activity of a macrolide antibiotic, roxithromycin: Analysis of possible mechanisms in vitro and in vivo. Int Arch Allergy Immunol 105:308-316.
21. Labro MT, El Benna J and Babin-Chevaye C (1989) Comparison of the in vitro effect of several macrolides on the oxidative burst of human neutrophils. J Antimicrob Chemother 24:561-572.
22. Laufen H, Wildfeuer A and Räder K (1985) Uptake of antimicrobial agents by human polymorphonuclear leucocytes. Arzneimittel-Forschung 35:1097-1099.
23. Lindner V and Collins T (1996) Expression of NF-κB and IκB-α by aortic endothelium in an arterial injury model. Am J Pathol 148:427-438.
24. 1α. Methods Enzymol 86:273-286.
25. Matsuoka N, Eguchi K, Kawakami A, Tsuboi M, Kawabe Y, Aoyagi T and Nagataki S (1996) Inhibitory effect of clarithromycin on costimulatory molecule expression and cytokine production by synovial fibroblast-like cells. Clin Exp Immunol 104: 501-508.
26. Mikasa K, Kita E, Sawaki M, Kunimatsu M, Hamada K, Konishi M, Kashiba S and Narita N (1992) The anti-inflammatory effect of erythromycin in zymosan-induced peritonitis of mice. J Antimicrob Chemother 30:339-348.
27. Miyachi Y, Yoshioka A, Imamura S and Niwa Y (1986) Effect of antibiotics on the generation of reactive oxygen species. J Invest Dermatol 86:449-453.
28. Müller JM, Loms Ziegler-Heitbrock HW and Baeuerle PA (1993) Nuclear factor kappa B, a mediator of lipopolysaccharide effects. Immunobiology 187:233-256.
29. Plewig G and Schöpf E (1976) Anti-inflammatory effects of antimicrobial agents. Drugs 11:472-473.
30. Salmon JA, Simmons PM and Palmer RMJ (1982) A radioimmunoassay for LTB4. Prostaglandins 24:225-235.
31. Sautebin L, Iatenti A, Ianaro A and Di Rosa M (1998) Relationship between nitric oxide and prostaglandins in carrageenin pleurisy. Biochem Pharmacol 55:1113-1117.
32. Schreiber E, Matthias P, Muller MM and Schaffner W (1989) Rapid detection of octamer binding proteins with "mini-extracts," prepared from a small number of cells. Nucleic Acids Res 17:6419.
33. Takeshita K, Yamagishi I, Harada M, Otomo S, Nakagawa T and Mizushima Y (1989) Immunological and anti-inflammatory effects of clarithromycin: Inhibition of interleukin 1 production of murine peritoneal macrophages. Drugs Exp Clin Res XV:527-533.
34. Tarayre JP, Aliaga M, Barbara M, Villanova G, Ballester R, Tisne-Versailles J and Couzinier JP (1987) Cutaneously applied erythromycin base reduces various types of inflammatory reactions in mouse ear. Int J Tiss Reac IX:77-85.
35. Thomsen LL, Ching LM, Zuang L, Gavin JB and Baguley BC (1991) Tumor-dependent increased plasma nitrate concentrations as an indication of the antitumor effect of flavone-8-acetic acid and analogues in mice. Cancer Res 51:71-81.
36. Tomlison A, Appleton I, Moore AR, Gilroy DW, Mitchell JA and Willoughby DA (1994) Cyclo-oxygenase and nitric oxide synthase ísoforms in rat carrageenin-induced pleurisy. Br J Pharmacol 113:693-698.
37. Yamamoto K, Arakawa T, Ueda N and Yamamoto S (1995) Transcriptional roles of nuclear factor κB and nuclear factor-interleukin-6 in the tumor necrosis factor α-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J Biol Chem 270: 31315-31320.
38. Yoshimura T, Kurita C, Yamazaki K, Shindo J, Morishima I, Machida K, Sumita T, Horiba M and Nagai H (1995) Effects of roxithromycin on proliferation of peripheral blood mononuclear cells and production of lipopolysaccharide-induced cytokines. Biol Pharmaceut Bull 18:876-881.
39. Young RA, Gonzalez JP and Sorkin EM (1989) Roxithromycin: A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy. Drugs 37: 8-41.
40. Xie Q, Kashiwabara Y and Nathan C (1994) Role of transcription factor NF-κB in induction of nitric oxide synthase. J Biol Chem 269:4705-4708.