Design, synthesis and evaluation of telomerase inhibitory, hTERT repressing, and anti-proliferation activities of symmetrical 1,8-disubstituted amidoanthraquinones

European Journal of Medicinal Chemistry

Volumn 50, Issue , 2012, Pages 102-112

  Lee, Chia Chung ^a   Huang, Kuo Feng ^b   Chang, Deh Ming ^a,c   Hsu, Jung Jung ^a   Huang, Fong Chun ^d   Shih, Kai Ning ^d   Chen, Chun Liang ^a   Chen, Tsung Chih ^a   Chen, Ruei Huei ^e   Lin, Jing Jer ^d   Huang, Hsu Shan ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b CHI MEI MEDICAL CENTER   (Taiwan)

^c TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

^e HUNGKUANG UNIVERSITY   (Taiwan)

Author keywords

Amidoanthraquinones; hTERT expression; NCI 60 cell panel assay; SEAP assay; Telomerase; TRAP assay

Indexed keywords

ANTHRAQUINONE DERIVATIVE; ANTIMITOTIC AGENT; TELOMERASE INHIBITOR; TELOMERASE REVERSE TRANSCRIPTASE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROLIFERATION; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; PHARMACOPHORE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TELOMERIC REPEAT AMPLIFICATION PROTOCOL;

ALKALINE PHOSPHATASE; ANTHRAQUINONES; APOPTOSIS; CELL PROLIFERATION; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; NEOPLASMS; TELOMERASE; TUMOR CELLS, CULTURED;

EID: 84862782325     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.01.044     Document Type: Article

References (28)

1. C. Monneret Eur. J. Med. Chem. 36 2001 483 493
2. H.S. Huang, T.C. Chen, R.H. Chen, K.F. Huang, F.C. Huang, J.R. Jhan, C.L. Chen, C.C. Lee, Y. Lo, and J.J. Lin Bioorg. Med. Chem. 17 2009 7418 7428
3. H. Seimiya Br. J. Cancer 94 2006 341 345
4. H.S. Huang, J.F. Chiou, Y. Fong, C.C. Hou, Y.C. Lu, J.Y. Wang, J.W. Shih, Y.R. Pan, and J.J. Lin J. Med. Chem. 46 2003 3300 3307
5. J.W. Shay, and S. Bacchetti Eur. J. Cancer 33 1997 787 791
6. E. Miri-Moghaddam, A. Deezagi, Z.S. Soheili, and P. Shariati Acta Haematol. 124 2010 72 78
7. W.E. Wright, and J.W. Shay Nat. Biotechnol. 20 2002 682 688
8. K. Masutomi, E.Y. Yu, S. Khurts, I. Ben-Porath, J.L. Currier, G.B. Metz, M.W. Brooks, S. Kaneko, S. Murakami, J.A. DeCaprio, R.A. Weinberg, S.A. Stewart, and W.C. Hahn Cell 114 2003 241 253
9. G.B. Morin J. Natl. Cancer Inst. 87 1995 859 861
10. E.K. Parkinson Br. J. Cancer 73 1996 1 4
11. R.A. Greenberg, L. Chin, A. Femino, K.H. Lee, G.J. Gottlieb, R.H. Singer, C.W. Greider, and R.A. DePinho Cell 97 1999 515 525
12. H.S. Huang, I.B. Chen, K.F. Huang, W.C. Lu, F.Y. Shieh, Y.Y. Huang, F.C. Huang, and J.J. Lin Chem. Pharm. Bull. (Tokyo) 55 2007 284 292
13. H.S. Huang, H.F. Chiu, A.L. Lee, C.L. Guo, and C.L. Yuan Bioorg. Med. Chem. 12 2004 6163 6170
14. H.S. Huang, H.F. Chiu, C.W. Tao, and I.B. Chen Chem. Pharm. Bull. (Tokyo) 54 2006 458 464
15. H.S. Huang, C.L. Chou, C.L. Guo, C.L. Yuan, Y.C. Lu, F.Y. Shieh, and J.J. Lin Bioorg. Med. Chem. 13 2005 1435 1444
16. H.S. Huang, K.F. Huang, C.C. Lee, C.L. Chen, C.L. Li, and J.J. Lin Anticancer Drugs 21 2010 169 180
17. H.S. Huang, K.F. Huang, C.L. Li, Y.Y. Huang, Y.H. Chiang, F.C. Huang, and J.J. Lin Bioorg. Med. Chem. 16 2008 6976 6986
18. C.C. Lee, K.F. Huang, P.Y. Lin, F.C. Huang, C.L. Chen, T.C. Chen, J.H. Guh, J.J. Lin, and H.S. Huang Eur. J. Med. Chem. 47 2012 323 336
19. H.S. Huang, H.F. Chiu, W.C. Lu, and C.L. Yuan Chem. Pharm. Bull. (Tokyo) 53 2005 1136 1139
20. H.O. House, W.J. Campbell, and D.G. Koepsell J. Org. Chem. 37 1972 1003 1011
21. P.J. Perry, S.M. Gowan, A.P. Reszka, P. Polucci, T.C. Jenkins, L.R. Kelland, and S. Neidle J. Med. Chem. 41 1998 3253 3260
22. B.S. Goueli, and R. Janknecht Mol. Cell Biol. 24 2004 25 35
23. B.R. Cullen, and M.H. Malim Methods Enzymol. 216 1992 362 368
24. T. Mosmann J. Immunol. Methods 65 1983 55 63
25. F. Denizot, and R. Lang J. Immunol. Methods 89 1986 271 277
26. N.W. Kim, M.A. Piatyszek, K.R. Prowse, C.B. Harley, M.D. West, P.L. Ho, G.M. Coviello, W.E. Wright, S.L. Weinrich, and J.W. Shay Science 266 1994 2011 2015
27. T.J. Trust, S.M. Logan, C.E. Gustafson, P.J. Romaniuk, N.W. Kim, V.L. Chan, M.A. Ragan, P. Guerry, and R.R. Gutell J. Bacteriol. 176 1994 4597 4609
28. C.B. Harley, N.W. Kim, K.R. Prowse, S.L. Weinrich, K.S. Hirsch, M.D. West, S. Bacchetti, H.W. Hirte, C.M. Counter, and C.W. Greider Cold Spring Harb. Symp. Quant. Biol. 59 1994 307 315