Synthesis, antiproliferative activity, and mechanism of action of a series of 2-{[(2E)-3-phenylprop-2-enoyl]amino}benzamides

European Journal of Medicinal Chemistry

Volumn 46, Issue 7, 2011, Pages 2786-2796

  Raffa, Demetrio ^a   Maggio, Benedetta ^a   Plescia, Fabiana ^a   Cascioferro, Stella ^a   Plescia, Salvatore ^a   Raimondi, Maria Valeria ^a   Daidone, Giuseppe ^a   Tolomeo, Manlio ^b   Grimaudo, Stefania ^b   Di Cristina, Antonietta ^b   Pipitone, Rosaria Maria ^b   Bai, Ruoli ^c   Hamel, Ernest ^c  

^a Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

2 2E 3 phenylprop 2 enoylamino benzamides; Antimitotic agents; Cytotoxic activity

Indexed keywords

2 [(3 PHENYLPROP 2 ENOYL)AMINO]BENZAMIDE; 5 BROMO 2 [[3 (2 BROMOPHENYL)PROP 2 ENOYL]AMINO]BENZAMIDE; 5 BROMO 2 [[3 (2 CHLOROPHENYL)PROP 2 ENOYL]AMINO]BENZAMIDE; 5 BROMO 2 [[3 (2 METHYLPHENYL)PROP 2 ENOYL]AMINO]BENZAMIDE; 5 BROMO 2 [[3 (3 BROMOPHENYL)PROP 2 ENOYL]AMINO]BENZAMIDE; 5 BROMO 2 [[3 (3 CHLOROPHENYL)PROP 2 ENOYL]AMINO]BENZAMIDE; 5 BROMO 2 [[3 (3 METHYLPHENYL)PROP 2 ENOYL]AMINO]BENZAMIDE; 5 BROMO 2 [[3 (4 CHLOROPHENYL)PROP 2 ENOYL]AMINO]BENZAMIDE; 5 BROMO 2 [[3 (4 METHYLPHENYL)PROP 2 ENOYL]AMINO]BENZAMIDE; 5 BROMO 2[(3 PHENYLPROP 2 ENOYL)AMINO]BENZAMIDE; 5 CHLORO 2 [[3 (2 BROMOPHENYL)PROP 2 ENOYL]AMINO]BENZAMIDE; 5 CHLORO 2 [[3 (2 CHLOROPHENYL)PROP 2 ENOYL]AMINO]BENZAMIDE; 5 CHLORO 2 [[3 (2 METHYLPHENYL)PROP 2 ENOYL]AMINO]BENZAMIDE; 5 CHLORO 2 [[3 (3 BROMOPHENYL)PROP 2 ENOYL]AMINO]BENZAMIDE; 5 CHLORO 2 [[3 (3 CHLOROPHENYL)PROP 2 ENOYL]AMINO]BENZAMIDE; 5 CHLORO 2 [[3 (3 METHYLPHENYL)PROP 2 ENOYL]AMINO]BENZAMIDE; 5 CHLORO 2 [[3 (4 CHLOROPHENYL)PROP 2 ENOYL]AMINO]BENZAMIDE; 5 CHLORO 2 [[3 (4 METHYLPHENYL)PROP 2 ENOYL]AMINO]BENZAMIDE; 5 CHLOROL 2[(3 PHENYLPROP 2 ENOYL)AMINO]BENZAMIDE; 5 IODO 2 [(3 PHENYLPROP 2 ENOYL)AMINO]BENZAMIDE; 5 IODO 2 [[3 (2 CHLOROPHENYL)PROP 2 ENOYL]AMINO]BENZAMIDE; 5 IODO 2 [[3 (2 METHYLPHENYL)PROP 2 ENOYL]AMINO]BENZAMIDE; 5 METHYL 2[(3 PHENYLPROP 2 ENOYL)AMINO]BENZAMIDE; ANTINEOPLASTIC AGENT; BENZAMIDE DERIVATIVE; LIPOCORTIN 5; TUBULIN; UNCLASSIFIED DRUG; ACRYLIC ACID DERIVATIVE; ANTHRANILIC ACID DERIVATIVE; PYRIDINE; PYRIDINE DERIVATIVE; TUBULIN MODULATOR;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE; CELLULAR DISTRIBUTION; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; POLYMERIZATION; TUMOR CELL LINE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; IC50; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACRYLATES; ANTINEOPLASTIC AGENTS; BENZAMIDES; CELL CYCLE; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; ORTHO-AMINOBENZOATES; POLYMERIZATION; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS;

EID: 79957501021     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.03.067     Document Type: Article

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