Synthesis of propiophenone derivatives as new class of antidiabetic agents reducing body weight in db/db mice

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 6, 2012, Pages 2172-2179

  Kumar, Atul ^a   Sharma, Siddharth ^a   Gupta, Lalit Prakash ^a   Ahmad, Pervez ^a   Srivastava, Swayam Prakash ^a   Rahuja, Neha ^a   Tamrakar, A K ^a   Srivastava, Arvind K ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Antidiabetic; Body weight; db db Mice; Propiophenone; PTP 1B

Indexed keywords

1 [2 (3 CHLOROPROPOXY) 6 HYDROXYPHENYL]PROPAN 1 ONE; 1 [2 [2 (DIETHYLAMINO)ETHOXY] 6 HYDROXYPHENYL] PROPAN 1 ONE; 1 [2 [2 (DIMETHYLAMINO)ETHOXY] 6 HYDROXYPHENYL] PROPAN 1 ONE; 1 [2 [3 (BUTYLAMINO)PROPOXY] 6 HYDROXYPHENYL]PROPAN 1 ONE; 1 [2 [3 [BUTYL(METHYL)AMINO]PROPOXY] 6 HYDROXYPHENYL]PROPAN 1 ONE; 1 [2 HYDROXY 6 [2 (PIPERIDIN 1 YL)ETHOXY]PHENYL] PROPAN 1 ONE; 1 [2 HYDROXY 6 [2 (PYRROLIDIN 1 YL)ETHOXY]PHENYL] PROPAN 1 ONE; 1 [2 HYDROXY 6 [3 (4 METHOXYPHENYLAMINO)PROPOXY]PHENYL]PROPAN 1 ONE; 1 [2 HYDROXY 6 [3 (P TOLYLAMINO)PROPOXY]PHENYL]PROPAN 1 ONE; 1 [2 HYDROXY 6 [3 (PIPERIDIN 1 YL)PROPOXY]PHENYL]PROPAN 1 ONE; 1 [2 HYDROXY 6 [3 (PYRROLIDIN 1 YL)PROPOXY]PHENYL]PROPAN 1 ONE; 1 [2,6 BIS(3 CHLOROPROPOXY)PHENYL]PROPAN 1 ONE; 2 ALKOXY 1 (6 HYDROXYPHENYL) PROPANE 1 ONE DERIVATIVE; 4 DIETHYL 2 [3 [3 (3 CHLOROPROPOXY) 2PROPIONYLPHENOXY]PROPYL]MALONATE; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; BUTYLAMINE; DIETHYL 2 [3 [2 PROPIONYL 3 [3 (P TOLYAMINO)PROPOXY]PHENOXY]PROPYL]MALONATE; DIETHYLAMINE; DIMETHYLAMINE; GLIBENCLAMIDE; INSULIN; METFORMIN; PIPERIDINE DERIVATIVE; PROPIOPHENONE DERIVATIVE; PYRROLIDINE DERIVATIVE; ROSIGLITAZONE; STREPTOZOCIN; SUCROSE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT DISORDER; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FOOD INTAKE; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIA; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; RAT; STREPTOZOCIN DIABETES; WEIGHT REDUCTION;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; EATING; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; LIPIDS; MALE; MICE; MICE, INBRED C57BL; PROPIOPHENONES; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; STREPTOZOCIN; WEIGHT LOSS;

MUS; RATTUS;

EID: 84862776567     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.12.027     Document Type: Article

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