Design and synthesis of 2,4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 11, 2010, Pages 4138-4148

  Kumar, Atul ^a   Sharma, Siddharth ^a   Tripathi, Vishwa Deepak ^a   Maurya, Ram Awatar ^a   Srivastava, Swayam Prakash ^a   Bhatia, Gitika ^a   Tamrakar, A K ^a   Srivastava, Arvind Kumar ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Antidyslipidemic; Antihyperglcemic; Glycogen phosphorylase; Polyhydroquinoline; PTP 1B

Indexed keywords

2 (4 METHOXYPHENYL) 7,7 DIMETHYL 2 PHENYL 4,6,7,8 TETRAHYDROQUINOLIN 5 (1H)ONE; 2 PHENYL 4 4 TOLYL 4,6,7,8 TETRAHYDROQUINOLIN 5 (1H)ONE; 2,4 DIPHENYL 4,6,7,8 TETRAHYDROQUINOLIN 5 (1H)ONE; 4 (1H INDOL 3 YL) 7,7 DIMETHYL 2 PHENYL 4,6,7,8 TETRAHYDROQUINOLIN 5 (1H)ONE; 4 (4 CHLOROPHENYL) 2 PHENYL 4,6,7,8 TETRAHYDROQUINOLIN 5 (1H)ONE; 4 (4 CHLOROPHENYL) 7,7 DIMETHYL 2 PHENYL 4,6,7,8 TETRAHYDROQUINOLIN 5 (1H)ONE; 4 (4 FLUOROPHENYL) 2 PHENYL 4,6,7,8 TETRAHYDROQUINOLIN 5 (1H)ONE; 4 (4 FLUOROPHENYL) 7,7 DIMETHYL 2 PHENYL 4,6,7,8 TETRAHYDROQUINOLIN 5 (1H)ONE; 4 (4 METHOXYPHENYL) 2 PHENYL 4,6,7,8 TETRAHYDROQUINOLIN 5 (1H)ONE; 4 (4 METHOXYPHENYL) 7,7 DIMETHYL 2 PHENYL 4,6,7,8 TETRAHYDROQUINOLIN 5 (1H)ONE; 4 (FURAN 2 YL) 7,7 DIMETHYL 2 PHENYL 4,6,7,8 TETRAHYDROQUINOLIN 5 (1H)ONE; 7,7 DIMETHYL 2 PHENYL 4 4 TOLYL 4,6,7,8 TETRAHYDROQUINOLIN 5 (1H)ONE; 7,7 DIMETHYL 2,4 DIPHENYL 4,6,7,8 TETRAHYDROQUINOLIN 5 (1H)ONE; 7,7 DIMETHYL 4 (4 NITROPHENYL) 2 PHENYL 4,6,7,8 TETRAHYDROQUINOLIN 5 (1H)ONE; ANTIDIABETIC AGENT; ETHYL 2 HYDROXY 7,7 DIMETHYL 5 OXO 4 PHENYL 3,4,5,6,7,8 HEXAHYDRO 2H CHROMENE 2 CARBOXYLATE; ETHYL 4 (4 BROMOPHENYL) 7,7 DIMETHYL 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 2 CARBOXYLATE; ETHYL 4 (4 CHLOROPHENYL) 2 HYDROXY 7,7 DIMETHYL 5 OXO 3,4,5,6,7,8 HEXAHYDRO 2H CHROMENE 2 CARBOXYLATE; ETHYL 4 (4 CHLOROPHENYL) 7,7 DIMETHYL 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 2 CARBOXYLATE; ETHYL 4 (4 FLUOROPHENYL) 2 HYDROXY 7,7 DIMETHYL 5 OXO 3,4,5,6,7,8 HEXAHYDRO 2H CHROMENE 2 CARBOXYLATE; ETHYL 4 (4 FLUOROPHENYL) 7,7 DIMETHYL 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 2 CARBOXYLATE; ETHYL 4 (4 METHOXYPHENYL) 7,7 DIMETHYL 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 2 CARBOXYLATE; ETHYL 7,7 DIMETHYL 5 OXO 4 PHENYL 1,4,5,6,7,8 HEXAHYDROQUINOLINE 2 CARBOXYLATE; GEMFIBROZIL; GLIBENCLAMIDE; LIPID; METFORMIN; PROTEIN TYROSINE PHOSPHATASE 1B; ROSIGLITAZONE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DESIGN; DRUG DOSE COMPARISON; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; PROSPECTIVE STUDY; RAT; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DRUG DESIGN; DYSLIPIDEMIAS; GLYCOGEN PHOSPHORYLASE; HYPOGLYCEMIC AGENTS; MICE; MICE, INBRED STRAINS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; QUINOLINES;

MUS;

EID: 77953139649     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.11.061     Document Type: Article

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