Design and synthesis of 3,5-diarylisoxazole derivatives as novel class of anti-hyperglycemic and lipid lowering agents

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 14, 2009, Pages 5285-5292

  Kumar, Atul ^a   Maurya, Ram Awatar ^a   Sharma, Siddharth ^a   Ahmad, Pervez ^a   Singh, A B ^a   Tamrakar, A K ^a   Srivastava, Arvind K ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

3,5 Diarylisoxazole; Anti hyperglycemic activity; Lipid lowering activity; PTP1B

Indexed keywords

1 [2 [5 METHOXY 2 (3 PHENYLISOXAZOL 5 YL)PHENOXY]ETHYL]PIPERIDINE; 1 [5 METHOXY 2 (3 PHENYLISOXAZOL 5 YL)PHENOXY] 3 (PYRROLIDIN 1 YL)PROPAN 2 OL; [4 METHOXY 2 (2 PYRROLIDIN 1 YLETHOXY)PHENYL] 3 PHENYLISOXAZOLE; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; CHOLESTEROL; DIETHYL [2 [5 METHOXY 2 (3 PHENYLISOXAZOL 5 YL)PHENOXY]ETHYL]AMINE; DIPEPTIDYL PEPTIDASE IV; GLIBENCLAMIDE; GLICLAZIDE; GUM ARABIC; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ISOXAZOLE DERIVATIVE; METFORMIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN TYROSINE PHOSPHATASE 1B; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DESIGN; DRUG DOSE ESCALATION; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; RAT; STREPTOZOCIN DIABETES; TREATMENT OUTCOME;

ANIMALS; ANTILIPEMIC AGENTS; BLOOD GLUCOSE; CHOLESTEROL; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPOGLYCEMIC AGENTS; ISOXAZOLES; MALE; MICE; MICE, INBRED C57BL; PPAR GAMMA; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; STREPTOZOCIN; SUCROSE; TRIGLYCERIDES;

MUS; RATTUS;

EID: 67650092641     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.033     Document Type: Article

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