The potential usefulness of taurine on diabetes mellitus and its complications

Amino Acids

Volumn 42, Issue 5, 2012, Pages 1529-1539

  Ito, Takashi ^a   Schaffer, Stephen W ^b   Azuma, Junichi ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

Author keywords

Diabetic complications; Diabetic mellitus; Insulin resistance; Obesity; Taurine

Indexed keywords

ADVANCED GLYCATION END PRODUCT; FRUCTOSE; GLUCOSE; INSULIN; INTERCELLULAR ADHESION MOLECULE 1; LIPID; LOW DENSITY LIPOPROTEIN; PLACEBO; TAURINE; TRANSFORMING GROWTH FACTOR BETA;

ALBUMINURIA; ATHEROSCLEROSIS; CATARACT; DIABETES MELLITUS; DIABETIC CARDIOMYOPATHY; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; DRUG EFFICACY; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; GLOMERULOSCLEROSIS; GLUCOSE TRANSPORT; HUMAN; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; KIDNEY FIBROSIS; LIPID PEROXIDATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; REVIEW; SUPPLEMENTATION; THROMBOSIS;

ANIMALS; DIABETES COMPLICATIONS; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; INSULIN RESISTANCE; OBESITY; OXIDATIVE STRESS; RATS; TAURINE;

ANIMALIA; MAMMALIA;

EID: 84862774746     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-011-0883-5     Document Type: Review

References (105)

1. Abebe W (2008) Effects of taurine on the reactivity of aortas from diabetic rats. Life Sci 82:279-289
2. Alvarado-Vasquez N, Zamudio P, Ceron E, Vanda B, Zenteno E, Carvajal-Sandoval G (2003) Effect of glycine in streptozotocininduced diabetic rats. Comp Biochem Physiol C Toxicol Pharmacol 134:521-527 (Pubitemid 36515002)
3. Anthrayose CV, Shashidhar S (2004) Studies on protein and taurine in normal, senile and diabetic cataractous human lenses. Indian J Physiol Pharmacol 48:357-360 (Pubitemid 38954959)
4. Arany E, Strutt B, Romanus P, Remacle C, Reusens B, Hill DJ (2004) Taurine supplement in early life altered islet morphology, decreased insulitis and delayed the onset of diabetes in nonobese diabetic mice. Diabetologia 47:1831-1837 (Pubitemid 40022420)
5. Askwith T, Zeng W, Eggo MC, Stevens MJ (2009) Oxidative stress and dysregulation of the taurine transporter in high-glucoseexposed human Schwann cells: implications for pathogenesis of diabetic neuropathy. Am J Physiol Endocrinol Metab 297:E620-E628
6. Azuma J, Hasegawa H, Sawamura A, Awata N, Ogura K, Harada H, Yamamura Y, Kishimoto S (1983) Therapy of congestive heart failure with orally administered taurine. Clin Ther 5:398-408 (Pubitemid 13059885)
7. Azuma J, Sawamura A, Awata N, Ohta H, Hamaguchi T, Harada H, Takihara K, Hasegawa H, Yamagami T, Ishiyama T et al (1985) Therapeutic effect of taurine in congestive heart failure: a double-blind crossover trial. Clin Cardiol 8:276-282 (Pubitemid 15037650)
8. Bellentani S, Pecorari M, Cordoma P, Marchegiano P, Manenti F, Bosisio E, De Fabiani E, Galli G (1987) Taurine increases bile acid pool size and reduces bile saturation index in the hamster. J Lipid Res 28:1021-1027
9. Brons C, Spohr C, Storgaard H, Dyerberg J, Vaag A (2004) Effect of taurine treatment on insulin secretion and action, and on serum lipid levels in overweight men with a genetic predisposition for type II diabetes mellitus. Eur J Clin Nutr 58:1239-1247 (Pubitemid 39264021)
10. Casey RG, Gang C, Joyce M, Bouchier-Hayes DJ (2007) Taurine attenuates acute hyperglycaemia-induced endothelial cell apoptosis, leucocyte-endothelial cell interactions and cardiac dysfunction. J Vasc Res 44:31-39 (Pubitemid 46115950)
11. Chang KJ, Kwon W (2000) Immunohistochemical localization of insulin in pancreatic beta-cells of taurine-supplemented or taurine-depleted diabetic rats. Adv Exp Med Biol 483:579-587
12. Chauncey KB, Tenner TE Jr, Lombardini JB, Jones BG, Brooks ML, Warner RD, Davis RL, Ragain RM (2003) The effect of taurine supplementation on patients with type 2 diabetes mellitus. Adv Exp Med Biol 526:91-96 (Pubitemid 41582768)
13. De Luca G, Calpona PR, Caponetti A, Romano G, Di Benedetto A, Cucinotta D, Di Giorgio RM (2001) Taurine and osmoregulation: platelet taurine content, uptake, and release in type 2 diabetic patients. Metabolism 50:60-64 (Pubitemid 32058550)
14. Di Leo MA, Santini SA, Cercone S, Lepore D, Gentiloni Silveri N, Caputo S, Greco AV, Giardina B, Franconi F, Ghirlanda G (2002) Chronic taurine supplementation ameliorates oxidative stress and Na? K? ATPase impairment in the retina of diabetic rats. Amino Acids 23:401-406 (Pubitemid 35435598)
15. Di Leo MA, Ghirlanda G, Gentiloni Silveri N, Giardina B, Franconi F, Santini SA (2003) Potential therapeutic effect of antioxidants in experimental diabetic retina: a comparison between chronic taurine and vitamin E plus selenium supplementations. Free Radic Res 37:323-330 (Pubitemid 36181889)
16. Di Leo MA, Santini SA, Gentiloni Silveri N, Giardina B, Franconi F, Ghirlanda G (2004) Long-term taurine supplementation reduces mortality rate in streptozotocin-induced diabetic rats. Amino Acids 27:187-191 (Pubitemid 39506579)
17. El Mesallamy HO, El-Demerdash E, Hammad LN, El Magdoub HM (2010) Effect of taurine supplementation on hyperhomocysteinemia and markers of oxidative stress in high fructose diet induced insulin resistance. Diabetol Metab Syndr 2(46):46
18. Elizarova EP, Nedosugova LV (1996) First experiments in taurine administration for diabetes mellitus. The effect on erythrocyte membranes. Adv Exp Med Biol 403:583-588 (Pubitemid 26365240)
19. Fennessy FM, Moneley DS, Wang JH, Kelly CJ, Bouchier-Hayes DJ (2003) Taurine and vitamin C modify monocyte and endothelial dysfunction in young smokers. Circulation 107:410-415 (Pubitemid 36158042)
20. Franconi F, Bennardini F, Mattana A, Miceli M, Ciuti M, Mian M, Gironi A, Anichini R, Seghieri G (1995) Plasma and platelet taurine are reduced in subjects with insulin-dependent diabetes mellitus: effects of taurine supplementation. Am J Clin Nutr 61:1115-1119
21. Franconi F, Miceli M, Fazzini A, Seghieri G, Caputo S, DiLeo MA, Lepore D, Ghirlanda G (1996) Taurine and diabetes. Humans and experimental models. Adv Exp Med Biol 403:579-582 (Pubitemid 26365239)
22. Franconi F, Di Leo MA, Bennardini F, Ghirlanda G (2004) Is taurine beneficial in reducing risk factors for diabetes mellitus? Neurochem Res 29:143-150 (Pubitemid 38181708)
23. Franconi F, Loizzo A, Ghirlanda G, Seghieri G (2006) Taurine supplementation and diabetes mellitus. Curr Opin Clin Nutr Metab Care 9:32-36
24. Gandhi VM, Cherian KM, Mulky MJ (1992) Hypolipidemic action of taurine in rats. Indian J Exp Biol 30:413-417
25. Gavrovskaya LK, Ryzhova OV, Safonova AF, Matveev AK, Sapronov NS (2008) Protective effect of taurine on rats with experimental insulin-dependent diabetes mellitus. Bull Exp Biol Med 146:226-228
26. Goodman HO, Shihabi ZK (1990) Supplemental taurine in diabetic rats: effects on plasma glucose and triglycerides. Biochem Med Metab Biol 43:1-9
27. Haber CA, Lam TK, Yu Z, Gupta N, Goh T, Bogdanovic E, Giacca A, Fantus IG (2003) N-acetylcysteine (NAC) and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress. Am J Physiol Endocrinol Metab 285:E744-E753 (Pubitemid 37176425)
28. Han J, Bae JH, Kim SY, Lee HY, Jang BC, Lee IK, Cho CH, Lim JG, Suh SI, Kwon TK et al (2004) Taurine increases glucose sensitivity of UCP2-overexpressing beta-cells by ameliorating mitochondrial metabolism. Am J Physiol Endocrinol Metab 287:E1008-E1018 (Pubitemid 39382940)
29. Hansen SH (2001) The role of taurine in diabetes and the development of diabetic complications. Diabetes Metab Res Rev 17:330-346 (Pubitemid 33050973)
30. Hansen SH, Andersen ML, Cornett C, Gradinaru R, Grunnet N (2010) A role for taurine in mitochondrial function. J Biomed Sci 17(Suppl 1):S23
31. Harada N, Ninomiya C, Osako Y, Morishima M, Mawatari K, Takahashi A, Nakaya Y (2004) Taurine alters respiratory gas exchange and nutrient metabolism in type 2 diabetic rats. Obes Res 12:1077-1084 (Pubitemid 41132486)
32. Hayes KC, Carey RE, Schmidt SY (1975) Retinal degeneration associated with taurine deficiency in the cat. Science 188:949-951
33. Hayes KC, Pronczuk A, Addesa AE, Stephan ZF (1989) Taurine modulates platelet aggregation in cats and humans. Am J Clin Nutr 49:1211-1216 (Pubitemid 19169682)
34. Higo S, Miyata S, Jiang QY, Kitazawa R, Kitazawa S, Kasuga M (2008) Taurine administration after appearance of proteinuria retards progression of diabetic nephropathy in rats. Kobe J Med Sci 54:E35-E45
35. Huang JS, Chuang LY, Guh JY, Huang YJ, Hsu MS (2007) Antioxidants attenuate high glucose-induced hypertrophic growth in renal tubular epithelial cells. Am J Physiol Renal Physiol 293:F1072-F1082
36. Huang JS, Chuang LY, Guh JY, Yang YL, Hsu MS (2008) Effect of taurine on advanced glycation end products-induced hypertrophy in renal tubular epithelial cells. Toxicol Appl Pharmacol 233:220-226
37. Huang JS, Chuang LY, Guh JY, Huang YJ (2009) Effects of nitric oxide and antioxidants on advanced glycation end productsinduced hypertrophic growth in human renal tubular cells. Toxicol Sci 111(1):109-119
38. Huxtable RJ (1992) Physiological actions of taurine. Physiol Rev 72:101-163
39. Huxtable R, Bressler R (1974) Taurine concentrations in congestive heart failure. Science 184:1187-1188
40. Ito T, Kimura Y, Uozumi Y, Takai M, Muraoka S, Matsuda T, Ueki K, Yoshiyama M, Ikawa M, Okabe M, Schaffer SW, Fujio Y, Azuma J (2008) Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy. J Mol Cell Cardiol 44:927-937
41. Kamata K, Sugiura M, Kojima S, Kasuya Y (1996) Restoration of endothelium-dependent relaxation in both hypercholesterolemia and diabetes by chronic taurine. Eur J Pharmacol 303:47-53 (Pubitemid 26191439)
42. Kaniuk NA, Kiraly M, Bates H, Vranic M, Volchuk A, Brumell JH (2007) Ubiquitinated-protein aggregates form in pancreatic betacells during diabetes-induced oxidative stress and are regulated by autophagy. Diabetes 56:930-939 (Pubitemid 46525060)
43. Kirino Y, Yasukawa T, Ohta S, Akira S, Ishihara K, Watanabe K, Suzuki T (2004) Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease. Proc Natl Acad Sci USA 101:15070-15075 (Pubitemid 39391720)
44. Kondo Y, Murakami S, Oda H, Nagate T (2000) Taurine reduces atherosclerotic lesion development in apolipoprotein E-deficient mice. Adv Exp Med Biol 483:193-202
45. Li C, Cao L, Zeng Q, Liu X, Zhang Y, Dai T, Hu D, Huang K, Wang Y, Wang X et al (2005a) Taurine may prevent diabetic rats from developing cardiomyopathy also by downregulating angiotensin II type2 receptor expression. Cardiovasc Drugs Ther 19:105-112 (Pubitemid 41126196)
46. Li F, Obrosova IG, Abatan O, Tian D, Larkin D, Stuenkel EL, Stevens MJ (2005b) Taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats. Am J Physiol Endocrinol Metab 288:E29-E36 (Pubitemid 40023787)
47. Li F, Abatan OI, Kim H, Burnett D, Larkin D, Obrosova IG, Stevens MJ (2006) Taurine reverses neurological and neurovascular deficits in Zucker diabetic fatty rats. Neurobiol Dis 22:669-676 (Pubitemid 43832137)
48. Malone JI, Lowitt S, Cook WR (1990) Nonosmotic diabetic cataracts. Pediatr Res 27:293-296 (Pubitemid 20096418)
49. Merheb M, Daher RT, Nasrallah M, Sabra R, Ziyadeh FN, Barada K (2007) Taurine intestinal absorption and renal excretion test in diabetic patients: a pilot study. Diabetes Care 30:2652-2654 (Pubitemid 47547815)
50. Militante JD, Lombardini JB, Schaffer SW (2000) The role of taurine in the pathogenesis of the cardiomyopathy of insulin-dependent diabetes mellitus. Cardiovasc Res 46:393-402 (Pubitemid 30319325)
51. Mochizuki H, Takido J, Oda H, Yokogoshi H (1999) Improving effect of dietary taurine on marked hypercholesterolemia induced by a high-cholesterol diet in streptozotocin-induced diabetic rats. Biosci Biotechnol Biochem 63:1984-1987 (Pubitemid 129548998)
52. Moloney MA, Casey RG, O'Donnell DH, Fitzgerald P, Thompson C, Bouchier-Hayes DJ (2010) Two weeks taurine supplementation reverses endothelial dysfunction in young male type 1 diabetics. Diab Vasc Dis Res 7:300-310
53. Murakami S, Kondo Y, Tomisawa K, Nagate T (1999a) Prevention of atherosclerotic lesion development in mice by taurine. Drugs Exp Clin Res 25:227-234 (Pubitemid 29497743)
54. Murakami S, Kondo-Ohta Y, Tomisawa K (1999b) Improvement in cholesterol metabolism in mice given chronic treatment of taurine and fed a high-fat diet. Life Sci 64:83-91 (Pubitemid 29012752)
55. Murakami S, Kondo Y, Sakurai T, Kitajima H, Nagate T (2002) Taurine suppresses development of atherosclerosis in Watanabe heritable hyperlipidemic (WHHL) rabbits. Atherosclerosis 163:79-87 (Pubitemid 34615728)
56. Nakamura T, Ushiyama C, Suzuki S, Shimada N, Ohmuro H, Ebihara I, Koide H (1999) Effects of taurine and vitamin E on microalbuminuria, plasma metalloproteinase-9, and serum type IV collagen concentrations in patients with diabetic nephropathy. Nephron 83:361-362
57. Nakamura-Yamanaka Y, Tsuji K, Ichikawa T (1987) Effect of dietary taurine on cholesterol 7 alpha-hydroxylase activity in the liver of mice fed a lithogenic diet. J Nutr Sci Vitaminol (Tokyo) 33:239-243
58. Nakaya Y, Minami A, Harada N, Sakamoto S, Niwa Y, Ohnaka M (2000) Taurine improves insulin sensitivity in the Otsuka Long- Evans Tokushima Fatty rat, a model of spontaneous type 2 diabetes. Am J Clin Nutr 71:54-58 (Pubitemid 30033584)
59. Nanami K, Oda H, Yokogoshi H (1996) Antihypercholesterolemic action of taurine on streptozotocin-diabetic rats or on rats fed a high cholesterol diet. Adv Exp Med Biol 403:561-568 (Pubitemid 26365237)
60. Nandhini AT, Anuradha CV (2002) Taurine modulates kallikrein activity and glucose metabolism in insulin resistant rats. Amino Acids 22:27-38 (Pubitemid 34158542)
61. Nandhini TA, Anuradha CV (2003) Inhibition of lipid peroxidation, protein glycation and elevation of membrane ion pump activity by taurine in RBC exposed to high glucose. Clin Chim Acta 336:129-135 (Pubitemid 37324764)
62. Nandhini AT, Anuradha CV (2004) Hoe 140 abolishes the blood pressure lowering effect of taurine in high fructose-fed rats. Amino Acids 26:299-303 (Pubitemid 38829794)
63. Nandhini AT, Thirunavukkarasu V, Anuradha CV (2004) Stimulation of glucose utilization and inhibition of protein glycation and AGE products by taurine. Acta Physiol Scand 181:297-303 (Pubitemid 38869741)
64. Nandhini AT, Thirunavukkarasu V, Ravichandran MK, Anuradha CV (2005) Effect of taurine on biomarkers of oxidative stress in tissues of fructose-fed insulin-resistant rats. Singapore Med J 46:82-87 (Pubitemid 40203743)
65. Obrosova IG, Stevens MJ (1999) Effect of dietary taurine supplementation on GSH and NAD(P)-redox status, lipid peroxidation, and energy metabolism in diabetic precataractous lens. Invest Ophthalmol Vis Sci 40:680-688 (Pubitemid 29109446)
66. Obrosova IG, Fathallah L, Stevens MJ (2001a) Taurine counteracts oxidative stress and nerve growth factor deficit in early experimental diabetic neuropathy. Exp Neurol 172:211-219 (Pubitemid 33141166)
67. Obrosova IG, Minchenko AG, Marinescu V, Fathallah L, Kennedy A, Stockert CM, Frank RN, Stevens MJ (2001b) Antioxidants attenuate early up regulation of retinal vascular endothelial growth factor in streptozotocin-diabetic rats. Diabetologia 44:1102-1110 (Pubitemid 32835501)
68. Ogasawara M, Nakamura T, Koyama I, Nemoto M, Yoshida T (1993) Reactivity of taurine with aldehydes and its physiological role. Chem Pharm Bull (Tokyo) 41:2172-2175 (Pubitemid 24042869)
69. Oprescu AI, Bikopoulos G, Naassan A, Allister EM, Tang C, Park E, Uchino H, Lewis GF, Fantus IG, Rozakis-Adcock M et al (2007) Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo. Diabetes 56:2927-2937 (Pubitemid 350223627)
70. Park SH, Choi HJ, Lee JH, Woo CH, Kim JH, Han HJ (2001) High glucose inhibits renal proximal tubule cell proliferation and involves PKC, oxidative stress, and TGF-beta 1. Kidney Int 59:1695-1705
71. Pennathur S, Heinecke JW (2007) Oxidative stress and endothelial dysfunction in vascular disease. Curr Diab Rep 7:257-264 (Pubitemid 47249084)
72. Pion PD, Kittleson MD, Rogers QR, Morris JG (1987) Myocardial failure in cats associated with low plasma taurine: a reversible cardiomyopathy. Science 237:764-768 (Pubitemid 17128269)
73. Pop-Busui R, Sullivan KA, Van Huysen C, Bayer L, Cao X, Towns R, Stevens MJ (2001) Depletion of taurine in experimental diabetic neuropathy: implications for nerve metabolic, vascular, and functional deficits. Exp Neurol 168:259-272 (Pubitemid 32289762)
74. Satoh H (1998) Cardiac actions of taurine as a modulator of the ion channels. Adv Exp Med Biol 442:121-128 (Pubitemid 28313064)
75. Schaffer S, Takahashi K, Azuma J (2000) Role of osmoregulation in the actions of taurine. Amino Acids 19:527-546
76. Schaffer SW, Azuma J, Mozaffari M (2009) Role of antioxidant activity of taurine in diabetes. Can J Physiol Pharmacol 87:91-99
77. Selvaraj N, Bobby Z, Sathiyapriya V (2006) Effect of lipid peroxides and antioxidants on glycation of hemoglobin: an in vitro study on human erythrocytes. Clin Chim Acta 366:190-195 (Pubitemid 43330982)
78. Shao A, Hathcock JN (2008) Risk assessment for the amino acids taurine, L-glutamine and L-arginine. Regul Toxicol Pharmacol 50:376-399
79. Sjovall J (1959) Dietary glycine and taurine on bile acid conjugation in man; bile acids and steroids 75. Proc Soc Exp Biol Med 100:676-678
80. Son HY, Kim H, Y HK (2007) Taurine prevents oxidative damage of high glucose-induced cataractogenesis in isolated rat lenses. J Nutr Sci Vitaminol (Tokyo) 53:324-330 (Pubitemid 47442352)
81. Spohr C, Brons C, Winther K, Dyerberg J, Vaag A (2005) No effect of taurine on platelet aggregation in men with a predisposition to type 2 diabetes mellitus. Platelets 16:301-305 (Pubitemid 40943925)
82. Stevens MJ, Lattimer SA, Kamijo M, Van Huysen C, Sima AA, Greene DA (1993) Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat. Diabetologia 36:608-614 (Pubitemid 23186452)
83. Stevens MJ, Hosaka Y, Masterson JA, Jones SM, Thomas TP, Larkin DD (1999) Downregulation of the human taurine transporter by glucose in cultured retinal pigment epithelial cells. Am J Physiol 277:E760-E771 (Pubitemid 29522630)
84. Sturman JA (1991) Dietary taurine and feline reproduction and development. J Nutr 121:S166-S170
85. Suzuki T, Suzuki T, Wada T, Saigo K, Watanabe K (2002) Taurine as a constituent of mitochondrial tRNAs: new insights into the functions of taurine and human mitochondrial diseases. EMBO J 21:6581-6589 (Pubitemid 35448435)
86. Tang C, Han P, Oprescu AI, Lee SC, Gyulkhandanyan AV, Chan GN, Wheeler MB, Giacca A (2007) Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo. Diabetes 56:2722-2731 (Pubitemid 350044915)
87. Tenner TE Jr, Zhang XJ, Lombardini JB (2003) Hypoglycemic effects of taurine in the alloxan-treated rabbit, a model for type 1 diabetes. Adv Exp Med Biol 526:97-104 (Pubitemid 41582769)
88. Tokunaga H, Yoneda Y, Kuriyama K (1979) Protective actions of taurine against streptozotocin-induced hyperglycemia. Biochem Pharmacol 28:2807-2811 (Pubitemid 10228094)
89. Tokunaga H, Yoneda Y, Kuriyama K (1983) Streptozotocin-induced elevation of pancreatic taurine content and suppressive effect of taurine on insulin secretion. Eur J Pharmacol 87:237-243 (Pubitemid 13138541)
90. Trachtman H, Futterweit S, Maesaka J, Ma C, Valderrama E, Fuchs A, Tarectecan AA, Rao PS, Sturman JA, Boles TH et al (1995) Taurine ameliorates chronic streptozocin-induced diabetic nephropathy in rats. Am J Physiol 269:F429-F438
91. Tsuboyama-Kasaoka N, Shozawa C, Sano K, Kamei Y, Kasaoka S, Hosokawa Y, Ezaki O (2006) Taurine (2-aminoethanesulfonic acid) deficiency creates a vicious circle promoting obesity. Endocrinology 147:3276-3284 (Pubitemid 43901118)
92. Ulrich-Merzenich G, Zeitler H, Vetter H, Bhonde RR (2007) Protective effects of taurine on endothelial cells impaired by high glucose and oxidized low density lipoproteins. Eur J Nutr 46:431-438 (Pubitemid 350276229)
93. Vilchis C, Salceda R (1996) Effect of diabetes on levels and uptake of putative amino acid neurotransmitters in rat retina and retinal pigment epithelium. Neurochem Res 21:1167-1171 (Pubitemid 26357266)
94. Wang LJ, Yu YH, Zhang LG, Wang Y, Niu N, Li Q, Guo LM (2008) Taurine rescues vascular endothelial dysfunction in streptozocininduced diabetic rats: correlated with downregulation of LOX-1 and ICAM-1 expression on aortas. Eur J Pharmacol 597:75-80
95. Winiarska K, Szymanski K, Gorniak P, Dudziak M, Bryla J (2009) Hypoglycaemic, antioxidative and nephroprotective effects of taurine in alloxan diabetic rabbits. Biochimie 91:261-270
96. Wu N, Lu Y, He B, Zhang Y, Lin J, Zhao S, Zhang W, Li Y, Han P (2010) Taurine prevents free fatty acid-induced hepatic insulin resistance in association with inhibiting JNK1 activation and improving insulin signaling in vivo. Diabetes Res Clin Pract 90(3):288-296
97. Xiao C, Giacca A, Lewis GF (2008) Oral taurine but not N-acetylcysteine ameliorates NEFA-induced impairment in insulin sensitivity and beta cell function in obese and overweight, non-diabetic men. Diabetologia 51:139-146 (Pubitemid 50003768)
98. Yamori Y, Liu L, Ikeda K, Miura A, Mizushima S, Miki T, Nara Y (2001) Distribution of twenty-four hour urinary taurine excretion and association with ischemic heart disease mortality in 24 populations of 16 countries: results from the WHO-CARDIAC study. Hypertens Res 24:453-457 (Pubitemid 32791822)
99. Yao HT, Lin P, Chang YW, Chen CT, Chiang MT, Chang L, Kuo YC, Tsai HT, Yeh TK (2009) Effect of taurine supplementation on cytochrome P450 2E1 and oxidative stress in the liver and kidneys of rats with streptozotocin-induced diabetes. Food Chem Toxicol 47:1703-1709
100. Yokogoshi H, Mochizuki H, Nanami K, Hida Y, Miyachi F, Oda H (1999) Dietary taurine enhances cholesterol degradation and reduces serum and liver cholesterol concentrations in rats fed a high-cholesterol diet. J Nutr 129:1705-1712 (Pubitemid 29406625)
101. Yu X, Xu Z, Mi M, Xu H, Zhu J, Wei N, Chen K, Zhang Q, Zeng K, Wang J et al (2008) Dietary taurine supplementation ameliorates diabetic retinopathy via anti-excitotoxicity of glutamate in streptozotocin-induced Sprague-Dawley rats. Neurochem Res 33:500-507 (Pubitemid 351230452)
102. Zeng K, Xu H, Mi M, Zhang Q, Zhang Y, Chen K, Chen F, Zhu J, Yu X (2009) Dietary taurine supplementation prevents glial alterations in retina of diabetic rats. Neurochem Res 34:244-254
103. Zeng K, Xu H, Mi M, Chen K, Zhu J, Yi L, Zhang T, Zhang Q, Yu X (2010a) Effects of taurine on glial cells apoptosis and taurine transporter expression in retina under diabetic conditions. Neurochem Res 35:1566-1574
104. Zeng K, Xu H, Chen K, Zhu J, Zhou Y, Zhang Q, Mantian M (2010b) Effects of taurine on glutamate uptake and degradation in Müller cells under diabetic conditions via antioxidant mechanism. Mol Cell Neurosci 45:192-199
105. Zhang C, Yang J, Jennings LK (2004) Leukocyte-derived myeloperoxidase amplifies high-glucose-induced endothelial dysfunction through interaction with high-glucose-stimulated, vascular nonleukocyte- derived reactive oxygen species. Diabetes 53:2950-2959 (Pubitemid 39425921)