Taurine prevents free fatty acid-induced hepatic insulin resistance in association with inhibiting JNK1 activation and improving insulin signaling in vivo

Diabetes Research and Clinical Practice

Volumn 90, Issue 3, 2010, Pages 288-296

  Wu, Na ^a   Lu, Yan ^a   He, Bing ^a   Zhang, Yongyan ^a   Lin, Jingfeng ^b   Zhao, Sheng ^a   Zhang, Wei ^a   Li, Yan ^a   Han, Ping ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b THE AFFILIATED BENQ HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Free fatty acids; Hepatic glucose production; Insulin resistance; Oxidative stress; Taurine

Indexed keywords

8 ISOPROSTAGLANDIN E2; ANTIOXIDANT; FATTY ACID; GLUCOSE; HEPARIN; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; INTRALIPID; MALONALDEHYDE; PROTEIN KINASE B; SERINE; STRESS ACTIVATED PROTEIN KINASE 1; TAURINE; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FATTY ACID BLOOD LEVEL; GLUCONEOGENESIS; GLUCOSE CLAMP TECHNIQUE; GLUCOSE INFUSION; HYPERINSULINEMIA; IN VIVO STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIVER PROTECTION; LONG TERM EXPOSURE; MALE; NONHUMAN; OXIDATIVE STRESS; PROSTAGLANDIN BLOOD LEVEL; PROTEIN BLOOD LEVEL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; EMULSIONS; FATTY ACIDS, NONESTERIFIED; HEPARIN; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; LIVER; MALE; MALONATES; MITOGEN-ACTIVATED PROTEIN KINASE 8; OXIDATIVE STRESS; PHOSPHOLIPIDS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SOYBEAN OIL; TAURINE;

EID: 78649462104     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2010.08.020     Document Type: Article

References (39)

1. Lam T.K., Yoshii H., Haber C.A., Bogdanovic E., Lam L., Fantus I.G., et al. Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta. Am J Physiol Endocrinol Metab 2002, 283:E682-E691.
2. Lam T.K., van de Werve G., Giacca A. Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites. Am J Physiol Endocrinol Metab 2003, 284:E281-E290.
3. Boden G., She P., Mozzoli M., Cheung P., Gumireddy K., Reddy P., et al. Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-B pathway in rat liver. Diabetes 2005, 54:3458-3465.
4. Oakes N.D., Cooney G.J., Camilleri S., Chisholm D.J., Kraegen E.W. Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 1997, 46:1768-1774.
5. Bevilacqua S., Bonadonna R., Buzzigoli G., Boni C., Ciociaro D., Maccari F., et al. Acute elevation of free fatty acid levels leads to hepatic insulin resistance in obese subjects. Metabolism 1987, 36:502-506.
6. Wiesenthal S.R., Sandhu H., McCall R.H., Tchipashvili V., Yoshii H., Polonsky K., et al. Free fatty acids impair hepatic insulin extraction in vivo. Diabetes 1999, 48:766-774.
7. Park E., Wong V., Guan X., Giacca A. Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivo. Endocrinology 2007, 195:323-331.
8. Solinas G., Naugler W., Galimi F., Lee M.S., Karin M. Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. Proc Natl Acad Sci USA 2006, 103:16454-16459.
9. Nakaya Y., Minami A., Harada N., Sakamoto S., Niwa Y., Ohnaka M. Taurine improves insulin sensitivity in the Otsuka Long-Evans Tokushima fatty rat, a model of spontaneous type 2 diabetes. Am J Clin Nutr 2000, 71:54-58.
10. Harada N., Ninomiya C., Osako Y., Morishima M., Mawatari K., Takahashi A., et al. Taurine alters respiratory gas exchange and nutrient metabolism in type 2 diabetic rats. Obes Res 2004, 12:1077-1084.
11. Nandhini A.T., Thirunavukkarasua V., Anuradha C.V. Taurine modifies insulin signaling enzymes in the fructose-fed insulin resistant rats. Diabetes Metab 2005, 31:337-344.
12. Ragheb R., Medhat A.M., Shanab G.M., Seoudi D.M., Fantus I.G. Links between enhanced fatty acid flux, protein kinase C and NFκB activation, and apoB-lipoprotein production in the fructose-fed hamster model of insulin resistance. Biochem Biophys Res Commun 2008, 370:134-139.
13. Haber C.A., Lam T.K., Yu Z., Gupta N., Goh T., Bogdanovic E., et al. N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress. Am J Physiol Endocrinol Metab 2003, 285:744-753.
14. Xiao C., Giacca A., Lewis G.F. Oral taurine but not N-acetylcysteine ameliorates NEFA-induced impairment in insulin sensitivity and beta cell function in obese and overweight, non-diabetic men. Diabetologia 2008, 51:139-146.
15. Ragheb R., Shanab G.M., Medhat A.M., Seoudi D.M., Adeli K., Fantus I.G. Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: evidence for PKC activation and oxidative stress-activated signaling pathways. Biochem Biophys Res Commun 2009, 389:211-216.
16. Carneiro E.M., Latorraca M.Q., Araujo E., Beltrá M., Oliveras M.J., Navarro M., et al. Taurine supplementation modulates glucose homeostasis and islet function. J Nutr Biochem 2009, 20:503-511.
17. Han P., Zhang Y.Y., Lu Y., He B., Zhang W., Xia F. Effects of different free fatty acids on insulin resistance in rats. Hepatobiliary Pancreat Dis Int 2008, 7:91-96.
18. Mason T.M., Goh T., Tchipashvili V., Sandhu H., Gupta N., Lewis G.F., et al. Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats. Diabetes 1999, 48:524-530.
19. Steele R., Wall J.S., De Bodo R.C., Altszuler N. Measurement of size and turnover rate of body glucose pool by the isotope dilution method. Am J Physiol 1956, 187:15-24.
20. Finegood D.T., Bergman R.N., Vranic M. Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates. Diabetes 1987, 36:914-924.
21. Maassen J.A., Romijn J.A., Heine R.J. Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: a new concept in the pathogenesis of obesity-associated type 2 diabetes mellitus. Diabetologia 2007, 50:2036-2041.
22. Morrow J.D. Quantification of isoprostanes as indices of oxidant stress and the risk of atherosclerosis in humans. Arterioscler Thromb Vasc Biol 2005, 25:279-286.
23. He B., Zhao S., Zhang W., Li Y., Han P. Effect of sodium salicylate on oxidative stress and insulin resistance induced by free fatty acids. Hepatobiliary Pancreat Dis Int 2010, 9:49-53.
24. He B., Zhao S., Zhang W., Li Y., Lu Y., Han P. Salicylate prevents hepatic oxidative stress activation caused by short-term elevation of free fatty acids in vivo. Diab Res Clin Pract 2010 May, [Epub ahead of print].
25. Carpentier A.C., Frisch F., Cyr D., Genereux P., Patterson B.W., Giguere R., et al. On the suppression of plasma nonesterified fatty acids by insulin during enhanced intravascular lipolysis in humans. Am J Physiol Endocrinol Metab 2005, 289:E849-E856.
26. Larbi A., Grenier A., Frisch F., Douziech N., Fortin C., Carpentier A.C., et al. Acute in vivo elevation of intravascular triacylglycerol lipolysis impairs peripheral T cell activation in humans. Am J Clin Nutr 2005, 82:949-956.
27. Nandhini A.T., Balakrishnan S.D., Anuradha C.V. Response of liver antioxidant system to taurine in rats fed high fructose diet. Ind J Exp Biol 2002, 40:1016-1019.
28. Adler V., Yin Z., Tew K.D., Ronai Z. Role of redox potential and reactive oxygen species in stress signaling. Oncogene 1999, 18:6104-6111.
29. Qiao L.Y., Goldberg J.L., Russell J.C., Sun X.J. Identification of enhanced serine kinase activity in insulin resistance. J Biol Chem 1999, 274:10625-10632.
30. Evans J.L., Goldfine I.D., Maddux B.A., Grodsky G.M. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 2002, 23:599-622.
31. Samuel V.T., Liu Z.X., Qu X., Elder B.D., Bilz S., Befroy D., et al. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 2004, 279:32345-32353.
32. Aguirre V., Werner E.D., Giraud J., Lee Y.H., Shoelson S.E., White M.F. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem 2002, 277:1531-1537.
33. Yu C., Chen Y., Cline G.W., Zhang D., Zong H., Wang Y., et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 2002, 277:50230-50236.
34. Vinayagamoorthi R., Bobby Z., Sridhar M.G. Antioxidants preserve redox balance and inhibit c-Jun-N-terminal kinase pathway while improving insulin signaling in fat-fed rats: evidence for the role of oxidative stress on IRS-1 serine phosphorylation and insulin resistance. J Endocrinol 2008, 197:287-296.
35. Tomie Furuya D., Binsack R., Onishi M.E., Monteiro Seraphim P., Fabres Machado U. Low ethanol consumption induces enhancement of insulin sensitivity in liver of normal rats. Life Sci 2005, 77:1813-1824.
36. Previs S.F., Withers D.J., Ren J.M., White M.F., Shulman G.I. Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo. J Biol Chem 2000, 275:38990-38994.
37. Kido Y., Burks D.J., Withers D., Bruning J.C., Kahn C.R., White M.F., et al. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest 2000, 105:199-205.
38. Higaki Y., Wojtaszewski J.F., Hirshman M.F., Withers D.J., Towery H., White M.F., et al. Insulin receptor substrate-2 is not necessary for insulin- and exercise-stimulated glucose transport in skeletal muscle. J Biol Chem 1999, 274:20791-20795.
39. Rother K.I., Imai Y., Caruso M., Beguinot F., Formisano P., Accili D. Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes. J Biol Chem 1998, 273:17491-17497.