Methothrexate attenuates early neutrophil infiltration and the associated lipid peroxidation in the injured spinal cord but does not induce neurotoxicity in the uninjured spinal cord in rats

Acta Neurochirurgica

Volumn 154, Issue 6, 2012, Pages 1045-1054

  ŞanlI, Ahmet Metin ^a,d   Serbes, Gökhan ^a   Sargon, Mustafa F ^b   ÇalIşkan, Murat ^c   KIlInç, Kamer ^b   Bulut, Hüsamettin ^a   Şekerci, Zeki ^a  

^a DISKAPI YILDIRIM BEYAZIT TRAINING AND RESEARCH HOSPITAL   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

^c ANKARA UNIVERSITY   (Turkey)

^d Mebusevleri Mah Ayten Sokak   (Turkey)

Author keywords

Inflammation; Lipid peroxidation; Methotrexate; Methylprednisolone sodium succinate; Neuroprotection; Spinal cord injury

Indexed keywords

MALONALDEHYDE; METHOTREXATE; METHYLPREDNISOLONE SODIUM SUCCINATE; MYELOPEROXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; ENZYME ACTIVITY; HISTOPATHOLOGY; LIPID PEROXIDATION; LOW DRUG DOSE; MYELINATED NERVE; NEUROPROTECTION; NEUROTOXICITY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; SPINAL CORD INJURY; TISSUE STRUCTURE; TREATMENT RESPONSE; ULTRASTRUCTURE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CHEMOTAXIS, LEUKOCYTE; DISEASE MODELS, ANIMAL; FEMALE; IMMUNOSUPPRESSIVE AGENTS; LIPID PEROXIDATION; METHOTREXATE; NEUTROPHIL INFILTRATION; RATS; RATS, WISTAR; SPINAL CORD INJURIES;

EID: 84862765376     PISSN: 00016268     EISSN: 09420940     Source Type: Journal    
DOI: 10.1007/s00701-012-1302-8     Document Type: Article

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