Synthesis of a phosphoserine mimetic prodrug with potent 14-3-3 protein inhibitory activity

Chemistry and Biology

Volumn 19, Issue 6, 2012, Pages 764-771

  Arrendale, Allison ^a   Kim, Keunho ^a   Choi, Jun Young ^a   Li, Wei ^a   Geahlen, Robert L ^a   Borch, Richard F ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CYTOTOXIC AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PEPTIDOMIMETIC AGENT; PHOSPHOSERINE; PRODRUG; PROTEIN 14 3 3; PROTEIN KINASE B; TRANSCRIPTION FACTOR FKHRL1;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CYTOTOXICITY; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; LEUKEMIA CELL; PROTEIN CLEAVAGE; PROTEIN PROTEIN INTERACTION;

14-3-3 PROTEINS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LIGANDS; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; PHOSPHOSERINE; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84862735784     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2012.05.011     Document Type: Article

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