Neuron density and serotonin receptor binding in prefrontal cortex in suicide

International Journal of Neuropsychopharmacology

Volumn 15, Issue 4, 2012, Pages 435-447

  Underwood, Mark D ^a,b   Kassir, Suham A ^b   Bakalian, Mihran J ^b   Galfalvy, Hanga ^a,b   Mann, J John ^a,b   Arango, Victoria ^a,b  

^a Columbia University ^*  (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

Autoradiography; human; receptor binding; serotonin; stereology

Indexed keywords

SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; SEROTONIN TRANSPORTER 1A; SEROTONIN TRANSPORTER 2A; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; AUTORADIOGRAPHY; BRAIN NERVE CELL; CELL DENSITY; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; FEMALE; HUMAN; HUMAN TISSUE; INNERVATION; MALE; PH MEASUREMENT; PREFRONTAL CORTEX; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RECEPTOR BINDING; STEREOLOGY; SUICIDE; UPREGULATION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ADOLESCENT; ADULT; AGED; AUTORADIOGRAPHY; CASE-CONTROL STUDIES; DEPRESSIVE DISORDER, MAJOR; FEMALE; HUMANS; IMIPRAMINE; KETANSERIN; MALE; MIDDLE AGED; NEURONS; POSTMORTEM CHANGES; PREFRONTAL CORTEX; PROTEIN BINDING; RECEPTORS, SEROTONIN; SEROTONIN AGENTS; SUICIDE; TRITIUM; UP-REGULATION; YOUNG ADULT;

EID: 84862686203     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145711000691     Document Type: Article

References (82)

1. Alexander GM, Schwartzman RJ, Bell RD, Yu J, et al. (1981). Quantitative measurement of local cerebral metabolic rate for glucose utilizing tritiated 2-deoxyglucose. Brain Research 223, 59-67. (Pubitemid 11022439)
2. Amargos-Bosch M, Bortolozzi A, Puig MV, Serrats J, et al. (2004). Co-expression and in vivo interaction of serotonin1A and serotonin2A receptors in pyramidal neurons of prefrontal cortex. Cerebral Cortex 14, 281-299. (Pubitemid 38252721)
3. Amunts K, Schleicher A, Burgel U, Mohlberg H, et al. (1999). Broca's region revisited: cytoarchitecture and intersubject variability. Journal of Comparative Neurology 412, 319-341. (Pubitemid 29395368)
4. Arango V, Ernsberger P, Marzuk PM, Chen JS, et al. (1990). Autoradiographic demonstration of increased serotonin 5-HT2 and beta-adrenergic receptor binding sites in the brain of suicide victims. Archives of General Psychiatry 47, 1038-1047. (Pubitemid 20377514)
5. Arango V, Ernsberger P, Sved AF, Mann JJ (1993). Quantitative autoradiography of alpha 1-and alpha 2-adrenergic receptors in the cerebral cortex of controls and suicide victims. Brain Research 630, 271-282.
6. Arango V, Underwood MD, Boldrini M, Tamir H, et al. (2001). Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology 25, 892-903. (Pubitemid 34031894)
7. Arango V, Underwood MD, Gubbi AV, Mann JJ (1995). Localized alterations in pre-and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Research 688, 121-133.
8. Arango V, Underwood MD, Mann JJ (1996). Fewer pigmented locus coeruleus neurons in suicide victims: preliminary results. Biological Psychiatry 39, 112-120. (Pubitemid 26045298)
9. Arango V, Underwood MD, Mann JJ (1997). Postmortem findings in suicide victims. Implications for in vivo imaging studies. Annals of the New York Academy of Sciences 836, 269-287. (Pubitemid 28044030)
10. Arango V, Underwood MD, Mann JJ (2002). Serotonin brain circuits involved in major depression and suicide. Progress in Brain Research 136, 443-453. (Pubitemid 35460998)
11. Austin MC, Whitehead RE, Edgar CL, Janosky JE, et al. (2002). Localized decrease in serotonin transporterimmunoreactive axons in the prefrontal cortex of depressed subjects committing suicide. Neuroscience 114, 807-815. (Pubitemid 35247665)
12. Azmitia EC, Gannon PJ, Kheck NM, Whitaker-Azmitia PM (1996). Cellular localization of the 5-HT1A receptor in primate brain neurons and glial cells. Neuropsychopharmacology 14, 35-46. (Pubitemid 26047184)
13. Beasley CL, Reynolds GP (1997). Parvalbuminimmunoreactive neurons are reduced in the prefrontal cortex of schizophrenics. Schizophrenia Research 24, 349-355. (Pubitemid 27163247)
14. Beck E (1949). A cytoarchitectural investigation into the boundaries of cortical areas 13 and 14 in the human brain. Journal of Anatomy 83, 147-157.
15. Benes FM, McSparren J, Bird ED, SanGiovanni JP, et al. (1991). Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients. Archives of General Psychiatry 48, 996-1001.
16. Benes FM, Vincent SL, Todtenkopf M (2001). The density of pyramidal and nonpyramidal neurons in anterior cingulate cortex of schizophrenic and bipolar subjects. Biological Psychiatry 50, 395-406. (Pubitemid 32885589)
17. Boldrini M, Underwood MD, Hen R, Rosoklija GB, et al. (2009). Antidepressants increase neural progenitor cells in the human hippocampus. Neuropsychopharmacology 34, 2376-2389.
18. Bouras C, Kovari E, Hof PR, Riederer BM, et al. (2001). Anterior cingulate cortex pathology in schizophrenia and bipolar disorder. Acta Neuropathologica (Berlin) 102, 373-379. (Pubitemid 32894708)
19. Burnet PWJ, Eastwood SL, Lacey K, Harrison PJ (1995). The distribution of 5-HT1A and 5-HT2A receptor mRNA in human brain. Brain Research 676, 157-168.
20. Carroll BJ (1968). 5-hydroxytryptamine in the hindbrain of depressive suicides. British Journal of Psychiatry 114, 782-783.
21. Cotter D, Mackay D, Chana G, Beasley C, et al. (2002). Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder. Cerebral Cortex 12, 386-394. (Pubitemid 34226063)
22. Daviss SR, Lewis DA (1995). Local circuit neurons of the prefrontal cortex in schizophrenia: selective increase in the density of calbindin-immunoreactive neurons. Psychiatry Research 59, 81-96. (Pubitemid 26024505)
23. Deecher DC, Wilcox BD, Dave V, Rossman PA, et al. (1993). Detection of 5-hydroxytryptamine2 receptors by radioligand binding, northern blot analysis, and Ca2+ responses in rat primary astrocyte cultures. Journal of Neuroscience Research 35, 246-256. (Pubitemid 23182724)
24. Glennon RA (1990). Serotonin receptors: clinical implications. Neuroscience and Behavioral Reviews 14, 35-47. (Pubitemid 20115611)
25. Gos T, Gunther K, Bielau H, Dobrowolny H, et al. (2009). Suicide and depression in the quantitative analysis of glutamic acid decarboxylase- Immunoreactive neuropil. Journal of Affective Disorders 113, 45-55.
26. Gross-Isseroff R, Salama D, Israeli M, Biegon A (1990). Autoradiographic analysis of [3H]ketanserin binding in the human brain postmortem: effect of suicide. Brain Research 507, 208-215. (Pubitemid 20054101)
27. Hercher C, Turecki G, Mechawar N (2009). Through the looking glass: examining neuroanatomical evidence for cellular alterations in major depression. Journal of Psychiatric Research 43, 947-961.
28. Hrdina PD, Demeter E, Vu TB, Sótónyi P, et al. (1993). 5-HT uptake sites and 5-HT2 receptors in brain of antidepressant-free suicide victims/depressives: increase in 5-HT2 sites in cortex and amygdala. Brain Research 614, 37-44. (Pubitemid 23181149)
29. Hsiung SC, Adlersberg M, Arango V, Mann JJ, et al. (2003). Attenuated 5-HT1A receptor signaling in brains of suicide victims: involvement of adenylyl cyclase, phosphatidylinositol 3-kinase, Akt and mitogen-activated protein kinase. Journal of Neurochemistry 87, 182-194. (Pubitemid 37210652)
30. Kovachich GB, Aronson CE, Brunswick DJ, Frazer A (1988). Quantitative autoradiography of serotonin uptake sites in rat brain using 3H-cyanoimipramine. Brain Research 454, 78-88.
31. Laruelle M, Abi-Dargham A, Casanova MF, Toti R, et al. (1993). Selective abnormalities of prefrontal serotonergic receptors in schizophrenia: a postmortem study. Archives of General Psychiatry 50, 810-818. (Pubitemid 23303102)
32. Lau T, Horschitz S, Berger S, Bartsch D, et al. (2008). Antidepressant-induced internalization of the serotonin transporter in serotonergic neurons. FASEB Journal 22, 1702-1714. (Pubitemid 351811448)
33. Leake A, Fairbairn AF, McKeith IG, Ferrier IN (1991). Studies on the serotonin uptake binding site in major depressive disorder and control post-mortem brain: neurochemical and clinical correlates. Psychiatry Research 39, 155-165.
34. Lewis DA (2002). The human brain revisited. Opportunities and challenges in postmortem studies of psychiatric disorders. Neuropsychopharmacology 26, 143-154. (Pubitemid 34093077)
35. Lloyd KG, Farley IJ, Deck JHN, Hornykiewicz O (1974). Serotonin and 5-hydroxyindoleacetic acid in discrete areas of the brainstem of suicide victims and control patients. Advances in Biochemical Psychopharmacology 11, 387-397.
36. Lowther S, De Paermentier F, Crompton MR, Katona CLE, et al. (1994). Brain 5-HT2 receptors in suicide victims: violence of death, depression and effects of antidepressant treatment. Brain Research 642, 281-289.
37. Mann JJ, Currier D (2007). A review of prospective studies of biologic predictors of suicidal behavior in mood disorders. Archives of Suicide Research 11, 3-16.
38. Mann JJ, Huang YY, Underwood MD, Kassir SA, et al. (2000). A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Archives of General Psychiatry 57, 729-738. (Pubitemid 30650106)
39. Mann JJ, Stanley M, McBride PA, McEwen BS (1986). Increased serotonin2 and beta-adrenergic receptor binding in the frontal cortices of suicide victims. Archives of General Psychiatry 43, 954-959. (Pubitemid 17168415)
40. Mayberg HS (2007). Defining the neural circuitry of depression: toward a new nosology with therapeutic implications. Biological Psychiatry 61, 729-730. (Pubitemid 46343724)
41. Milak MS, Parsey RV, Keilp J, Oquendo MA, et al. (2005). Neuroanatomic correlates of psychopathologic components of major depressive disorder. Archives of General Psychiatry 62, 397-408. (Pubitemid 40471689)
42. Miner LA, Backstrom JR, Sanders-Bush E, Sesack SR (2003). Ultrastructural localization of serotonin2A receptors in the middle layers of the rat prelimbic prefrontal cortex. Neuroscience 116, 107-117. (Pubitemid 36110438)
43. Nishiyama H, Linden DJ (2004). Differential maturation of climbing fiber innervation in cerebellar vermis. Journal of Neuroscience 24, 3926-3932. (Pubitemid 38544219)
44. Ongur D, Drevets WC, Price JL (1998). Glial reduction in the subgenual prefrontal cortex in mood disorders. Proceedings of the National Academy of Sciences USA 95, 13290-13295. (Pubitemid 28509564)
45. Oquendo MA, Krunic A, Parsey RV, Milak M, et al. (2005). Positron emission tomography of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without borderline personality disorder. Neuropsychopharmacology 30, 1163-1172. (Pubitemid 40720975)
46. Oquendo MA, Russo SA, Underwood MD, Kassir SA, et al. (2006). Higher postmortem prefrontal 5-HT2A receptor binding correlates with lifetime aggression in suicide. Biological Psychiatry 59, 235-243. (Pubitemid 43208970)
47. Pandey GN, Dwivedi Y, Ren X, Rizavi HS, et al. (2006). Regional distribution and relative abundance of serotonin(2c) receptors in human brain: effect of suicide. Neurochemical Research 31, 167-176.
48. Pandey GN, Dwivedi Y, Ren X, Robert RC, et al. (2001) Increased 5HT2A receptors and impaired phosphoinositide siginaling in the postmortem brain of suicide victims. In: Miyoshi K, Shapiro CM, Gaviria M, Morita Y (Eds), Contemporary Neuropsychiatry (pp. 314-321). Tokyo: Springer-Verlag.
49. Pandey GN, Dwivedi Y, Rizavi HS, Ren X, et al. (2002). Higher expression of serotonin 5-HT(2A) receptors in the postmortem brains of teenage suicide victims. American Journal of Psychiatry 159, 419-429. (Pubitemid 34184737)
50. Pare CMB, Yeung DPH, Price K, Stacey RS (1969). 5-Hydroxytryptamine, noradrenaline, and dopamine in brainstem, hypothalamus, and caudate nucleus of controls and of patients committing suicide by coal-gas poisoning. Lancet ii, 133-135.
51. Parsey RV, Hastings RS, Oquendo MA, Hu X, et al. (2006a). Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. American Journal of Psychiatry 163, 48-51. (Pubitemid 43050102)
52. Parsey RV, Hastings RS, Oquendo MA, Huang YY, et al. (2006b). Lower serotonin transporter binding potential in the human brain during major depressive episodes. American Journal of Psychiatry 163, 52-58. (Pubitemid 43050103)
53. Parsey RV, Oquendo MA, Ogden RT, Olvet DM, et al. (2006c). Altered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography study. Biological Psychiatry 59, 106-113. (Pubitemid 43117499)
54. Petrides M, Pandya DN (2002). Comparative cytoarchitectonic analysis of the human and the macaque ventrolateral prefrontal cortex and corticocortical connection patterns in the monkey. European Journal of Neuroscience 16, 291-310. (Pubitemid 36160249)
55. Raadsheer FC, Hoogendijk WJG, Stam FC, Tilders FJH, et al. (1994). Increased numbers of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients. Neuroendocrinology 60, 436-444. (Pubitemid 24284827)
56. Rajkowska G (2000a). Histopathology of the prefrontal cortex in major depression: what does it tell us about dysfunctional monoaminergic circuits? Progress in Brain Research 126, 397-412. (Pubitemid 35461302)
57. Rajkowska G (2000b). Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells. Biological Psychiatry 48, 766-777.
58. Rajkowska G (2002). Cell pathology in mood disorders. Seminars in Clinical Neuropsychiatry 7, 281-292.
59. Rajkowska G, Goldman-Rakic PS (1995a). Cytoarchitectonic definition of prefrontal areas in the normal human cortex: I. Remapping of areas 9 and 46 using quantitative criteria. Cerebral Cortex 5, 307-322.
60. Rajkowska G, Goldman-Rakic PS (1995b). Cytoarchitectonic definition of prefrontal areas in the normal human cortex: II. Variability in locations of areas 9 and 46 and relationship to the Talairach Coordinate System. Cerebral Cortex 5, 323-337.
61. Rajkowska G, Halaris A, Selemon LD (2001). Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder. Biological Psychiatry 49, 741-752. (Pubitemid 32452295)
62. Rajkowska G, Miguel-Hidalgo JJ, Dubey P, Stockmeier CA, et al. (2005). Prominent reduction in pyramidal neurons density in the orbitofrontal cortex of elderly depressed patients. Biological Psychiatry 58, 297-306. (Pubitemid 41133623)
63. Rajkowska G, Miguel-Hidalgo JJ, Wei J, Dilley G, et al. (1999). Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression. Biological Psychiatry 45, 1085-1098. (Pubitemid 29236550)
64. Rajkowska G, Selemon LD, Goldman-Rakic PS (1998). Neuronal and glial somal size in the prefrontal cortex. A postmortem morphometric study of schizophrenia and Huntington disease. Archives of General Psychiatry 55, 215-224.
65. Selemon LD, Rajkowska G, Goldman-Rakic PS (1995). Abnormally high neuronal density in the schizophrenic cortex-a morphometric analysis of prefrontal area 9 and occipital area 17. Archives of General Psychiatry 52, 805-818.
66. Shaw DM, Camps FE, Eccleston EG (1967). 5-Hydroxytryptamine in the hind-brain of depressive suicides. British Journal of Psychiatry 113, 1407-1411.
67. Smith GS, Kramer E, Hermann C, Ma Y, et al. (2009). Serotonin modulation of cerebral glucose metabolism in depressed older adults. Biological Psychiatry 66, 259-266.
68. Soares JC, Mann JJ (1997a). The anatomy of mood disorders-review of structural neuroimaging studies. Biological Psychiatry 41, 86-106. (Pubitemid 27050649)
69. Soares JC, Mann JJ (1997b). The functional neuroanatomy of mood disorders. Journal of Psychiatric Research 31, 393-432. (Pubitemid 27412315)
70. Stanley M, Mann JJ (1983). Increased serotonin-2 binding sites in frontal cortex of suicide victims. Lancet 1, 214-216. (Pubitemid 13171106)
71. Stockmeier CA (2003). Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter. Journal of Psychiatric Research 37, 357-373. (Pubitemid 36808810)
72. Stockmeier CA, Dilley GE, Shapiro LA, Overholser JC, et al. (1997). Serotonin receptors in suicide victims with major depression. Neuropsychopharmacology 16, 162-173. (Pubitemid 27086431)
73. Stockmeier CA, Howley E, Shi X, Sobanska A, et al. (2009). Antagonist but not agonist labeling of serotonin-1A receptors is decreased in major depressive disorder. Journal of Psychiatric Research 43, 887-894.
74. Toro R, Burnod Y (2005). A morphogenetic model for the development of cortical convolutions. Cerebral Cortex 15, 1900-1913. (Pubitemid 41628331)
75. Turecki G, Briere R, Dewar K, Antonetti T, et al. (1999). Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide. American Journal of Psychiatry 156, 1456-1458. (Pubitemid 29416550)
76. Underwood MD, Mann JJ, Arango V (2004). Serotonergic and noradrenergic neurobiology of alcoholic suicide. Alcoholism: Clinical and Experimental Research 28, 57S-69S. (Pubitemid 38658124)
77. Underwood MD, Mann JJ, Arango V (2007). Morphometry of dorsal raphe nucleus serotonergic neurons in alcoholism. Alcoholism: Clinical and Experimental Research 31, 837-845. (Pubitemid 46587661)
78. Wedzony K, Chocyk A, Mackowiak M (2008). A search for colocalization of serotonin 5-HT2A and 5-HT1A receptors in the rat medial prefrontal and entorhinal cortices-immunohistochemical studies. Journal of Physiology and Pharmacology 59, 229-238. (Pubitemid 351955749)
79. Young KA, Holcomb LA, Yazdani U, Hicks PB, et al. (2004). Elevated neuron number in the limbic thalamus in major depression. American Journal of Psychiatry 161, 1270-1277. (Pubitemid 38859178)
80. Young KA, Manaye KF, Liang C, Hicks PB, et al. (2000). Reduced number of mediodorsal and anterior thalamic neurons in schizophrenia. Biological Psychiatry 47, 944-953. (Pubitemid 30320739)
81. Zald DH, Kim SW (1996). Anatomy and function of the orbital frontal cortex, I: anatomy, neurocircuitry ; and obsessive-compulsive disorder. Journal of Neuropsychiatry and Clinical Neurosciences 8, 125-138. (Pubitemid 26138918)
82. Zhao Z, Zhang HT, Bootzin E, Millan MJ, et al. (2009). Association of changes in norepinephrine and serotonin transporter expression with the long-term behavioral effects of antidepressant drugs. Neuropsychopharmacology 34, 1467-1481.