Anatomy and function of the orbital frontal cortex, I: Anatomy, neurocircuitry, and obsessive-compulsive disorder

Journal of Neuropsychiatry and Clinical Neurosciences

Volumn 8, Issue 2, 1996, Pages 125-138

  Zald, David Harold ^a   Kim, Suck Won ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASAL GANGLION; CYTOARCHITECTURE; FRONTAL CORTEX; LIMBIC CORTEX; MEDICAL LITERATURE; NEUROANATOMY; NONHUMAN; OBSESSION; PRIORITY JOURNAL; REVIEW; SENSORY CORTEX; SENSORY NERVE; THALAMUS;

EID: 0029961104     PISSN: 08950172     EISSN: None     Source Type: Journal    
DOI: 10.1176/jnp.8.2.125     Document Type: Review

References (119)

1. Baxter LR Jr, Phelps ME, Mazziotta JC, et al: Local cerebral glucose metabolic rates in obsessive-compulsive disorder: a comparison with rates in unipolar depression and in normal controls. Arch Gen Psychiatry 1987; 44:211-218
2. Baxter LR Jr, Schwartz JM, Mazziotta JC, et al: Cerebral glucose metabolic rates in nondepressed patients with obsessive-compulsive disorder. Am J Psychiatry 1988; 145:1560-1563
3. Nordahl TE, Benkelfat C, Semple WE, et al: Cerebral glucose metabolic rates in obsessive compulsive disorder. Neuropsychopharmacology 1989; 2:23-28
4. Swedo SE, Schapiro MB, Grady CL, et al: Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder. Arch Gen Psychiatry 1989; 46:518-523
5. Breiter HC, Kwong KK, Baker JR, et al: Functional magnetic resonance imaging of symptom provocation in patients with obsessive-compulsive disorder versus controls (abstract). Society for Neuroscience Abstracts 1993; 19:7
6. Rauch SL, Jenike MA, Alpert NM, et al: Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography. Arch Gen Psychiatry 1994; 51:62-70
7. McGuire PK, Bench CJ, Frith CD, et al: Functional anatomy of obsessive-compulsive phenomena. BrJ Psychiatry 1994; 164:459-468
8. Baxter LR Jr, Schwartz JM, Bergman KS, et al: Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder. Arch Gen Psychiatry 1992; 49:681-689
9. Benkelfat C, Nordahl TE, Semple WE, et al: Local cerebral glucose metabolic rates in obsessive-compulsive disorder: patients treated with clomipramine. Arch Gen Psychiatry 1990; 47:840-848
10. Swedo SE, Pietrini P, Leonard HL, et al: Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder: revisualization during pharmacotherapy. Arch Gen Psychiatry 1992; 49:690-694
11. Walker AE: A cytoarchitectural study of the prefrontal area of the macaque monkey. J Comp Neurol 1940; 73:59-86
12. Barbas H: Anatomic organization of basoventral and mediodorsal visual recipient prefrontal regions in the rhesus monkey. J Comp Neurol 1988; 276:313-342
13. Mesulam MM, Mufson EJ: Insula of the old world monkey, I: architectonics in the insulo-orbito-temporal component of the paralimbic brain. J Comp Neurol 1982; 212:1-22
14. Morecraft RJ, Geula C, Mesulam MM: Cytoarchitecture and neural afferents of orbitofrontal cortex in the brain of the monkey. J Comp Neurol 1992; 323:341-358
15. Amaral DG, Price JL: Amygdalo-cortical projections in the monkey (Macaca fascicularis). J Comp Neurol 1984; 230:465-496
16. Carmichael ST, Price JL: Architectonic subdivision of the orbital and medial prefrontal cortex in the macaque monkey. J Comp Neurol 1994; 346:366-402
17. Beck E: A cytoarchitectural investigation into the boundaries of cortical areas 13 and 14 in the human brain. J Anat 1949; 83:147-157
18. Brodmann K: Physiologie des Gehrins. Neue Deutsche Chirugie 1914; 2:85-426
19. von Econome C, Koskinas GN: Die Cytoarchitektonik der Hirnrinde des erwachsenen Menschen. Berlin, Springer, 1925
20. von Bonin G, Bailey P: The neocortex of Macaca mulatta, in Illinois Monographs in the Medical Sciences. Urbana, IL, University of Illinois Press, 1947, pp 1-163
21. Sanides F: Comparative architects of the neocortex of mammals and their evolutionary interpretation. Ann NY Acad Sci 1969; 167:404-423
22. Sanides F: Representation in the cerebral cortex and its areal lamination patterns, in Structure and Function of Nervous Tissue, edited by Bourne GF. New York, Academic Press, 1972, pp 329-453
23. Pandya DN, Yeterian EH: Prefrontal cortex in relation to other cortical areas in rhesus monkey: architecture and connections. Prog Brain Res 1990; 85:63-94
24. Tanabe T, Yarita H, lino M, et al: An olfactory projection area in orbitofrontal cortex of the monkey. J Neurophysiol 1975; 38:1269-1283
25. Takagi SF: Studies on the olfactory nervous system of the Old World monkey. Prog Neurobiol 1986; 27:195-250
26. Tanabe T, Iino M, Takagi SF: Discrimination of odors in olfactory bulb, pyriform-amygdaloid areas, and orbitofrontal cortex of the monkey. J Neurophysiol 1975; 38:1284-1296
27. Carmichael ST, Clugnet MC, Price JL: Central olfactory connections in the macaque monkey. J Comp Neurol 1994; 346:403-434
28. Barbas H: Organization of cortical afferent input to orbitofrontal areas in the rhesus monkey. Neuroscience 1993; 56:841-864
29. Yarita H, Iino M, Tanabe T, et al: A transthalamic olfactory pathway to orbitofrontal cortex in the monkey. J Neurophysiol 1980; 43:69-85
30. Russchen FT, Amaral DG, Price JL: The afferent input to the magnocellular division of the mediodorsal thalamic nucleus in the monkey, Macaca fascicularis. J Comp Neurol 1987; 256:175-210
31. Price JL: The central olfactory and accessory olfactory systems, in Neurobiology of Taste and Smell, edited by Finger TE, Silver WL. Malabar, FL, Krieger, 1991, pp 179-203
32. Ray JP, Price JL: The organization of projections from the mediodorsal nucleus of the thalamus to orbital and medial prefrontal cortex in macaque monkeys. J Comp Neurol 1993; 337:1-31
33. Zatorre RJ, Jones-Gotman M, Evans AC, et al: Functional localization and lateralization of human olfactory cortex. Nature 1992; 360:339-340
34. Rolls ET: Information processing in the taste system of primates. J Exp Biol 1989; 146:141-164
35. Rolls ET, Yaxley S, Sienkiewicz ZJ: Gustatory responses of single neurons in the caudolateral orbitofrontal cortex of the macaque monkey. J Neurophysiol 1990; 64:1055-1066
36. Wiggins LL, Rolls ET, Baylis GC: Afferent connections of the caudolateral orbitofrontal cortex taste area of the primate (abstract). Society for Neuroscience Abstracts 1987; 13:1406
37. Baylis LL, Rolls ET, Baylis GC: Afferent connections of the caudolateral orbitofrontal cortex taste area of the primate. Neuroscience 1995; 64:801-812
38. Rolls ET, Sienkiewicz ZJ, Yaxley S: Hunger modulates the responses to gustatory stimuli of single neurons in the caudolateral orbitofrontal cortex of the macaque monkey. Eur J Neurosci 1989; 1:53-60
39. Rolls ET, Baylis LL: Gustatory, olfactory, and visual convergence within the primate orbitofrontal cortex. J Neurosci 1994; 14:5437-5452
40. Barbas H: Architecture and cortical connections of the prefrontal cortex in the rhesus monkey. Adv Neurol 1992; 57:91-115
41. Thorpe SJ, Rolls ET, Maddison S: The orbitofrontal cortex: neuronal activity in the behaving monkey. Exp Brain Res 1983; 49:93-115
42. Jones EG, Powell TP: An anatomical study of converging sensory pathways within the cerebral cortex of the monkey. Brain 1970; 93:793-820
43. 14C]deoxyglucose. Science 1982; 218:394-397
44. Mishkin M: A memory system in the monkey. Philos Trans R Soc Lond [Biol] 1982; B298:85-92
45. Mishkin M, Ungerleider LG, Macko KA: Object vision and spatial vision: two cortical pathways. Trends Neurosci 1983; 6:414-417
46. Benevento LA, Fallon J, Davis BJ, et al: Auditory-visual interaction in single cells in the cortex of the superior temporal sulcus and the orbital frontal cortex of the macaque monkey. Exp Neurol 1977; 57:849-872
47. Wilson FA, Scalaidhe SP, Goldman-Rakic PS: Dissociation of object and spatial processing domains in primate prefrontal cortex. Science 1993; 260:1955-1958
48. Chavis DA, Pandya DN: Further observations on corticofrontal connections in the rhesus monkey. Brain Res 1976; 117:369-386
49. Preuss TM, Goldman-Rakic PS: Connections of the ventral granular frontal cortex of macaques with perisylvian premotor and somatosensory areas: anatomical evidence for somatic representation in primate frontal association cortex. J Comp Neurol 1989; 282:293-316
50. Mufson EJ, Mesulam MM: Insula of the old world monkey, II: afferent cortical input and comments on the daustrum. J Comp Neurol 1982; 212:23-37
51. Mesulam MM, Mufson EJ: Insula of the old world monkey, III: efferent cortical output and comments on function. J Comp Neurol 1982; 212:38-52
52. Moran MA, Mufson EJ, Mesulam MM: Neural inputs into the temporopolar cortex of the rhesus monkey. J Comp Neurol 1987; 256:88-103
53. Barbas H, Henion TH, Dermon CR: Diverse thalamic projections to the prefrontal cortex in the rhesus monkey. J Comp Neurol 1991; 313:65-94
54. Giguere M, Goldman-Rakic PS: Mediodorsal nucleus: areal, laminar, and tangential distribution of afferents and efferents in the frontal lobe of rhesus monkeys. J Comp Neurol 1988; 277:195-213
55. Siwek DF, Pandya DN: Prefrontal projections to the mediodorsal nucleus of the thalamus in the rhesus monkey. J Comp Neurol 1991; 312:509-524
56. Ilinsky IA, Kultas-Ilinsky K: Sagittal cytoarchitectonic maps of the Macaca mulatta thalamus with a revised nomenclature of the motor-related nuclei validated by observations on their connectivity. J Comp Neurol 1987; 262:331-364
57. Nakano K, Tokushige A, Kohno M, et al: An autoradiographic study of cortical projections from motor thalamic nuclei in the macaque monkey. Neurosci Res 1992; 13:119-137
58. Peschanski M, Guilbaud G, Gautron M: Posterior intralaminar region in rat: neuronal responses to noxious and nonnoxious cutaneous stimuli. Exp Neurol 1981; 72:226-238
59. Buchanan SL, Thompson RH, Powell DA: Midline thalamic lesions enhance conditioned bradycardia and the cardiac orienting reflex in rabbits. Psychobiology 1989; 17:300-306
60. Porrino LJ, Crane AM, Goldman-Rakic PS: Direct and indirect pathways from the amygdala to the frontal lobe in rhesus monkeys. J Comp Neurol 1981; 198:121-136
61. Aggleton JP (ed): The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction. New York, Wiley, 1992
62. Aggleton JP, Mishkin M: The amygdala: sensory gateway to the emotions, in Biological Foundations of Emotion, edited by Plutchik E, Kellerman H. New York, Academic Press, 1986, pp 281-299
63. Ledoux JE: Emotion, in Handbook of Physiology: The Nervous System, edited by Plum F, Mountcastle V. Bethesda, MD, American Physiological Society, 1987, pp 419-459
64. Amaral DG, Price JL, Pitkänen A, et al: Anatomical organization of the primate amygdaloid complex, in The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction, edited by Aggleton JP. New York, Wiley, 1992, pp 1-66
65. Barbas H, De Olmos J: Projections from the amygdala to basoventral and mediodorsal prefrontal regions in the rhesus monkey. J Comp Neurol 1990; 300:549-571
66. Amaral DG, Dolorfo C, Alvarez-Royo P: Organization of CA1 projections to the subiculum: a PHA-L analysis in the rat. Hippocampus 1991; 1:415-435
67. Davis M: The role of the amygdala in fear and anxiety. Ann Rev Neurosci 1992; 15:353-375
68. Van Hoesen GW: The differential distribution, diversity and sprouting of cortical projections to the amygdala in the rhesus monkey, in The Amygdaloid Complex, edited by Ben-Ari Y. Amsterdam, Elsevier/North Holland, 1981, pp 77-90
69. Van Hoesen G, Pandya DN, Butters N: Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey, II: frontal lobe afferents. Brain Res 1975; 95:25-38
70. Van Hoesen GW: The parahippocampal gyms: new observations regarding its cortical connections in the monkey. Trends Neurosci 1982; 5:345-350
71. Jones RS: Entorhinal-hippocampal connections: a speculative view of their function. Trends Neurosci 1993; 16:58-64
72. Vogt BA, Pandya DN: Cingulate cortex of the rhesus monkey, II: cortical afferents. J Comp Neurol 1987; 262:271-289
73. Pandya DN, Van Hoesen GW, Mesulam MM: Efferent connections of the cingulate gyrus in the rhesus monkey. Exp Brain Res 1981; 42:319-330
74. Van Hoèsen GW, Moreoraft RJ, and Vogt BA: Connections of the monkey cingulate cortex, in Neurobiology of Cingulate Cortex and Limbic Thalamus: A Comprehensive Handbook, edited by Vogt BA, Gabriel M. Boston, Birkhauser, 1993, pp 249-284
75. Johnson TN, Rosvold HE, Mishkin M: Projections from behaviorally defined sectors of the prefrontal cortex to the basal ganglia, septum, and diencephalon of the monkey. Exp Neurol 1968; 21:20-34
76. Nauta WJ: The problem of the frontal lobe: a reinterpretation. J Psychiatr Res 1971; 8:167-187
77. Nauta WJH: Connections of the frontal lobe with the limbic system, in Surgical Approaches in Psychiatry, edited by Laitinen LV, Livingston KE. Baltimore, University Park Press, 1973, pp 303-314
78. Barbas H, Mesulam MM: Organization of afferent input to subdivisions of area 8 in the rhesus monkey. J Comp Neurol 1981; 200:407-431
79. Pandya DN, Dye P, Butters N: Efferent cortico-cortical projections of the prefrontal cortex in the rhesus monkey. Brain Res 1971; 31:35-46
80. Selemon LD, Goldman-Rakic PS: Common cortical and subcortical targets of the dorsolateral prefrontal and posterior parietal cortices in the rhesus monkey: evidence for a distributed neural network subserving spatially guided behavior. J Neurosci 1988; 8:4049-4068
81. Morecraft RJ, Geula C, Mesulam MM: Architecture of connectivity within a cingulo-fronto-parietal neurocognitive network for directed attention. Arch Neurol 1993; 50:279-284
82. Goldman-Rakic PS: Circuitry of primate prefrontal cortex and regulation of behavior by representational memory, in Handbook of Physiology: The Nervous System, edited by Plum F, Mountcastle V. Bethesda, MD, American Physiological Society, 1987, pp 373-417
83. Mesulam MM: A cortical network for directed attention and unilateral neglect. Ann Neurol 1981; 10:309-325
84. Alexander GE, DeLong MR, Strick PL: Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Ann Rev Neurosci 1986; 9:357-381
85. Alexander GE, Crutcher MD, DeLong MR: Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions. Prog Brain Res 1990; 85:119-146
86. DeLong MR: Primate models of movement disorders of basal ganglia origin. Trends Neurosci 1990; 13:281-285
87. Alexander GE, Crutcher MD: Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends Neurosci 1990; 13:266-271
88. Heimer L, Switzer RD, Van Hoesen GW: Ventral striatum and ventral pallidum: components of the motor system? Trends Neurosci 1982; 5:83-87
89. Nauta HJ: A proposed conceptual reorganization of the basal ganglia and telencephalon. Neuroscience 1979; 4:1875-1881
90. Rauch SL, Savage CR, Alpert NM, et al: A positron emission tomographic study of simple phobic symptom provocation. Arch Gen Psychiatry 1995; 52:20-28
91. Klüver H, Bucy PC: Preliminary analysis of functions of the temporal lobes in monkeys. Archives of Neurology and Psychiatry 1939; 42:979-1000
92. Kling A, Steklis HD: A neural substrate for affiliative behavior in nonhuman primates. Brain Behav Evol 1976; 13:216-238
93. Kling A: Influence of temporal lobe lesions on radio-telemetered electrical activity of amygdala to social stimuli in monkeys, in The Amygdaloid Complex, edited by Ben-Ari Y. Amsterdam, Elsevier Science, 1987, pp 317-329
94. Gaffan D, Murray EA: Amygdalar interaction with the mediodorsal nucleus of the thalamus and the ventromedial prefrontal cortex in stimulus-reward associative learning in the monkey. J Neurosci 1990; 10:3479-3493
95. Hoffman BL, Rasmussen T: Stimulation studies of insular cortex of Macaca mulatta. J Neurophysiol 1953; 16:343-351
96. Kaada BR: Cingulate, posterior orbital, anterior insular and temporal pole cortex, in Handbook of Physiology, edited by Field F, Magoun HW, Hall VE. Baltimore, Williams and Wilkins, 1960, pp 1345-1372
97. Showers MJC, Lauer EW: Somatovisceral motor patterns in the insula. J Comp Neurol 1961; 117:107-114
98. Reiman EM, Fusselman MJ, Fox PT, et al: Neuroanatomical correlates of anticipatory anxiety. Science 1989; 243(4894, part 1):1071-1074
99. Reiman EM, Raichle ME, Robins E, et al: Neuroanatomical correlates of a lactate-induced anxiety attack. Arch Gen Psychiatry 1989; 46:493-500
100. Drevets WC, Videen TO, Snyder AZ, et al: Regional cerebral blood flow changes during anticipatory anxiety (abstract). Society for Neuroscience Abstracts 1994; 20:368
101. Rolls ET: Neurophysiology and functions of the primate amygdala, in The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction, edited by Aggleton JP. New York, Wiley, 1992, pp 143-166
102. Ono T, Nishijo H: Neurophysiological basis of the Klüver-Bucy syndrome: responses of monkey amygdaloid neurons to biologically significant objects, in The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction, edited by Aggleton JP. New York, Wiley, 1992, pp 167-190
103. Davis M: The role of the amygdala in conditioned fear, in The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction, edited by Aggleton JP. New York, Wiley, 1992, pp 255-306
104. Ledoux JE: Emotion, memory and the brain. Sci Am 1994; 270:50-57
105. Alexander GE, Fuster JM: Effects of cooling prefrontal cortex on cell firing in the nucleus medialis dorsalis. Brain Res 1973; 61:93-105
106. Fuster JM, Alexander GE: Neuron activity related to short-term memory. Science 1971; 173:652-654
107. Fuster JM, Alexander GE: Firing changes in cells of the nucleus medialis dorsalis associated with delayed response behavior. Brain Res 1973; 61:79-91
108. Aggleton JP, Mishkin M: Memory impairments following restricted medial thalamic lesions in monkeys. Exp Brain Res 1983; 52:199-209
109. Aggleton JP, Mishkin M: Visual recognition impairment following medial thalamic lesions in monkeys. Neuropsychologia 1983; 21:189-197
110. Brierley JB, Beck E: Effects upon behaviour of lesions in dorsomedial and anterior thalamic nuclei of cat and monkey, in Neurological Basis of Behaviour, edited by Wolstenholme GEW, O'Connor CM. Boston, Little, Brown, 1958, pp 90-104
111. Schulman S: Impaired delayed response from thalamic lesions. Arch Neurol 1964; 11:477-499
112. Baylis LL, Gaffan D: Amygdalectomy and ventromedial prefrontal ablation produce similar deficits in food choice and in simple object discrimination learning for an unseen reward. Exp Brain Res 1991; 86:617-622
113. Markowitsch HJ: Thalamic mediodorsal nucleus and memory: a critical evaluation of studies in animals and man. Neurosci Biobehav Rev 1982; 6:351-380
114. Zola-Morgan S, Squire LR: Amnesia in monkeys after lesions of the mediodorsal nucleus of the thalamus. Ann Neurol 1985; 17:558-564
115. Friedman HR, Janas JD, Goldman-Rakic PS: Enhancement of metabolic activity in the diencephalon of monkeys performing working memory tasks: a 2-deoxyglucose study in behaving rhesus monkeys. Journal of Cognitive Neuroscience 1990; 2:18-31
116. Baxter LR: Brain imaging as a tool in establishing a theory of brain pathology in obsessive compulsive disorder. J Clin Psychiatry 1990; 51(suppl):22-26
117. Modell JG, Mountz JM, Curtis GC, et al: Neurophysiologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenetic mechanism of obsessive-compulsive disorder. J Neuropsychiauy Clin Neurosci 1989; 1:27-36
118. Rapoport JL, Wise SP: Obsessive-compulsive disorder: evidence for basal ganglia dysfunction. Psychopharmacol Bull 1988; 24:380-384
119. Penney JB Jr, Young AB: Speculations on the functional anatomy of basal ganglia disorders. Ann Rev Neurosci 1983; 6:73-94