Histopathology of the prefrontal cortex in major depression: What does it tell us about dysfunctional monoaminergic circuits?

Progress in Brain Research

Volumn 126, Issue , 2000, Pages 397-412

  Rajkowska, Grazyna ^a  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN MONOAMINE; DOPAMINE; GLUTAMATE RECEPTOR; NEUROTRANSMITTER; NEUROTROPHIC FACTOR; NORADRENALIN; SEROTONIN;

CONFERENCE PAPER; DEPRESSION; DOPAMINERGIC SYSTEM; HISTOPATHOLOGY; HUMAN; LIMBIC CORTEX; MONOAMINERGIC SYSTEM; MORPHOMETRICS; NEUROANATOMY; NEUROTRANSMISSION; PREFRONTAL CORTEX; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM;

EID: 0034589368     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6123(00)26026-3     Document Type: Conference Paper

References (97)

1. Arango, V., Ernsberger, P., Marzuk, P.M. et al. (1990) Autoradiographic demonstration of increased serotonin 5-HT-2 and β-adrenergic receptor binding sites in the brain of suicide victims. Arch. Gen. Psychiatry, 47: 1038-1047.
2. Arango, V., Underwood, M.D., McDevitt, P.J., Gubbi, A.V. and Mann, J.J. (1995) Localized alterations in pre- and post-synaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Res., 688: 121-133.
3. Baxter, L.R., Schwartz, J.M., Phelps, M.E., Mazziotta, J.C., Guze, B.M., Selin, C.E., Gerner, R.H. and Sumida, R.M. (1989) Reduction of prefrontal cortex glucose metabolism common to three types of depression. Arch. Gen. Psychiatry, 46: 243-250.
4. Bench, C.J., Friston, K.J., Brown, R.G., Frackowiak, R.S.J. and Dolan, R.J. (1993) Regional cerebral blood flow in depression measured by positron emission tomography: The relationship with clinical dimensions. Psychol. Med., 23: 579-590.
5. Biver, F., Goldman, S., Delvenne, V., Luxen, A., Maertelaer, V.D., Hubain, P., Mendlewicz, J. and Lotstra, F. (1994) Frontal and parietal metabolic disturbances in unipolar depression. Biol. Psychiatry, 36: 381-388.
6. Biver, F., Wikler, D., Lotstra, F., Damhaut, P., Goldman, S. and Mendlewicz. J. (1997) Serotonin 5-HT2 receptor imaging in major depression: Focal changes in orbito-insular cortex. Br. J. Psychiatry. 171: 444-448.
7. Blier, P. and de Montigny, C. (1994) Current advances and trends in the treatment of depression. Trends Pharmacol. Sci., 15: 220-226.
8. Caldecott-Hazard, S., Morgan, D.G., DeLeon-Jones, F., Over-street, D.H. and Janowsky, D. (1991) Clinical and biochemical aspects of depressive disorders: II. Transmitter/ receptor theories. Synapse, 9: 251-301.
9. Celada, P., Siuciak, J.A., Tran, T.M., Altar, C.A. and Tepper, J.M. (1996) Local infusion of brain-derived neurotrophic factor modifies the firing pattern of dorsal raphe serotonergic neurons. Brain Res., 712: 293-298.
10. Drevets, W., Price, J., Simpson, Jr, J., Todd, R., Reich, T., Vannier, M. and Raichle, M. (1997) Subgenual prefrontal cortex abnormalities in mood disorders. Nature, 386: 824-827.
11. Duman, R.S. (1999) The neurochemistry of mood disorders: Preclinical studies. In: D.S. Charney, E.J. Nestler and B.S. Bunney (Eds), Neurobiology of Mental Illness, Oxford University Press, New York, pp. 333-347.
12. Duman, R.S., Heninger, G.R. and Nestler, E.J. (1997) A molecular and cellular theory of depression. Arch. Gen. Psychiatry, 54: 597-606.
13. Ferrier, I.N., McKeith, I.G., Cross, A.J., Perry, E.K., Candy, J.M. and Perry, R.H. (1986) Postmortem neurochemical studies in depression. Ann. NY Acad. Sci., 487: 128-142.
14. Fuster, J.M. (1997) Anatomy of the prefrontal cortex. In: The Prefrontal Cortex: Anatomy Physiology, and Neuropsychology of the Frontal Lobe, Lippincott-Raven, Philadelphia, 3rd ed., pp. 6-42.
15. Gellman, R.L. and Aghajanian, G.K. (1993) Pyramidal cells in piriform cortex receive a convergence of inputs from monoamine activated GABAergic interneurons. Brain Res., 600: 63-73.
16. Ghosh, A., Carnahan, J. and Greenberg, M.E. (1994) Requirement for BDNF in activity-dependent survival of cortical neurons. Science, 263: 1618-1623.
17. Goldman-Rakic, P. (1998) The prefrontal landscape: Implications of functional architecture for understanding human mentation and the central executive. In: A.C. Roberts, T.W. Robbins and L. Weiskrantz (Eds), The Prefrontal Cortex. Executive and Cognitive Functions, Oxford University Press, Oxford, pp. 87-102.
18. Goldman-Rakic, P.S., Lidow, M.S., Smiley, J.F. and Williams, M.S. (1992) The anatomy of dopamine in monkey and human prefrontal cortex. J. Neur. Transm., 36: 163-177.
19. Goldman-Rakic, P.S. and Selemon, L.D. (1997) Functional and anatomical aspects of prefrontal pathology in schizophrenia. Schizophr. Bull., 23: 437-458.
20. Gross-Isseroff, R., Dillon, K.A., Fieldust, S.J. and Biegon, A. (1990) Autoradiographic analysis of alpha 1-noradrenergic receptors in the human brain postmortem: Effect of suicide Arch. Gen. Psychiatry, 47: 1049-1053 [published erratum appears in Arch. Gen. Psychiatry, 1991, 48(9): 862].
21. Gundersen, H.J.G. (1986) Stereology of arbitrary particles: A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. J. Microscopy, 143: 3-45.
22. Heninger, G.R. and Charney, D.S. (1987) Mechanisms of action of antidepressant treatments: Implications for the etiology and treatment of depressive disorders. In: H.Y. Meltzer (Ed.), Psychopharmacology: The Third Generation of Progress, Raven Press, New York, pp. 535-544.
23. Hollister, L.E. and Claghorn, J.L. (1993) New antidepressants. Annu. Rev. Pharmacol. Toxicol., 33: 165-177.
24. Holsboer, F., Spengler, D. and Heuser, I. (1992) The role of corticotropin-releasing hormone in the pathogenesis of Cushing's disease, anorexia nervosa, alcoholism, affective disorders and dementia. Prog. Brain Res., 93: 385-417.
25. Jimerson, D.C. (1987) Role of dopamine mechanisms in the affective disorders. In: H.Y. Meltzer, Psychopharmacology: The Third Generation of Progress, Raven Press, New York, pp. 505-511.
26. Kasir, S.A., Underwood, M.D., Bakalian, M.J., Mann, J.J. and Arango, V. (1998) 5-HT1A binding in dorsal and median raphe nuclei of suicide victims. Soc. Neurosci. Abstr., 24: 505.503.
27. Kawamoto, Y., Nakamura, S., Kawamata, T., Akiguchi, I. and Kimura, J. (1999) Cellular localization of brain-derived neurotrophic factor-like immunoreactivity in adult monkey brain. Brain Res., 821: 341-349.
28. Kettenmann, H. and Ransom, R.B. (1995) Neuroglia, Oxford University Press, New York.
29. Klimek, V. and Ordway, G.A. (1996) Distribution of alpha 2-adrenoceptors in the human locus coeruleus. Brain Res., 741: 263-274.
30. Klimek, V., Stockmeier, C., Overholser, J., Meltzer, H., Kalka, S., Dilley, G. and Ordway, G. (1997) Reduced levels of norepinephrine transporters in the locus coeruleus in major depression. J. Neurosci., 17: 8451-8458.
31. Krimer, L.S., Jakab, R.L. and Goldman-Rakic, P.S. (1997) Quantitative three-dimensional analysis of the catecholaminergic innervation of identified neurons in the macaque prefrontal cortex. J. Neurosci., 17: 7450-7461.
32. Laming, P.R. (1998) Changing concepts on the role of glia. In: P.R. Laming (Ed.), Glial Cell. Their Role in Behaviour, Cambridge University Press, pp. 1-21.
33. Lewis, D.A. (1992) The catecholaminergic innervation of primate prefrontal cortex. J. Neur Transm., 36: 179-200.
34. Lewis, D.A., Campbell, M.J., Foote, S.L., Goldstein, M. and Morrison, J.H. (1987) The distribution of tyrosine hydroxylase-immunoreactive fibers on primate neocortex is widespread but regionally specific. J. Neurosci., 7: 279-290.
35. Lewis, D.A., Campbell, M.J., Foote, S.L. and Morrison, J.H. (1986) The monoaminergic innervation of primate neocortex. Hum. Neurobiol., 5: 181-188.
36. Lewis, D.A. and Morrison, J.H. (1989) Noradrenergic innervation of monkey prefrontal cortex: A dopamine β-hydroxylase immunohistochemical study. J. Comp. Neurol., 282: 317-330.
37. Lewis, D.A., Sesack, S.R., Levey, A.I. and Rosenberg, D.R. (1998) Dopamine axons in primate prefrontal cortex: Specificity of distribution, synaptic targets, and development. Adv. Pharmacol., 42: 703-706.
38. Maas, J.W., Koslow, S.H., Davis, J.M., Katz, M.M., Frazer, A., Bowden, C.L., Berman, N., Gibbons, R., Stokes, P. and Landis, H. (1987) Catecholamine metabolism and disposition in healthy and depressed subjects. Arch. Gen. Psychiatry, 44: 337-344.
39. Mamounas, L.A., Blue, M.E., Siuciak, J.A. and Altar, C.A. (1995) Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. J. Neurosci., 15: 7929-7939.
40. Martinot, J.L., Hardy, P., Feline, A., Huret, J., Mazoyer, B., Attar-Levy, D., Pappata, S. and Syrota, A. (1990) Left prefrontal glucose hypometabolism in the depressed state: A confirmation. Am. J. Psychiatry, 147: 1313-1317.
41. Mayberg, H.S. (1997) Limbic-Cortical dysregulation. In: S. Salloway, P. Malloy and J.L. Cummings (Eds), The Psychiatry of Limbic and Subcortical Disorders, American Psychiatric Press, Washington, pp. 167-167.
42. Meana, J.J., Barturen, F. and Garcia-Sevilla, J.A. (1992) Alpha 2-Adrenoceptors in the brain of suicide victims: Increased receptor density associated with major depression. Biol. Psychiatry, 31: 471-490.
43. 2-adrenoceptor density in the frontal cortex of depressed suicide victims. J. Neural Transm., 70: 377-381.
44. Melchitzky, D.S., Sesack, S.R. and Lewis, D.A. (1999) Parvalbumin-immunoreactive axon terminals in macaque monkey and human prefrontal cortex: Laminar, regional, and target specificity of type I and type II synapses. J. Comp. Neurol., 408: 11-22.
45. Miguel-Hidalgo, J.J. and Rajkowska, G. (1999) Immunohistochemistry of neural markers for the study of the laminar cytoarchitecture in celloidin sections from the human cerebral cortex. J. Neurosci. Meth., 93: 69-79.
46. Murer, M.G., Boissiere, F., Yan, Q., Hunot, S., Villares, J., Faucheux, B., Agid, Y., Hirsch, E. and Raisman-Vozari, R. (1999) An immunohistochemical study of the distribution of brain-derived neurotrophic factor in the adult human brain, with particular reference to Alzheimer's disease. Neuroscience, 88: 1015-1032.
47. Nibuya, M., Morinobu, S. and Duman, R.S. (1995) Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J. Neurosci., 15: 7539-7547.
48. Nibuya, M., Nestler, E.J. and Duman, R.S. (1996) Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J. Neurosci., 16: 2365-2372.
49. Nowak, G., Trullas, R., Layer, R.T., Skolnick, P. and Paul, I.A. (1993) Adaptive changes in the N-methyl-D-aspartate receptor complex after chronic treatment with imipramine and 1-aminocyclopropanecarboxylic acid. J. Pharmacol. Exp. Ther., 265: 1380-1386.
50. Nowak, G., Ordway, G.A. and Paul, I.A. (1995) Alterations in the N-methyl-D-aspartate (NMDA) receptor complex in the frontal cortex of suicide victims. Brain Res., 675: 157-164.
51. Öngür, D., An, X. and Price, J.L. (1998a) Prefrontal cortical projections to the hypothalamus in macaque monkeys. J. Comp. Neurol., 401: 480-505.
52. Öngür, D., Drevets, W.C. and Price, J.L. (1998b) Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc. Natl. Acad. Sci. USA, 95: 13290-13295.
53. Ordway, G., Smith, K. and Haycock, J. (1994a) Elevated tyrosine hydroxylase in the locus coeruleus of suicide victims. J. Neurochem., 62: 680-685.
54. 2-Adrenoceptors is elevated in the locus coeruleus from victims of suicide. J. Neurochem., 63: 617-624.
55. Pacheco, M.A., Stockmeier, C., Meltzer, H.Y., Overholser, J.C., Dilley, G.E. and Jope, R.S. (1996) Alterations in phosphoinositide signaling and G-protein levels in depressed suicide brain. Brain Res., 723: 37-45.
56. Paul, I.A., Trullas, R., Skolnick, P. and Nowak, G. (1992) Down-regulation of cortical beta-adrenoceptors by chronic treatment with functional NMDA antagonists. Psychopharmacology, 106: 285-287.
57. Paul, I.A., Layer, R.T., Skolnick, P. and Nowak, G. (1993) Adaptation of the NMDA receptor in rat cortex following chronic electroconvulsive shock or imipramine. Eur. J. Pharmacol., 247: 305-311.
58. Paul, I.A., Nowak, G., Layer, R.T., Popik, P. and Skolnick, P. (1994) Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments. J. Pharmacol. Exp. Ther., 269: 95-102.
59. Pazos, A., Probst, A. and Palacios, J. (1987) Serotonin receptors in the human brain-III. Autoradiographic mapping of serotonin-1 receptors. Neuroscience, 21: 97-122.
60. Prange, A.J. (1964) The pharmacology and biochemistry of depression. Dis. Nerv. Sist., 25: 217-221.
61. Purba, J.S., Hoogendijk, W.J., Hofman, M.A. and Swaab, D.F. (1996) Increased number of vasopressin- and oxytocinexpressing neurons in the paraventricular nucleus of the hypothalamus in depression. Arch. Gen. Psychiatry, 53: 137-143.
62. Raadsheer, F.C., van Heerikhuize, J.J., Lucassen, P.J., Hoogendijk, W.J., Tilders, F.J. and Swaab, D.F. (1995) Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer's disease and depression. Am. J. Psychiatry, 152: 1372-1376.
63. Rajkowska, G. (1997a) Morphometric methods for studying the prefrontal cortex in suicide victims and psychiatric patients. Ann. NY Acad. Sc., 836: 253-268.
64. Rajkowska, G. and Goldman-Rakic, P.S. (1995a) Cytoarchitectonic definition of prefrontal areas in the normal human cortex: I. Quantitative criteria for distinguishing areas 9 and 46. Cereb. Cort., 4: 307-322.
65. Rajkowska, G. and Goldman-Rakic, P.S. (1995b) Cytoarchitectonic definition of prefrontal areas in the normal human cortex: II. Variability in locations of areas 9 and 46. Cereb. Cort., 4: 323-337.
66. Rajkowska, G., Miguel-Hidalgo, J.J., Wei, J., Dilley, G., Pittman, S.D., Meltzer, H.Y., Overholser, J.C., Roth B.L. and Stockmeier C.A. (1999) Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression. Biol. Psychiatry, 45: 1085-1098.
67. Rajkowska, G., Pool, C.W., Roland, P.E., Zilles, K. and Uylings, H. (1998a) 3D cytoarchitectonic parcellation of human orbitofrontal cortex. Correlation with postmortem MRI. Soc. Neurosci. Abstr., 24: 1165.
68. Rajkowska, G., Selemon, L. and Goldman-Rakic, P. (1998b) Neuronal and glial somal size in the prefrontal cortex: A postmortem morphometric study of schizophrenia and Huntington's disease. Arch. Gen. Psychiatry, 55: 215-224.
69. Rajkowska, G., Selemon, L.D. and Goldman-Rakic, P.S. (1997) Marked glial neuropathology in prefrontal cortex distinguishes bipolar disorder from schizophrenia. Schizophr. Res., 24: 41.
70. Rempel-Clower, N.L. and Barbas, H. (1998) Topographic organization of connections between the hypothalamus and prefrontal cortex in the rhesus monkey. J. Comp. Neurol., 398: 393-419.
71. Schildkraut, J.J. (1965) The catecholamine hypothesis of affective disorders: A review of supporting evidence. Am. J. Psychiatry, 122: 509-522.
72. Selemon, L.D., Rajkowska, G. and Goldman-Rakic, P.S. (1995) Abnormally high neuronal density in the schizophrenic cortex: A morphometric analysis of prefrontal area 9 and occipital area 17. Arch. Gen. Psychiatry, 52: 805-818.
73. Sesack, S.R., Bressler, C.N. and Lewis, D.A. (1995a) Ultra-structural associations between dopamine terminals and local circuit neurons in the monkey prefrontal cortex: A study of calretinin-immunoreactive cells. Neurosci. Lett., 200: 9-12.
74. Sesack, S.R., Hawrylak, V.A., Melchitzky, D.S. and Lewis, D.A. (1998) Dopamine innervation of a subclass of local circuit neurons in monkey prefrontal cortex: Ultrastructural analysis of tyrosine hydroxylase and parvalbumin immunoreactive structures. Cereb. Cort., 8: 614-622.
75. Sesack, S.R., Snyder, C.L. and Lewis, D.A. (1995b) Axon terminals immunolabeled for dopamine or tyrosine hydroxylase synapse on gaba-immunoreactive dendrites in rat and monkey cortex. J. Comp. Neurol., 363: 264-280.
76. Siuciak, J.A., Boylan, C., Fritsche, M., Altar, C.A. and Lindsay, R.M. (1996) BDNF increases monoaminergic activity in rat brain following X intracerebroventricular or intraparenchymal administration. Brain Res., 710: 11-20.
77. Siuciak, J.A., Clark, M.S., Rind, H.B., Whittemore, S.R. and Russo, A.F. (1998) BDNF induction of tryptophan hydroxylase mRNA levels in the rat brain. J. Neurosci. Res., 52: 149-158.
78. Smiley, J.F. and Goldman-Rakic, P.S. (1993) Heterogenous targets of dopamine synapses in monkey prefrontal cortex demonstrated by serial section electron microscopy: A laminar analysis using the silver-enhanced diaminobenzidine sulfide (SEDS) immunolabeling technique. Cereb. Cort., 3: 223-238.
79. Smiley, J.F. and Goldman-Rakic, P.S. (1996) Serotonergic axons in monkey prefrontal cerebral cortex synapse predominantly on interneurons as demonstrated by serial section electron microscopy. J. Comp. Neurol., 367: 431-443.
80. 1 dopamine receptor immunoreactivity in human and monkey cerebral cortex: Predominant and extrasynaptic localization in dendritic spines. Proc. Natl. Acad. Sci. USA, 91: 5720-5724.
81. Smiley, J.F., Williams, S.M., Szigeti, K. and Goldman-Rakic, P.S. (1992) Light and electron microscopic characterization of dopamine-immunoreactive axons in human cerebral cortex. J. Comp. Neurol., 321: 325-335.
82. Spitzer, R. and Endicott, J. (1978) Schedule for Affective Disorders and Schizophrenia (SADS). 3. New York: New York State Psychiatric Institute.
83. Stockmeier, C.A., Dilley, G.E., Kulnane, L.S., Miguel-Hidalgo, J.J. and Rajkowska-Markow, G. (1999) Morphometric evaluation of the midbrain dorsal raphe nucleus (DR) in suicide victims with major depression (MD). Abstr. Soc. Neurosci., 25: 2098.
84. Stockmeier, C.A. and Meltzer, H.Y. (1991) β-adrenergic receptor, binding in frontal cortex of suicide victims. Biol. Psychiatry, 29: 183-191.
85. Stockmeier, C.A., Shapiro, L.A., Dilley, G.E., Kolli, T.N., Friedman, L. and Rajkowska, G. (1998) Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity. J. Neurosci., 18: 7394-7401.
86. Swann, A.C., Katz, M.M., Bowden, C.L., Berman, N.G. and Stokes, P.E. (1999) Psychomotor performance and monoamine function in bipolar and unipolar affective disorders [In Process Citation]. Biol. Psychiatry, 45: 979-988.
87. Swann, A.C., Koslow, S.H., Katz, M.M., Maas, J.W., Javaid, J., Secunda, S. and Robins, E. (1987) Lithium carbonate treatment of mania: Cerebrospinal fluid and urinary monoamine metabolites and treatment outcome. Arch. Gen. Psychiatry, 44: 345-354.
88. Trullas, R. and Skolnick, P. (1990) Functional antagonists at the NMDA receptor complex exhibit antidepressant actions. Eur. J. Pharmacol., 185: 1-10.
89. Tsacopoulos, M. and Magistretti, P.J. (1996) Metabolic coupling between glia and neurons. J. Neurosci., 16: 877-885.
90. Underwood, M.D., Khaibulina, A.A., Ellis, S.P., Moran, A., Rice, P.M., Mann, J.J. and Arango, V. (1999) Morphometry of the dorsal raphe nucleus serotonergic neurons in suicide victims. Biol. Psychiatry, 46: 473-483.
91. Vaidya, V., Marek, G., Aghajanian, G. and Duman, R. (1997) 5-HT2A receptor-mediated regulation of brain-derived neurotrophic factor mRNA in the hippocampus and the neocortex. J. Neurosci., 17: 2785-2795.
92. Waterhouse, B.D., Gould, E.M. and Bekavac, I. (1996) Monoaminergic substrates underlying cocaine-induced enhancement of somatosensory-evoked discharges in rat barrel field cortical neurons. J. Pharmacol. Exp. Ther., 279: 582-592.
93. Williams, R.W. (1989) Three-dimensional counting: An accurate and direct method to estimate numbers of cells in sectioned material. (Erratum). J. Comp. Neurol., 281: 335.
94. Williams, R.W. and Rakic, P. (1988) Three-dimensional counting: An accurate and direct method to estimate numbers of cells in sectioned material. J. Comp. Neurol., 278: 344-352.
95. Williams, S.M. and Goldman-Rakic, P.S. (1993) Characterization of the dopaminergic innervation of the primate frontal cortex using a dopamine-specific antibody. Cereb. Cort., 3: 199-222.
96. Williams, S.M. and Goldman-Rakic, P.S. (1998) Widespread origin of the primate mesofrontal dopamine system. Cereb. Cort., 8: 321-345.
97. Zhu, M.-Y., Klimek, V., Dilley, G.E., Haycock, J.W., Stockmeier, C., Overholser, J.C., Meltzer, H.Y. and Ordway, G.A. (1999) Elevated levels of tyrosine hydroxilase in the locus coeruleus in major depression. Biol. Psychiatry, 46, 1275-1286.