Regional distribution and relative abundance of serotonin2c receptors in human brain: Effect of suicide

Neurochemical Research

Volumn 31, Issue 2, 2006, Pages 167-176

  Pandey, Ghanshyam N ^a   Dwivedi, Yogesh ^a   Ren, Xinguo ^a   Rizavi, Hooriyah S ^a   Faludi, Gabor ^b   Sarosi, Andrea ^b   Palkovits, Miklos ^b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

5HT2C brain distribution; 5HT2C mRNA; 5HT2C receptors; mRNA editing; Postmortem brain; Suicide

Indexed keywords

MESSENGER RNA; RECEPTOR SUBTYPE; SEROTONIN 2C RECEPTOR; SEROTONIN RECEPTOR;

ARTICLE; AUTOPSY; BRAIN REGION; CEREBELLUM; CHOROID PLEXUS; COMPARATIVE STUDY; CONTROLLED STUDY; GENE LOCATION; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; HYPOTHALAMUS; NUCLEOTIDE SEQUENCE; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUICIDE;

ADULT; AGED; AGED, 80 AND OVER; BASE SEQUENCE; BRAIN; DNA PRIMERS; FEMALE; HUMANS; MALE; MIDDLE AGED; RECEPTOR, SEROTONIN, 5-HT2C; RNA EDITING; RNA, MESSENGER; SUICIDE;

EID: 33646535647     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-005-9006-6     Document Type: Article

References (34)

1. Mann JJ, Arango V, Marzuk PM, Theccanat S, Reis DJ (1989) Evidence for the 5HT hypothesis of suicide. A review of post-mortem studies. Br J Psych 155 suppl: 7-14
2. Ashberg M, Traskman L, Thoren P, (1976) 5HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Arch Gen Psych 33:1193-1197
3. Traskman L, Asberg M, Bertilsson L, Sjostrand L (1981) Monoamine metabolites in CSF and suicidal behavior. Arch Gen Psych 38:631-636
4. Lidberg L, Belfrage H, Bertilsson L, Evenden MM, Asberg M (2000) Suicide attempts and impulse control disorder are related to low cerebrospinal fluid 5HIAA in mentally disordered violent offenders. Acta Psych Scand 101:395-402
5. Spreux-Varoquaux O, Alvarez JC, Berlin I, Batista G, Despierre PG, Gilton A, Cremniter D (2001) Differential abnormalities in plasma 5HIAA and platelet serotonin concentrations in violent suicide attempters: relationships with impulsivity and depression. Life Sci 69:647-657
6. Barnes NM, Sharp T (1999) A review of central 5HT receptors and their function. Neuropharmacology 38:1083-1152
7. Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PA (1994) VII. International Union of Pharmacology classification of receptor for 5-hydroxytrytamine (serotonin). Pharmacol Rev 46:157-203
8. Hoyer D, Martin G (1997) 5HT receptor classification and nomenclature: towards a harmonization with the human genome. Neuropharmacology 36:419-428
9. Gross-Isseroff R, Biegon A, Voet H, Weizman A (1998) The suicide brain: a review of postmortem receptor/transporter binding studies. Neurosci Biobehav 22:653-661
10. Stockmeier CA (2003) Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter. J Psych Res 37:357-373
11. Pandey GN, Dwivedi Y, Rizavi HS, Ren X, Pandey SC, Pesold C, Roberts RC, Conley RR, Tamminga CA (2002) Higher expression of serotonin 5-HT(2A) receptors in the postmortem brains of teenage suicide victims. Am J Psych 159:419-429
12. Pazos A, Hoyer D, Palacios JM, (1984) The binding of serotonergic ligands to the porcine choroid plexus: characterization of a new type of serotonin recognition site. Eur J Pharmacol 106:539-546
13. 2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors. Proc Natl Acad Sci USA 87:928-932
14. 2C receptors. Eur J Pharmacol 480:151-162
15. Soubrie P (1986) Reconciling the role of central serotonin neurons in human and animal behaviour. Behav Brain Sci 9:319-364
16. 2C receptor G-protein coupling by RNA editing. Nature 387:303-308
17. 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims. Neuron 34:349-356
18. Niswender CM, Herrick-Davis K, Dilley GE, Meltzer HY, Overholser JC, Stockmeier CA, Emeson RB, Sanders-Bush E (2001) RNA editing of the human serotonin 5-HT2C receptor. Alterations in suicide and implications for serotonergic pharmacotherapy. Neuropsychopharmacology 24:478-491
19. 2C receptor in human postmortem brains of major mental disorders. Neurosci Lett 346:169-172
20. 2C receptors: suicide, serotonin, and runaway RNA editing. Neuroscientist 9:237-242
21. Niswender CM, Copeland SC, Herrick-Davis K, Emeson RB, Sanders-Bush E (1999) RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity. J Biol Chem 274:9472-9478
22. Marazziti D, Rossi A, Giannaccini G, Zavaglia KM, Dell'Osso L, Lucacchini A, Cassano GB (1999) Distribution and characterization of [3H]mesulergine binding in human brain postmortem. Eur Neuropsychopharmacol 10:21-26
23. 2C receptor messenger RNA in human brain. Neuroscience 92:601-611
24. 3H]mesulergine binding sites and choline acetyltransferase mRNA. Synapse 42:12-26
25. Spitzer RL, Williams JBW, Gibbon M, First MB (1995) Structured Clinical Interview for DSM-IV (SCID). New York State Psychiatric Institute, Biometrics Research, New York
26. Dwivedi Y, Rizavi HS, Conley RR, Roberts RC, Tamminga CA, Pandey GN (2002) mRNA and protein expression of selective alpha subunits of G proteins are abnormal in prefrontal cortex of suicide victims. Neuropsychopharmacology 27:499-517
27. Dwivedi Y, Rizavi HS, Shukla PK, Lyons J, Faludi G, Palkovits M, Sarosi A, Conley RR, Roberts RC, Tamminga CA, Pandey GN (2004) Protein kinase A in postmortem brain of depressed suicide victims: altered expression of specific regulatory and catalytic subunits. Biol Psych 55:234-243
28. 2C receptors to multiple actions of central serotonin systems. Eur J Pharmacol 488:1-9
29. 2C serotonin receptors. Nature 374:542-546
30. 2C receptor. Neuropsychopharmacology 21:825-905
31. 2C receptor editing by sustained changes in serotonergic neurotransmission. J Neurosci 22:10529-10532
32. 2C receptor is reduced in schizophrenia. Mol Psych 6:373-379
33. 2C in schizophrenia brains identified by high-resolution mRNA expression analysis. Biol. Psych 54:1212-1221
34. 2C receptor induced by interferon: implications for depression associated with cytokine therapy. Brain Res Mol Brain Res 124:70-78