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Volumn 33, Issue 6, 2012, Pages 1239-1246

Deficiency of the Kruppel-like factor KLF4 correlates with increased cell proliferation and enhanced skin tumorigenesis

Author keywords

[No Author keywords available]

Indexed keywords

KRUPPEL LIKE FACTOR 4; TAMOXIFEN;

EID: 84862657001     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgs143     Document Type: Article
Times cited : (45)

References (53)
  • 1
    • 0029829236 scopus 로고    scopus 로고
    • Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest
    • Shields, J.M. et al. (1996) Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest. J. Biol. Chem., 271, 20009-20017.
    • (1996) J. Biol. Chem. , vol.271 , pp. 20009-20017
    • Shields, J.M.1
  • 2
    • 0031594189 scopus 로고    scopus 로고
    • Human EZF, a Kruppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains
    • Yet, S.F. et al. (1998) Human EZF, a Kruppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. J. Biol. Chem., 273, 1026-1031.
    • (1998) J. Biol. Chem. , vol.273 , pp. 1026-1031
    • Yet, S.F.1
  • 3
    • 0029969727 scopus 로고    scopus 로고
    • A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells
    • Garrett-Sinha, L.A. et al. (1996) A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. J. Biol. Chem., 271, 31384-31390.
    • (1996) J. Biol. Chem. , vol.271 , pp. 31384-31390
    • Garrett-Sinha, L.A.1
  • 4
    • 18944372399 scopus 로고    scopus 로고
    • Kruppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation
    • Ghaleb, A.M. et al. (2005) Kruppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation. Cell Res., 15, 92-96.
    • (2005) Cell Res , vol.15 , pp. 92-96
    • Ghaleb, A.M.1
  • 5
    • 47549096256 scopus 로고    scopus 로고
    • Roles of Krupel-like factor 4 in normal homeostasis, cancer and stem cells
    • Evans, P.M. et al. (2008) Roles of Krupel-like factor 4 in normal homeostasis, cancer and stem cells. Acta Biochim. Biophys. Sin. (Shanghai), 40, 554-564.
    • (2008) Acta Biochim. Biophys. Sin. (Shanghai) , vol.40 , pp. 554-564
    • Evans, P.M.1
  • 6
    • 0033485811 scopus 로고    scopus 로고
    • Characterization of the structure and regulation of the murine gene encoding gut-enriched Kruppel-like factor (Kruppellike factor 4)
    • Mahatan, C.S. et al. (1999) Characterization of the structure and regulation of the murine gene encoding gut-enriched Kruppel-like factor (Kruppellike factor 4). Nucleic Acids Res., 27, 4562-4569.
    • (1999) Nucleic Acids Res , vol.27 , pp. 4562-4569
    • Mahatan, C.S.1
  • 7
    • 0036314311 scopus 로고    scopus 로고
    • Redox-sensitive vascular smooth muscle cell proliferation is mediated by GKLF and Id3 in vitro and in vivo
    • Nickenig, G. et al. (2002) Redox-sensitive vascular smooth muscle cell proliferation is mediated by GKLF and Id3 in vitro and in vivo. FASEB J., 16, 1077-1086.
    • (2002) FASEB J , vol.16 , pp. 1077-1086
    • Nickenig, G.1
  • 8
    • 0037459050 scopus 로고    scopus 로고
    • Transcriptional profiling of Kruppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation
    • Chen, X. et al. (2003) Transcriptional profiling of Kruppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation. J. Mol. Biol., 326, 665-677.
    • (2003) J. Mol. Biol. , vol.326 , pp. 665-677
    • Chen, X.1
  • 9
    • 0034238112 scopus 로고    scopus 로고
    • Gut-enriched Kruppel-like factor represses cyclin D1 promoter activity through Sp1 motif
    • Shie, J.L. et al. (2000) Gut-enriched Kruppel-like factor represses cyclin D1 promoter activity through Sp1 motif. Nucleic Acids Res., 28, 2969-2976.
    • (2000) Nucleic Acids Res , vol.28 , pp. 2969-2976
    • Shie, J.L.1
  • 10
    • 1042301369 scopus 로고    scopus 로고
    • Requirement of Kruppel-like factor 4 in preventing entry into mitosis following DNA damage
    • Yoon, H.S. et al. (2004) Requirement of Kruppel-like factor 4 in preventing entry into mitosis following DNA damage. J. Biol. Chem., 279, 5035-5041.
    • (2004) J. Biol. Chem. , vol.279 , pp. 5035-5041
    • Yoon, H.S.1
  • 11
    • 11244281579 scopus 로고    scopus 로고
    • Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4
    • Li, Y. et al. (2005) Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4. Blood, 105, 635-637.
    • (2005) Blood , vol.105 , pp. 635-637
    • Li, Y.1
  • 12
    • 38349126303 scopus 로고    scopus 로고
    • Dynamic transcription programs during ES cell differentiation towards mesoderm in serum versus serum-freeBMP4 culture
    • Bruce, S.J. et al. (2007) Dynamic transcription programs during ES cell differentiation towards mesoderm in serum versus serum-freeBMP4 culture. BMC Genomics, 8, 365.
    • (2007) BMC Genomics , vol.8 , pp. 365
    • Bruce, S.J.1
  • 13
    • 77955846452 scopus 로고    scopus 로고
    • Induction of pluripotency by defined factors
    • Okita, K. et al. (2010) Induction of pluripotency by defined factors. Exp. Cell Res., 316, 2565-2570.
    • (2010) Exp. Cell Res. , vol.316 , pp. 2565-2570
    • Okita, K.1
  • 14
    • 79955608022 scopus 로고    scopus 로고
    • Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion
    • Yu, F. et al. (2011) Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion. Oncogene, 30, 2161-2172.
    • (2011) Oncogene , vol.30 , pp. 2161-2172
    • Yu, F.1
  • 15
    • 0032813661 scopus 로고    scopus 로고
    • Klf4 is a transcription factor required for establishing the barrier function of the skin
    • Segre, J.A. et al. (1999) Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat. Genet., 22, 356-360.
    • (1999) Nat. Genet. , vol.22 , pp. 356-360
    • Segre, J.A.1
  • 16
    • 17144401799 scopus 로고    scopus 로고
    • Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach
    • Katz, J.P. et al. (2005) Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach. Gastroenterology, 128, 935-945.
    • (2005) Gastroenterology , vol.128 , pp. 935-945
    • Katz, J.P.1
  • 17
    • 30144442965 scopus 로고    scopus 로고
    • KLF4, p21 and context-dependent opposing forces in cancer
    • Rowland, B.D. et al. (2006) KLF4, p21 and context-dependent opposing forces in cancer. Nat. Rev. Cancer, 6, 11-23.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 11-23
    • Rowland, B.D.1
  • 18
    • 39549098128 scopus 로고    scopus 로고
    • RAGE signaling sustains inflammation and promotes tumor development
    • Gebhardt, C. et al. (2008) RAGE signaling sustains inflammation and promotes tumor development. J. Exp. Med., 205, 275-285.
    • (2008) J. Exp. Med. , vol.205 , pp. 275-285
    • Gebhardt, C.1
  • 19
    • 0029896212 scopus 로고    scopus 로고
    • Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus
    • Dominguez, M. et al. (1996) Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus. Science, 272, 1621-1625.
    • (1996) Science , vol.272 , pp. 1621-1625
    • Dominguez, M.1
  • 20
    • 15844381336 scopus 로고    scopus 로고
    • Human homolog of patched, a candidate gene for the basal cell nevus syndrome
    • Johnson, R.L. et al. (1996) Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science, 272, 1668-1671.
    • (1996) Science , vol.272 , pp. 1668-1671
    • Johnson, R.L.1
  • 21
    • 0030932869 scopus 로고    scopus 로고
    • Cancer-susceptibility genes. Gatekeepers and caretakers
    • Kinzler, K.W. et al. (1997) Cancer-susceptibility genes. Gatekeepers and caretakers. Nature, 386, 761, 763.
    • (1997) Nature , vol.386 , pp. 763
    • Kinzler, K.W.1
  • 22
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog and Wnt signalling pathways in cancer
    • Taipale, J. et al. (2001) The Hedgehog and Wnt signalling pathways in cancer. Nature, 411, 349-354.
    • (2001) Nature , vol.411 , pp. 349-354
    • Taipale, J.1
  • 23
    • 0344413420 scopus 로고    scopus 로고
    • Live and let die in the intestinal epithelium
    • Sancho, E. et al. (2003) Live and let die in the intestinal epithelium. Curr. Opin. Cell Biol., 15, 763-770.
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 763-770
    • Sancho, E.1
  • 24
    • 20144382755 scopus 로고    scopus 로고
    • Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia
    • Foster, K.W. et al. (2005) Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia. Oncogene, 24, 1491-1500.
    • (2005) Oncogene , vol.24 , pp. 1491-1500
    • Foster, K.W.1
  • 25
    • 29844454865 scopus 로고    scopus 로고
    • Emerging role of KLF4 in human gastrointestinal cancer
    • Wei, D. et al. (2006) Emerging role of KLF4 in human gastrointestinal cancer. Carcinogenesis, 27, 23-31.
    • (2006) Carcinogenesis , vol.27 , pp. 23-31
    • Wei, D.1
  • 26
    • 0042093653 scopus 로고    scopus 로고
    • Downregulation and growth inhibitory effect of epithelial-type Kruppel-like transcription factor KLF4, but not KLF5, in bladder cancer
    • Ohnishi, S. et al. (2003) Downregulation and growth inhibitory effect of epithelial-type Kruppel-like transcription factor KLF4, but not KLF5, in bladder cancer. Biochem. Biophys. Res. Commun., 308, 251-256.
    • (2003) Biochem. Biophys. Res. Commun. , vol.308 , pp. 251-256
    • Ohnishi, S.1
  • 27
    • 33745964737 scopus 로고    scopus 로고
    • Altered expression of the KLF4 in colorectal cancers
    • Choi, B.J. et al. (2006) Altered expression of the KLF4 in colorectal cancers. Pathol. Res. Pract., 202, 585-589
    • (2006) Pathol. Res. Pract. , vol.202 , pp. 585-589
    • Choi, B.J.1
  • 28
    • 11144358328 scopus 로고    scopus 로고
    • Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancer
    • Pandya, A.Y. et al. (2004) Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancer. Clin. Cancer Res., 10, 2709-2719.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 2709-2719
    • Pandya, A.Y.1
  • 29
    • 79955829815 scopus 로고    scopus 로고
    • The role of KLF4 in UVB-induced murine skin tumor development and its correlation with cyclin D1, p53, and p21(Waf1/ Cip1) in epithelial tumors of the human skin
    • Choi, W.J. et al. (2011) The role of KLF4 in UVB-induced murine skin tumor development and its correlation with cyclin D1, p53, and p21(Waf1/ Cip1) in epithelial tumors of the human skin. Arch. Dermatol. Res., 303, 191-200.
    • (2011) Arch. Dermatol. Res. , vol.303 , pp. 191-200
    • Choi, W.J.1
  • 30
    • 33644776032 scopus 로고    scopus 로고
    • Novel cross talk of Kruppel-like factor 4 and betacatenin regulates normal intestinal homeostasis and tumor repression
    • Zhang, W. et al. (2006) Novel cross talk of Kruppel-like factor 4 and betacatenin regulates normal intestinal homeostasis and tumor repression. Mol. Cell. Biol., 26, 2055-2064.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 2055-2064
    • Zhang, W.1
  • 31
    • 30144440248 scopus 로고    scopus 로고
    • The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene
    • Rowland, B.D. et al. (2005) The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nat. Cell Biol., 7, 1074-1082.
    • (2005) Nat. Cell Biol. , vol.7 , pp. 1074-1082
    • Rowland, B.D.1
  • 32
    • 1542365401 scopus 로고    scopus 로고
    • Kruppel-like factor 4 (KLF4) represses histidine decarboxylase gene expression through an upstream Sp1 site and downstream gastrin responsive elements
    • Ai, W. et al. (2004) Kruppel-like factor 4 (KLF4) represses histidine decarboxylase gene expression through an upstream Sp1 site and downstream gastrin responsive elements. J. Biol. Chem., 279, 8684-8693.
    • (2004) J. Biol. Chem. , vol.279 , pp. 8684-8693
    • Ai, W.1
  • 33
    • 38649125918 scopus 로고    scopus 로고
    • Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing
    • Hara-Chikuma, M. et al. (2008) Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing. J. Mol. Med., 86, 221-231.
    • (2008) J. Mol. Med. , vol.86 , pp. 221-231
    • Hara-Chikuma, M.1
  • 34
    • 16644376120 scopus 로고    scopus 로고
    • Method for the harvest and assay of in vitro clonogenic keratinocytes stem cells from mice
    • Wu, W.Y. et al. (2005) Method for the harvest and assay of in vitro clonogenic keratinocytes stem cells from mice. Methods Mol. Biol., 289, 79-86.
    • (2005) Methods Mol. Biol. , vol.289 , pp. 79-86
    • Wu, W.Y.1
  • 35
    • 77955489664 scopus 로고    scopus 로고
    • Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis
    • Jensen, K.B. et al. (2010) Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis. Nat. Protoc., 5, 898-911.
    • (2010) Nat. Protoc. , vol.5 , pp. 898-911
    • Jensen, K.B.1
  • 36
    • 0035308590 scopus 로고    scopus 로고
    • A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA
    • Lee, E.C. et al. (2001) A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics, 73, 56-65.
    • (2001) Genomics , vol.73 , pp. 56-65
    • Lee, E.C.1
  • 37
    • 0036340041 scopus 로고    scopus 로고
    • The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon
    • Katz, J.P. et al. (2002) The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development, 129, 2619-2628.
    • (2002) Development , vol.129 , pp. 2619-2628
    • Katz, J.P.1
  • 38
    • 0035839554 scopus 로고    scopus 로고
    • Kruppel-like factor 4 (gut-enriched Kruppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycle
    • Chen, X. et al. (2001) Kruppel-like factor 4 (gut-enriched Kruppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycle. J. Biol. Chem., 276, 30423-30428.
    • (2001) J. Biol. Chem. , vol.276 , pp. 30423-30428
    • Chen, X.1
  • 39
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis
    • Yang, J. et al. (2008) Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev. Cell, 14, 818-829.
    • (2008) Dev. Cell , vol.14 , pp. 818-829
    • Yang, J.1
  • 40
    • 49649101156 scopus 로고    scopus 로고
    • Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells
    • Wei, D. et al. (2008) Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells. Cancer Res., 68, 4631-4639.
    • (2008) Cancer Res , vol.68 , pp. 4631-4639
    • Wei, D.1
  • 41
    • 78649710595 scopus 로고    scopus 로고
    • KLF4alpha up-regulation promotes cell cycle progression and reduces survival time of patients with pancreatic cancer
    • Wei, D. et al. (2010) KLF4alpha up-regulation promotes cell cycle progression and reduces survival time of patients with pancreatic cancer. Gastroenterology, 139, 2135-2145.
    • (2010) Gastroenterology , vol.139 , pp. 2135-2145
    • Wei, D.1
  • 42
    • 77953882290 scopus 로고    scopus 로고
    • Esophageal squamous cell dysplasia and delayed differentiation with deletion of kruppel-like factor 4 in murine esophagus
    • e9
    • Tetreault, M.P. et al. (2010) Esophageal squamous cell dysplasia and delayed differentiation with deletion of kruppel-like factor 4 in murine esophagus. Gastroenterology, 139, 171-181 e9.
    • (2010) Gastroenterology , vol.139 , pp. 171-181
    • Tetreault, M.P.1
  • 43
    • 78649698768 scopus 로고    scopus 로고
    • Klf4 overexpression activates epithelial cytokines and inflammation-mediated esophageal squamous cell cancer in mice
    • e9
    • Tetreault, M.P. et al. (2010) Klf4 overexpression activates epithelial cytokines and inflammation-mediated esophageal squamous cell cancer in mice. Gastroenterology, 139, 2124-2134 e9.
    • (2010) Gastroenterology , vol.139 , pp. 2124-2134
    • Tetreault, M.P.1
  • 44
    • 33644663235 scopus 로고    scopus 로고
    • Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages
    • Feinberg, M.W. et al. (2005) Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages. J. Biol. Chem., 280, 38247- 38258.
    • (2005) J. Biol. Chem. , vol.280 , pp. 38247-38258
    • Feinberg, M.W.1
  • 45
    • 45949099415 scopus 로고    scopus 로고
    • Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo
    • Alder, J.K. et al. (2008) Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo. J. Immunol., 180, 5645-5652.
    • (2008) J. Immunol. , vol.180 , pp. 5645-5652
    • Alder, J.K.1
  • 46
    • 67650550499 scopus 로고    scopus 로고
    • Chronic inflammation, the tumor microenvironment and carcinogenesis
    • Gonda, T.A. et al. (2009) Chronic inflammation, the tumor microenvironment and carcinogenesis. Cell Cycle, 8, 2005-2013.
    • (2009) Cell Cycle , vol.8 , pp. 2005-2013
    • Gonda, T.A.1
  • 47
    • 0029084423 scopus 로고
    • H-ras oncogene mutation spectra in B6C3F1 and C57BL/6 mouse liver tumors provide evidence for TCDD promotion of spontaneous and vinyl carbamate-initiated liver cells
    • Watson, M.A. et al. (1995) H-ras oncogene mutation spectra in B6C3F1 and C57BL/6 mouse liver tumors provide evidence for TCDD promotion of spontaneous and vinyl carbamate-initiated liver cells. Carcinogenesis, 16, 1705-1710.
    • (1995) Carcinogenesis , vol.16 , pp. 1705-1710
    • Watson, M.A.1
  • 48
    • 0032188887 scopus 로고    scopus 로고
    • Squamous cell hyperplastic foci: precursors of cutaneous papillomas induced in SENCAR mice by a two-stage carcinogenesis regimen
    • Binder, R.L. et al. (1998) Squamous cell hyperplastic foci: precursors of cutaneous papillomas induced in SENCAR mice by a two-stage carcinogenesis regimen. Cancer Res., 58, 4314-4323.
    • (1998) Cancer Res , vol.58 , pp. 4314-4323
    • Binder, R.L.1
  • 49
    • 0141993691 scopus 로고    scopus 로고
    • Cell cycle control, DNA damage checkpoints and cancer
    • Laiho, M. et al. (2003) Cell cycle control, DNA damage checkpoints and cancer. Ann. Med., 35, 391-397.
    • (2003) Ann. Med. , vol.35 , pp. 391-397
    • Laiho, M.1
  • 50
    • 0035900766 scopus 로고    scopus 로고
    • Kruppel-like factor 4 regulates laminin alpha 3A expression in mammary epithelial cells
    • Miller, K.A. et al. (2001) Kruppel-like factor 4 regulates laminin alpha 3A expression in mammary epithelial cells. J. Biol. Chem., 276, 42863- 42868.
    • (2001) J. Biol. Chem. , vol.276 , pp. 42863-42868
    • Miller, K.A.1
  • 51
    • 2542488138 scopus 로고    scopus 로고
    • The Kruppel-like KLF4 transcription factor, a novel regulator of urokinase receptor expression, drives synthesis of this binding site in colonic crypt luminal surface epithelial cells
    • Wang, H. et al. (2004) The Kruppel-like KLF4 transcription factor, a novel regulator of urokinase receptor expression, drives synthesis of this binding site in colonic crypt luminal surface epithelial cells. J. Biol. Chem., 279, 22674-22683.
    • (2004) J. Biol. Chem. , vol.279 , pp. 22674-22683
    • Wang, H.1
  • 52
    • 0037780740 scopus 로고    scopus 로고
    • Overexpression of Kruppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity
    • Dang, D.T. et al. (2003) Overexpression of Kruppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity. Oncogene, 22, 3424-3430.
    • (2003) Oncogene , vol.22 , pp. 3424-3430
    • Dang, D.T.1
  • 53
    • 83455224263 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: implications in cancer progression and metastasis
    • Gomes, L.R. et al. (2011) Epithelial-mesenchymal transition: implications in cancer progression and metastasis. Curr. Pharm. Biotechnol., 12, 1881- 1890.
    • (2011) Curr. Pharm. Biotechnol. , vol.12 , pp. 1881-1890
    • Gomes, L.R.1


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