메뉴 건너뛰기




Volumn 139, Issue 6, 2010, Pages 2135-2145

KLF4α up-regulation promotes cell cycle progression and reduces survival time of patients with pancreatic cancer

Author keywords

Cell Cycle Regulation; Pancreatic Cancer; Prognosis; Proliferation

Indexed keywords

AZD 3355; AZD 9343; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; KRUPPEL LIKE FACTOR 4; KRUPPEL LIKE FACTOR 4ALPHA; KRUPPEL LIKE FACTOR 4BETA; KRUPPEL LIKE FACTOR 4DELTA; KRUPPEL LIKE FACTOR 4GAMMA; MESSENGER RNA; UNCLASSIFIED DRUG;

EID: 78649710595     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.08.022     Document Type: Article
Times cited : (72)

References (35)
  • 1
    • 67650410937 scopus 로고    scopus 로고
    • American Cancer Society American Cancer Society Atlanta, GA
    • American Cancer Society Cancer facts & figures 2009 2009 American Cancer Society Atlanta, GA
    • (2009) Cancer Facts & Figures 2009
  • 2
    • 33646577163 scopus 로고    scopus 로고
    • Genetics and biology of pancreatic ductal adenocarcinoma
    • A.F. Hezel, A.C. Kimmelman, and B.Z. Stanger Genetics and biology of pancreatic ductal adenocarcinoma Genes Dev 20 2006 1218 1249
    • (2006) Genes Dev , vol.20 , pp. 1218-1249
    • Hezel, A.F.1    Kimmelman, A.C.2    Stanger, B.Z.3
  • 4
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • S. Jones, X. Zhang, and D.W. Parsons Core signaling pathways in human pancreatic cancers revealed by global genomic analyses Science 321 2008 1801 1806
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3
  • 5
    • 0032813661 scopus 로고    scopus 로고
    • Klf4 is a transcription factor required for establishing the barrier function of the skin
    • J.A. Segre, C. Bauer, and E. Fuchs Klf4 is a transcription factor required for establishing the barrier function of the skin Nat Genet 22 1999 356 360
    • (1999) Nat Genet , vol.22 , pp. 356-360
    • Segre, J.A.1    Bauer, C.2    Fuchs, E.3
  • 6
    • 0029829236 scopus 로고    scopus 로고
    • Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest
    • J.M. Shields, R.J. Christy, and V.W. Yang Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest J Biol Chem 271 1996 20009
    • (1996) J Biol Chem , vol.271 , pp. 20009
    • Shields, J.M.1    Christy, R.J.2    Yang, V.W.3
  • 7
    • 1042301369 scopus 로고    scopus 로고
    • Requirement of Kruppel-like factor 4 in preventing entry into mitosis following DNA damage
    • H.S. Yoon, and V.W. Yang Requirement of Kruppel-like factor 4 in preventing entry into mitosis following DNA damage J Biol Chem 279 2004 5035 5041
    • (2004) J Biol Chem , vol.279 , pp. 5035-5041
    • Yoon, H.S.1    Yang, V.W.2
  • 8
    • 28544438941 scopus 로고    scopus 로고
    • Destabilization of Kruppel-like factor 4 protein in response to serum stimulation involves the ubiquitin-proteasome pathway
    • Z.Y. Chen, X. Wang, and Y. Zhou Destabilization of Kruppel-like factor 4 protein in response to serum stimulation involves the ubiquitin-proteasome pathway Cancer Res 65 2005 10394 10400
    • (2005) Cancer Res , vol.65 , pp. 10394-10400
    • Chen, Z.Y.1    Wang, X.2    Zhou, Y.3
  • 9
    • 62049083112 scopus 로고    scopus 로고
    • Mouse embryonic fibroblasts null for the Krppel-like factor 4 gene are genetically unstable
    • E.G. Hagos, A.M. Ghaleb, and W.B. Dalton Mouse embryonic fibroblasts null for the Krppel-like factor 4 gene are genetically unstable Oncogene 28 2009 1197 1205
    • (2009) Oncogene , vol.28 , pp. 1197-1205
    • Hagos, E.G.1    Ghaleb, A.M.2    Dalton, W.B.3
  • 10
    • 17144401799 scopus 로고    scopus 로고
    • Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach
    • J.P. Katz, N. Perreault, and B.G. Goldstein Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach Gastroenterology 128 2005 935 945
    • (2005) Gastroenterology , vol.128 , pp. 935-945
    • Katz, J.P.1    Perreault, N.2    Goldstein, B.G.3
  • 11
    • 16844386207 scopus 로고    scopus 로고
    • Drastic down-regulation of Kruppel-like factor 4 expression is critical in human gastric cancer development and progression
    • D. Wei, W. Gong, and M. Kanai Drastic down-regulation of Kruppel-like factor 4 expression is critical in human gastric cancer development and progression Cancer Res 65 2005 2746 2754
    • (2005) Cancer Res , vol.65 , pp. 2746-2754
    • Wei, D.1    Gong, W.2    Kanai, M.3
  • 12
    • 0037780740 scopus 로고    scopus 로고
    • Overexpression of Kruppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity
    • D.T. Dang, X. Chen, and J. Feng Overexpression of Kruppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity Oncogene 22 2003 3424 3430
    • (2003) Oncogene , vol.22 , pp. 3424-3430
    • Dang, D.T.1    Chen, X.2    Feng, J.3
  • 13
    • 0042093653 scopus 로고    scopus 로고
    • Downregulation and growth inhibitory effect of epithelial-type Kruppel-like transcription factor KLF4, but not KLF5, in bladder cancer
    • S. Ohnishi, S. Ohnami, and F. Laub Downregulation and growth inhibitory effect of epithelial-type Kruppel-like transcription factor KLF4, but not KLF5, in bladder cancer Biochem Biophys Res Commun 308 2003 251 256
    • (2003) Biochem Biophys Res Commun , vol.308 , pp. 251-256
    • Ohnishi, S.1    Ohnami, S.2    Laub, F.3
  • 14
    • 4344635044 scopus 로고    scopus 로고
    • Identification of aberrantly methylated genes in association with adult T-cell leukemia
    • J. Yasunaga, Y. Taniguchi, and K. Nosaka Identification of aberrantly methylated genes in association with adult T-cell leukemia Cancer Res 64 2004 6002 6009
    • (2004) Cancer Res , vol.64 , pp. 6002-6009
    • Yasunaga, J.1    Taniguchi, Y.2    Nosaka, K.3
  • 15
    • 0842329848 scopus 로고    scopus 로고
    • Identification of Kruppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer
    • W. Zhao, I.M. Hisamuddin, and M.O. Nandan Identification of Kruppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer Oncogene 23 2004 395 402
    • (2004) Oncogene , vol.23 , pp. 395-402
    • Zhao, W.1    Hisamuddin, I.M.2    Nandan, M.O.3
  • 16
    • 0033693134 scopus 로고    scopus 로고
    • Increase of GKLF messenger RNA and protein expression during progression of breast cancer
    • K.W. Foster, A.R. Frost, and P. McKie-Bell Increase of GKLF messenger RNA and protein expression during progression of breast cancer Cancer Res 60 2000 6488 6495
    • (2000) Cancer Res , vol.60 , pp. 6488-6495
    • Foster, K.W.1    Frost, A.R.2    McKie-Bell, P.3
  • 17
    • 31144468445 scopus 로고    scopus 로고
    • KLF4 and PCNA identify stages of tumor initiation in a conditional model of cutaneous squamous epithelial neoplasia
    • C.C. Huang, Z. Liu, and X. Li KLF4 and PCNA identify stages of tumor initiation in a conditional model of cutaneous squamous epithelial neoplasia Cancer Biol Ther 4 2005 1401 1408
    • (2005) Cancer Biol Ther , vol.4 , pp. 1401-1408
    • Huang, C.C.1    Liu, Z.2    Li, X.3
  • 18
    • 30144442965 scopus 로고    scopus 로고
    • KLF4, p21 and context-dependent opposing forces in cancer
    • B.D. Rowland, and D.S. Peeper KLF4, p21 and context-dependent opposing forces in cancer Nat Rev Cancer 6 2006 11 23
    • (2006) Nat Rev Cancer , vol.6 , pp. 11-23
    • Rowland, B.D.1    Peeper, D.S.2
  • 19
    • 29844454865 scopus 로고    scopus 로고
    • Emerging role of KLF4 in human gastrointestinal cancer
    • D. Wei, M. Kanai, and S. Huang Emerging role of KLF4 in human gastrointestinal cancer Carcinogenesis 27 2006 23 31
    • (2006) Carcinogenesis , vol.27 , pp. 23-31
    • Wei, D.1    Kanai, M.2    Huang, S.3
  • 20
    • 49649101156 scopus 로고    scopus 로고
    • Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells
    • D. Wei, M. Kanai, and Z. Jia Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells Cancer Res 68 2008 4631 4639
    • (2008) Cancer Res , vol.68 , pp. 4631-4639
    • Wei, D.1    Kanai, M.2    Jia, Z.3
  • 21
    • 0037468567 scopus 로고    scopus 로고
    • A novel model system for studying the double-edged roles of nitric oxide production in pancreatic cancer growth and metastasis
    • B. Wang, D. Wei, and V.E. Crum A novel model system for studying the double-edged roles of nitric oxide production in pancreatic cancer growth and metastasis Oncogene 22 2003 1771 1782
    • (2003) Oncogene , vol.22 , pp. 1771-1782
    • Wang, B.1    Wei, D.2    Crum, V.E.3
  • 22
    • 1542615084 scopus 로고    scopus 로고
    • Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity
    • D. Wei, L. Wang, and Y. He Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity Cancer Res 64 2004 2030 2038
    • (2004) Cancer Res , vol.64 , pp. 2030-2038
    • Wei, D.1    Wang, L.2    He, Y.3
  • 23
    • 58149250649 scopus 로고    scopus 로고
    • Expression of MAP4K4 is associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma
    • J.J. Liang, H. Wang, and A. Rashid Expression of MAP4K4 is associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma Clin Cancer Res 14 2008 7043 7049
    • (2008) Clin Cancer Res , vol.14 , pp. 7043-7049
    • Liang, J.J.1    Wang, H.2    Rashid, A.3
  • 24
    • 0348223971 scopus 로고    scopus 로고
    • Transcription factor Sp1 expression is a significant predictor of survival in human gastric cancer
    • L. Wang, D. Wei, and S. Huang Transcription factor Sp1 expression is a significant predictor of survival in human gastric cancer Clin Cancer Res 9 2003 6371 6380
    • (2003) Clin Cancer Res , vol.9 , pp. 6371-6380
    • Wang, L.1    Wei, D.2    Huang, S.3
  • 25
    • 17144401799 scopus 로고    scopus 로고
    • Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach
    • J.P. Katz, N. Perreault, and B.G. Goldstein Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach Gastroenterology 128 2005 935 945
    • (2005) Gastroenterology , vol.128 , pp. 935-945
    • Katz, J.P.1    Perreault, N.2    Goldstein, B.G.3
  • 26
    • 0034674712 scopus 로고    scopus 로고
    • The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter
    • W. Zhang, D.E. Geiman, and J.M. Shields The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter J Biol Chem 275 2000 18391 18398
    • (2000) J Biol Chem , vol.275 , pp. 18391-18398
    • Zhang, W.1    Geiman, D.E.2    Shields, J.M.3
  • 27
    • 0034623068 scopus 로고    scopus 로고
    • The tissue-dependent keratin 19 gene transcription is regulated by GKLF/KLF4 and Sp1
    • F.H. Brembeck, and A.K. Rustgi The tissue-dependent keratin 19 gene transcription is regulated by GKLF/KLF4 and Sp1 J Biol Chem 275 2000 28230 28239
    • (2000) J Biol Chem , vol.275 , pp. 28230-28239
    • Brembeck, F.H.1    Rustgi, A.K.2
  • 28
    • 0034995919 scopus 로고    scopus 로고
    • The keratin 19 promoter is potent for cell-specific targeting of genes in transgenic mice
    • F.H. Brembeck, J. Moffett, and T.C. Wang The keratin 19 promoter is potent for cell-specific targeting of genes in transgenic mice Gastroenterology 120 2001 1720 1728
    • (2001) Gastroenterology , vol.120 , pp. 1720-1728
    • Brembeck, F.H.1    Moffett, J.2    Wang, T.C.3
  • 29
    • 16444378654 scopus 로고    scopus 로고
    • Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells
    • N.B. Prasad, A.V. Biankin, and N. Fukushima Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells Cancer Res 65 2005 1619 1626
    • (2005) Cancer Res , vol.65 , pp. 1619-1626
    • Prasad, N.B.1    Biankin, A.V.2    Fukushima, N.3
  • 30
    • 7444220147 scopus 로고    scopus 로고
    • Aberrant and alternative splicing in cancer
    • J.P. Venables Aberrant and alternative splicing in cancer Cancer Res 64 2004 7647 7654
    • (2004) Cancer Res , vol.64 , pp. 7647-7654
    • Venables, J.P.1
  • 31
    • 38449111154 scopus 로고    scopus 로고
    • Pre-mRNA splicing aberrations and cancer
    • C.A. Pettigrew, and M.A. Brown Pre-mRNA splicing aberrations and cancer Front Biosci 13 2008 1090 1105
    • (2008) Front Biosci , vol.13 , pp. 1090-1105
    • Pettigrew, C.A.1    Brown, M.A.2
  • 32
    • 13944252065 scopus 로고    scopus 로고
    • A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk
    • G. Narla, A. Difeo, and H.L. Reeves A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk Cancer Res 65 2005 1213 1222
    • (2005) Cancer Res , vol.65 , pp. 1213-1222
    • Narla, G.1    Difeo, A.2    Reeves, H.L.3
  • 33
    • 21344473196 scopus 로고    scopus 로고
    • Targeted inhibition of the KLF6 splice variant, KLF6 SV1, suppresses prostate cancer cell growth and spread
    • G. Narla, A. DiFeo, and S. Yao Targeted inhibition of the KLF6 splice variant, KLF6 SV1, suppresses prostate cancer cell growth and spread Cancer Res 65 2005 5761 5768
    • (2005) Cancer Res , vol.65 , pp. 5761-5768
    • Narla, G.1    Difeo, A.2    Yao, S.3
  • 34
    • 3042642783 scopus 로고    scopus 로고
    • Splice variants as cancer biomarkers
    • B.M. Brinkman Splice variants as cancer biomarkers Clin Biochem 37 2004 584 594
    • (2004) Clin Biochem , vol.37 , pp. 584-594
    • Brinkman, B.M.1
  • 35
    • 42949176197 scopus 로고    scopus 로고
    • Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma
    • S. Yea, G. Narla, and X. Zhao Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma Gastroenterology 134 2008 1521 1531
    • (2008) Gastroenterology , vol.134 , pp. 1521-1531
    • Yea, S.1    Narla, G.2    Zhao, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.