The role of KLF4 in UVB-induced murine skin tumor development and its correlation with cyclin D1, p53, and p21Waf1/Cip1 in epithelial tumors of the human skin

Archives of Dermatological Research

Volumn 303, Issue 3, 2011, Pages 191-200

  Choi, Woo Jin ^a   Youn, Sung Hwan ^a   Back, Jung Ho ^b   Park, Saebomi ^a   Park, Eun Joo ^a   Kim, Kwang Joong ^a   Park, Hye Rim ^a   Kim, Arianna L ^b   Kim, Kwang Ho ^a  

^a Hallym University   (South Korea)

^b NewYork Presbyterian Hospital   (United States)

Author keywords

Cyclin D1; Kruppel like factor 4; p21Waf1 Cip1; p53; Skin tumor

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; KRUPPEL LIKE FACTOR 4; PROTEIN P53;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HAIRLESS MOUSE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIATION EXPOSURE; SKIN CANCER; SKIN CARCINOGENESIS; ULTRAVIOLET RADIATION;

ANIMALS; BOWEN'S DISEASE; CELLS, CULTURED; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P21; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, HAIRLESS; SKIN; SKIN NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 79955829815     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00403-010-1101-0     Document Type: Article

References (33)

1. Athar M, Back JH, Tang X et al (2007) Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol 224(3):274-283 (Pubitemid 47575677)
2. Auepemkiate S, Boonyaphiphat P, Thongsuksai P (2002) p53 expression related to the aggressive infiltrative histopathological feature of basal cell carcinoma. Histopathology 40:568-573 (Pubitemid 34621816)
3. Baur JA, Sinclair DA (2006) Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 5(6):493-506 (Pubitemid 44136961)
4. Bishop JM (1991) Molecular themes in oncogenesis. Cell 64:235-248
5. Brash DE, Heffernan T, Ngheim P (2008) Carcinogenesis: ultraviolet radiation. In: Wolff K (ed) Fizpatrick's dermatology in general medicine, 7th edn. McGraw-Hill, New York, pp 999-1006
6. Chen YJ, Wu CY, Chang CC, Ma CJ, Li MC, Chen CM (2008) Nuclear Krüppel-like factor 4 expression is associated with human skin squamous cell carcinoma progression and metastasis. Cancer Biol Ther 7:777-782
7. Dang DT, Pevsner J, Yang VW (2000) The biology of the mammalian Kruppel-like family of transcription factors. Int J Biochem Cell Biol 32:1103-1121 (Pubitemid 32008299)
8. Dlugosz AA, Yuspa SH (2008) Carcinogenesis: chemical. In: Wolff K (ed) Fizpatrick's dermatology in general medicine, 7th edn. McGraw-Hill, New York, pp 986-995
9. El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75:817-825 (Pubitemid 23346378)
10. Evans PM, Liu C (2008) Roles of kruppel-like factor 4 in normal homeostasis, cancer, stem cells. Acta Biochim Biophys Sin 40:554-564 (Pubitemid 352009081)
11. Foster KW, Frost AR, McKie-Bell P, Lin CY, Engler JA, Grizzle WE, Ruppert JM (2000) Increase of GKLF messenger RNA and protein expression during progression of breast cancer. Cancer Res 60:6488-6495
12. Foster KW, Liu Z, Nail CD, Li X, Fitzgerald TJ, Bailey SK, Frost AR, Louro ID, Townes TM, Paterson AJ, Kudlow JE, Lobo-Ruppert SM, Ruppert JM (2005) Induction of KLF4 in basal keratinocytes blocks the proliferation- differentiation switch and initiates squamous epithelial dysplasia. Oncogene 24:1491-1500 (Pubitemid 40396079)
13. Huang CC, Liu Z, Li X, Bailey SK, Nail CD, Foster KW, Frost AR, Ruppert JM, Lobo-Ruppert SM (2005) KLF4 and PCNA identify stages of tumor initiation in a conditional model of cutaneous squamous epithelial neoplasia. Cancer Biol Ther 4:1401-1408 (Pubitemid 43131188)
14. Jaubert J, Cheng J, Segre JA (2003) Ectopic expression of kruppel like factor 4 (Klf4) accelerates formation of the epidermal permeability barrier. Development 130:2767-2777 (Pubitemid 37069591)
15. Kaczynski J, Cook T, Urrutia R (2003) Sp1-and Kruppel-like transcription factors. Genome Biol 4:206
16. Kan CE, Patton JT, Stark GR, Jackson MW (2007) p53-mediated growth suppression in response to nutlin-3 in cyclin D1-transformed cells occurs independently of p21. Cancer Res 67:9862-9868 (Pubitemid 47621234)
17. Katz JP, Perreault N, Goldstein BG, Actman L, McNally SR, Silberg DG, Furth EE, Kaestner KH (2005) Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach. Gastroenterology 28:935-945 (Pubitemid 40523545)
18. Leiter U, Garbe C (2008) Epidemiology of melanoma and nonmelanoma skin cancer - the role of sunlight. Adv Exp Med Biol 624:89-103
19. Levine AJ, Momand J, Finlay CA (1991) The p53 tumor suppressor gene. Nature 351:453-456
20. Liang SB, Furihata M, Takeuchi T, Iwata J, Chen BK, Sonobe H, Ohtsuki Y (2000) Overexpression of cyclin D1 in nonmelanocytic skin cancer. Virchow Arch 436:370-376 (Pubitemid 30219236)
21. Michieli P, Chedid M, Lin D, Pierce JH, Mercer WE, Givol D (1994) Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res 54:3391-3395 (Pubitemid 24225956)
22. Murias M, Jager W, Handler N et al (2005) Antioxidant, prooxidant and cytotoxic activity of hydroxylated resveratrol analogues: structure-activity relationship. Biochem Pharmacol 69(6):903-912 (Pubitemid 40312708)
23. Pandya AY, Talley LI, Frost AR, Fitzgerald TJ, Trivedi V, Chakravarthy M, Chhieng DC, Grizzle WE, Engler JA, Krontiras H, Bland KI, LoBuglio AF, Lobo-Ruppert SM, Ruppert JM (2004) Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancer. Clin Cancer Res 10:2709-2719 (Pubitemid 38509146)
24. Rehman I, Takata M, Wu YY, Rees JL (1996) Genetic change in actinic keratosis. Oncogene 12:2483-2490
25. Rowland BD, Bernards R, Peeper DS (2005) The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nat Cell Biol 7:1074-1082
26. Rowland BD, Peeper DS (2006) KLF4, p21 and context-dependent opposing forces in cancer. Nat Rev Cancer 6:11-23 (Pubitemid 43053649)
27. Segre JA, Bauer C, Fuchs E (1999) Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat Genet 22:356-360 (Pubitemid 29369526)
28. Shea CR, McNutt NS, Volkenandt M, Lugo J, Prioleau PG, Albino AP (1992) Overexpression of p53 protein in basal cell carcinoma of the skin. Am J Pathol 141:25-29
29. Suske G, Brudford E, Philipsen S (2005) Mammalian SP/KLF transcription factors: bring in the family. Genomics 85:551-556 (Pubitemid 40463690)
30. Wei D, Kanai M, Huang S, Xie K (2006) Emerging role of KLF4 in human gastrointestinal cancer. Carcinogenesis 27:23-31 (Pubitemid 43032979)
31. Xu J, Lü B, Xu F, Gu H, Fang Y, Huang Q, Lai M (2008) Dynamic down-regulation of Krüppel-like factor 4 in colorectal adenoma-carcinoma sequence. J Cancer Res Clin Oncol 134:891-898
32. Yang Y, Goldstein BG, Chao HH, Katz JP (2005) KLF4 and KLF5 regulate proliferation, apoptosis and invasion in esophageal cancer cells. Cancer Biol Ther 4:1216-1221
33. Yet SF, McA'Nulty MM, Folta SC, Yen HW, Yoshizumi M, Hsieh CM, Layne MD, Chin MT, Wang H, Perrella MA, Jain MK, Lee ME (1998) Human EZF, a Kruppel-like zinc Wnger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. J Biol Chem 273:1026-1031 (Pubitemid 28049199)