Maternal protein-and-energy restriction reduces the developmental toxicity of cyclophosphamide and hydroxyurea in rats

Toxicology

Volumn 179, Issue 1-2, 2002, Pages 137-149

  Chahoud, Ibrahim ^a   Kuriyama, Sérgio N ^b   Paumgartten, Francisco J R ^b  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

2H 1,3,2 Oxazaphosphorin 2 amine, N,N bis(2 chloroethyl)tetrahydro 2 oxide; Antineoplasic drugs; Hydroxyurea; Malnutrition; Maternal toxicity; Teratogenicity

Indexed keywords

CYCLOPHOSPHAMIDE; HYDROXYUREA; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; FEEDING; FEMALE; FETUS; FETUS WEIGHT; FOOD INTAKE; LETHALITY; MALE; METHODOLOGY; NONHUMAN; PREGNANCY; PREGNANCY COMPLICATION; PRIORITY JOURNAL; PROTEIN CALORIE MALNUTRITION; RAT; STERNUM; TERATOGENESIS; WEIGHT GAIN;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, ALKYLATING; BODY WEIGHT; CYCLOPHOSPHAMIDE; DIET; DIETARY CARBOHYDRATES; EMBRYO; FEMALE; FETUS; HYDROXYUREA; MALE; PLACENTA; PLACENTAL INSUFFICIENCY; PREGNANCY; PROTEIN-ENERGY MALNUTRITION; RATS; RATS, WISTAR; WEIGHT GAIN;

EID: 0037200770     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00373-6     Document Type: Article

References (27)

1. Chahoud I., Ligensa A., Dietzel L., Faqi A.S. Correlation between maternal toxicity and embryo/fetal effects. Reprod. Toxicol. 13:1999;375-381.
2. Da-Silva V.A., Riul T.R., Golovattei M.A.R., Paumgartten F.J.R. Ethanol embryotoxicity in malnourished rats. Nutr. Rep. Int. 36:1987;887-895.
3. Da-Silva V.A., Malheiros L.R., Paumgartten F.J.R., SaRego M.M., Riul T.R., Golovattei M.A.R. Developmental toxicity of in utero exposure to toluene on malnourished and well-nourished rats. Toxicology. 64:1990;155-168.
4. Dawson A.A. A note on the staining of the skeleton of cleared specimen with alizarin red S. Stain Technol. 1:1926;123-124.
5. DeCarvalho R.R., Delgado I.F., Souza C.A.M., Chahoud I., Paumgartten F.J.R. Embryotoxicity of methanol in well-nourished and malnourished rats. Braz. J. Med. Biol. Res. 27:1994;2915-2923.
6. DeSesso J.M., Goeringer G.C. The nature of the embryo-protective interaction of propyl gallate with hydroxyurea. Reprod. Toxicol. 4:1990a;145-152.
7. DeSesso J.M., Goeringer G.C. Ethoxyquin and nordihydroguaiaretic acid reduce hydroxyurea developmental toxicity. Reprod. Toxicol. 4:1990b;267-275.
8. DeSesso J.M., Scialli A.R., Goeringer G.C. D-Mannitol, a specific hydroxyl free radical scavenger, reduces the developmental toxicity of hydroxyurea in rabbits. Teratology. 49:1994;159-248.
9. Ellis W.G., Semple J.L., Hoogenboom E.R., Kavlock R.J., Zeman F.J. Benomyl-induced craniocerebral anomalies in fetuses of adequately nourished and protein-deprived rats. Teratog. Carcinog. Mutag. 7:1987;357-375.
10. Kavlock R.J., Chernoff N., Rogers E.H. The effect of acute maternal toxicity on fetal development in the mouse. Teratog. Carcinog. Mutag. 5:1985;3-13.
11. Hamed M.R., Al-Assy Y.S., Ezzeldin E. Influence of protein malnutrition on teratogenicity of acetylsalicylic acid in rats. Hum. Exp. Toxicol. 13:1994;83-88.
12. Khera K.S. Maternal toxicity - a possible factor in fetal malformations in mice. Teratology. 29:1984;411-416.
13. Kritchevsky D. The effect of over- and undernutrition on cancer. Eur. J. Cancer Prev. 4:1995;445-451.
14. Kuriyama S.N., DeOliveira A.C.A.X., Fidalgo-Neto A.A., Paumgartten F.J.R. Effects of pregnancy and protein-energy malnutrition on monooxygenase O-dealkylation activity in rat liver microsomes. Braz. J. Med. Biol. Res. 33:2000;103-109.
15. MacDanell R.E., McLean A.E.M. Role of nutritional status in drug metabolism and toxicity. Sidransky H., Nutritional Pathology. Pathobiochemistry of Dietary Imbalances. 1985;321-356 Marcel Dekker, New York.
16. Malheiros L.R., Paumgartten F.J.R., Riul T.R., DaSilva V.A. Protein-energy malnutrition increases teratogenicity of hypervitaminosis A in rats. Braz. J. Med. Biol. Res. 21:1988;659-662.
17. Mayura K., Hayes A.W., Berndt W.O. Effects of dietary protein on teratogenicity of ochratoxin A in rats. Toxicology. 27:1983;147-157.
18. Millicovsky G., DeSesso J.M., Clark K.E., Kleinman L.I. Effects of hydroxyurea on maternal hemodynamics during pregnancy: a maternally mediated mechanism of embryotoxicity. Am. J. Obstet. Gynecol. 140:1981;747-752.
19. Nolen G.A. The effects of various levels of dietary protein on retinoic acid-induced teratogenicity in rats. Teratology. 5:1972;143-152.
20. Salewski E. Färbemethoden zum makroskopischen Nachweis von Implantationsstellen am Uterus der Ratte. Naunyn-Schmiedeberg's Arch. Exp. Pathol. Pharmakol. 247:1964;367.
21. Scott W.J., Ritter E.J., Wilson J.G. DNA synthesis inhibition and cell death associated with hydroxyurea teratogenesis in rat embryos. Dev. Biol. 26:1971;306-315.
22. Singh J., Aggison L. Jr, Moore-Cheatum L. Teratogenicity and developmental toxicity of carbon monoxide in protein-deficient mice. Teratology. 48:1993;149-159.
23. Sohal R.S., Weindruch R. Oxidative stress, caloric restriction, and aging. Science. 273:(5271):1996;59-63.
24. Wachsman J.T. The beneficial effects of dietary restriction: reduced oxidative damage and enhanced apoptosis. Mutat. Res. 350:1996;25-34.
25. Yu L.J., Drewers P., Gustafsson K., Brain E.G.C., Hecht J.E.D., Waxman D.J. In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: Impact on phamacokinetics and antitumor activity. J. Pharmacol. Exp. Ther. 288:1999;928-937.
26. Zeman F.J., Hoogenboom E.R., Chase-Deesing C., Kavlock R.J., Semple J.L. Effects on the fetus of maternal nitrofen exposure in the protein-deprived rat. Toxicology. 38:1986a;55-68.
27. Zeman F.J., Hoogenboom E.R., Kavlock R.J., Semple J.L. Effects on the fetus of maternal benomyl exposure in the protein-deprived rat. J. Toxicol. Environ. Health. 17:1986b;405-417.