Teratogenic effects of the demethylating agent 5-aza-2'-deoxycytidine in the Swiss Webster mouse

Toxicology

Volumn 112, Issue 1, 1996, Pages 37-43

  Branch, Stacy ^a   Francis, Bettina M ^b   Brownie, Cecil F ^a   Chernoff, Neil ^c  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

5 Aza 2' deoxycytidine (DNA demethylating agent); Intraperitoneal injection; Limb defects; Swiss Webster (CD 1) mice; Teratogenicity

Indexed keywords

5 AZA 2' DEOXYCYTIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; EMBRYO; FETUS; GENE EXPRESSION; LIMB DEFECT; MOUSE; NONHUMAN; PRIORITY JOURNAL; TERATOGENICITY;

ANIMALIA;

EID: 0030221389     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0300-483X(96)88183-2     Document Type: Article

References (26)

1. Bird, A.P. (1978) Use of restriction enzymes to study eukaryotic DNA methylation: II. The symmetry of methylated sites supports semi-conservative copying of the methylation pattern. J. Mol. Biol. 118, 49-60.
2. Boyes, J. and Bird, A. (1991) DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein. Cell. 64, 1123-1134.
3. Branch, S., Rogers, J.M., Brownie, C.F. and Chernoff, N. (1996) Supernumerary lumbar rib: manifestation of basic alteration in embryonic development of ribs. J. Appl. Toxicol., 16, 115-119.
4. Chabot, G.G., Rivard, G.E. and Momparler, R.L. (1983) Plasma and cerebrospinal fluid pharmacokinetics of 5-aza-2′-deoxycytidine in rabbits and dogs. Cancer Res. 43, 592-597.
5. Dostal, M. and Jelinek, R. (1979) Embryotoxicity of transplacentally and intraamniotically administered 6-aza-uridine in mice. Teratology 19, 143-148.
6. Holliday, R. and Grigg, G.W. (1993) DNA methylation and mutation. Mutat. Res. 285, 61-67.
7. Jones, P.A. and Taylor, S.M. (1980) Cellular differentiation, cytidine analogs and DNA methylation. Cell 20, 85-93.
8. Kafri, T., Ariel, M., Brandeis, M., Shemer, R., Urven, L., McCarrey, J., Cedar, H. and Razin, A (1992) Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line. Genes Dev. 6, 705-714.
9. Kessel, M. (1992) Respecification of vertebral identities by retinoic acid. Development 115, 487-501.
10. Li, E., Bestor, T.H and Jaenisch, R. (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell. 69, 915-926.
11. pGs. Cell 58, 499-507.
12. Michalowsky, L.A. and Jones P.A. (1989) DNA methylation and differentiation. Environ. Health Perspect. 80, 189-197.
13. Monk, M., Boubelik, M. and Lehnart, S. (1987) Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. Development 99, 371-382.
14. Peterson, R.L., Papenbrock, T., Davda, M.M. and Awgulewitsch, A. (1994) The murine Hoxc cluster contains five neighboring AbdB-related Hox genes that show unique spatially coordinated expression in posterior embryonic subregions. Mech. Dev. 47, 253-260.
15. Rogers, J.M., Francis, B.M., Sulik, K.K., Alles, A.J., Massaro, E.J., Zucker, R.M., Elstein, K.H., Rosen, M.B. and Chernoff, N. (1994) Cell death and cell cycle perturbation in the developmental toxicity of the demethylation agent, 5-aza-2′-deoxycytidine. Teratology 50, 332-339.
16. Rosen, M.B., House, H.S., Francis, B.M. and Chernoff, N. (1990) Teratogenicity of 5-azacytidine in the sprague-dawley rat. J. Toxicol. Environ. Health 29, 201-210.
17. SAS Institute, Inc. (1990) 'SAS User's Guide' Cary, NC: SAS Institute.
18. Schmahl, W., Torok, P. and Kriegel, H. (1984) Embryotoxicity of 5-azacytidine in mice. Phase-and dose-specificity studes. Arch. Toxicol. 55, 143-147.
19. Shemer, R., Eisenberg, S., Breslow, J.L. and Razin, A. (1991a) Methylation Patterns of the human ApoA-I/C-III/A-IV gene cluster in adult and embryonic tissues suggest dynamic changes in methylation during development. J. Biol. Chem. 266, 23676-23681.
20. Shemer, R., Kafri, T., O'Connell, A., Eisenberg, S., Breslow, J.L. and Razin, A. (1991b) Methylation changes in the apolipoprotein AI gene during embryoic development of the mouse. Proc. Natl. Acad. Sci. USA. 88, 11300-11304.
21. Tabin, C.J. (1989) Isolation of potential vertebrate limb-identity genes. Development 105, 813-820.
22. Tawa, R., Ono, T., Kurishita, A., Okada, S. and Hirose, S. (1990) Changes of DNA methylation level during pre-and postnatal periods in mice. Differentiation 45, 44-48.
23. Venolia, L., Gartler, S.M., Wassman, E.R., Yen, P., Mohandas, T. and Shapiro, L.J. (1982) Transformation with DNA from 5-azacytidine-reactivated X chromosomes. Proc. Natl. Acad. Sci. USA. 79, 2352-2354.
24. Veslỳ, J. and Čihàk, A. (1980) 5-aza-2′-deoxycytidine: precliical studies in mice. Neoplasma 27, 113-119.
25. Veslỳ, J. and Čihàk, A. (1978) 5-azacytidine: mechanism of action and bioiogical effects in mammalian cells. Pharm. Therap. 2, 813-840.
26. Wolf, S.F., Jolly, J.D., Lunnen, K.D., Freidmann, T. and Migeon, B.R. (1984) Methylation of the hypoxanthine phosphoribosyltransferase locus on the human X chromosome: implications for X-chromosome inactiviation. Proc. Natl. Acad. Sci. USA. 81, 2806-2810.