SB-236057: Critical window of sensitivity study and embryopathy of a potent musculoskeletal teratogen

Birth Defects Research Part A - Clinical and Molecular Teratology

Volumn 70, Issue 10, 2004, Pages 773-788

  Augustine Rauch, Karen A ^a,b   Zhang, Qin J ^a   Posobiec, Lorraine ^a   Mirabile, Rosanna ^a   DeBoer, Lisa S ^a   Solomon, Howard M ^a   Wier, Patrick J ^a  

^a GLAXOSMITHKLINE   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; SB 236057; SEROTONIN 1B AGONIST; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG POTENCY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYOPATHY; ENZYME ANALYSIS; FEMALE; FETUS; FETUS DEVELOPMENT; FETUS MALFORMATION; HISTOCHEMISTRY; LIMB; MESODERM; MOUSE; MYOTOME; NERVE CELL DIFFERENTIATION; NERVE FIBER; NONHUMAN; NOTOCHORD; PERIPHERAL NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; RIB MALFORMATION; RODENT; SIGNAL TRANSDUCTION; SKELETON MALFORMATION; TERATOGENICITY; VERTEBRA MALFORMATION;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; FEMALE; IN SITU HYBRIDIZATION; INDOLES; MUSCULOSKELETAL ABNORMALITIES; PREGNANCY; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; TERATOGENS;

ERINACEIDAE; ORYCTOLAGUS CUNICULUS; RODENTIA;

EID: 8144221260     PISSN: 15420752     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdra.20079     Document Type: Article

References (27)

1. Arndt M, Bank U, Frank K, et al. 1999. R-esp1, a rat homologue of Drosophila groucho, is differentially expressed after optic nerve crush and mediates NGF-induced survival of PC12 cells. FEBS Lett 457:246-250.
2. Braun T, Rudnicki MA, Arnold HH, Jaenisch R. 1992. Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death. Cell 71:369-382.
3. Bresnick EH, Chu J, Christensen HM, et al. 2000. Linking notch signaling, chromatin remodeling, and T-cell leukemogenesis. J Cell Bio 35(Suppl): 46-53.
4. Brunner D, Buhot MC, Hen R, Hofer M. 1999. Anxiety, motor activation, and maternal-infant interactions in 5-HT1B knockout mice. Behav Neurosci 113:587-601.
5. Burgess R, Rawis A, Brown D, et al. 1996. Requirement of the paraxis gene for somite formation and musculoskeletal patterning. Nature 384:570-573.
6. Choudhury BK, Kim J, Kung HF, Li S S-L. 1997. Cloning and developmental expression of Xenopus cDNAs encoding the enhancer of split groucho and related proteins. Gene 195:41-48.
7. Conway SJ, Henderson DJ, Copp AJ. 1997. Pax3 is required for cardiac neural crest migration in the mouse: evidence from the splotch (Sp2H) mutant. Development 124(Suppl):505-514.
8. Davis RL, Turner DL. 2001. Vertebrate hairy and enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning. Oncogene 20:8342-8357.
9. Dickman ED, Rogers R, Conway SJ. 1999. Abnormal skeletogenesis occurs coincident with increased apoptosis in the splotch (Sp2H) mutant: putative roles for Pax3 and PDGFR alpha in rib patterning. Anat Rec 255:353-361.
10. Fan CM, Tessier Lavigne M. 1994. Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homologue. Cell 79:1175-1186.
11. Filosa S, Riveraperez JA, Gomez AP, et al. 1997. Goosecoid and HNF3-B genetically interact to regulate neural tube patterning during mouse embryogenesis. Development 124:2843-2854.
12. Franz T, Kothary R, Surani MAH, Halata Z, et al. 1993. The splotch mutation interferes with muscle development in the limbs. Anat Embryol (Berl) 187:153-160.
13. Gossler A, Hrabe de Angelis M. 1998. Somitogenesis. Curr Top Dev Biol 38:225-287.
14. Goulding M, Paquette A. 1994. Pax genes and neural tube defects in the mouse. Ciba Found Symp 181:103-113.
15. Greco TL, Takada S, Newhouse MM, et al. 1996. Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. Genes Dev 10:313-324.
16. Henderson DJ, Conway SJ, Copp AJ. 1999. Rib truncations and fusions in the Sp2H mouse reveal a role for Pax3 in specification of the ventrolateral and posterior parts of the somite. Dev Biol 209:143-158.
17. Herrmann BG. 1991. Expression pattern of the Brachyury gene in wholemount Twis/Twis mutant embryos. Development 113(Suppl):913-917.
18. Jackson CD, Fishbein L. 1986. A toxicological review of beta-adrenergic blockers. Fundam Appl Toxicol 6:395-422.
19. Jarriault S, Brou C, Logeat F, et al. 1995. Signaling downstream of activated mammalian notch. Nature 377:355-358.
20. Karsenty G. Genetics of skeletogenesis. 1998. Dev Genet 22:301-313.
21. Middlemiss DN. 1984. Stereoselective blockade at [3H]5-HT binding sites and at the 5-HT autoreceptor by propranolol. Eur J Pharm 101:289-293.
22. Nehlig A, Debry G. 1994. Potential teratogenic and neurodevelopmental consequences of coffee and caffeine exposure: a review on human and animal data. Neurotoxicol Teratol 16:531-543.
23. Paroush Z, Finley RL, Jr, Kidd T, et al. 1994. Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins. Cell 70:805-815.
24. Portin P. 2002. General outlines of the molecular genetics of the Notch signalling pathway in Drosophila melanogaster: a review. Hereditas 136:89-96.
25. Solomon HM, Posobiec LM, Augustine KA, et al. 2003. SB-236057 with potent teratogenicity in rats, rabbits and mice. Birth Defects Res Part A Clin Mol Teratol 67:357.
26. Wilkinson DG, Bhatt S, Herrmann BG. 1990. Expression pattern of the mouse T gene and its role in mesoderm formation. Nature 343:657-659.
27. Williams BA, Ordahl CP. 1994. Pax-3 expression in segmental mesoderm marks early stages in myogenic cell specification. Development 120:785-796.