Nelfinavir inhibits regulated intramembrane proteolysis of sterol regulatory element binding protein-1 and activating transcription factor 6 in castration-resistant prostate cancer

FEBS Journal

Volumn 279, Issue 13, 2012, Pages 2399-2411

  Guan, Min ^a   Fousek, Kristen ^a   Chow, Warren A ^a,b  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b Department of Medical Oncology and Therapeutics Research ^*  (United States)

Author keywords

Activating transcription factor 6 (ATF6); Nelfinavir; Prostate cancer; Sterol regulatory element binding protein 1 (SREBP 1)

Indexed keywords

1,10 PHENANTHROLINE; 3,4 DICHLOROISOCOUMARIN; ACTIVATING TRANSCRIPTION FACTOR 6; ANDROGEN RECEPTOR; DRUG METABOLITE; ENHANCED GREEN FLUORESCENT PROTEIN; FATTY ACID SYNTHASE; HYBRID PROTEIN; HYDROXYCHLOROQUINE; HYDROXYL T BUTYLAMIDE; M 8; NELFINAVIR; PROTEIN; PROTEINASE; RAPAMYCIN; SITE 1 PROTEASE; SITE 2 PROTEASE; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL; CASTRATION RESISTANT PROSTATE CANCER; CELL DEATH; CELL NUCLEUS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG POTENTIATION; DRUG TARGETING; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; GENE SILENCING; HUMAN; HUMAN CELL; LIPOSARCOMA; PHENOTYPE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN TRANSPORT; UNFOLDED PROTEIN RESPONSE; WESTERN BLOTTING;

ACTIVATING TRANSCRIPTION FACTOR 6; APOPTOSIS; AUTOPHAGY; BLOTTING, WESTERN; CASPASES; CASTRATION; CELL NUCLEUS; CELL PROLIFERATION; ENDOPLASMIC RETICULUM STRESS; FATTY ACID SYNTHETASE COMPLEX, TYPE I; GREEN FLUORESCENT PROTEINS; HIV PROTEASE INHIBITORS; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; METALLOENDOPEPTIDASES; NELFINAVIR; PROPROTEIN CONVERTASES; PROSTATIC NEOPLASMS; PROTEIN TRANSPORT; PROTEOLYSIS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ANDROGEN; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SERINE ENDOPEPTIDASES; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 84862580422     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2012.08619.x     Document Type: Article

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