Simultaneous screening of glutathione and cyanide adducts using precursor ion and neutral loss scans-dependent product ion spectral acquisition and data mining tools

Journal of the American Society for Mass Spectrometry

Volumn 23, Issue 5, 2012, Pages 964-976

  Jian, Wenying ^a   Liu, Hua Fen ^b   Zhao, Weiping ^c   Jones, Elliott ^b   Zhu, Mingshe ^c  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b MDS SCIEX   (Canada)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

Cyanide adducts; Glutathione adducts; Nefazodone; Neutral loss scan; Polarity switch; Precursor ion scan; Qtrap; Reactive metabolites; Triple quadrupole linear ion trap mass spectrometry

Indexed keywords

GLUTATHIONES; LINEAR ION TRAP; NEFAZODONE; NEUTRAL LOSS; POLARITY SWITCHES; PRECURSOR-ION SCAN; QTRAP; REACTIVE METABOLITES;

BIOMOLECULES; CYANIDES; DATA MINING; ISOTOPES; MASS SPECTROMETRY; MERGERS AND ACQUISITIONS; METABOLITES; PEPTIDES;

IONS;

DRUG METABOLITE; GLUTATHIONE; NEFAZODONE; POTASSIUM CYANIDE;

ANIMAL CELL; ARTICLE; CHEMICAL STRUCTURE; DATA MINING; DRUG SCREENING; ION TRAP MASS SPECTROMETRY; LIVER MICROSOME; MOLECULAR WEIGHT; NONHUMAN; RAT;

ANIMALS; DATA MINING; DRUG DISCOVERY; GLUTATHIONE; HIGH-THROUGHPUT SCREENING ASSAYS; MASS SPECTROMETRY; MICROSOMES, LIVER; MODELS, CHEMICAL; MOLECULAR WEIGHT; PHARMACEUTICAL PREPARATIONS; POTASSIUM CYANIDE; RATS;

EID: 84862562247     PISSN: 10440305     EISSN: 18791123     Source Type: Journal    
DOI: 10.1007/s13361-012-0354-6     Document Type: Article

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