Potent inhibition of dinuclear zinc(II) peptidase, an aminopeptidase from Aeromonas proteolytica, by 8-quinolinol derivatives: Inhibitor design based on Zn 2+ fluorophores, kinetic, and X-ray crystallographic study

Journal of Biological Inorganic Chemistry

Volumn 17, Issue 4, 2012, Pages 517-529

  Hanaya, Kengo ^a   Suetsugu, Miho ^a   Saijo, Shinya ^a,b   Yamato, Ichiro ^a   Aoki, Shin ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b 1 1 1 Kouto ^*  (Japan)

Author keywords

8 Quinolinol; Aminopeptidase; Dinuclear Zn2+ hydrolases; Inhibitor

Indexed keywords

1,2,3,4 TETRAHYDRO 8 HYDROXYQUINOLINE; 2 (2 HYDROXYPHENYL)PYRIDINE; 5 HALO 8 HYDROXYQUINOLINE; 5 IODO 8 HYDROXYQUINOLINE; 5 N,N DIMETHYLAMINOSULFONYL 8 HYDROXYQUINOLINE; 5,7 DIHALO 8 HYDROXYQUINOLINE; 8 HYDROXYQUINOLINE 3 METHYLQUINOLINE; 8 QUINOLINOL DERIVATIVE; ACETAZOLAMIDE; ALKALINE PHOSPHATASE; AMASTATIN; AMINOPEPTIDASE; CAPTOPRIL; DINUCLEAR ZINC PEPTIDASE; HYDROXIDE; HYPOXANTHINE; NITROGEN; NITROXOLINE; UNCLASSIFIED DRUG; ZINC ION;

AEROMONAS; AEROMONAS PROTEOLYTICA; ARTICLE; COMPETITIVE INHIBITION; COMPUTER MODEL; COMPUTER PROGRAM; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; FLUORESCENCE ANALYSIS; NONHUMAN; PH; PRIORITY JOURNAL; TITRIMETRY; X RAY CRYSTALLOGRAPHY;

AEROMONAS; AMINOPEPTIDASES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; OXYQUINOLINE; QUANTUM THEORY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC;

VIBRIO PROTEOLYTICUS;

EID: 84862536578     PISSN: 09498257     EISSN: 14321327     Source Type: Journal    
DOI: 10.1007/s00775-012-0873-4     Document Type: Article

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