Estradiol acts as a germ cell survival factor in the human testis in vitro

Journal of Clinical Endocrinology and Metabolism

Volumn 85, Issue 5, 2000, Pages 2057-2067

  Pentikäinen, Virve ^a   Erkkilä, Krista ^a   Suomalainen, Laura ^a   Parvinen, Martti ^b   Dunkel, Leo ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; TESTOSTERONE;

ADULT; AGED; APOPTOSIS; ARTICLE; CELL SURVIVAL; GERM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MALE; MALE FERTILITY; MALE GENITAL SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPERMATID; SPERMATOCYTE; TESTIS FUNCTION;

ADULT; AGED; ANIMALS; APOPTOSIS; CELL SURVIVAL; EPITHELIAL CELLS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HUMANS; MALE; MICE; MICE, KNOCKOUT; MIDDLE AGED; MODELS, BIOLOGICAL; PROSTATIC NEOPLASMS; RECEPTORS, ESTROGEN; SEMINIFEROUS TUBULES; SPERMATOZOA;

EID: 0034457552     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.85.5.2057     Document Type: Article

References (64)

1. Evidence for decreasing quality of semen during past 50 years
2. Declining sperm counts in men: Is there an endocrine cause?
3. Development and cellular localization of rat testicular aromatase activity
4. Cellular localization of rat testicular aromatase activity during development
5. Human testicular aromatase: Immunocytochemical and biochemical studies
6. Germ cells of the mouse testis express P450 aromatase
7. Expression and immunolocalization of functional cytochrome P450 aromatase in mature rat testicular cells
8. Immunohistochemical localization of cytochrome P450 aromatase in equine gonads
9. arom in the hokkaido brown bear (Ursus arctos yesoensis) testis
10. Rooster testicular germ cells and epididymal sperm contain P450 aromatase
11. Sequence and expression of human estrogen receptor complementary DNA
12. Human oestrogen receptor cDNA: Sequence, expression and homology to v-erb-A
13. Cloning of a novel estrogen receptor expressed in rat prostate and ovary
14. ERβ: Identification and characterization of a novel human estrogen receptor
15. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β
16. Immunolocalisation of oestrogen receptor-α within the testis and excurrent ducts of the rat and marmoset monkey from perinatal life to adulthood
17. Estrogen receptor expression in developing epididymis, efferent ductules, and other male reproductive organs
18. Immunolocalization of receptors for androgen and estrogen in male caprine reproductive tissues: Unique distribution of estrogen receptors in efferent ductule epithelium
19. Estrogen receptor in the ductuli efferentes, epididymis, and testis of rhesus and cynomolgus macaques
20. Estrogen receptors in the human prostate, seminal vesicle, epididymis, testis, and genital skin: A marker for estrogen-responsive tissues?
21. Human estrogen receptor β-gene structure, chromosomal localization, and expression pattern
22. Transcription and translation of estrogen receptor-β in the male reproductive tract of estrogen receptor-α knock-out and wild-type mice
23. Ontogeny of estrogen receptor-β expression in rat testis
24. Expression of oestrogen receptor β (ER β) occurs in multiple cell types, including some germ cells, in the rat testis
25. Identification and characterization of a novel functional estrogen receptor on human sperm membrane that interferes with progesterone effects
26. Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility
27. A role for oestrogens in the male reproductive system
28. Impairment of spermatogenesis in mice lacking a functional aromatase (cyp 19) gene
29. Clinical aspects of male germ cell apoptosis during testis development and spermatogenesis
30. Testosterone regulates apoptosis in adult human seminiferous tubules
31. Identification of living spermatogenic cells of the mouse by transillumination-phase contrast microscopic technique for 'in situ' analyses of DNA polymerase activities
32. The cytology of the human testis
33. Direct inhibition of Leydig cell function by estradiol
34. The effect of estradiol on testicular testosterone biosynthesis
35. Modulation of Leydig cell androgen biosynthesis and cytochrome P-450 levels during estrogen treatment and human chorionic gonadotropin-induced desensitization
36. Studies of the human testis. III. Effect of estrogen on testosterone formation in human testis in vitro
37. RNA synthesis in the Leydig cells of the mature rat: Effect of oestradiol-17β
38. Acquisition of estradiol-mediated regulatory mechanism of steroidogenesis in cultured fetal rat Leydig cells
39. Direct inhibitory effects of estrogens on rat Leydig cells in vitro
40. Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites
41. Estrogen hits the surface
42. Nitric oxide as a bifimctional regulator of apoptosis
43. The secretion of estrone and estradiol-17 by human testis
44. Secretion of unconjugated androgens and estrogens by the normal and abnormal human testis before and after human chorionic gonadotropin
45. The concentration of oestrone and oestradiol-17 in spermatic venous blood in man
46. Effects of estrogens on the testosterone levels of peripheral and spermatic vein blood in patients with prostatic cancer
47. Testosterone concentration in different functional compartments of the male reproductive tract
48. Concentrations of unconjugated 5α-androstane-3α,17β-diol and 5α-androstane-3β,17β-diol and their precursor in human testicular tissue. Comparison with testosterone, 5α-dihydrotestosterone, estradiol-17β, and with steroid concentrations in human epididymis
49. Testosterone concentrations in testes of normal men: Effects of testosterone propionate administration
50. Immunocytochemical localization of androgen receptor with polyclonal antibody in paraffin-embedded human tissues
51. Immunohistochemical detection of the androgen receptor with monoclonal antibody F39.4 in routinely processed, paraffin-embedded human tissues after microwave pre-treatment
52. Androgen receptor distribution in rat testis: New implications for androgen regulation of spermatogenesis
53. Immunohistochemical localization of androgen receptor in mouse testicular germ cells during fetal and postnatal development
54. Androgen receptor distribution in adult human testis
55. Immunohistochemical localization of the androgen receptor in rat and human tissues
56. Immunohistochemical localization of androgen receptors in the rat testis: Evidence for stage-dependent expression and regulation by androgens
57. Androgen receptor immunostaining and its tissue distribution in formalin-fixed, paraffin-embedded sections after microwave treatment
58. Androgen receptor expression in human tissues: An immunohistochemical study
59. Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene
60. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man
61. Effect of testosterone and estradiol in a man with aromatase deficiency
62. Generation and reproductive phenotypes of mice lacking estrogen receptor β
63. Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene
64. The cycle of the seminiferous epithelium in man