The mechanosensory role of primary cilia in vascular hypertension

International Journal of Vascular Medicine

Volumn 2011, Issue , 2011, Pages

  Nauli, Surya M ^a   Jin, Xingjian ^a   Hierck, Beerend P ^b  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84862516675     PISSN: 20902824     EISSN: 20902832     Source Type: Journal    
DOI: 10.1155/2011/376281     Document Type: Review

References (108)

1. Krimer L. S., Christopher Muly E. III, Williams G. V., Goldman-Rakic P. S., Dopaminergic regulation of cerebral cortical microcirculation. Nature Neuroscience 1998 1 4 286 289 2-s2.0-0032129731
2. Taylor E. W., Jordan D., Coote J. H., Central control of the cardiovascular and respiratory systems and their interactions in vertebrates. Physiological Reviews 1999 79 3 855 916 2-s2.0-0032778261 (Pubitemid 29330174)
3. Korner P. I., Head G. A., Badoer E., Bobik A., Angus J. A., Role of brain amine transmitters and some neuromodulators in blood pressure, heart rate, and baroreflex control. Journal of Cardiovascular Pharmacology 1987 10 12 S26 S32 2-s2.0-0023624898
4. Luff S. E., Ultrastructure of sympathetic axons and their structural relationship with vascular smooth muscle. Anatomy and Embryology 1996 193 6 515 531 2-s2.0-0030003908 (Pubitemid 26162308)
5. Sloan E. K., Capitanio J. P., Cole S. W., Stress-induced remodeling of lymphoid innervation. Brain, Behavior, and Immunity 2008 22 1 15 21 2-s2.0-36849052948 10.1016/j.bbi.2007.06.011 (Pubitemid 350225653)
6. Steinbusch H. W. M., Distribution of histaminergic neurons and fibers in rat brain. Comparison with noradrenergic and serotonergic innervation of the vestibular system. Acta Oto-Laryngologica 1991 479, supplement 12 23 2-s2.0-0025924550
7. Greisen G., Autoregulation of cerebral blood flow in newborn babies. Early Human Development 2005 81 5 423 428 2-s2.0-20344403956 10.1016/j.earlhumdev.2005.03.005 (Pubitemid 40791132)
8. Bolz S. S., Pieperhoff S., De Wit C., Pohl U., Chronic increases in transmural pressure reduce NO-mediated dilations in isolated resistance arteries of the hamster. Acta Physiologica Scandinavica 2000 168 1 113 117 2-s2.0-0034009028 10.1046/j.1365-201X.2000.00633.x (Pubitemid 30128676)
9. Rubanyi G. M., Ionic mechanisms involved in the flow- and pressure-sensor function of the endothelium. Zeitschrift fur Kardiologie 1991 80 7 91 94 2-s2.0-0026348589
10. Spurrell B. E., Murphy T. V., Hill M. A., Intraluminal pressure stimulates MAPK phosphorylation in arterioles: temporal dissociation from myogenic contractile response. American Journal of Physiology 2003 285 4 H1764 H1773 2-s2.0-0141453805 (Pubitemid 37169534)
11. Bevan J. A., Shear stress, the endothelium and the balance between flow-induced contraction and dilation in animals and man. International Journal of Microcirculation 1997 17 5 248 256 (Pubitemid 127793873)
12. Pyke K. E., Tschakovsky M. E., The relationship between shear stress and flow-mediated dilatation: implications for the assessment of endothelial function. Journal of Physiology 2005 568 2 357 369 2-s2.0-27644445989 10.1113/jphysiol.2005.089755 (Pubitemid 41555444)
13. Raitakari O. T., Celermajer D. S., Flow-mediated dilatation. British Journal of Clinical Pharmacology 2000 50 5 397 404 2-s2.0-0033737304 10.1046/j.1365-2125.2000.00277.x
14. Chien S., Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell. American Journal of Physiology 2007 292 3 H1209 H1224 2-s2.0-33847767113 10.1152/ajpheart.01047.2006 (Pubitemid 46377111)
15. Chien S., Effects of disturbed flow on endothelial cells. Annals of Biomedical Engineering 2008 36 4 554 562 2-s2.0-40949093622 10.1007/s10439-007- 9426-3
16. Aboualaiwi W. A., Takahashi M., Mell B. R., Jones T. J., Ratnam S., Kolb R. J., Nauli S. M., Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades. Circulation Research 2009 104 7 860 869 2-s2.0-65249117068 10.1161/CIRCRESAHA.108.192765
17. Agutter P. S., Cell mechanics and stress: from molecular details to the "universal cell reaction" and hormesis. BioEssays 2007 29 4 324 333 2-s2.0-34247159023 10.1002/bies.20550 (Pubitemid 46597864)
18. Brown T. D., Techniques for mechanical stimulation of cells in vitro: a review. Journal of Biomechanics 2000 33 1 3 14 2-s2.0-0033990783 10.1016/S0021-9290(99)00177-3
19. Janmey P. A., McCulloch C. A., Cell mechanics: integrating cell responses to mechanical stimuli. Annual Review of Biomedical Engineering 2007 9 1 34 2-s2.0-35348847063 10.1146/annurev.bioeng.9.060906.151927 (Pubitemid 350252899)
20. Stossel T. P., Condeelis J., Cooley L., Hartwig J. H., Noegel A., Schleicher M., Shapiro S. S., Filamins as integrators of cell mechanics and signalling. Nature Reviews Molecular Cell Biology 2001 2 2 138 145 2-s2.0-0035259681 10.1038/35052082 (Pubitemid 33674042)
21. Nauli S. M., Haymour H. S., AbouAlaiwi W. A., Lo S. T., Nauli A. M., Primary cilia are mechanosensory organelles in vestibular tissues. Mechanosensitivity and Mechanotransduction 2011 chapter 14
22. Abdul-Majeed S., Nauli S. M., Calcium-mediated mechanisms of cystic expansion. Biochimica et Biophysica Acta. In press 10.1016/j.bbadis.2010.09.016
23. AbouAlaiwi W. A., Lo S. T., Nauli S. M., Primary cilia: highly sophisticated biological sensors. Sensors 2009 9 9 7003 7020 2-s2.0-70350023377 10.3390/s90907003
24. Nauli S. M., Kawanabe Y., Kaminski J. J., Pearce W. J., Ingber D. E., Zhou J., Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation 2008 117 9 1161 1171 2-s2.0-39849099174 10.1161/CIRCULATIONAHA.107.710111 (Pubitemid 351544064)
25. Berk B. C., Corson M. A., Peterson T. E., Tseng H., Protein kinases as mediators of fluid shear stress stimulated signal transduction in endothelial cells: a hypothesis for calcium-dependent and calcium-independent events activated by flow. Journal of Biomechanics 1995 28 12 1439 1450 2-s2.0-0029589990 10.1016/0021-9290(95)00092-5 (Pubitemid 26004290)
26. Félétou M., Vanhoutte P. M., Endothelium-dependent hyperpolarizations: past beliefs and present facts. Annals of Medicine 2007 39 7 495 516 2-s2.0-35748931462 10.1080/07853890701491000 (Pubitemid 350041557)
27. Ignarro L. J., Cirino G., Casini A., Napoli C., Nitric oxide as a signaling molecule in the vascular system: an overview. Journal of Cardiovascular Pharmacology 1999 34 6 879 886 2-s2.0-0032707717 10.1097/00005344-199912000-00016
28. Nakane M., Soluble guanylyl cyclase: physiological role as an NO receptor and the potential molecular target for therapeutic application. Clinical Chemistry and Laboratory Medicine 2003 41 7 865 870 2-s2.0-0042975272 10.1515/CCLM.2003.131 (Pubitemid 37010177)
29. Bystrevskaia V. B., Antonov A. S., Perov N. A., Primary cilium in the endothelial cells of the human aorta. Doklady Akademii Nauk SSSR 1987 297 5 1233 1236 2-s2.0-0023515787
30. Bystrevskaya V. B., Lichkun V. V., Antonov A. S., Perov N. A., An ultrastructural study of centriolar complexes in adult and embryonic human aortic endothelial cells. Tissue and Cell 1988 20 4 493 503 2-s2.0-0024206489 (Pubitemid 19000938)
31. Haust M. D., Endothelial cilia in human aortic atherosclerotic lesions. Virchows Archiv 1987 410 4 317 326 2-s2.0-0023144794 (Pubitemid 17014607)
32. AbouAlaiwi W. A., wissam.aboualaiwi@utoledo.edu Ratnam S., Booth R. L., Shah J. V., Nauli S. M., surya.nauli@utoledo.edu Endothelial cells from humans and mice with polycystic kidney disease are characterized by polyploidy and chromosome segregation defects through survivin down-regulation. Human Molecular Genetics 2011 20 2 354 367 10.1093/hmg/ddq470
33. Iomini C., Tejada K., Mo W., Vaananen H., Piperno G., Primary cilia of human endothelial cells disassemble under laminar shear stress. Journal of Cell Biology 2004 164 6 811 817 2-s2.0-1642390921 10.1083/jcb.200312133 (Pubitemid 38366893)
34. Collin S. P., Collin H. B., Primary cilia in vertebrate corneal endothelial cells. Cell Biology International 2004 28 2 125 130 2-s2.0-1342324124 10.1016/j.cellbi.2003.11.011 (Pubitemid 38249323)
35. Doughty M. J., Changes in cell surface primary cilia and microvilli concurrent with measurements of fluid flow across the rabbit corneal endothelium ex vivo. Tissue and Cell 1998 30 6 634 643 2-s2.0-0032409213 10.1016/S0040-8166(98)80082-7 (Pubitemid 29043766)
36. Gallagher B. C., Primary cilia of the corneal endothelium. American Journal of Anatomy 1980 159 4 475 484 2-s2.0-0019250082
37. Kojimahara M., Endothelial cilia in rat mesenteric arteries and intramyocardial capillaries. Zeitschrift fur Mikroskopisch-Anatomische Forschung 1990 104 3 412 416 2-s2.0-0025175411 (Pubitemid 20330431)
38. Van der Heiden K., Hierck B. P., Krams R., de Crom R., Cheng C., Baiker M., Pourquie M. J. B. M., Alkemade F. E., DeRuiter M. C., Gittenberger-de Groot A. C., Poelmann R. E., Endothelial primary cilia in areas of disturbed flow are at the base of atherosclerosis. Atherosclerosis 2008 196 2 542 550 2-s2.0-38349126724 10.1016/j.atherosclerosis.2007.05.030
39. Chauvet V., Qian F., Boute N., Cai Y., Phakdeekitacharoen B., Onuchic L. F., Attié-Bitach T., Guicharnaud L., Devuyst O., Germino G. G., Gubler M. C., Expression of PKD1 and PKD2 transcripts and proteins in human embryo and during normal kidney development. American Journal of Pathology 2002 160 3 973 983 2-s2.0-0036118336 (Pubitemid 34224586)
40. Garcia-Gonzalez M. A., Outeda P., Zhou Q., Zhou F., Menezes L. F., Qian F., Huso D. L., Germino G. G., Piontek K. B., kpiontek@jhmi.edu Watnick T., twatnick@jhmi.edu Pkd1 and Pkd2 are required for normal placental development. PLoS ONE 2010 5 9 1 12 10.1371/journal.pone.0012821
41. Ibraghimov-Beskrovnaya O., Dackowski W. R., Foggensteineri L., Coleman N., Thiru S., Petry L. R., Burn T. C., Connors T. D., Van Raay T., Bradley J., Qian F., Onuchic L. F., Watnick T. J., Piontek K., Hakim R. M., Landes G. M., Germino G. G., Sandford R., Klinger K. W., Polycystin: in vitro synthesis, in vivo tissue expression, and subcellular localization identifies a large membrane-associated protein. Proceedings of the National Academy of Sciences of the United States of America 1997 94 12 6397 6402 2-s2.0-2142715025 10.1073/pnas.94.12.6397 (Pubitemid 27270696)
42. Ong A. C., Harris P. C., Biddolph S., Bowker C., Ward C. J., Characterisation and expression of the PKD-1 protein, polycystin, in renal and extrarenal tissues. Kidney International 1999 55 5 2091 2116
43. Pries A. R., Secomb T. W., Control of blood vessel structure: insights from theoretical models. American Journal of Physiology 2005 288 3 H1010 H1015 2-s2.0-13944268316 10.1152/ajpheart.00752.2004 (Pubitemid 40270000)
44. Torres V. E., Role of vasopressin antagonists. Clinical Journal of the American Society of Nephrology 2008 3 4 1212 1218
45. Pries A. R., Secomb T. W., Gaehtgens P., Structural autoregulation of terminal vascular beds: vascular adaptation and development of hypertension. Hypertension 1999 33 1 I 153 161 2-s2.0-0032950486 (Pubitemid 29061856)
46. Shields R. K., Muscular, skeletal, and neural adaptations following spinal cord injury. Journal of Orthopaedic and Sports Physical Therapy 2002 32 2 65 74 2-s2.0-0036158197 (Pubitemid 34113515)
47. Poelmann R. E., Van Der Heiden K., Gittenberger-De Groot A., Hierck B. P., Deciphering the endothelial shear stress sensor. Circulation 2008 117 9 1124 1126 2-s2.0-39849107130 10.1161/CIRCULATIONAHA.107.753889 (Pubitemid 351544055)
48. Van Der Heiden K., Groenendijk B. C. W., Hierck B. P., Hogers B., Koerten H. K., Mommaas A. M., Gittenberger-de Groot A. C., Poelmann R. E., Monocilia on chicken embryonic endocardium in low shear stress areas. Developmental Dynamics 2006 235 1 19 28 2-s2.0-33644975719 10.1002/dvdy.20557 (Pubitemid 46939699)
49. Tarbell J. M., Pahakis M. Y., Mechanotransduction and the glycocalyx. Journal of Internal Medicine 2006 259 4 339 350 2-s2.0-33644931089 10.1111/j.1365-2796.2006.01620.x (Pubitemid 43384225)
50. Weinbaum S., Tarbell J. M., Damiano E. R., The structure and function of the endothelial glycocalyx layer. Annual Review of Biomedical Engineering 2007 9 121 167 2-s2.0-35348904935 10.1146/annurev.bioeng.9.060906.151959 (Pubitemid 350246654)
51. Kolb R. J., Nauli S. M., Ciliary dysfunction in polycystic kidney disease: an emerging model with polarizing potential. Frontiers in Bioscience 2008 13 12 4451 4466 2-s2.0-42549083788 10.2741/3016 (Pubitemid 351589177)
52. Nauli S. M., Alenghat F. J., Luo Y., Williams E., Vassilev P., Li X., Elia A. E. H., Lu W., Brown E. M., Quinn S. J., Ingber D. E., Zhou J., Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nature Genetics 2003 33 2 129 137 2-s2.0-0037317302 10.1038/ng1076 (Pubitemid 36177063)
53. Fick G. M., Johnson A. M., Hammond W. S., Gabow P. A., Causes of death in autosomal dominant polycystic kidney disease. Journal of the American Society of Nephrology 1995 5 12 2048 2056 2-s2.0-0029066047
54. Guay-Woodford L. M., lgw@uab.edu Renal cystic diseases: diverse phenotypes converge on the cilium/centrosome complex. Pediatric Nephrology 2006 21 10 1369 1376 10.1007/s00467-006-0164-9 (Pubitemid 44283467)
55. Lilova M. I., Lilovss@iinf.bas.bg Petkov D. L., Intracranial aneurysms in a child with autosomal recessive polycystic kidney disease. Pediatric Nephrology 2001 16 12 1030 1032 10.1007/s004670100019 (Pubitemid 34026716)
56. Ecder T., Schrier R. W., Cardiovascular abnormalities in autosomal-dominant polycystic kidney disease. Nature Reviews Nephrology 2009 5 4 221 228 2-s2.0-67049114683 10.1038/nrneph.2009.13
57. Perrone R. D., Extrarenal manifestations of ADPKD. Kidney International 1997 51 6 2022 2036 2-s2.0-0031005534 (Pubitemid 27252778)
58. Fick-Brosnahan G. M., Vu Tran Z., Johnson A. M., Strain J. D., Gabow P. A., Progression of autosomal-dominant polycystic kidney disease in children. Kidney International 2001 59 5 1654 1662 2-s2.0-0035058557 10.1046/j.1523-1755. 2001.0590051654.x (Pubitemid 32366566)
59. Gabow P. A., Chapman A. B., Johnson A. M., Tangel T. J., Duley I. T., Kaehny W. D., Manco-Johnson M., Schrier R. W., Renal structure and hypertension in autosomal dominant polycystic kidney disease. Kidney International 1990 38 6 1177 1180 2-s2.0-0025222614
60. Gonzalo A., Gallego A., Rivera M., Orte L., Ortuño J., Influence of hypertension on early renal insufficiency in autosomal dominant polycystic kidney disease. Nephron 1996 72 2 225 230 2-s2.0-0030027322 (Pubitemid 26035381)
61. Kelleher C. L., McFann K. K., Johnson A. M., Schrier R. W., Characteristics of hypertension in young adults with autosomal dominant polycystic kidney disease compared with the general U.S. population. American Journal of Hypertension 2004 17 11 1029 1034 2-s2.0-7944234504 10.1016/j.amjhyper.2004.06.020 (Pubitemid 39469325)
62. Schrier R. W., Johnson A. M., McFann K., Chapman A. B., The role of parental hypertension in the frequency and age of diagnosis of hypertension in offspring with autosomal-dominant polycystic kidney disease. Kidney International 2003 64 5 1792 1799 2-s2.0-0142218066 10.1046/j.1523-1755.2003. 00264.x (Pubitemid 37323709)
63. Sedman A., Bell P., Manco-Johnson M., Autosomal dominant polycystic kidney disease in childhood: a longitudinal study. Kidney International 1987 31 4 1000 1005 (Pubitemid 17044908)
64. Fick G. M., Duley I. T., Johnson A. M., Strain J. D., Manco-Johnson M. L., Gabow P. A., The spectrum of autosomal dominant polycystic kidney disease in children. Journal of the American Society of Nephrology 1994 4 9 1654 1660 2-s2.0-0028391224
65. Ivy D. D., Shaffer E. M., Johnson A. M., Kimberling W. J., Dobin A., Gabow P. A., Cardiovascular abnormalities in children with autosomal dominant polycystic kidney disease. Journal of the American Society of Nephrology 1995 5 12 2032 2036 2-s2.0-0029060684
66. Shamshirsaz A., Bekheirnia R. M., Kamgar M., Johnson A. M., McFann K., Cadnapaphornchai M., Haghighi N. N., Schrier R. W., Autosomal-dominant polycystic kidney disease in infancy and childhood: progression and outcome. Kidney International 2005 68 5 2218 2224 2-s2.0-30944440481 10.1111/j.1523-1755. 2005.00678.x (Pubitemid 43117796)
67. Chapman A. B., Schrier R. W., Pathogenesis of hypertension in autosomal dominant polycystic kidney disease. Seminars in Nephrology 1991 11 6 653 660 2-s2.0-0025876084
68. Ecder T., Schrier R. W., Hypertension in autosomal-dominant polycystic kidney disease: early occurrence and unique aspects. Journal of the American Society of Nephrology 2001 12 1 194 200 2-s2.0-0035161149 (Pubitemid 32056806)
69. Clausen P., Feldt-Rasmussen B., Iversen J., Lange M., Eidemak I., Strandgaard S., Flow-associated dilatory capacity of the brachial artery is intact in early autosomal dominant polycystic kidney disease. American Journal of Nephrology 2006 26 4 335 339 2-s2.0-33748703467 10.1159/000094402 (Pubitemid 44394151)
70. Wang D., Strandgaard S., Borresen M. L., Luo Z., Connors S. G., Yan Q., Wilcox C. S., Asymmetric dimethylarginine and lipid peroxidation products in early autosomal dominant polycystic kidney disease. American Journal of Kidney Diseases 2008 51 2 184 191 2-s2.0-38349070335 10.1053/j.ajkd.2007.09.020
71. Wang D., Iversen J., Strandgaard S., Endothelium-dependent relaxation of small resistance vessels is impaired in patients with autosomal dominant polycystic kidney disease. Journal of the American Society of Nephrology 2000 11 8 1371 1376 2-s2.0-0033914195 (Pubitemid 30483453)
72. Wang D., Iversen J., Wilcox C. S., Strandgaard S., Endothelial dysfunction and reduced nitric oxide in resistance arteries in autosomal-dominant polycystic kidney disease. Kidney International 2003 64 4 1381 1388 2-s2.0-0141786849 10.1046/j.1523-1755.2003.00236.x (Pubitemid 37153804)
73. Wang D., Strandgaard S., The pathogenesis of hypertension in autosomal dominant polycystic kidney disease. Journal of Hypertension 1997 15 9 925 933 2-s2.0-0030847563 10.1097/00004872-199715090-00002 (Pubitemid 27399806)
74. Al-Nimri M. A., Komers R., Oyama T. T., Subramanya A. R., Lindsley J. N., Anderson S., Endothelial-derived vasoactive mediators in polycystic kidney disease. Kidney International 2003 63 5 1776 1784 2-s2.0-0037407250 10.1046/j.1523-1755.2003.00913.x (Pubitemid 36513323)
75. Merta M., Merta@mbox.cesnet.cz Reiterová J., Ryšavá R., Tesař V., Závada J., Jáchymová M., Zima T., Role of endothelin and nitric oxide in the pathogenesis of arterial hypertension in autosomal dominant polycystic kidney disease. Physiological Research 2003 52 4 433 437 (Pubitemid 37039907)
76. Chapman A. B., Johnson A., Gabow P. A., Schrier R. W., The renin-angiotensin-aldosterone system and autosomal dominant polycystic kidney disease. New England Journal of Medicine 1990 323 16 1091 1096 2-s2.0-0025047248 (Pubitemid 20370729)
77. Ecder T., Chapman A. B., Brosnahan G. M., Edelstein C. L., Johnson A. M., Schrier R. W., Effect of antihypertensive therapy on renal function and urinary albumin excretion in hypertensive patients with autosomal dominant polycystic kidney disease. American Journal of Kidney Diseases 2000 35 3 427 432
78. Graham P. C., Lindop G. B. M., The anatomy of the renin-secreting cell in adult polycystic kidney disease. Kidney International 1988 33 6 1084 1090 2-s2.0-0023928183
79. Keith D. S., Torres V. E., Johnson C. M., Holley K. E., Effect of sodium chloride, enalapril, and losartan on the development of polycystic kidney disease in Han:SPRD rats. American Journal of Kidney Diseases 1994 24 3 491 498 2-s2.0-0027935786 (Pubitemid 24277947)
80. Schrier R., McFann K., Johnson A., Chapman A., Edelstein C., Brosnahan G., Ecder T., Tison L., Cardiac and renal effects of standard versus rigorous blood pressure control in autosomal-dominant polycystic kidney disease: results of a seven-year prospective randomized study. Journal of the American Society of Nephrology 2002 13 7 1733 1739 2-s2.0-0036295073 10.1097/01.ASN.0000018407. 60002.B9 (Pubitemid 34700597)
81. Ramunni A., Saracino A., Esposito T., Saliani M. T., Coratelli P., Renal vascular resistance and renin-angiotensin system in the pathogenesis of early hypertension in autosomal dominant polycystic kidney disease. Hypertension Research 2004 27 4 221 225 2-s2.0-2342452477 10.1291/hypres.27.221 (Pubitemid 38594392)
82. Kaspareit-Rittinghausen J., Deerberg F., Rapp K. G., Wcislo A., Renal hypertension in rats with hereditary polycystic kidney disease. Zeitschrift fur Versuchstierkunde 1990 33 5 201 204 2-s2.0-0025669073
83. Lavoie J. L., Lake-Bruse K. D., Sigmund C. D., Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule. American Journal of Physiology 2004 286 5 F965 F971 2-s2.0-1942535146 10.1152/ajprenal.00402.2003 (Pubitemid 38508997)
84. Chapman A. B., Gabow P. A., Hypertension in autosomal dominant polycystic kidney disease. Kidney International 1997 51 61, supplement S71 S73 2-s2.0-0001216793
85. Mcpherson E. A., Luo Z., Brown R. A., Lebard L. S., Corless C. C., Speth R. C., Bagby S. P., Chymase-like angiotensin II-generating activity in end-stage human autosomal dominant polycystic kidney disease. Journal of the American Society of Nephrology 2004 15 2 493 500 2-s2.0-0942298005 10.1097/01.ASN. 0000109782.28991.26 (Pubitemid 38140792)
86. Azurmendi P. J., Fraga A. R., Galan F. M., Kotliar C., Arrizurieta E. E., Valdez M. G., Forcada P. J., Stefan J. S. S., Martin R. S., Early renal and vascular changes in ADPKD patients with low-grade albumin excretion and normal renal function. Nephrology Dialysis Transplantation 2009 24 8 2458 2463 2-s2.0-67651102712 10.1093/ndt/gfp136
87. Itty C. T., Farshid A., Talaulikar G., Spontaneous coronary artery dissection in a woman with polycystic kidney disease. American Journal of Kidney Diseases 2009 53 3 518 521 2-s2.0-60149094531 10.1053/j.ajkd.2008.08.027
88. Rong S., Jin X., Ye C., Chen J., Mei C., Carotid vascular remodelling in patients with autosomal dominant polycystic kidney disease. Nephrology 2009 14 1 113 117 2-s2.0-63149188655 10.1111/j.1440-1797.2008.01049.x
89. Sawicki M., Walecka A., Rozanski J., Safranow K., Ciechanowski K., Doppler sonography measurements of renal vascular resistance in autosomal-dominant polycystic kidney disease. Medical Science Monitor 2009 15 8 MT101 MT104 2-s2.0-68449093983
90. Turkmen K., Oflaz H., Uslu B., Cimen A. O., Elitok A., Kasikcioglu E., Alisir S., Tufan F., Namli S., Uysal M., Ecder T., Coronary flow velocity reserve and carotid intima media thickness in patients with autosomal dominant polycystic kidney disease: from impaired tubules to impaired carotid and coronary arteries. Clinical Journal of the American Society of Nephrology 2008 3 4 986 991 2-s2.0-49149106386 10.2215/CJN.02330607
91. Arnaout M. A., Molecular genetics and pathogenesis of autosomal dominant polycystic kidney disease. Annual Review of Medicine 2001 52 93 123 2-s2.0-0035127256 10.1146/annurev.med.52.1.93 (Pubitemid 32195317)
92. Boulter C., Mulroy S., Webb S., Fleming S., Brindle K., Sandford R., Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene. Proceedings of the National Academy of Sciences of the United States of America 2001 98 21 12174 12179 2-s2.0-0035834136 10.1073/pnas. 211191098 (Pubitemid 32959846)
93. Kim K., Drummond I., Ibraghimov-Beskrovnaya O., Klinger K., Arnaout M. A., Polycystin 1 is required for the structural integrity of blood vessels. Proceedings of the National Academy of Sciences of the United States of America 2000 97 4 1731 1736 2-s2.0-0034652247 10.1073/pnas.040550097 (Pubitemid 30118511)
94. Muto S., Aiba A., Saito Y., Nakao K., Nakamura K., Tomita K., Kitamura T., Kurabayashi M., Nagai R., Higashihara E., Harris P. C., Katsuki M., Horie S., Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant. Human Molecular Genetics 2002 11 15 1731 1742 2-s2.0-0037098955 (Pubitemid 34812094)
95. Wu G., Markowitz G. S., Li L., D'Agati V. D., Factor S. M., Geng L., Tibara S., Tuchman J., Cai Y., Park J. H., Van Adelsberg J., Hou H., Kucherlapati R., Edelmann W., Somlo S., Cardiac defects and renal failure in mice with targeted mutations in Pkd2. Nature Genetics 2000 24 1 75 78 2-s2.0-0033989173 10.1038/71724 (Pubitemid 30041425)
96. Klein I. H. H. T., Ligtenberg G., Oey P. L., Koomans H. A., Blankestijn P. J., Sympathetic activity is increased in polycystic kidney disease and is associated with hypertension. Journal of the American Society of Nephrology 2001 12 11 2427 2433 2-s2.0-0034758803 (Pubitemid 33021120)
97. Neumann J., Ligtenberg G., Klein I. H. H. T., Blankestijn P. J., Pathogenesis and treatment of hypertension in polycystic kidney disease. Current Opinion in Nephrology and Hypertension 2002 11 5 517 521 2-s2.0-0036736788 10.1097/00041552-200209000-00007
98. Zeltner R., Poliak R., Stiasny B., Schmieder R. E., Schulze B. D., Renal and cardiac effects of antihypertensive treatment with ramipril vs metoprolol in autosomal dominant polycystic kidney disease. Nephrology Dialysis Transplantation 2008 23 2 573 579 2-s2.0-44449147488 10.1093/ndt/gfm731 (Pubitemid 351767642)
99. Masoumi A., Reed-Gitomer B., Kelleher C., Bekheirnia M. R., Schrier R. W., Developments in the management of autosomal dominant polycystic kidney disease. Therapeutics and Clinical Risk Management 2008 4 2 393 407 2-s2.0-44049091438 (Pubitemid 351711998)
100. Mancia G., Dell'Oro R., Quarti-Trevano F., Scopelliti F., Grassi G., Angiotensin-sympathetic system interactions in cardiovascular and metabolic disease. Journal of Hypertension 2006 24 1 S51 S56 2-s2.0-33745538005 10.1097/01.hjh.0000220407.84363.fb (Pubitemid 44336824)
101. Van Den Meiracker A. H., Boomsma F., The angiotensin II-sympathetic nervous system connection. Journal of Hypertension 2003 21 8 1453 1454 2-s2.0-0043240011 10.1097/00004872-200308000-00005 (Pubitemid 36994120)
102. Gattone II V. H., vgattone@iupui.edu Siqueira Jr. T. M., Powell C. R., Trambaugh C. M., Lingeman J. E., Shalhav A. L., Contribution of renal innervation to hypertension in rat autosomal dominant polycystic kidney disease. Experimental Biology and Medicine 2008 233 8 952 957 10.3181/0802-RM-54
103. Florijn K. W., Chang P. C., Van der Woude F. J., Van Bockel J. H., Van Saase J. L. C. M., Long-term cardiovascular morbidity and mortality in autosomal dominant polycystic kidney disease patients after renal transplantation. Transplantation 1994 57 1 73 81 (Pubitemid 24032743)
104. Shiroyanagi Y., Tanabe K., Hashimoto Y., Okuda H., Oshima T., Tokumoto T., Ishikawa N., Tomq H., Kidney transplantation in the recipient with autosomal-dominant polycystic kidney disease: a single center experience. Transplantation Proceedings 2000 32 7 1841 1843 2-s2.0-0033674949 10.1016/S0041-1345(00)01457-3
105. AbouAlaiwi W. A., wissam.aboualaiwi@utoledo.edu Ratnam S., Booth R. L., Shah J. V., Nauli S. M., surya.nauli@utoledo.edu Endothelial cells from humans and mice with polycystic kidney disease are characterized by polyploidy and chromosome segregation defects through survivin down-regulation. Human Molecular Genetics 2011 20 2 354 367 10.1093/hmg/ddq470
106. Egorova A. D., Khedoe P. P., Goumans M.-J., Yoder B. K., Nauli S. M., Ten Dijke P., Poelmann R. E., Hierck B. P., B.P.Hierck@LUMC.nl Lack of primary cilia primes shear-induced endothelial-to-mesenchymal transition. Circulation Research 2011 108 9 1093 1101 10.1161/CIRCRESAHA.110.231860
107. Lu C. J., Du H., Wu J., Jansen D. A., Jordan K. L., Xu N., Sieck G. C., Qian Q., Non-random distribution and sensory functions of primary cilia in vascular smooth muscle cells. Kidney and Blood Pressure Research 2008 31 3 171 184 2-s2.0-46249097666 10.1159/000132462 (Pubitemid 351915044)
108. Wu J., Du H., Wang X., Mei C., Sieck G. C., Qian Q., Characterization of primary cilia in human airway smooth muscle cells. Chest 2009 136 2 561 570 2-s2.0-68849099883 10.1378/chest.08-1549