Mitochondrial DNA copy number, but not haplogroup, confers a genetic susceptibility to leprosy in Han Chinese from Southwest China

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Wang, Dong ^a,e   Su, Ling Yan ^a,e   Zhang, A Mei ^a   Li, Yu Ye ^b   Li, Xiao An ^c   Chen, Ling Ling ^b   Long, Heng ^d   Yao, Yong Gang ^a  

^a KUNMING INSTITUTE OF ZOOLOGY   (China)

^b KUNMING MEDICAL UNIVERSITY   (China)

^c Yuxi City Center for Disease Control and Prevention   (China)

^d Wenshan Institute of Dermatology   (China)

^e UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

ADOLESCENT; ADULT; AGED; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; GENE DOSAGE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HUMAN; LEPROSY; MAJOR CLINICAL STUDY; MALE; RISK ASSESSMENT;

BASE SEQUENCE; CASE-CONTROL STUDIES; CHINA; DNA PRIMERS; DNA, MITOCHONDRIAL; ETHNIC GROUPS; GENE DOSAGE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LEPROSY;

EID: 84862504928     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038848     Document Type: Article

References (44)

1. WHO (2010) Global leprosy situation, 2010. Wkly Epidemiol Rec 85: 337-348.
2. Li Y-Y, Li X-A, He L, Wang D, Chen W-Y, et al. (2011) Trends in new leprosy case detection over 57 years (1952-2008) in Yuxi, Yunnan Province of Southwest China. Lepr Rev 82: 6-16.
3. Monot M, Honoré N, Garnier T, Zidane N, Sherafi D, et al. (2009) Comparative genomic and phylogeographic analysis of Mycobacterium leprae. Nat Genet 41: 1282-1289.
4. Cole ST, Eiglmeier K, Parkhill J, James KD, Thomson NR, et al. (2001) Massive gene decay in the leprosy bacillus. Nature 409: 1007-1011.
5. Misch EA, Berrington WR, Vary JC Jr, Hawn TR, (2010) Leprosy and the human genome. Microbiol Mol Biol Rev 74: 589-620.
6. Britton WJ, Lockwood DN, (2004) Leprosy. Lancet 363: 1209-1219.
7. Alcaïs A, Mira M, Casanova JL, Schurr E, Abel L, (2005) Genetic dissection of immunity in leprosy. Curr Opin Immunol 17: 44-48.
8. Alter A, Grant A, Abel L, Alcaïs A, Schurr E, (2011) Leprosy as a genetic disease. Mamm Genome 22: 19-31.
9. McWhirter SM, TenOever BR, Maniatis T, (2005) Connecting mitochondria and innate immunity. Cell 122: 645-647.
10. Arnoult D, Soares F, Tattoli I, Girardin SE, (2011) Mitochondria in innate immunity. EMBO Rep 12: 901-910.
11. Kong Q-P, Bandelt H-J, Sun C, Yao Y-G, Salas A, et al. (2006) Updating the East Asian mtDNA phylogeny: a prerequisite for the identification of pathogenic mutations. Hum Mol Genet 15: 2076-2086.
12. Torroni A, Achilli A, Macaulay V, Richards M, Bandelt H-J, (2006) Harvesting the fruit of the human mtDNA tree. Trends Genet 22: 339-345.
13. Ji Y, Zhang A-M, Jia X, Zhang Y-P, Xiao X, et al. (2008) Mitochondrial DNA haplogroups M7b1'2 and M8a affect clinical expression of Leber hereditary optic neuropathy in Chinese families with the m.11778G>A mutation. Am J Hum Genet 83: 760-768.
14. Hudson G, Carelli V, Spruijt L, Gerards M, Mowbray C, et al. (2007) Clinical expression of Leber hereditary optic neuropathy is affected by the mitochondrial DNA-haplogroup background. Am J Hum Genet 81: 228-233.
15. Achilli A, Olivieri A, Pala M, Hooshiar Kashani B, Carossa V, et al. (2011) Mitochondrial DNA backgrounds might modulate diabetes complications rather than T2DM as a whole. PLoS One 6: e21029.
16. Fuku N, Park KS, Yamada Y, Nishigaki Y, Cho YM, et al. (2007) Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians. Am J Hum Genet 80: 407-415.
17. Hendrickson SL, Hutcheson HB, Ruiz-Pesini E, Poole JC, Lautenberger J, et al. (2008) Mitochondrial DNA haplogroups influence AIDS progression. AIDS 22: 2429-2439.
18. Baudouin SV, Saunders D, Tiangyou W, Elson JL, Poynter J, et al. (2005) Mitochondrial DNA and survival after sepsis: a prospective study. Lancet 366: 2118-2121.
19. Moraes CT, (2001) What regulates mitochondrial DNA copy number in animal cells? Trends Genet 17: 199-205.
20. Xing J, Chen M, Wood CG, Lin J, Spitz MR, et al. (2008) Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma. J Natl Cancer Inst 100: 1104-1112.
21. Lan Q, Lim U, Liu C-S, Weinstein SJ, Chanock S, et al. (2008) A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma. Blood 112: 4247-4249.
22. Clay Montier LL, Deng JJ, Bai Y, (2009) Number matters: control of mammalian mitochondrial DNA copy number. J Genet Genomics 36: 125-131.
23. Rötig A, Poulton J, (2009) Genetic causes of mitochondrial DNA depletion in humans. Biochim Biophys Acta 1792: 1103-1108.
24. Ridley DS, Jopling WH, (1966) Classification of leprosy according to immunity. A five-group system. Int J Lepr Other Mycobact Dis 34: 255-273.
25. WHO (1982) WHO Technical Report Series, no. 675. Geneva: World Health Organization; Chemotherapy of leprosy for control programmes.
26. WHO (1988) WHO expert committee on leprosy. Sixth report. Geneva (WHO technical report series, no. 768).
27. Yao Y-G, Childs RW, Kajigaya S, McCoy JP Jr, Young NS, (2007) Mitochondrial DNA sequence heterogeneity of single CD34+ cells after nonmyeloablative allogeneic stem cell transplantation. Stem Cells 25: 2670-2676.
28. Zhang A-M, Jia X, Bi R, Salas A, Li S, et al. (2011) Mitochondrial DNA haplogroup background affects LHON, but not suspected LHON, in Chinese patients. PLoS One 6: e27750.
29. Andrews RM, Kubacka I, Chinnery PF, Lightowlers RN, Turnbull DM, et al. (1999) Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA. Nat Genet 23: 147.
30. Kong Q-P, Sun C, Wang H-W, Zhao M, Wang W-Z, et al. (2011) Large-scale mtDNA screening reveals a surprising matrilineal complexity in east Asia and its implications to the peopling of the region. Mol Biol Evol 28: 513-522.
31. Bi R, Zhang A-M, Zhang W, Kong Q-P, Wu B-L, et al. (2010) The acquisition of an inheritable 50-bp deletion in the human mtDNA control region does not affect the mtDNA copy number in peripheral blood cells. Hum Mutat 31: 538-543.
32. Miller FJ, Rosenfeldt FL, Zhang C, Linnane AW, Nagley P, (2003) Precise determination of mitochondrial DNA copy number in human skeletal and cardiac muscle by a PCR-based assay: lack of change of copy number with age. Nucleic Acids Res 31: e61.
33. Pyle A, Burn DJ, Gordon C, Swan C, Chinnery PF, et al. (2010) Fall in circulating mononuclear cell mitochondrial DNA content in human sepsis. Intensive Care Med 36: 956-962.
34. Wang C, Liu X, Wei B, (2011) Mitochondrion: an emerging platform critical for host antiviral signaling. Expert Opin Ther Targets 15: 647-665.
35. Modlin RL, (2010) The innate immune response in leprosy. Current Opinion in Immunology 22: 48-54.
36. Montoya D, Modlin RL, (2010) Learning from leprosy: insight into the human innate immune response. Adv Immunol 105: 1-24.
37. Huebinger RM, Gomez R, McGee D, Chang LY, Bender JE, et al. (2010) Association of mitochondrial allele 4216C with increased risk for sepsis-related organ dysfunction and shock after burn injury. Shock 33: 19-23.
38. Yang Y, Shou Z, Zhang P, He Q, Xiao H, et al. (2008) Mitochondrial DNA haplogroup R predicts survival advantage in severe sepsis in the Han population. Genet Med 10: 187-192.
39. García-Álvarez M, Guzmán-Fulgencio M, Berenguer J, Micheloud D, Campos Y, et al. (2011) European mitochondrial DNA haplogroups and liver fibrosis in HIV and hepatitis C virus coinfected patients. AIDS 25: 1619-1926.
40. Salas A, Fachal L, Marcos-Alonso S, Vega A, Martinon-Torres F, (2009) Investigating the role of mitochondrial haplogroups in genetic predisposition to meningococcal disease. PLoS One 4: e8347.
41. Côté HC, Day AG, Heyland DK, (2007) Longitudinal increases in mitochondrial DNA levels in blood cells are associated with survival in critically ill patients. Crit Care 11: R88.
42. Walker SL, Lockwood DN, (2006) The clinical and immunological features of leprosy. Br Med Bull 77-78: 103-121.
43. Lee H-C, Yin P-H, Lu C-Y, Chi C-W, Wei Y-H, (2000) Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells. Biochem J 348: 425-432.
44. Soriano A, Miró O, Mensa J, (2005) Mitochondrial toxicity associated with linezolid. N Engl J Med 353: 2305-2306.